DK2021330T3 - Benzimidazolmodulatorer af VR1 - Google Patents

Benzimidazolmodulatorer af VR1

Info

Publication number: DK2021330T3
Authority: DK; Denmark
Prior art keywords: benzimidazole; modulators; benzimidazole modulators
Prior art date: 2006-05-03

Application number

DK07760746.3T

Other languages

English (en)

Inventor

Mark A Youngman

Derek A Beauchamp

Raul L Calvo

Mark R Player

Scott L Dax

William H Parsons

Michael Brandt

Sharmila Patel

Jian Liu

Wing S Cheung

Michele C Jetter

Yu-Kai Lee

Wenxi Pan

Kenneth M Wells

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-05-03

Filing date

2007-04-17

Publication date

2010-12-06

2007-04-17 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2010-12-06 Application granted granted Critical

2010-12-06 Publication of DK2021330T3 publication Critical patent/DK2021330T3/da

Links

HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK07760746.3T 2006-05-03 2007-04-17 Benzimidazolmodulatorer af VR1 DK2021330T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US79750406P	2006-05-03	2006-05-03
PCT/US2007/066748 WO2007130780A2 (en)	2006-05-03	2007-04-17	Benzimidazole modulators of vr1

Publications (1)

Publication Number	Publication Date
DK2021330T3 true DK2021330T3 (da)	2010-12-06

Family

ID=38566108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK07760746.3T DK2021330T3 (da)	2006-05-03	2007-04-17	Benzimidazolmodulatorer af VR1

Country Status (36)

Country	Link
US (3)	US7951829B2 (da)
EP (1)	EP2021330B1 (da)
JP (1)	JP5302884B2 (da)
KR (1)	KR101434883B1 (da)
CN (1)	CN101511797B (da)
AR (1)	AR060840A1 (da)
AT (1)	ATE482201T1 (da)
AU (1)	AU2007248341C1 (da)
BR (1)	BRPI0709803B8 (da)
CA (1)	CA2651128C (da)
CO (1)	CO6160329A2 (da)
CR (1)	CR10479A (da)
CY (1)	CY1111269T1 (da)
DE (1)	DE602007009378D1 (da)
DK (1)	DK2021330T3 (da)
EA (1)	EA019386B1 (da)
EC (1)	ECSP088854A (da)
ES (1)	ES2350959T3 (da)
HR (1)	HRP20100700T1 (da)
IL (1)	IL194916A (da)
JO (1)	JO3602B1 (da)
MX (1)	MX2008014108A (da)
MY (1)	MY154595A (da)
NI (1)	NI200800290A (da)
NO (1)	NO341965B1 (da)
NZ (1)	NZ572251A (da)
PE (1)	PE20080065A1 (da)
PL (1)	PL2021330T3 (da)
PT (1)	PT2021330E (da)
RS (1)	RS51473B (da)
SI (1)	SI2021330T1 (da)
TW (1)	TWI419882B (da)
UA (1)	UA94749C2 (da)
UY (1)	UY30322A1 (da)
WO (1)	WO2007130780A2 (da)
ZA (1)	ZA200810234B (da)

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KR101503286B1 (ko) *	2006-12-15	2015-03-17	얀센 파마슈티카 엔.브이.	벤즈이미다졸 ｔｒｐｖ1 저해제
US20090092574A1 (en)	2006-12-29	2009-04-09	Scott Richard W	Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
WO2009078999A1 (en) *	2007-12-17	2009-06-25	Janssen Pharmaceutica N.V.	Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1
WO2009079000A1 (en) *	2007-12-17	2009-06-25	Janssen Pharmaceutica N.V.	Imidazolopyrimidine modulators of trpv1
EP2264031B1 (en) *	2008-04-18	2015-04-15	Daewoong Pharmaceutical Co., Ltd.	A novel benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof
US8232409B2 (en)	2008-10-15	2012-07-31	Janssen Pharmaceutica N.V.	Heterocyclic benzimidazoles as TRPM8 modulators
US8217060B2 (en)	2009-05-15	2012-07-10	Janssen Pharmaceutica, Nv	Benzimidazole derivatives useful as TRP M8 receptor modulators
US8323805B2 (en) *	2009-06-04	2012-12-04	Nitto Denko Corporation	Emissive aryl-heteroaryl acetylenes
CN102002010A (zh) *	2009-08-31	2011-04-06	住友化学株式会社	双噁唑啉基烷烃化合物的精制方法
RU2606128C2 (ru)	2011-05-16	2017-01-10	Селлсьютикс Корпорейшн	Соединения для применения в лечении мукозита
US9056874B2 (en)	2012-05-04	2015-06-16	Novartis Ag	Complement pathway modulators and uses thereof
CN105229003B (zh)	2013-03-14	2017-03-15	诺华股份有限公司	作为补体因子b抑制剂用于治疗眼科疾病的2‑(1h‑吲哚‑4‑基甲基)‑3h‑咪唑并[4,5‑b]吡啶‑6‑甲腈衍生物
CA2917964A1 (en) *	2013-07-11	2015-01-15	Bristol-Myers Squibb Company	Ido inhibitors
CN105849090A (zh)	2013-10-30	2016-08-10	诺华股份有限公司	2-苄基-苯并咪唑补体因子b抑制剂及其用途
EP3348554B1 (en) *	2015-09-08	2020-05-06	Sumitomo Chemical Company, Limited	Method for producing triazole compound
EP3534888B1 (en) *	2016-11-01	2022-04-06	Merck Sharp & Dohme Corp.	Substituted bicyclic heteroaryl allosteric modulators of nicotinic acetylcholine receptors
HUE062273T2 (hu) *	2018-05-03	2023-10-28	Jiangsu Hengrui Pharmaceuticals Co Ltd	Benzimidazolszármazékok mint a retinsavreceptor rokon árvareceptor-gamma (RORy) modulátorai és gyógyszerészeti felhasználásaik
CN108997398B (zh) *	2018-07-23	2020-12-15	被忽略疾病药物研发组织	一种3,3-二甲基苯并[c][1,2]氧杂戊硼烷-1(3h)-醇的制备方法
CN112745268B (zh) *	2019-10-31	2022-09-16	江苏恒瑞医药股份有限公司	苯并咪唑衍生物的晶型及制备方法
AU2020377114A1 (en) *	2019-10-31	2022-06-16	Jiangsu Hengrui Medicine Co., Ltd.	Acid addition salt of RORγ regulator
US11771694B2 (en)	2020-06-05	2023-10-03	Innovation Pharmaceuticals Inc.	Arylamide compounds for treatment and prevention of viral infections

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US5612360A (en) *	1992-06-03	1997-03-18	Eli Lilly And Company	Angiotensin II antagonists
US6299796B1 (en)	1997-12-18	2001-10-09	Fuji Photo Film Co., Ltd.	Styryl compound, method for the preparation thereof and electroluminescent element employing the same
US6748803B1 (en) *	2000-02-22	2004-06-15	Simmonds Precison Products, Inc.	Liquid measurement system and shared interface apparatus for use therein
AU2003301436A1 (en) *	2002-10-17	2004-05-04	Amgen Inc.	Benzimidazole derivatives and their use as vanilloid receptor ligands
TW200418806A (en) *	2003-01-13	2004-10-01	Fujisawa Pharmaceutical Co	HDAC inhibitor
PT1660491E (pt) *	2003-07-28	2008-10-10	Janssen Pharmaceutica Nv	Derivados de benzimidazole, benzotiazole e benzoxazole e a sua utilização como moduladores de lta4h
KR20060115396A (ko) *	2003-10-28	2006-11-08	버텍스 파마슈티칼스 인코포레이티드	이온 채널 조절인자로서 유용한 벤즈이미다졸
WO2006058338A2 (en) *	2004-11-29	2006-06-01	Janssen Pharmaceutica N.V.	4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor
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KR101503286B1 (ko) *	2006-12-15	2015-03-17	얀센 파마슈티카 엔.브이.	벤즈이미다졸 ｔｒｐｖ1 저해제

2007
- 2007-04-13 US US11/734,984 patent/US7951829B2/en active Active
- 2007-04-17 SI SI200730410T patent/SI2021330T1/sl unknown
- 2007-04-17 RS RSP-2010/0493A patent/RS51473B/sr unknown
- 2007-04-17 DK DK07760746.3T patent/DK2021330T3/da active
- 2007-04-17 HR HR20100700T patent/HRP20100700T1/hr unknown
- 2007-04-17 BR BRPI0709803A patent/BRPI0709803B8/pt active IP Right Grant
- 2007-04-17 WO PCT/US2007/066748 patent/WO2007130780A2/en not_active Ceased
- 2007-04-17 JP JP2009509920A patent/JP5302884B2/ja active Active
- 2007-04-17 MX MX2008014108A patent/MX2008014108A/es active IP Right Grant
- 2007-04-17 AU AU2007248341A patent/AU2007248341C1/en active Active
- 2007-04-17 EP EP07760746A patent/EP2021330B1/en active Active
- 2007-04-17 KR KR1020087029196A patent/KR101434883B1/ko active Active
- 2007-04-17 PL PL07760746T patent/PL2021330T3/pl unknown
- 2007-04-17 CN CN2007800247619A patent/CN101511797B/zh active Active
- 2007-04-17 AT AT07760746T patent/ATE482201T1/de active
- 2007-04-17 CA CA2651128A patent/CA2651128C/en active Active
- 2007-04-17 PT PT07760746T patent/PT2021330E/pt unknown
- 2007-04-17 ES ES07760746T patent/ES2350959T3/es active Active
- 2007-04-17 NZ NZ572251A patent/NZ572251A/xx unknown
- 2007-04-17 DE DE602007009378T patent/DE602007009378D1/de active Active
- 2007-04-17 UA UAA200813889A patent/UA94749C2/ru unknown
- 2007-04-17 EA EA200870497A patent/EA019386B1/ru unknown
- 2007-04-25 JO JOP/2007/0165A patent/JO3602B1/ar active
- 2007-05-02 PE PE2007000543A patent/PE20080065A1/es active IP Right Grant
- 2007-05-02 TW TW096115519A patent/TWI419882B/zh active
- 2007-05-02 AR ARP070101901A patent/AR060840A1/es active IP Right Grant
- 2007-05-03 UY UY30322A patent/UY30322A1/es not_active Application Discontinuation
2008
- 2008-10-26 IL IL194916A patent/IL194916A/en active IP Right Grant
- 2008-10-29 CO CO08115664A patent/CO6160329A2/es unknown
- 2008-10-30 MY MYPI20084339A patent/MY154595A/en unknown
- 2008-10-31 EC EC2008008854A patent/ECSP088854A/es unknown
- 2008-11-03 NI NI200800290A patent/NI200800290A/es unknown
- 2008-12-02 ZA ZA2008/10234A patent/ZA200810234B/en unknown
- 2008-12-02 NO NO20085031A patent/NO341965B1/no unknown
- 2008-12-03 CR CR10479A patent/CR10479A/es not_active Application Discontinuation
2010
- 2010-12-17 CY CY20101101167T patent/CY1111269T1/el unknown
2011
- 2011-04-12 US US13/084,705 patent/US20110190344A1/en not_active Abandoned
- 2011-04-12 US US13/084,718 patent/US20110190364A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JO3602B1 (ar)	2020-07-05
CA2651128A1 (en)	2007-11-15
UA94749C2 (en)	2011-06-10
KR20090008428A (ko)	2009-01-21
EA019386B1 (ru)	2014-03-31
US7951829B2 (en)	2011-05-31
EA200870497A1 (ru)	2009-06-30
TW200808738A (en)	2008-02-16
SI2021330T1 (sl)	2011-01-31
WO2007130780A3 (en)	2008-02-14
RS51473B (sr)	2011-04-30
KR101434883B1 (ko)	2014-08-27
AU2007248341B2 (en)	2011-12-08
IL194916A0 (en)	2009-08-03
HRP20100700T1 (hr)	2011-02-28
BRPI0709803B8 (pt)	2021-05-25
US20110190364A1 (en)	2011-08-04
MX2008014108A (es)	2008-11-14
CY1111269T1 (el)	2015-08-05
CR10479A (es)	2009-03-31
WO2007130780A2 (en)	2007-11-15
PE20080065A1 (es)	2008-02-25
NO20085031L (no)	2009-01-06
EP2021330A2 (en)	2009-02-11
NO341965B1 (no)	2018-03-05
PL2021330T3 (pl)	2011-03-31
TWI419882B (zh)	2013-12-21
CN101511797A (zh)	2009-08-19
AR060840A1 (es)	2008-07-16
IL194916A (en)	2013-01-31
PT2021330E (pt)	2010-12-03
ATE482201T1 (de)	2010-10-15
EP2021330B1 (en)	2010-09-22
ECSP088854A (es)	2008-11-27
ZA200810234B (en)	2010-02-24
US20070259936A1 (en)	2007-11-08
AU2007248341C1 (en)	2013-01-17
JP2009535414A (ja)	2009-10-01
HK1131971A1 (en)	2010-02-12
BRPI0709803B1 (pt)	2019-12-10
BRPI0709803A2 (pt)	2011-07-26
CO6160329A2 (es)	2010-05-20
ES2350959T3 (es)	2011-01-28
CN101511797B (zh)	2013-01-02
US20110190344A1 (en)	2011-08-04
NZ572251A (en)	2010-08-27
JP5302884B2 (ja)	2013-10-02
MY154595A (en)	2015-06-30
UY30322A1 (es)	2007-08-31
AU2007248341A1 (en)	2007-11-15
DE602007009378D1 (de)	2010-11-04
NI200800290A (es)	2012-01-30
CA2651128C (en)	2014-09-02

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ATE482201T1 (de)	2010-10-15	Vr1-benzimidazolmodulatoren
CY2020011I1 (el)	2020-11-25	Διαμορφωτες φαρμακοκινητικων ιδιοτητων θεραπευτικων παραγοντων
DK2038290T3 (da)	2013-12-02	Modulatorer af toll-lignende receptor 7
EP2050881A4 (en)	2015-01-21	ARROW
EP2036158A4 (en)	2009-09-09	Waveguide interface
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DE602007008222D1 (de)	2010-09-16	Diazepanderivate als modulatoren von chemokinrezeptoren
DK1979314T3 (da)	2013-02-04	Indolsulfonamidmodulatorer af progesteronreceptorer
ITRM20060613A1 (it)	2008-05-14	Treppiede perfezionato
FR2901817B1 (fr)	2015-03-27	Pont temporaire
DK2358714T3 (da)	2012-08-20	Alkylcyclohexylethere af dihydrotetraazabenzoazulener
DK2114147T3 (da)	2012-06-25	Reduktion af bivirkninger af tramadol
DE502006005983D1 (de)	2010-03-11	Seilwinde
ATE520316T1 (de)	2011-09-15	Ballaststoff
EP2106628A4 (en)	2015-07-01	FIBER LASER
DE602007011483D1 (de)	2011-02-03	Sulfonamidderivate
EP1981456A4 (en)	2013-03-27	AURICLE
DK2004815T3 (da)	2013-12-02	Funktional ekspression af triacylglycerol-lipaser
FI20065834A0 (fi)	2006-12-21	Iskulaite
EP2195490A4 (en)	2013-08-14	INCLUDED BRIDGE
DE602007008589D1 (de)	2010-09-30	Pyridooxazepin-progesteronrezeptor-modulatoren
DE602006003616D1 (de)	2008-12-24	Optisches System
ATE488416T1 (de)	2010-12-15	Bob
FI20085306A0 (fi)	2008-04-11	Siltarakenne
FI20065799L (fi)	2008-06-14	Tietoliikennejärjestelmä