DK209985A - Lipofile muramylpeptidderivater og midler indeholdende disse, samt fremgangsmaade til fremstilling af derivaterne - Google Patents

Lipofile muramylpeptidderivater og midler indeholdende disse, samt fremgangsmaade til fremstilling af derivaterne Download PDF

Info

Publication number: DK209985A
Authority: DK; Denmark
Prior art keywords: group; groups; carbon atoms; different; lipophile
Prior art date: 1984-05-11

Application number

DK209985A

Other languages

English (en)

Other versions

DK164918B (da

DK164918C (da

DK209985D0 (da

Inventor

Nigel Phillips

Francoise Audibert

Jean-Marie Bernard

Louis Chedid

Pierre Lefrancier

Michel Level

Monique Parant

Original Assignee

Anvar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-11

Filing date

1985-05-10

Publication date

1985-11-12

1985-05-10 Application filed by Anvar filed Critical Anvar

1985-05-10 Publication of DK209985D0 publication Critical patent/DK209985D0/da

1985-11-12 Publication of DK209985A publication Critical patent/DK209985A/da

1992-09-07 Publication of DK164918B publication Critical patent/DK164918B/da

1993-01-25 Application granted granted Critical

1993-01-25 Publication of DK164918C publication Critical patent/DK164918C/da

Links

238000000034 method Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000004432 carbon atom Chemical group C* 0.000 abstract 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 4
125000002252 acyl group Chemical group 0.000 abstract 3
125000000266 alpha-aminoacyl group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
239000004215 Carbon black (E152) Substances 0.000 abstract 1
125000001980 alanyl group Chemical group 0.000 abstract 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000001942 asparaginyl group Chemical group 0.000 abstract 1
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
125000001939 glutaminyl group Chemical group 0.000 abstract 1
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 abstract 1
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
229930195733 hydrocarbon Natural products 0.000 abstract 1
150000002430 hydrocarbons Chemical class 0.000 abstract 1
125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 abstract 1
229950003188 isovaleryl diethylamide Drugs 0.000 abstract 1
125000001998 leucyl group Chemical group 0.000 abstract 1
125000002073 methionyl group Chemical group 0.000 abstract 1
-1 norleucyl Chemical group 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000000405 phenylalanyl group Chemical group 0.000 abstract 1
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000002072 seryl group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000001239 threonyl group Chemical group 0.000 abstract 1
125000005454 tryptophanyl group Chemical group 0.000 abstract 1
125000002233 tyrosyl group Chemical group 0.000 abstract 1
125000002114 valyl group Chemical group 0.000 abstract 1

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nanotechnology (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Medical Informatics (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

DK209985A 1984-05-11 1985-05-10 Lipofile muramylpeptidderivater med egenskaber til aktivering af makrofager og midler indeholdende disse muramylpeptidderivater DK164918C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8407340		1984-05-11
FR8407340A FR2564096B1 (fr)	1984-05-11	1984-05-11	Derives lipophiles de muramylpeptides ayant des proprietes d'activation des macrophages, compositions les contenant et procede pour les obtenir

Publications (4)

Publication Number	Publication Date
DK209985D0 DK209985D0 (da)	1985-05-10
DK209985A true DK209985A (da)	1985-11-12
DK164918B DK164918B (da)	1992-09-07
DK164918C DK164918C (da)	1993-01-25

Family

ID=9303899

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK209985A DK164918C (da)	1984-05-11	1985-05-10	Lipofile muramylpeptidderivater med egenskaber til aktivering af makrofager og midler indeholdende disse muramylpeptidderivater

Country Status (8)

Country	Link
US (2)	US4939122A (da)
EP (1)	EP0165123B1 (da)
JP (1)	JPH0670080B2 (da)
AT (1)	ATE55394T1 (da)
CA (1)	CA1259750A (da)
DE (1)	DE3579051D1 (da)
DK (1)	DK164918C (da)
FR (1)	FR2564096B1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0256989A1 (en) *	1986-08-18	1988-02-24	Board Of Regents, The University Of Texas System	Pharmaceutical administration systems containing chemotactic peptides
FR2609393A1 (fr) *	1988-02-23	1988-07-15	Serobiologiques Lab Sa	Composition notamment utile comme matiere de base pour la preparation de compositions pharmaceutiques, notamment dermatologiques et/ou cosmetiques comprenant une substance azotee, notamment aminoacides, oligo- ou polypeptides, proteines, et leurs derives, et composition pharmaceutique ou cosmetique ainsi preparee.
JPH0832638B2 (ja) *	1989-05-25	1996-03-29	カイロンコーポレイション	サブミクロン油滴乳剤を含んで成るアジュバント製剤
HU205147B (en) *	1989-06-29	1992-03-30	Sandoz Ag	Process for producing muramyl dipeptide derivative and pharmaceutical compostions comprising same
FR2664813B1 (fr) *	1990-07-18	1995-01-13	Vacsyn France Sa	Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique.
FR2672496B3 (fr) *	1990-07-18	1993-05-28	Vacsyn France Sa	Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique.
FR2692149B1 (fr) *	1992-06-12	1995-06-09	Vacsyn France Sa	Composition adjuvante de l'immunite humorale et a mediation cellulaire n'induisant pas de reponse vis-a-vis de determinants auto-antigeniques.
US5462735A (en) *	1993-06-10	1995-10-31	The United States Of America As Represented By The Secretary Of Agriculture	Pasteurella haemolytica subunit vaccine containing capsular polysaccharide and muramyl dipeptide
AU3006697A (en) *	1996-05-10	1997-12-05	Endorex Corporation	Lipophile derivatives of muramylpeptides for treatment of retroviral infection and induction of chemokines
EP1909758A1 (en) *	2005-08-02	2008-04-16	I.D.M. Immuno-Designed Molecules	Process for the preparation of liposomal formulations
WO2016153938A1 (en) *	2015-03-25	2016-09-29	Biosynthetic Technologies, Llc	Ester compounds including triesters having terminal vicinal acyl groups

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2343035C2 (de) *	1973-08-25	1982-04-01	Hoechst Ag, 6000 Frankfurt	Pyroglutamyl-histidyl-prolinamide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
GB1563561A (en) *	1976-06-23	1980-03-26	Daiichi Seiyaku Co	Muramyldipeptide derivatives and process for the preparation thereof
JPS55111499A (en) *	1979-02-21	1980-08-28	Takeda Chem Ind Ltd	Glucosamine derivative and its preparation
FI75578C (fi) *	1979-07-25	1988-07-11	Ciba Geigy Ag	Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
US4406889A (en) *	1980-02-15	1983-09-27	Ciba-Geigy Corporation	Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use
US4310514A (en) *	1980-05-05	1982-01-12	Merck & Co., Inc.	Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
US4315913A (en) *	1980-06-09	1982-02-16	Merck & Co. Inc.	Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation
GR78246B (da) *	1981-01-23	1984-09-26	Ciba Geigy Ag
EP0102319B1 (de) *	1982-07-23	1987-08-19	Ciba-Geigy Ag	Verwendung von Muramylpeptiden oder deren Analogen zur Prophylaxe und Therapie von Virusinfektionen
US4579840A (en) *	1983-08-12	1986-04-01	Immunetech Pharmaceuticals	Method of blocking immune complex binding to immunoglobulin Fc receptors
US4683292A (en) *	1983-08-12	1987-07-28	Immunetech, Inc.	Immunotherapeutic polypeptide agents which bind to lymphocyte immunoglobulin FC receptors
JPS6042398A (ja) *	1983-08-18	1985-03-06	Toshiyuki Hamaoka	ムラミルジペプチド活性エステル誘導体
ZA846192B (en) *	1984-08-09	1986-03-26	Merck Patent Gmbh	Immunotherapeutic polypeptide agents
JPS6157597A (ja) *	1984-08-29	1986-03-24	Toshiyuki Hamaoka	ムラミルペプチド活性エステル誘導体

1984
- 1984-05-11 FR FR8407340A patent/FR2564096B1/fr not_active Expired
1985
- 1985-05-10 DK DK209985A patent/DK164918C/da not_active IP Right Cessation
- 1985-05-10 JP JP60099454A patent/JPH0670080B2/ja not_active Expired - Lifetime
- 1985-05-10 EP EP85400921A patent/EP0165123B1/fr not_active Expired - Lifetime
- 1985-05-10 AT AT85400921T patent/ATE55394T1/de not_active IP Right Cessation
- 1985-05-10 DE DE8585400921T patent/DE3579051D1/de not_active Expired - Fee Related
- 1985-05-13 CA CA000481425A patent/CA1259750A/fr not_active Expired
1988
- 1988-06-09 US US07/206,959 patent/US4939122A/en not_active Ceased
1994
- 1994-10-25 US US08/329,142 patent/USRE35706E/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK164918B (da)	1992-09-07
EP0165123A2 (fr)	1985-12-18
JPH0670080B2 (ja)	1994-09-07
USRE35706E (en)	1997-12-30
ATE55394T1 (de)	1990-08-15
EP0165123A3 (en)	1986-03-05
FR2564096B1 (fr)	1988-02-19
DE3579051D1 (de)	1990-09-13
CA1259750A (fr)	1989-09-19
DK164918C (da)	1993-01-25
FR2564096A1 (fr)	1985-11-15
DK209985D0 (da)	1985-05-10
US4939122A (en)	1990-07-03
EP0165123B1 (fr)	1990-08-08
JPS60252497A (ja)	1985-12-13

Legal Events

Date	Code	Title	Description
1999-03-29	PBP	Patent lapsed

Publication	Publication Date	Title
DK209985D0 (da)	1985-05-10	Lipofile muramylpeptidderivater og midler indeholdende disse, samt fremgangsmaade til fremstilling af derivaterne
DE69800178D1 (de)	2000-07-20	Glycerolipide verbindungen und ihre anwendung zum transport einer aktiven substanz in eine zielzelle
NL350015I1 (nl)	2004-02-02	Heterocyclische verbindingen.
MX9803761A (es)	1998-09-30	Nuevos agentes de transfeccion y sus aplicaciones farmaceuticas.
FR2518088B1 (fr)	1987-11-27	Nouveaux derives d'aminoacides, et leur application therapeutique
DE60133181D1 (de)	2008-04-24	Stabilisatormischungen für polyolefine
HUP0003355A2 (hu)	2001-02-28	Tieno[2,3-d]pirimidindion-származékok és ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra és alkalmazásuk
KR920701200A (ko)	1992-08-11	신규의 4h-3,1-벤조옥사진-4-온 유도체
NZ290757A (en)	2000-09-29	Delivery of nucleic acid into a cell
DE69932424D1 (de)	2006-08-31	Melanocortin 1 rezeptorselektive verbindungen
EP0135758A3 (en)	1987-05-13	Derivatives of oligoglucosides
IL57691A (en)	1983-10-31	Delta-4,9-gonadiene-21-ol-3,20-diones,process for preparing them and pharmaceutical compositions containing them
DE3875346D1 (de)	1992-11-19	Zusammensetzungen, die mit 1-oxo- oder thiokohlenwassserstoff substituierte azacycloalkane enthalten.
KR870001233A (ko)	1987-03-12	헤테로시클릭 화합물의 제조 방법
KR900006014A (ko)	1990-05-07	기체 혼합물로부터 황화 수소를 제거시키는 방법
NO982505L (no)	1998-12-07	Sammensetning og fremgangsmÕte for avsvovling av gassformige eller flytende hydrokarboner, vandige systemer og blandinger derav
PH24709A (en)	1990-10-01	Allylmercaptoacetylsydnonimines and pharmaceutical compositions thereof
KR900016441A (ko)	1990-11-13	액체 세정제 조성물
ATE106881T1 (de)	1994-06-15	Neue propanamine, ihre pharmakologischen eigenschaften und ihre therapeutischen verwendungen, besonders als antidiarrhöewirkstoffe.
SE8200757L (sv)	1982-02-10	Biologiskt aktiva peptider
DE69609946D1 (de)	2000-09-28	Aromatische amide, verfahren zu ihrer darstellung, diese enthaltende zusammensetzungen und ihre verwendung als pestizide
ATE274912T1 (de)	2004-09-15	Etherderivate von pseudopterosin
ES8306099A1 (es)	1983-05-01	Un procedimiento para la preparacion de derivados de acido 2-(2-cianoetil)-2-benzoilamino-alcanoicos.
TW367318B (en)	1999-08-21	Process for the production of C-substituted diethylenetriamines
SE9003652D0 (sv)	1990-11-15	New heterocyclic compounds