DK2094278T3 - Anvendelse af lipidindholdende partikler, omfattende quillaja saponins til behandling af cancer - Google Patents
Anvendelse af lipidindholdende partikler, omfattende quillaja saponins til behandling af cancer Download PDFInfo
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- DK2094278T3 DK2094278T3 DK07835461.0T DK07835461T DK2094278T3 DK 2094278 T3 DK2094278 T3 DK 2094278T3 DK 07835461 T DK07835461 T DK 07835461T DK 2094278 T3 DK2094278 T3 DK 2094278T3
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- saponin
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- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 229940053867 xeloda Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
- Oncology (AREA)
Claims (10)
1. Anvendelse af iscom matrixpartikler omfattende mindst et lipid valgt blandt cholesterol og phospholipid og mindst en saponin, hvor saponinen er en rå saponinfraktion fra Quillaja Saponaria Molina eller en delfraktion deraf, hvilke partikler ikke indeholder cancer antigener til fremstilling af et lægemiddel til behandling af cancer.
2. Anvendelse ifølge krav 1, hvor saponinen er valgt fra fraktion A, fraktion B, fraktion C, fraktioner QA 1-22 af Quillaja Saponaria Molina, Spicoside og Q VAC.
3. Anvendelse ifølge et hvilket som helst af kravene 1 og 2, hvor saponinfraktionen er hydrofektisk, såsom fraktioner, der ikke indeholder fedtsyrer, f.eks. Fraktion A, Quil 4-15, og det stimulerer og modulerer immunresponset, såsom cellemedieret immunitet.
4. Anvendelse ifølge et hvilket som helst af kravene 1 -3, hvor saponinfraktionen er hydrofob, såsom fraktioner, der indeholder fedtsyrer, f.eks. i saponins 4-position, såsom fraktion C og B i Quil A eller fraktioner fra regionen mellem fraktionerne A og B, fraktioner QA 15-21 af Quillaja Saponaria Molina og har en drabende virkning på cancerceller.
5. Anvendelse ifølge krav 4, hvor iscom matrixpartiklerne endvidere også omfatter hydrofile saponiner.
6. Anvendelse ifølge et hvilket som helst af kravene 1-5, hvor iscom matrixpartikler indeholder mindst to forskellige saponinfraktioner i en og samme lipidholdige partikel.
7. Anvendelse ifølge et hvilket som helst af kravene 1-6, hvor iscom matrixpartiklerne indeholder mindst to forskellige saponinfraktioner, hvorved en af de mindst to forskellige saponinfraktioner er kompleksbundet i en lipidholdig partikel, og den anden (de andre ) af de mindst to forskellige saponinfraktioner er komplekse bundet i en anden (anden) fysisk forskellig lipid indeholdende partikel (er).
8. Anvendelse ifølge et hvilket som helst af kravene 6 og 7, hvor de forskellige saponiner er hydrofile og hydrofobe saponiner.
9. Anvendelse ifølge et hvilket som helst af kravene 1 -8, hvor yderligere cancerbehandlingsforbindelser anvendes sammen med iscom matrixpartiklerne, f.eks. valgt blandt platin koordinationsforbindelser, taxanforbindelser, camptothecinforbindelser, antitumor-vinca-alkaloider, antitumor-nukleosidderivater, nitrogen-sennep- eller nitrosoureaalkyleringsmidler, antitumor-anthracyclinderivater, trastzumab og antitumor podophyllotoxinderivater, Quila A og subfragmenter deraf.
10. Kit af dele til anvendelse i en fremgangsmåde til behandling af cancer, omfattende mindst to dele, hvor en del omfatter iscom matrixpartikler omfattende mindst en saponinfraktion, hvor saponinen er en rå saponinfraktion fra Quillaja Saponaria Molina eller en delfraktion deraf som er hydrofob med en dræbende virkning på cancerceller; og den anden del omfatter lipidholdige partikler med mindst en saponinfraktion, der er hydrofil, stimulerer og modulerer immunresponsen, såsom celleformidlet immunitet, hvor kittet ikke indeholder cancer antigener.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86644506P | 2006-11-20 | 2006-11-20 | |
| PCT/SE2007/050878 WO2008063129A1 (en) | 2006-11-20 | 2007-11-20 | Use of lipid containing particles comprising quillaja saponins for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2094278T3 true DK2094278T3 (da) | 2017-07-24 |
Family
ID=39429971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07835461.0T DK2094278T3 (da) | 2006-11-20 | 2007-11-20 | Anvendelse af lipidindholdende partikler, omfattende quillaja saponins til behandling af cancer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9040081B2 (da) |
| EP (1) | EP2094278B1 (da) |
| JP (1) | JP5301455B2 (da) |
| CN (1) | CN101563090B (da) |
| AU (1) | AU2007322424B2 (da) |
| CA (1) | CA2669209C (da) |
| DK (1) | DK2094278T3 (da) |
| ES (1) | ES2630205T3 (da) |
| WO (1) | WO2008063129A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR074844A1 (es) | 2008-12-23 | 2011-02-16 | Intervet Int Bv | Composiciones farmaceuticas con saponinas |
| JP6147954B2 (ja) * | 2011-05-10 | 2017-06-14 | 丸善製薬株式会社 | Ｔｉｅ２活性化剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤 |
| CN102210862B (zh) * | 2011-06-01 | 2013-06-12 | 中国人民解放军南京军区福州总医院 | 基于Livin的免疫刺激复合物及其制备方法和应用 |
| DK2750683T4 (da) * | 2011-10-03 | 2021-04-12 | Croda Int Plc | Nanopartikler, fremgangsmåde til fremstilling og anvendelse deraf som bærer for amfipatiske eller hydrofobe molekyler inden for medicin, herunder cancerbehandling, og i fødevarerelaterede forbindelser |
| AR095962A1 (es) | 2013-04-01 | 2015-11-25 | Moreinx Ab | Nanopartículas, compuestas de esterol y saponina de quillaja saponaria molina, proceso para preparación y uso de las mismas como portadores para moléculas anfipáticas o hidrófobas en el campo de la medicina incluyendo tratamiento de cáncer y compuestos relacionados con alimentos |
| AU2015263877B2 (en) | 2014-05-23 | 2021-01-21 | Desert King International Llc | Combination, composition, and method of administering the combination or composition to animals |
| US10422555B2 (en) * | 2017-07-19 | 2019-09-24 | Haier Us Appliance Solutions, Inc. | Refrigerator appliance with a caloric heat pump |
| FR3072880A1 (fr) * | 2017-10-30 | 2019-05-03 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Formulation liposomale et son utilisation en therapie anti-tumorale |
| WO2019105408A1 (en) * | 2017-11-29 | 2019-06-06 | Xiamen Ginposome Pharmaceutical Co., Ltd. | Novel liposomes with ginsenoside derivative as membrane material and preparations thereof |
| EP3669890A1 (en) * | 2018-12-18 | 2020-06-24 | Croda International PLC | Filamentous nanoparticles having vaccine adjuvant effect |
| SG11202106603UA (en) * | 2018-12-21 | 2021-07-29 | Sapreme Tech Bv | Biologically active cluster of molecules |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| SE502569C2 (sv) * | 1991-05-31 | 1995-11-13 | British Tech Group | Användning av en immunologiskt inert matris av en sterol och saponiner som kan bilda sfäriska nanopartiklar med snäv storleksfördelning som läkemedelsbärare, partiklar, komposition samt kit |
| AUPM873294A0 (en) * | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| GB9620795D0 (en) * | 1996-10-05 | 1996-11-20 | Smithkline Beecham Plc | Vaccines |
| US6846489B1 (en) * | 1995-04-25 | 2005-01-25 | Smithkline Beecham Biologicals S.A. | Vaccines containing a saponin and a sterol |
| UA56132C2 (uk) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| AUPO732997A0 (en) | 1997-06-12 | 1997-07-03 | Csl Limited | Ganglioside immunostimulating complexes and uses thereof |
| GB9712347D0 (en) * | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| PT1187629E (pt) * | 1999-04-19 | 2005-02-28 | Glaxosmithkline Biolog Sa | Composicao adjuvante que compreende saponina e um oligonucleotido imunoestimulador |
| SE0301998D0 (sv) * | 2003-07-07 | 2003-07-07 | Isconova Ab | Quil A fraction with low toxicity and use thereof |
| US20050175623A1 (en) * | 2004-02-10 | 2005-08-11 | Zheng-Pin Wang | Saponins as anticancer agent |
| US20060287263A1 (en) | 2004-07-18 | 2006-12-21 | Csl Limited | Methods and compositions for inducing antigen-specific immune responses |
-
2007
- 2007-11-20 DK DK07835461.0T patent/DK2094278T3/da active
- 2007-11-20 WO PCT/SE2007/050878 patent/WO2008063129A1/en not_active Ceased
- 2007-11-20 JP JP2009538372A patent/JP5301455B2/ja not_active Expired - Fee Related
- 2007-11-20 EP EP07835461.0A patent/EP2094278B1/en not_active Not-in-force
- 2007-11-20 US US12/515,684 patent/US9040081B2/en active Active
- 2007-11-20 ES ES07835461.0T patent/ES2630205T3/es active Active
- 2007-11-20 AU AU2007322424A patent/AU2007322424B2/en not_active Ceased
- 2007-11-20 CN CN2007800431072A patent/CN101563090B/zh not_active Expired - Fee Related
- 2007-11-20 CA CA2669209A patent/CA2669209C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010510308A (ja) | 2010-04-02 |
| CA2669209A1 (en) | 2008-05-29 |
| EP2094278B1 (en) | 2017-04-05 |
| AU2007322424A1 (en) | 2008-05-29 |
| EP2094278A1 (en) | 2009-09-02 |
| US9040081B2 (en) | 2015-05-26 |
| AU2007322424B2 (en) | 2013-05-16 |
| JP5301455B2 (ja) | 2013-09-25 |
| WO2008063129A1 (en) | 2008-05-29 |
| ES2630205T3 (es) | 2017-08-18 |
| US20100119591A1 (en) | 2010-05-13 |
| EP2094278A4 (en) | 2011-08-10 |
| CN101563090B (zh) | 2013-01-02 |
| CA2669209C (en) | 2016-01-26 |
| CN101563090A (zh) | 2009-10-21 |
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