DK2117571T3 - Urokinase-type plasminogenaktivatorreceptorepitop - Google Patents

Urokinase-type plasminogenaktivatorreceptorepitop Download PDF

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Publication number
DK2117571T3
DK2117571T3 DK07862653.8T DK07862653T DK2117571T3 DK 2117571 T3 DK2117571 T3 DK 2117571T3 DK 07862653 T DK07862653 T DK 07862653T DK 2117571 T3 DK2117571 T3 DK 2117571T3
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Denmark
Prior art keywords
upar
antibody
human
cells
binding
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DK07862653.8T
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English (en)
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Graham Parry
Andrew P Mazar
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Monopar Therapeutics Inc
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Publication of DK2117571T3 publication Critical patent/DK2117571T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (7)

1. Isoleret peptid af op til 40 aminosyrer omfattende aminosyresekvensen CCTKS-GCNHPDLDVQYRSG, CCTKSGCNHPDLDVQYRS, CCTKSGCNHPDLDVQYR, CCTKSGCNHPDLD-VQY eller CCTKSGCNHPDLDVQ, hvor den anden og tredje cysteinrest i sekvensen er disul-fidbundne til hinanden og danner en disulfidløkke.
2. Isoleret peptid ifølge krav 1 bestående af aminosyresekvensen CCTKSGCNHPDLD-VQYRSG, CCTKSGCNHPDLDVQYRS, CCTKSGCNHPDLDVQYR, CCTKSGCNHPDLDVQY eller CCTKSGCNHPDLDVQ.
3. Isoleret peptid ifølge krav 1 bestående af et fragment af humant uPAR som fremstillet i Figur 1.
4. Isoleret peptid ifølge krav 1 eller 3, hvor peptidet er op til 30 aminosyrer i længde.
5. Isoleret peptid ifølge krav 4, hvor peptidet er op til 20 aminosyrer i længde.
6. Isoleret peptid ifølge et hvilket som helst af kravene 1 og 3-5, hvor sekvensen af peptidet (i) består af et fragment af humant uPAR i hvilket Cys 265 er aminoterminus af peptidet; og (ii) omfatter aminosyresekvensen CCTKSGCNHPDLDVQYRS, CCTKSGCNHPDLDVQYR, CCTKSGCNHPDLDVQY eller CCTKSGCNHPDLDVQ.
7. Fremgangsmåde til fremstilling af et antistof, hvilken omfatter: (i) immunisering af et ikke-humant pattedyr med et immunogen omfattende et peptid ifølge et hvilket som helst af kravene 1 til 6; (ii) isolering af splenocytter fra pattedyret; (iii) splejsning af splenocytterne til myelomceller; og (iv) selektion af et hybridom, som secernerer et antistof, der binder peptidet.
DK07862653.8T 2006-12-08 2007-12-07 Urokinase-type plasminogenaktivatorreceptorepitop DK2117571T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87362706P 2006-12-08 2006-12-08
US93003407P 2007-05-11 2007-05-11
PCT/US2007/025105 WO2008073312A2 (en) 2006-12-08 2007-12-07 Urokinase-type plasminogen activator receptor epitope, monoclonal antibodies derived therefrom and methods of use thereof

Publications (1)

Publication Number Publication Date
DK2117571T3 true DK2117571T3 (da) 2017-05-08

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK07862653.8T DK2117571T3 (da) 2006-12-08 2007-12-07 Urokinase-type plasminogenaktivatorreceptorepitop

Country Status (9)

Country Link
US (1) US8105602B2 (da)
EP (1) EP2117571B1 (da)
JP (2) JP2010512324A (da)
CA (1) CA2671971C (da)
DK (1) DK2117571T3 (da)
ES (1) ES2636451T3 (da)
PL (1) PL2117571T3 (da)
PT (1) PT2117571T (da)
WO (1) WO2008073312A2 (da)

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Also Published As

Publication number Publication date
WO2008073312A2 (en) 2008-06-19
JP2010512324A (ja) 2010-04-22
WO2008073312B1 (en) 2008-12-18
EP2117571A4 (en) 2010-08-04
PL2117571T3 (pl) 2017-08-31
WO2008073312A3 (en) 2008-10-30
JP2014224134A (ja) 2014-12-04
US8105602B2 (en) 2012-01-31
CA2671971C (en) 2021-03-30
PT2117571T (pt) 2017-06-14
CA2671971A1 (en) 2008-06-19
US20080199476A1 (en) 2008-08-21
JP6019457B2 (ja) 2016-11-02
EP2117571A2 (en) 2009-11-18
ES2636451T3 (es) 2017-10-05
EP2117571B1 (en) 2017-03-08

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