DK2139457T3 - Lægemiddelafgivelsesindretning til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade - Google Patents
Lægemiddelafgivelsesindretning til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade Download PDFInfo
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- DK2139457T3 DK2139457T3 DK08719893.3T DK08719893T DK2139457T3 DK 2139457 T3 DK2139457 T3 DK 2139457T3 DK 08719893 T DK08719893 T DK 08719893T DK 2139457 T3 DK2139457 T3 DK 2139457T3
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- analgesia
- bupivacaine
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- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 231100000057 systemic toxicity Toxicity 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960002372 tetracaine Drugs 0.000 description 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
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- 230000008733 trauma Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (14)
1. Lægemiddelafgivelsesindretning egnet til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade ved et sted i et menneske eller dyr med behov derfor, indretningen omfatter en fibrillær kollagenmatriks; og mindst ét lægemiddelstof, det mindst ene lægemiddelstof er i det væsentlige homogent fordelt i kollagenmatriksen, og det mindst ene lægemiddelstofertil stede i en mængde tilstrækkelig til at tilvejebringe en varighed af lokal analgesi, lokal anæstesi eller nerveblokade der varer mindst én dag efter administration hvor lægemiddelindretningen omfatter en flerhed af kollagensvampe, hvert kollagensvamp har 3,6 til 8 mg/cm3 type I kollagen, og 2,0 til 6,0 mg/cm3 bupivacain-hydrochlorid.
2. Lægemiddelafgivelsesindretningen ifølge krav 1, hvor det mindst ene lægemiddelstof er til stede i en mængde der er tilstrækkelig til at tilvejebringe en varighed af lokal analgesi, lokal anæstesi eller nerveblokade der varer mindst to dage efter administration.
3. Lægemiddelafgivelsesindretningen ifølge krav 1 eller 2, hvor det mindst ene lægemiddelstof er til stede i en mængde der er tilstrækkelig til at tilvejebringe en varighed af lokal analgesi, lokal anæstesi eller nerveblokade der varer mindst tre dage efter administration.
4. Indretningen ifølge kravene 1-3, hvor analgesi er tilvejebragt uden bivirkninger forbundet med toksicitet fra bupivacain-kollagensvampen.
5. Indretningen ifølge kravene 1-4, hvor indretningen reducerer patientens behov for systemisk analgesi.
6. Anvendelse afen lægemiddelafgivelsesindretning omfattende en fibrillær kollagenmatriks; og mindst ét lægemiddelstof, det mindst ene lægemiddelstof er i det væsentlige homogent fordelt i kollagenmatriksen, og det mindst ene lægemiddelstof er til stede i en mængde tilstrækkelig til at tilvejebringe en varighed af lokal analgesi, lokal anæstesi eller nerveblokade der varer mindst én dag efter administration til fremstillingen af et medikament til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade i mennesket eller dyr med behov derfor, analgesien, anæstesi eller nerveblokade omfatter administrering af medikamentet ved det sted hos et menneske eller dyr med behov derfor, hvor lægemiddelindretningen omfatter en flerhed af kollagensvampe, hvert kollagensvamp har 3,6 til 8mg/cm3 type I kollagen, og 2,0 til 6,0 mg/cm3 bupivacain-hydrochlorid.
7. Anvendelsen ifølge krav 6, hvor mindst én svamp er anbragt tilgrænsende det kirurgiske sted, mindst én svamp er anbragt på tværs af indsnittet i legemeskaviteten og mindst ét kompres er anbragt mellem kappen og huden rundt om indsnittet.
8. Anvendelsen ifølge krav 7, hvor anvendelsen er til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade hos et menneske efter laparotomi.
9. Anvendelsen ifølge kravene 7-8, hvor anvendelsen er til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade i et menneske efterortopædisk, abdominal, gynækologisk eller bryst-kirurgiske procedurer.
10. Anvendelsen ifølge krav 9, hvor anvendelsen er til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade i et menneske efter af benign abdominal eller bryst-kirurgiske procedurer.
11. Anvendelsen ifølge krav 10, hvor anvendelsen is til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade i et menneske efter abdominal hysterektomier, myomektomy og adnexal kirurgi.
12. Indretningen ifølge kravene 1-5 eller anvendelsen ifølge kravene 6-11, hvor svampen har en dybde på 0,5 cm.
13. Anvendelsen ifølge kravene 6-11, hvor analgesi er tilvejebragt uden bivirkninger forbundet med toksicitet fra kollagensvampen.
14. Anvendelsen ifølge kravene 6-11, hvor indretningen reducerer patientens behov for systemisk analgesi.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE2007/0220A IE85880B1 (en) | 2007-03-28 | A drug delivery device for providing local analgesia, local anesthesia or nerve blockade | |
| US11/692,337 US20080241243A1 (en) | 2007-03-28 | 2007-03-28 | Drug delivery device for providing local analgesia, local anesthesia or nerve blockade |
| PCT/IE2008/000035 WO2008117268A2 (en) | 2007-03-28 | 2008-03-28 | A drug delivery device for providing local analgesia, local anesthesia or nerve blockade |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2139457T3 true DK2139457T3 (da) | 2016-07-25 |
Family
ID=39540798
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16154811.0T DK3085363T3 (da) | 2007-03-28 | 2008-03-28 | Lægemiddelindgivelsesindretning til at tilvejebringe lokalanalgesi, lokalanæstesi eller nerveblokade |
| DK08719893.3T DK2139457T3 (da) | 2007-03-28 | 2008-03-28 | Lægemiddelafgivelsesindretning til at tilvejebringe lokal analgesi, lokal anæstesi eller nerveblokade |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16154811.0T DK3085363T3 (da) | 2007-03-28 | 2008-03-28 | Lægemiddelindgivelsesindretning til at tilvejebringe lokalanalgesi, lokalanæstesi eller nerveblokade |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP2139457B1 (da) |
| JP (1) | JP5372905B2 (da) |
| CY (2) | CY1117814T1 (da) |
| DE (1) | DE202008018583U1 (da) |
| DK (2) | DK3085363T3 (da) |
| ES (2) | ES2582368T3 (da) |
| HR (2) | HRP20160743T1 (da) |
| HU (2) | HUE027803T2 (da) |
| IE (1) | IES20080229A2 (da) |
| LT (1) | LT3085363T (da) |
| PL (2) | PL2139457T3 (da) |
| PT (2) | PT3085363T (da) |
| SI (2) | SI3085363T1 (da) |
| TR (1) | TR201905174T4 (da) |
| WO (1) | WO2008117268A2 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE47826E1 (en) | 2007-03-28 | 2020-01-28 | Innocoll Pharmaceuticals Limited | Drug delivery device for providing local analgesia, local anesthesia or nerve blockage |
| WO2010052694A2 (en) * | 2008-11-06 | 2010-05-14 | Innocoll Technologies Limited | Drug delivery implants and processes for their preparation |
| US8858983B2 (en) | 2009-04-30 | 2014-10-14 | Medtronic, Inc. | Antioxidants and antimicrobial accessories including antioxidants |
| US8911427B2 (en) | 2010-12-28 | 2014-12-16 | Medtronic, Inc. | Therapeutic agent reservoir delivery system |
| JP6199883B2 (ja) | 2011-12-05 | 2017-09-20 | インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ | 医療用オルガノゲルプロセス及び組成物 |
| SI3536748T1 (sl) * | 2012-01-09 | 2021-08-31 | Innocoll Pharmaceuticals Limited | Modificiran kolagen |
| CN105120839B (zh) * | 2013-02-28 | 2020-07-28 | 湖州惠中济世生物科技有限公司 | 可注射长效局麻药半固体制剂及其组成成分 |
| US10220093B2 (en) | 2013-02-28 | 2019-03-05 | Mira Pharma Corporation | Long-acting semi-solid lipid formulations |
| RU2561301C1 (ru) * | 2014-10-06 | 2015-08-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Омский государственный аграрный университет имени П.А. Столыпина" | Способ трансфеморальной блокады нервов мочевого пузыря у мелких животных |
| US10561606B2 (en) | 2017-12-06 | 2020-02-18 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid gel formulations |
| US11426418B2 (en) | 2017-12-06 | 2022-08-30 | Mira Pharma Corporation | Injectable long-acting semi-solid gel formulations |
| AU2022213016A1 (en) * | 2021-02-01 | 2023-08-24 | Massey University | Post-operative pain management |
| WO2022219179A1 (en) * | 2021-04-15 | 2022-10-20 | Innocoll Pharmaceuticals Limited | Drug-release implant for soft tissue surgery |
| IL310517A (en) * | 2021-07-28 | 2024-03-01 | Innocoll Pharm Ltd | Bupivacaine-collagen drug delivery implant and methods of making and using thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4125400C2 (de) * | 1991-07-31 | 2000-08-17 | Edwin Klaus | Verwendung von unlöslichem Kollagen zur Behandlung von degenerativen, nicht entzündlichen Gelenkprozessen |
| JPH08143449A (ja) * | 1994-11-17 | 1996-06-04 | Lederle Japan Ltd | 徐放性局所麻酔用注射剤 |
| US7119062B1 (en) * | 2001-02-23 | 2006-10-10 | Neucoll, Inc. | Methods and compositions for improved articular surgery using collagen |
| WO2006002365A2 (en) * | 2004-06-24 | 2006-01-05 | Angiotech International Ag | Microparticles with high loadings of a bioactive agent |
| AU2005287175B2 (en) * | 2004-09-17 | 2011-12-01 | Durect Corporation | Sustained local anesthetic composition containing preferably a sugar ester such as SAIB |
| DK1793872T3 (da) * | 2004-09-30 | 2016-07-25 | Covalon Tech Inc | Non-adhesive elastic gelatin matrices |
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2008
- 2008-03-28 LT LTEP16154811.0T patent/LT3085363T/lt unknown
- 2008-03-28 EP EP08719893.3A patent/EP2139457B1/en active Active
- 2008-03-28 WO PCT/IE2008/000035 patent/WO2008117268A2/en not_active Ceased
- 2008-03-28 DK DK16154811.0T patent/DK3085363T3/da active
- 2008-03-28 DK DK08719893.3T patent/DK2139457T3/da active
- 2008-03-28 SI SI200832058T patent/SI3085363T1/sl unknown
- 2008-03-28 PL PL08719893.3T patent/PL2139457T3/pl unknown
- 2008-03-28 ES ES08719893.3T patent/ES2582368T3/es active Active
- 2008-03-28 SI SI200831641A patent/SI2139457T1/sl unknown
- 2008-03-28 ES ES16154811T patent/ES2718542T3/es active Active
- 2008-03-28 PT PT16154811T patent/PT3085363T/pt unknown
- 2008-03-28 PL PL16154811T patent/PL3085363T3/pl unknown
- 2008-03-28 HU HUE08719893A patent/HUE027803T2/en unknown
- 2008-03-28 HU HUE16154811A patent/HUE043185T2/hu unknown
- 2008-03-28 TR TR2019/05174T patent/TR201905174T4/tr unknown
- 2008-03-28 EP EP16154811.0A patent/EP3085363B1/en active Active
- 2008-03-28 IE IE20080229A patent/IES20080229A2/en not_active IP Right Cessation
- 2008-03-28 JP JP2010500426A patent/JP5372905B2/ja not_active Expired - Fee Related
- 2008-03-28 DE DE202008018583.1U patent/DE202008018583U1/de not_active Expired - Lifetime
- 2008-03-28 PT PT87198933T patent/PT2139457T/pt unknown
- 2008-03-28 HR HRP20160743TT patent/HRP20160743T1/hr unknown
-
2016
- 2016-07-14 CY CY20161100677T patent/CY1117814T1/el unknown
-
2019
- 2019-04-12 CY CY20191100409T patent/CY1121568T1/el unknown
- 2019-04-15 HR HRP20190699TT patent/HRP20190699T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK3085363T3 (da) | 2019-04-29 |
| EP3085363B1 (en) | 2019-03-20 |
| TR201905174T4 (tr) | 2019-05-21 |
| WO2008117268A2 (en) | 2008-10-02 |
| SI3085363T1 (sl) | 2019-07-31 |
| LT3085363T (lt) | 2019-06-25 |
| WO2008117268A3 (en) | 2009-03-26 |
| PT3085363T (pt) | 2019-05-16 |
| PL2139457T3 (pl) | 2016-11-30 |
| JP5372905B2 (ja) | 2013-12-18 |
| EP2139457A2 (en) | 2010-01-06 |
| IES20080229A2 (en) | 2008-12-24 |
| EP3085363A1 (en) | 2016-10-26 |
| CY1121568T1 (el) | 2020-05-29 |
| HRP20190699T1 (hr) | 2019-07-12 |
| HUE043185T2 (hu) | 2019-08-28 |
| EP2139457B1 (en) | 2016-05-04 |
| SI2139457T1 (sl) | 2016-09-30 |
| DE202008018583U1 (de) | 2016-03-14 |
| HRP20160743T1 (hr) | 2016-09-23 |
| HUE027803T2 (en) | 2016-10-28 |
| PL3085363T3 (pl) | 2019-08-30 |
| ES2582368T3 (es) | 2016-09-12 |
| ES2718542T3 (es) | 2019-07-02 |
| PT2139457T (pt) | 2016-07-26 |
| JP2010522738A (ja) | 2010-07-08 |
| CY1117814T1 (el) | 2017-05-17 |
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