DK2155243T3 - Sammensætninger og fremgangsmåder omfattende KLK3, PSCA, eller FOLH1 antigen - Google Patents

Sammensætninger og fremgangsmåder omfattende KLK3, PSCA, eller FOLH1 antigen Download PDF

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DK2155243T3
DK2155243T3 DK08754370.8T DK08754370T DK2155243T3 DK 2155243 T3 DK2155243 T3 DK 2155243T3 DK 08754370 T DK08754370 T DK 08754370T DK 2155243 T3 DK2155243 T3 DK 2155243T3
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Yvonne Paterson
John Rothman
Vafa Shahabi
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Univ Pennsylvania
Advaxis Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001194—Prostate specific antigen [PSA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/17—Metallocarboxypeptidases (3.4.17)
    • C12Y304/17021—Glutamate carboxypeptidase II (3.4.17.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21077—Semenogelase (3.4.21.77), i.e. prostate specific antigen or PSA or kallikrein 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (15)

1. En rekombinant Listeria stamme, der udtrykker et fusionspeptid af kallikrein-relateret peptidase 3 (KLK3) peptid, der er operabelt bundet til et N-terminalt, ikke-hæmolytisk, listeriolysin (LLO) peptid, hvilket fusionspeptid omfatter sekvensen af SEQ ID NO: 54, eller en sekvens, der er mindst 99 % homolog med denne, hvor det pågældende N-terminale LLO peptid øger immunogeniciteten af fusionspeptidet, og hvor KLK3 peptidet ikke indeholder en signalsekvens.
2. Den rekombinante Listeria stamme ifølge krav 1, hvor den rekombinante Listeria stamme er en auxotrof Listeria stamme eller en rekombinant Listeria monocytogenes stamme.
3. Den rekombinante Listeria stamme ifølge krav 2, hvor den auxotrofe Listeria stamme er en dal / dat mutant eller yderligere omfatter en deletion i det endogene ActA gen.
4. Den rekombinante Listeria stamme ifølge krav 2, hvor den auxotrofe Listeria stamme omfatter en episomal ekspressionsvektor omfattende et metabolisk enzym, der supplerer auxotrofien af den auxotrofe Listeria stamme.
5. Den rekombinante Listeria stamme ifølge krav 4, hvor det metaboliske enzym er et alanin-racemase enzym eller et D-aminosyre-transferase enzym.
6. Den rekombinante Listeria stamme ifølge krav 1, hvor den rekombinante Listeria stamme er blevet passeret gennem et værtsdyr.
7. Et rekombinant polypeptid omfattende et fusionspeptid af et kallikrein-relateret peptidase 3 (KLK3) peptid, der er operabelt bundet til et N-terminalt, ikke-hæmolytisk, listeriolysin (LLO) peptid, hvilket fusionspeptid omfatter sekvensen af SEQ ID NO: 54, eller en sekvens, der er mindst 99 % homolog med denne, hvor det pågældende N-terminale LLO peptid øger immunogeniciteten af fusionspeptidet, og hvor KLK3 peptidet ikke indeholder en signalsekvens.
8. Et nukleotidmolekyle, der koder det rekombinante polypeptid ifølge krav 7.
9. En vaccine omfattende den rekombinante Listeria stamme ifølge et hvilket som helst af kravene 1 til 6, det rekombinante polypeptid ifølge krav 7, eller nukleotidmolekylet ifølge krav 8, og et adjuvans.
10. En rekombinant vaccine vektor, der koder det rekombinante polypeptid ifølge krav 7 eller omfatter nukleotidmolekylet ifølge krav 8.
11. Den rekombinante Listeria stamme ifølge et hvilket som helst af kravene 1 til 6, et immunogent præparat, der omfatter det rekombinante polypeptid ifølge krav 7 eller nukleotidet ifølge krav 8, til anvendelse ved induktion af et anti-KLK3 immunrespons i et individ.
12. Den rekombinante Listeria stamme ifølge et hvilket som helst af kravene 1 til 6, det rekombinante polypeptid ifølge krav 7, eller nukleotidet ifølge krav 8, til anvendelse ved behandling afen kallikrein-relateret peptidase 3 (KLK3) proteinudtrykkende prostatacancer i et individ, hvorved individet rejser et immunrespons mod den KLK3 protein-udtrykkende prostatacancer.
13. Den rekombinante Listeria stamme ifølge et hvilket som helst af kravene 1 til 6, det rekombinante polypeptid ifølge krav 7, eller nukleotidet ifølge krav 8, til anvendelse ved inhibering eller undertrykkelse afen KLK3 protein-udtrykkende prostatacancer i et individ, hvorved individet rejser et immunrespons mod den KLK3 protein-udtrykkende prostatacancer, og derved inhiberer eller undertrykker den KLK3 protein-udtrykkende prostatacancer i individet.
14. Det rekombinante polypeptid ifølge krav 7, fremstillet ved en fremgangsmåde omfattende trinnet at konjugere kemisk et polypeptid omfattende KLK3 peptidet til et polypeptid omfattende det N-terminale LLO peptid.
15. Den rekombinante Listeria stamme ifølge et hvilket som helst af kravene 1 til 6, en immunogen sammensætning omfattende det rekombinante polypeptid ifølge krav 7 eller nukleotidet ifølge krav 8, til anvendelse som et lægemiddel.
DK08754370.8T 2007-05-10 2008-05-12 Sammensætninger og fremgangsmåder omfattende KLK3, PSCA, eller FOLH1 antigen DK2155243T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/798,177 US9012141B2 (en) 2000-03-27 2007-05-10 Compositions and methods comprising KLK3 of FOLH1 antigen
PCT/US2008/006048 WO2008140812A2 (en) 2007-05-10 2008-05-12 Compositions and methods comprising klk3, psca, or folh1 antigen

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DK2155243T3 true DK2155243T3 (da) 2015-03-09

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US (4) US9012141B2 (da)
EP (2) EP2155243B8 (da)
JP (3) JP2010526533A (da)
DK (1) DK2155243T3 (da)
ES (1) ES2531967T3 (da)
HU (1) HUE024509T2 (da)
PL (1) PL2155243T3 (da)
PT (1) PT2155243E (da)
SI (1) SI2155243T1 (da)
WO (1) WO2008140812A2 (da)

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