DK2087005T3 - Anti-humane il-6-antistoffer - Google Patents

Anti-humane il-6-antistoffer Download PDF

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DK2087005T3
DK2087005T3 DK07824720.2T DK07824720T DK2087005T3 DK 2087005 T3 DK2087005 T3 DK 2087005T3 DK 07824720 T DK07824720 T DK 07824720T DK 2087005 T3 DK2087005 T3 DK 2087005T3
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antibody
binding
human
ser
gly
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DK07824720.2T
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Philip Mallinder
Steven Godfrey Lane
Simon Charles Cruwys
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Astrazeneca Ab
Medimmune Ltd
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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Claims (6)

1. Isoleret antistofmolekyle til human IL-6 omfattende et VH-domæne med aminosyresekvensen ifølge SEQ ID NO: 112 og et VL-domæne med aminosyresekvensen ifølge SEQ ID NO: 117.
2. Sammensætning omfattende et isoleret antistofmolekyle ifølge krav 1, og en farmaceutisk acceptabel excipiens, til anvendelse i en fremgangsmåde til behandling af en forstyrrelse af menneske- eller dyrekroppen ved terapi.
3. Anvendelse af et isoleret antistofmolekyle ifølge krav 1 til fremstilling af et medikament til behandling af en forstyrrelse, der er forbundet med IL-6, hvor forstyrrelsen er en inflammatorisk og/eller autoimmun sygdom, eller hvor forstyrrelsen er en tumor og/eller cancer.
4. Sammensætning til anvendelse ifølge krav 2 eller anvendelse ifølge krav 3, hvor forstyrrelsen er udvalgt fra gruppen bestående af rheumatoid arthritis, osteoarthritis, kakeksi, kronisk obstruktiv lungesygdom, juvenil idiopatisk arthritis, juvenil kronisk arthritis, astma, systemisk lupus erythematosus, inflammatorisk tarmsygdom, Crohns sygdom, atherosklerose, Castlemans sygdom, melanom, nyrecellekarcinom, Kaposis sarkom, ovariekarcinom, lymfom, leukæmi, multipelt myelom, prostatakarcinom.
5. Isoleret nukleinsyremolekyle omfattende en nukleotidsekvens, der koder for et isoleret antistofmolekyle ifølge krav 1.
6. Værtsvelle in vitro transformeret med nukleinsyre ifølge krav 5.
DK07824720.2T 2006-11-30 2007-11-28 Anti-humane il-6-antistoffer DK2087005T3 (da)

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