DK205589D0 - Substituerede 1-(1h-imidazol-4-yl)alkylbenzamider og salte deraf, fremgangsmaader til fremstilling af disse forbindelser samt farmaceutiske praeparater med indhold af saadanne - Google Patents

Substituerede 1-(1h-imidazol-4-yl)alkylbenzamider og salte deraf, fremgangsmaader til fremstilling af disse forbindelser samt farmaceutiske praeparater med indhold af saadanne

Info

Publication number: DK205589D0
Authority: DK; Denmark
Prior art keywords: alkyl; imidazol; compounds; hydrogen; salts
Prior art date: 1988-04-28

Application number

DK205589A

Other languages

English (en)

Other versions

DK205589A (da

Inventor

Eric Cossement

Jean-Pierre Geerts

Jean Gobert

Philippe Michel

Ernst Wuelfert

Original Assignee

Ucb Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-28

Filing date

1989-04-27

Publication date

1989-04-27

1989-04-27 Application filed by Ucb Sa filed Critical Ucb Sa

1989-04-27 Publication of DK205589D0 publication Critical patent/DK205589D0/da

1989-10-29 Publication of DK205589A publication Critical patent/DK205589A/da

Links

150000001875 compounds Chemical class 0.000 title abstract 4
-1 1H-IMIDAZOL-4-YL Chemical class 0.000 title abstract 2
229940054066 benzamide antipsychotics Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
150000003936 benzamides Chemical class 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
239000005711 Benzoic acid Substances 0.000 abstract 1
125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 abstract 1
230000002253 anti-ischaemic effect Effects 0.000 abstract 1
JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Substances N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 abstract 1
DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
229910017464 nitrogen compound Inorganic materials 0.000 abstract 1
150000002830 nitrogen compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Adhesives Or Adhesive Processes (AREA)
Lubricants (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)

DK205589A 1988-04-28 1989-04-27 Substituerede 1-(1h-imidazol-4-yl)alkylbenzamider og salte deraf, fremgangsmaader til fremstilling af disse forbindelser samt farmaceutiske praeparater med indhold af saadanne DK205589A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888810067A GB8810067D0 (en)	1988-04-28	1988-04-28	Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides

Publications (2)

Publication Number	Publication Date
DK205589D0 true DK205589D0 (da)	1989-04-27
DK205589A DK205589A (da)	1989-10-29

Family

ID=10636026

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK205589A DK205589A (da)	1988-04-28	1989-04-27	Substituerede 1-(1h-imidazol-4-yl)alkylbenzamider og salte deraf, fremgangsmaader til fremstilling af disse forbindelser samt farmaceutiske praeparater med indhold af saadanne

Country Status (30)

Country	Link
US (1)	US4923865A (da)
EP (1)	EP0341231B1 (da)
JP (1)	JP2840288B2 (da)
KR (1)	KR970011275B1 (da)
AT (1)	ATE82571T1 (da)
AU (1)	AU610796B2 (da)
BR (2)	BR1100052A (da)
CA (1)	CA1310966C (da)
CY (1)	CY1758A (da)
DE (1)	DE68903531T2 (da)
DK (1)	DK205589A (da)
ES (1)	ES2052969T3 (da)
FI (1)	FI101791B (da)
GB (1)	GB8810067D0 (da)
GR (1)	GR3006836T3 (da)
HK (1)	HK9494A (da)
HU (1)	HU203877B (da)
IE (1)	IE63698B1 (da)
IL (1)	IL90087A0 (da)
LT (1)	LT3671B (da)
LV (1)	LV10437B (da)
MY (1)	MY104084A (da)
NO (1)	NO173331C (da)
NZ (1)	NZ228897A (da)
PH (1)	PH25461A (da)
PL (2)	PL161362B1 (da)
PT (1)	PT90368B (da)
RU (3)	RU1830063C (da)
UA (1)	UA12835A1 (da)
ZA (1)	ZA893140B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9310965D0 (en) *	1993-05-27	1993-07-14	Ucb Sa	2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides
NZ276883A (en) *	1993-11-15	1998-08-26	Schering Corp	1h-imidazol-4-yl)alkyl]benzene derivatives
JP3294961B2 (ja) *	1993-12-10	2002-06-24	杏林製薬株式会社	新規イミダゾール誘導体及びその製造法
GB9521680D0 (en) *	1995-10-23	1996-01-03	Orion Yhtymo Oy	New use of imidazole derivatives
DE10161818A1 (de) *	2001-12-14	2003-06-26	Gruenenthal Gmbh	Substituierte 1,5-Diaminopentan-3-ol-Verbindungen
JP5067968B2 (ja) *	2004-10-07	2012-11-07	ビテファーマシューティカルズ，インコーポレイテッド	ジアミノアルカンアスパラギン酸プロテアーゼ阻害剤
TWI411607B (zh) *	2005-11-14	2013-10-11	Vitae Pharmaceuticals Inc	天門冬胺酸蛋白酶抑制劑
CL2007002689A1 (es)	2006-09-18	2008-04-18	Vitae Pharmaceuticals Inc	Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
EP2167609A1 (en) *	2007-06-20	2010-03-31	Vitae Pharmaceuticals, Inc.	Renin inhibitors
US20100160424A1 (en) *	2007-06-20	2010-06-24	Baldwin John J	Renin inhibitors
WO2009111685A1 (en) *	2008-03-06	2009-09-11	Sensient Flavors Llc	Herbal extracts and flavor systems for oral products and methods of making the same
US20110160300A1 (en) *	2008-06-20	2011-06-30	Marlys Hammond	Renin Inhibitors and Methods of Use Thereof
AU2009262319A1 (en) *	2008-06-26	2009-12-30	Vitae Pharmaceuticals, Inc.	Salts of methyl 2-((R))-(3-chlorophenyl) ((R)-1-((S)-2- (methylamino)-3((R)-tetrahydro-2H-pyran-3-yl) propylcarbamoyl) piperidin-3-yl)methoxy)ethylcarbamate
AR077692A1 (es) *	2009-08-06	2011-09-14	Vitae Pharmaceuticals Inc	Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo
US9249087B2 (en)	2011-02-01	2016-02-02	The Board Of Trustees Of The University Of Illinois	HDAC inhibitors and therapeutic methods using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU518569B2 (en) *	1979-08-07	1981-10-08	Farmos-Yhtyma Oy	4-benzyl- and 4-benzoyl imidazole derivatives
US4303485A (en)	1979-08-20	1981-12-01	Minnesota Mining And Manufacturing Company	Ultraviolet polymerization of acrylate monomers using oxidizable tin compounds
GB2092569B (en) *	1981-02-05	1984-09-19	Farmos Oy	Substituted imidazole derivatives and their preparation and use
GB2101114B (en) *	1981-07-10	1985-05-22	Farmos Group Ltd	Substituted imidazole derivatives and their preparation and use
DE3635700A1 (de)	1986-10-21	1988-04-28	Michael Schmeller	Hubeinrichtung
GB8626287D0 (en) *	1986-11-04	1986-12-03	Ucb Sa	Substituted 1h-imidazoles
GB8714013D0 (en) *	1987-06-16	1987-07-22	Ici Plc	(substituted-aralkyl)heterocyclic compounds

1988
- 1988-04-28 GB GB888810067A patent/GB8810067D0/en active Pending
1989
- 1989-03-31 CA CA000595384A patent/CA1310966C/en not_active Expired - Lifetime
- 1989-04-06 US US07/334,854 patent/US4923865A/en not_active Expired - Fee Related
- 1989-04-20 DE DE8989870054T patent/DE68903531T2/de not_active Expired - Fee Related
- 1989-04-20 EP EP89870054A patent/EP0341231B1/fr not_active Expired - Lifetime
- 1989-04-20 AT AT89870054T patent/ATE82571T1/de active
- 1989-04-20 ES ES89870054T patent/ES2052969T3/es not_active Expired - Lifetime
- 1989-04-25 PL PL1989283865A patent/PL161362B1/pl unknown
- 1989-04-25 PH PH38563A patent/PH25461A/en unknown
- 1989-04-25 IL IL90087A patent/IL90087A0/xx not_active IP Right Cessation
- 1989-04-25 PL PL1989279104A patent/PL156250B1/pl unknown
- 1989-04-25 MY MYPI89000528A patent/MY104084A/en unknown
- 1989-04-26 PT PT90368A patent/PT90368B/pt not_active IP Right Cessation
- 1989-04-26 NZ NZ228897A patent/NZ228897A/xx unknown
- 1989-04-26 IE IE136089A patent/IE63698B1/en not_active IP Right Cessation
- 1989-04-26 FI FI891975A patent/FI101791B/fi not_active IP Right Cessation
- 1989-04-27 JP JP1109030A patent/JP2840288B2/ja not_active Expired - Lifetime
- 1989-04-27 RU SU894613927A patent/RU1830063C/ru active
- 1989-04-27 NO NO891760A patent/NO173331C/no not_active IP Right Cessation
- 1989-04-27 ZA ZA893140A patent/ZA893140B/xx unknown
- 1989-04-27 DK DK205589A patent/DK205589A/da unknown
- 1989-04-27 AU AU33730/89A patent/AU610796B2/en not_active Ceased
- 1989-04-28 HU HU892041A patent/HU203877B/hu not_active IP Right Cessation
- 1989-04-28 KR KR1019890005825A patent/KR970011275B1/ko not_active Expired - Fee Related
- 1989-10-04 UA UA4613927A patent/UA12835A1/uk unknown
- 1989-10-04 RU SU894742030A patent/RU1814647C/ru active
1990
- 1990-04-05 RU SU904743506A patent/RU1836353C/ru active
1993
- 1993-01-21 GR GR930400087T patent/GR3006836T3/el unknown
- 1993-06-11 LV LVP-93-548A patent/LV10437B/lv unknown
- 1993-08-03 LT LTIP827A patent/LT3671B/lt not_active IP Right Cessation
1994
- 1994-02-02 HK HK94/94A patent/HK9494A/xx not_active IP Right Cessation
- 1994-07-15 CY CY175894A patent/CY1758A/xx unknown
1996
- 1996-09-23 BR BR1100052-0A patent/BR1100052A/pt active IP Right Grant
- 1996-10-17 BR BR1100064-3A patent/BR1100064A/pt active IP Right Grant

Also Published As

Publication number	Publication date
ZA893140B (en)	1990-01-31
MY104084A (en)	1993-11-30
PT90368A (pt)	1989-11-10
FI101791B1 (fi)	1998-08-31
FI101791B (fi)	1998-08-31
IE891360L (en)	1989-10-28
HK9494A (en)	1994-02-09
CA1310966C (en)	1992-12-01
PT90368B (pt)	1994-08-31
IL90087A0 (en)	1989-12-15
LT3671B (en)	1996-01-25
KR970011275B1 (ko)	1997-07-09
PL156250B1 (pl)	1992-02-28
NO891760D0 (no)	1989-04-27
DE68903531D1 (de)	1992-12-24
HU203877B (en)	1991-10-28
JP2840288B2 (ja)	1998-12-24
GB8810067D0 (en)	1988-06-02
PH25461A (en)	1991-07-01
FI891975A7 (fi)	1989-10-29
NO891760L (no)	1989-10-30
ATE82571T1 (de)	1992-12-15
DK205589A (da)	1989-10-29
ES2052969T3 (es)	1994-07-16
GR3006836T3 (da)	1993-06-30
BR1100064A (pt)	1999-12-07
CY1758A (en)	1994-07-15
RU1836353C (ru)	1993-08-23
AU3373089A (en)	1989-11-02
PL161362B1 (pl)	1993-06-30
AU610796B2 (en)	1991-05-23
HUT51257A (en)	1990-04-28
EP0341231B1 (fr)	1992-11-19
NO173331C (no)	1993-12-08
IE63698B1 (en)	1995-05-31
JPH01313467A (ja)	1989-12-18
RU1814647C (ru)	1993-05-07
LTIP827A (en)	1995-02-27
RU1830063C (ru)	1993-07-23
FI891975A0 (fi)	1989-04-26
BR1100052A (pt)	1999-12-07
NZ228897A (en)	1990-08-28
US4923865A (en)	1990-05-08
LV10437A (lv)	1995-02-20
UA12835A1 (uk)	1997-02-28
KR890016017A (ko)	1989-11-28
LV10437B (en)	1996-04-20
NO173331B (no)	1993-08-23
DE68903531T2 (de)	1993-04-29
EP0341231A1 (fr)	1989-11-08

Publication	Publication Date	Title
DK205589A (da)	1989-10-29	Substituerede 1-(1h-imidazol-4-yl)alkylbenzamider og salte deraf, fremgangsmaader til fremstilling af disse forbindelser samt farmaceutiske praeparater med indhold af saadanne
DK91393D0 (da)	1993-08-06	Fremgangsmaade til fremstilling af optisk aktive s(-)-carbazolderivater, nye s(-)-carbazolderivater, samt laegemidler, der indeholder disse forbindelser
DK220386D0 (da)	1986-05-13	2-(4-benzoyl-1-piperidinyl)-alkanolderivater, fremgangsmaade til fremstilling af saadanne derivater og anvendelse af disse som laegemidler
DK84093D0 (da)	1993-07-14	Mellemprodukt bestaaende af 4-(2,4-difluorphenyl)-piperazin eller et syreadditionssalt deraf samt farmaceutisk praeparat og laegemiddel indeholdende mindst en af disse forbindelser
AR003469A1 (es)	1998-08-05	2-(4-sustituido)-bencilamino-2-metil-propanamidas, su uso, procedimiento para su preparación y composiciones farmaceuticas que las contienen.
DK235889D0 (da)	1989-05-16	Derivater af 6-phenyl-3-piperazinylalkyl-1h,3h-pyrimidindion-2,4, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
PT84424B (pt)	1989-10-04	Processo para a preparacao de derivados de heteroaril-oxi-beta-carbolina e de composicoes farmaceuticas que os contem
HUP9901007A2 (hu)	1999-07-28	C2a, D2 és E GE2270 faktor antibiotikum-származékok
DK13884D0 (da)	1984-01-12	Heterocycliske forbindelser, fremgangsmade til deres fremstilling og laegemidler indeholdende disse
ES8801637A1 (es)	1988-02-16	Un procedimiento para la preparacion de benzimidazoles.
IL71430A (en)	1987-12-31	2-imino-n-phenylsulfonyl-imidazolidine derivatives,process for the manufacture thereof and pharmaceutical preparations containing such compounds
EP0228061A3 (en)	1988-12-14	Cephem compounds
ATE53839T1 (de)	1990-06-15	2,3-dihydro-3-phenyl-benzofuran-2-onacetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
GB1411782A (en)	1975-10-29	Piperidine derivatives
DK1098901T3 (da)	2003-05-05	Nye 6-deoxyerythromycinderivater, fremgangsmåde til deres fremstilling samt deres anvendelse som lægemidler
ATE130843T1 (de)	1995-12-15	Aminoalkohole als reagenzien zur optischen auflösung.