DK2115029T3 - Lavsprængning poly-(laktid/glykolid) og fremgangsmåder til at fremstille polymerer - Google Patents
Lavsprængning poly-(laktid/glykolid) og fremgangsmåder til at fremstille polymerer Download PDFInfo
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- DK2115029T3 DK2115029T3 DK08725511.3T DK08725511T DK2115029T3 DK 2115029 T3 DK2115029 T3 DK 2115029T3 DK 08725511 T DK08725511 T DK 08725511T DK 2115029 T3 DK2115029 T3 DK 2115029T3
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- copolymer
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Claims (8)
1. Fremgangsmåde til fremstilling af et biokompatibelt, bionedbrydeligt, ikke-hydrolyseret PLG lavsprængning copolymer-materiale til en kontrolleret frigivelsesformulering med en vægtgennemsnitlig molekylevægt på 10 kilodaltons til 50 kilodaltons og et polydispersitetsindeks på 1,4-2,0 og fra hvilken en fjernet copolymer-fraktion kendetegnet ved en vægtgennemsnitlig molekylevægt på 4 kDa til 10 kDa og et polydispersitetsindeks på 1,4 til 2,5 er blevet adskilt, fremgangsmåden omfattende at adskille en fjernet copolymer-fraktion kendetegnet ved en vægtgennemsnitlig molekylevægt på 4 kDa til 10 kDa og et polydispersitetsindeks på 1,4 til 2,5 fra et PLG-copolymer udgangsmateriale, at opløse det PLG-copolymer udgangsmateriale i et solvent for at tilvejebringe en opløsning, derefter, at præcipitere PLG-lavsprængning copolymer-materialet ved at bringe opløsningen i kontakt med et ikke-solvent og at indsamle præcipiteret PLG-lavsprængning copolymer-materiale, hvor fremgangsmåden ikke omfatter trin til hydrolyse af en PLG-copolymer med højere molekylevægt.
2. Fremgangsmåden ifølge krav 1, hvor solventet og ikke-solventet er blandbare.
3. Fremgangsmåden ifølge krav 1, hvor solventet er dichlormethan eller kloroform, eller hvor ikke-solventet er methanol eller ethanol, eller begge.
4. Fremgangsmåden ifølge krav 1 hvor den fjernede copolymer-fraktion er 2% til 20% efter vægt, 3% til 15% efter vægt, eller 5% til 10% efter vægt, af copolymer-udgangsmateriale.
5. Anvendelse af et flydbart indgivelsessystem i en kontrolleret frigivelsesformulering, det flydbare indgivelsessystem omfattende et biokompatibelt, bionedbrydeligt, ikke-hydrolyseret PLG-lavsprængning copolymer-materiale til en kontrolleret frigivelsesformulering fremstillet ifølge fremgangsmåden ifølge krav 1 og med en vægtgennemsnitlig molekylevægt på 10 kilodaltons til 50 kilodaltons og et polydispersitetsindeks på 1,4-2,0 og fra hvilken en fjernet copolymer-fraktion kendetegnet ved en vægtgennemsnitlig molekylevægt på 4 kDa til 10 kDa og et polydispersitetsindeks af 1,4 til 2,5 er blevet adskilt, et organisk solvent, og et medicinsk indikeret bioaktivt stof til behandlingen afen tilstand hos en patient.
6. Anvendelsen ifølge krav 5, hvor tilstanden er valgt fra gruppen bestående af prostatakræft, akromegali, glaukom, uønsket fertilitet, smerte, onychomycosis i tåneglen, onychomycosis i fingerneglen, en bakterieinfektion, en svampeinfektion, en virusinfektion, psykose, en malignitet, og en immunreaktion.
7. Anvendelsen ifølge krav 6, hvor det bioaktive stof er valgt fra gruppen bestående af et antivirus-stof, et fødselskontrolsteroid, et antibiotikum, et smertestillende middel, et antipsykotisk middel, en prostaglandin, en carbonsyreanhydrasehæmmer, en α-adrenerg antagonist, og en β-adrenerg antagonist.
8. Anvendelsen ifølge krav 6, hvor det bioaktive stof er valgt fra gruppen bestående af leuprolid, octreotid, terbinafin, brimonidin, latanoprost, latanoprostsyre, travoprost, travoprostsyre, brinzolamid, dorzolamid, betaxolol, risperidon og rapamycin.
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