DK2101807T3 - Vegf-specifikke antagonister for adjuverende og neoadjuverende behandling og behandling af tumorer i tidligt stadium - Google Patents
Vegf-specifikke antagonister for adjuverende og neoadjuverende behandling og behandling af tumorer i tidligt stadium Download PDFInfo
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- DK2101807T3 DK2101807T3 DK07869456.9T DK07869456T DK2101807T3 DK 2101807 T3 DK2101807 T3 DK 2101807T3 DK 07869456 T DK07869456 T DK 07869456T DK 2101807 T3 DK2101807 T3 DK 2101807T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Claims (12)
1. Anti-VEGF-antistof, eller antigen-bindende fragment deraf, til anvendelse i en fremgangsmåde til behandling, hvor: (1) anti-VEGF-antistoffet eller det antigen-bindende fragment deraf blokkerer VEGF-binding til mere end én VEGF-receptor; og (2) anvendelsen er til reduktion eller forebyggelse af forekomst af en godartet, præcancerøs eller ikke-metastatisk cancer hos et individ med en slægts-anamnese med cancer, polypper eller et nedarvet cancersyndrom, hvor individet aldrig har haft klinisk påviselig cancer.
2. Anti-VEG F-antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 1, hvor anvendelsen er som en monoterapi.
3. Anti-VEG F-antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 1, hvor individet yderligere monitoreres for forekomst af canceren.
4. Anti-VEGF-antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 1, hvor canceren er en gastrointestinal, kolorektal, bryst-, ovarie-, lunge-, glioblastom eller nyrecancer.
5. Anti-VEGF-antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 1, hvor anvendelsen yderligere omfatter anvendelse af en yderligere anti-cancer-terapi, hvor den yderligere anti-cancer-terapi eventuelt er kemoterapi.
6. Anti-VEGF-antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 1, hvor anti-VEGF-antistoffet er et monoklonalt antistof.
7. Anti-VEGF-antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 6, hvor det monoklonale antistof er et kimært, humaniseret eller fuldt humant antistof.
8. Anti-VEGF-antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 6, hvor det monoklonale antistof er bevacizumab.
9. Anti-VEGF-antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 1, hvor anti-VEGF-antistoffet eller det antigen-bindende fragment deraf binder til den samme epitop som det monoklonale anti-VEGF-antistof A4.6.1.
10. Anti-VEG F-antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 1, hvor anti-VEGF-antistoffet eller det antigen-bindende fragment deraf binder til en funktionel epitop på human VEGF omfattende resterne F17, M18, D19, Y21, Y25, Q89, 191, K101, E103 og C104 af human VEGF.
11. Anti-VEG F-antistof eller antigen-bindende fragment deraf til anvendelse ifølge krav 1, hvor anti-VEGF-antistoffet eller det antigen-bindende fragment deraf binder til en funktionel epitop på human VEGF omfattende resterne F17, Y21, Q22, Y25, D63, I83 og Q89 af human VEGF.
12. Anvendelse af et anti-VEG F-antistof eller et antigen-bindende fragment deraf i fremstillingen af et medikament til anvendelse i en fremgangsmåde til behandling, hvor antistoffet eller det antigen-bindende fragment deraf og behandlingen er som defineret i et hvilket som helst af de foregående krav.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87074106P | 2006-12-19 | 2006-12-19 | |
| US87074506P | 2006-12-19 | 2006-12-19 | |
| US87726706P | 2006-12-27 | 2006-12-27 | |
| US91963807P | 2007-03-22 | 2007-03-22 | |
| US95838407P | 2007-07-05 | 2007-07-05 | |
| US98939707P | 2007-11-20 | 2007-11-20 | |
| PCT/US2007/088000 WO2008077077A2 (en) | 2006-12-19 | 2007-12-18 | Vegf-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2101807T3 true DK2101807T3 (da) | 2016-08-29 |
Family
ID=39323719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07869456.9T DK2101807T3 (da) | 2006-12-19 | 2007-12-18 | Vegf-specifikke antagonister for adjuverende og neoadjuverende behandling og behandling af tumorer i tidligt stadium |
Country Status (27)
| Country | Link |
|---|---|
| US (6) | US20080248033A1 (da) |
| EP (2) | EP2101807B1 (da) |
| JP (4) | JP2010513566A (da) |
| KR (5) | KR20090097188A (da) |
| CN (1) | CN103143017A (da) |
| AR (1) | AR064458A1 (da) |
| AU (1) | AU2007333735A1 (da) |
| BR (1) | BRPI0720552A2 (da) |
| CA (1) | CA2671734A1 (da) |
| CO (1) | CO6210829A2 (da) |
| CR (1) | CR10940A (da) |
| DK (1) | DK2101807T3 (da) |
| EC (1) | ECSP099523A (da) |
| ES (1) | ES2582656T3 (da) |
| HU (1) | HUE029445T2 (da) |
| IL (1) | IL238913A0 (da) |
| MA (1) | MA31150B1 (da) |
| MX (1) | MX2009006779A (da) |
| MY (1) | MY183404A (da) |
| NO (1) | NO20092604L (da) |
| NZ (1) | NZ578472A (da) |
| PL (1) | PL2101807T3 (da) |
| RU (1) | RU2013129450A (da) |
| SG (2) | SG10201503407WA (da) |
| SI (1) | SI2101807T1 (da) |
| TW (2) | TW200831538A (da) |
| WO (1) | WO2008077077A2 (da) |
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| HRP20160082T1 (hr) | 2006-09-29 | 2016-02-26 | Oncomed Pharmaceuticals, Inc. | Sastavi i postupci za dijagnosticiranje i lijeäśenje raka |
| TWI468417B (zh) * | 2007-11-30 | 2015-01-11 | Genentech Inc | 抗－ｖｅｇｆ抗體 |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| KR20180005753A (ko) | 2008-06-25 | 2018-01-16 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | Ｖｅｇｆ를 억제하는 안정하고 가용성인 항체 |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| KR20180117734A (ko) * | 2008-11-22 | 2018-10-29 | 제넨테크, 인크. | 유방암의 치료를 위한, 화학요법과 조합된 항-ｖｅｇｆ 항체의 용도 |
| WO2010091234A2 (en) * | 2009-02-06 | 2010-08-12 | The General Hospital Corporation | Methods of treating vascular lesions |
| BRPI1014089A2 (pt) | 2009-04-02 | 2016-04-19 | Roche Glycart Ag | anticorpos multiespecíficos que compreendem anticorpos de comprimento completo e fragmentos fab de cadeia simples |
| PT2417156E (pt) | 2009-04-07 | 2015-04-29 | Roche Glycart Ag | Anticorpos trivalentes, biespecíficos |
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| TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
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