DK2158319T3 - Knoglemålrettet alkalisk fosfatase, kits og fremgangsmåder til anvendelse deraf - Google Patents

Knoglemålrettet alkalisk fosfatase, kits og fremgangsmåder til anvendelse deraf

Info

Publication number: DK2158319T3
Authority: DK; Denmark
Prior art keywords: amino acid; alkaline phosphatase; kits; methods; bone
Prior art date: 2007-05-11

Application number

DK08757088.3T

Other languages

English (en)

Inventor

Hal Landy

Philippe Crine

Guy Boileau

Thomas P Loisel

Isabelle Lemire

Pierre Leonard

Robert Heft

Original Assignee

Enobia Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-05-11

Filing date

2008-05-12

Publication date

2012-03-19

2008-05-12 Application filed by Enobia Pharma Inc filed Critical Enobia Pharma Inc

2012-03-19 Application granted granted Critical

2012-03-19 Publication of DK2158319T3 publication Critical patent/DK2158319T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03001—Alkaline phosphatase (3.1.3.1)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Physical Education & Sports Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Materials For Medical Uses (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Cereal-Derived Products (AREA)
Adornments (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

DK08757088.3T 2007-05-11 2008-05-12 Knoglemålrettet alkalisk fosfatase, kits og fremgangsmåder til anvendelse deraf DK2158319T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US91758907P	2007-05-11	2007-05-11
PCT/CA2008/000923 WO2008138131A1 (en)	2007-05-11	2008-05-12	Bone targeted alkaline phosphatase, kits and methods of use thereof

Publications (1)

Publication Number	Publication Date
DK2158319T3 true DK2158319T3 (da)	2012-03-19

Family

ID=40001639

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK11004496.3T DK2368999T3 (da)	2007-05-11	2008-05-12	Knoglemålrettet alkalisk fosfatase, kits og fremgangsmåder til anvendelse deraf
DK13002327.8T DK2662448T3 (da)	2007-05-11	2008-05-12	Knoglemålrettet alkalisk phosphatase, kits og fremgangsmåder til anvendelse deraf
DK08757088.3T DK2158319T3 (da)	2007-05-11	2008-05-12	Knoglemålrettet alkalisk fosfatase, kits og fremgangsmåder til anvendelse deraf

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK11004496.3T DK2368999T3 (da)	2007-05-11	2008-05-12	Knoglemålrettet alkalisk fosfatase, kits og fremgangsmåder til anvendelse deraf
DK13002327.8T DK2662448T3 (da)	2007-05-11	2008-05-12	Knoglemålrettet alkalisk phosphatase, kits og fremgangsmåder til anvendelse deraf

Country Status (25)

Country	Link
US (1)	US20100297119A1 (da)
EP (3)	EP2662448B1 (da)
JP (1)	JP5732603B2 (da)
AT (1)	ATE536413T1 (da)
AU (1)	AU2008250945B2 (da)
BR (2)	BR122019000505B1 (da)
CA (1)	CA2687001C (da)
CY (1)	CY2016005I2 (da)
DE (1)	DE202008018131U1 (da)
DK (3)	DK2368999T3 (da)
ES (3)	ES2471915T3 (da)
FR (1)	FR16C0007I2 (da)
HR (1)	HRP20140416T1 (da)
HU (2)	HUE031655T2 (da)
IL (1)	IL202057A0 (da)
LT (1)	LTC2368999I2 (da)
LU (1)	LU92976I2 (da)
ME (1)	ME01828B (da)
NL (1)	NL300798I1 (da)
NO (1)	NO2016002I2 (da)
PL (3)	PL2662448T3 (da)
PT (3)	PT2158319E (da)
RS (1)	RS53302B (da)
SI (2)	SI2368999T1 (da)
WO (1)	WO2008138131A1 (da)

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PL2348114T3 (pl)	2004-04-21	2019-08-30	Alexion Pharmaceuticals, Inc.	Koniugaty do dostarczania do kości i sposób ich wykorzystania do nakierowywania białek na kość
US20070081984A1 (en)	2005-10-11	2007-04-12	Shunji Tomatsu	Compositions and methods for treating hypophosphatasia
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CN103897063B (zh)	2007-06-01	2017-04-12	马里兰大学巴尔的摩分校	免疫球蛋白恒定区Fc受体结合剂
EP2545080B1 (en)	2010-03-12	2017-05-10	Alexion Pharmaceuticals, Inc.	Npp1 fusion proteins
EP2563406A4 (en) *	2010-04-30	2013-11-13	Alexion Pharma Internat Sarl	METHOD, COMPOSITIONS AND KITS FOR TREATING MATRIX MINERALIZATION DISORDERS
EP3543257A1 (en)	2010-07-28	2019-09-25	Gliknik Inc.	Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions
EP2658979B1 (en)	2010-12-27	2018-02-14	Alexion Pharmaceuticals, Inc.	Compositions comprising natriuretic peptides and methods of use thereof
SG11201401605QA (en)	2011-10-19	2014-09-26	Alexion Pharma Holding	Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
US10052366B2 (en)	2012-05-21	2018-08-21	Alexion Pharmaceuticsl, Inc.	Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
KR20150058236A (ko)	2012-08-20	2015-05-28	글리크닉 인코포레이티드	항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자
EP3425048A1 (en) *	2014-01-24	2019-01-09	AM-Pharma B.V.	Chimeric alkaline phosphatase-like proteins
US10822596B2 (en)	2014-07-11	2020-11-03	Alexion Pharmaceuticals, Inc.	Compositions and methods for treating craniosynostosis
WO2016090251A1 (en) *	2014-12-05	2016-06-09	Alexion Pharmaceuticals, Inc.	Treating seizure with recombinant alkaline phosphatase
US10603361B2 (en)	2015-01-28	2020-03-31	Alexion Pharmaceuticals, Inc.	Methods of treating a subject with an alkaline phosphatase deficiency
SI3325011T1 (sl)	2015-07-24	2021-02-26	Gliknik Inc.	Fuzijski proteini humanih proteinskih fragmentov za tvorbo pravilnih multimeriziranih imunoglobulin FC sestavkov s povečanim vezanjem komplementa
AU2016308624B2 (en) *	2015-08-17	2022-06-23	Alexion Pharmaceuticals, Inc.	Manufacturing of alkaline phosphatases
EP3355904A4 (en) *	2015-09-28	2019-06-12	Alexion Pharmaceuticals, Inc.	IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA
JP2018533571A (ja)	2015-10-30	2018-11-15	アレクシオンファーマシューティカルズ，インコーポレイテッド	患者の頭蓋縫合早期癒合症を治療するための方法
EP3426286A4 (en) *	2016-03-08	2019-12-04	Alexion Pharmaceuticals, Inc.	PROCESS FOR TREATING HYPOPHOSPHATASIA IN CHILDREN
WO2017173395A1 (en) *	2016-04-01	2017-10-05	Alexion Pharmaceuticals, Inc.	Methods for treating hypophosphatasia in adolescents and adults
WO2017171871A1 (en) *	2016-04-01	2017-10-05	Alexion Pharmaceuticals, Inc.	Methods for treating hypophosphatasia in adolescents and adults
KR20180125979A (ko) *	2016-04-01	2018-11-26	알렉시온 파마슈티칼스, 인코포레이티드	알칼리성 포스파타아제로 근육 약화의 치료
US10988744B2 (en)	2016-06-06	2021-04-27	Alexion Pharmaceuticals, Inc.	Method of producing alkaline phosphatase
CA3026420A1 (en)	2016-06-07	2017-12-14	Gliknik Inc.	Cysteine-optimized stradomers
US20200306350A1 (en)	2016-06-27	2020-10-01	Alexion Pharmaceuticals, Inc.	Methods for treating hypophosphatasia in children and adolescents
JP7018933B2 (ja)	2016-08-18	2022-02-14	アレクシオンファーマシューティカルズ，インコーポレイテッド	気管気管支軟化症の治療方法
BR112019011070A2 (pt) *	2016-11-30	2019-10-01	Purdue Research Foundation	regeneração óssea direcionada à fratura através da estimulação do receptor de hormônio da paratireoide
EP3551647A4 (en)	2016-12-09	2021-01-13	Gliknik Inc.	MANUFACTURING OPTIMIZATION OF GL-2045, A MULTIMERIZING STRADOMER
IL266988B2 (en)	2016-12-09	2024-11-01	Gliknik Inc	Methods of treating inflammatory disorders with multivalent fc compounds
EP3592372A4 (en) *	2017-03-09	2021-01-13	Alexion Pharmaceuticals, Inc.	GLYCOPROTEIN MANUFACTURING PROCESS
MX2019011508A (es)	2017-03-31	2019-11-01	Alexion Pharma Inc	Metodos para tratar la hipofosfatasia (hpp) en adultos y adolescentes.
JP7511469B2 (ja)	2017-09-27	2024-07-05	イノザイムファーマ，インコーポレイテッド	組換えエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ（ｎｐｐ１）を使用して心血管機能を改善し、心血管疾患を処置するための方法。
EP3737750B1 (en)	2018-01-09	2024-06-05	Theriva Biologics, Inc.	Alkaline phosphatase agents for treatment of neurodevelopmental disorders
JP7214962B2 (ja) *	2018-01-17	2023-01-31	東ソー株式会社	アルカリホスファターゼ高発現動物細胞
ES3032290T3 (en)	2018-03-20	2025-07-16	Theriva Biologics Inc	Intestinal alkaline phosphatase formulations
WO2019183209A1 (en)	2018-03-20	2019-09-26	Synthetic Biologics, Inc.	Alkaline phosphatase agents for treatment of radiation disorders
US11913039B2 (en)	2018-03-30	2024-02-27	Alexion Pharmaceuticals, Inc.	Method for producing recombinant alkaline phosphatase
CN110499284A (zh) *	2018-05-17	2019-11-26	西安组织工程与再生医学研究所	Wnt信号通路激活剂在制备治疗基因ALPL敲除小鼠牙硬组织矿化异常产品中的应用
EP3790574A4 (en)	2018-05-30	2022-07-13	Purdue Research Foundation	TARGETING ANABOLIC DRUGS TO ACCELERATE FRACTURE REPAIR
JP7820148B2 (ja)	2018-08-10	2026-02-25	アレクシオンファーマシューティカルズ，インコーポレイテッド	アルカリホスファターゼを用いて神経線維腫症１型および関連状態を治療する方法
KR20220005560A (ko)	2019-05-06	2022-01-13	신세틱 바이오로직스, 인코퍼레이티드	알칼리성 포스페이트-기반 종양학 치료제
MX2022007114A (es) *	2019-12-09	2022-07-11	Alexion Pharma Inc	Polipeptidos de fosfatasa alcalina y metodos de uso de los mismos.
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2008
- 2008-05-12 RS RS20140237A patent/RS53302B/sr unknown
- 2008-05-12 PL PL13002327T patent/PL2662448T3/pl unknown
- 2008-05-12 ME MEP-2014-48A patent/ME01828B/me unknown
- 2008-05-12 DK DK11004496.3T patent/DK2368999T3/da active
- 2008-05-12 ES ES11004496.3T patent/ES2471915T3/es active Active
- 2008-05-12 HU HUE13002327A patent/HUE031655T2/hu unknown
- 2008-05-12 JP JP2010507770A patent/JP5732603B2/ja active Active
- 2008-05-12 PL PL11004496T patent/PL2368999T3/pl unknown
- 2008-05-12 US US12/599,679 patent/US20100297119A1/en not_active Abandoned
- 2008-05-12 BR BR122019000505-2A patent/BR122019000505B1/pt active Search and Examination
- 2008-05-12 DK DK13002327.8T patent/DK2662448T3/da active
- 2008-05-12 PT PT08757088T patent/PT2158319E/pt unknown
- 2008-05-12 EP EP13002327.8A patent/EP2662448B1/en active Active
- 2008-05-12 BR BRPI0811198A patent/BRPI0811198B8/pt active IP Right Grant
- 2008-05-12 EP EP08757088A patent/EP2158319B1/en active Active
- 2008-05-12 CA CA2687001A patent/CA2687001C/en active Active
- 2008-05-12 DK DK08757088.3T patent/DK2158319T3/da active
- 2008-05-12 PT PT130023278T patent/PT2662448T/pt unknown
- 2008-05-12 ES ES08757088T patent/ES2380546T3/es active Active
- 2008-05-12 PL PL08757088T patent/PL2158319T4/pl unknown
- 2008-05-12 ES ES13002327T patent/ES2619332T3/es active Active
- 2008-05-12 WO PCT/CA2008/000923 patent/WO2008138131A1/en not_active Ceased
- 2008-05-12 DE DE202008018131U patent/DE202008018131U1/de not_active Expired - Lifetime
- 2008-05-12 AU AU2008250945A patent/AU2008250945B2/en active Active
- 2008-05-12 PT PT110044963T patent/PT2368999E/pt unknown
- 2008-05-12 SI SI200831200T patent/SI2368999T1/sl unknown
- 2008-05-12 SI SI200831780A patent/SI2662448T1/sl unknown
- 2008-05-12 EP EP11004496.3A patent/EP2368999B1/en active Active
- 2008-05-12 AT AT08757088T patent/ATE536413T1/de active
2009
- 2009-11-11 IL IL202057A patent/IL202057A0/en unknown
2014
- 2014-05-08 HR HRP20140416AT patent/HRP20140416T1/hr unknown
2016
- 2016-01-15 HU HUS1600005C patent/HUS1600005I1/hu unknown
- 2016-01-28 LT LTPA2016004C patent/LTC2368999I2/lt unknown
- 2016-02-02 NO NO2016002C patent/NO2016002I2/no not_active IP Right Cessation
- 2016-02-10 LU LU92976C patent/LU92976I2/xx unknown
- 2016-02-19 FR FR16C0007C patent/FR16C0007I2/fr active Active
- 2016-02-23 CY CY2016005C patent/CY2016005I2/el unknown
- 2016-02-26 NL NL300798C patent/NL300798I1/nl unknown

Also Published As

Publication number	Publication date
JP5732603B2 (ja)	2015-06-10
NO2016002I1 (no)	2016-02-02
AU2008250945A1 (en)	2008-11-20
FR16C0007I2 (fr)	2017-01-27
CY2016005I1 (el)	2016-08-31
BRPI0811198B8 (pt)	2021-05-25
LTC2368999I2 (lt)	2017-09-25
CA2687001C (en)	2019-02-12
ES2380546T3 (es)	2012-05-16
HRP20140416T1 (hr)	2014-06-20
CY2016005I2 (el)	2016-08-31
EP2368999A1 (en)	2011-09-28
DK2368999T3 (da)	2014-05-26
NO2016002I2 (no)	2016-02-02
HK1141047A1 (en)	2010-10-29
FR16C0007I1 (da)	2016-04-15
ES2471915T3 (es)	2014-06-27
LTPA2016004I1 (lt)	2016-02-25
RS53302B (sr)	2014-08-29
EP2158319A1 (en)	2010-03-03
WO2008138131A1 (en)	2008-11-20
NL300798I2 (da)	2016-03-16
HK1162589A1 (en)	2012-08-31
PT2662448T (pt)	2017-03-29
ATE536413T1 (de)	2011-12-15
PL2662448T3 (pl)	2017-07-31
US20100297119A1 (en)	2010-11-25
BRPI0811198A8 (pt)	2018-08-14
BR122019000505A2 (pt)	2021-12-14
DK2662448T3 (da)	2017-03-20
ES2619332T3 (es)	2017-06-26
PL2368999T3 (pl)	2014-08-29
AU2008250945B2 (en)	2013-12-12
AU2008250945A2 (en)	2009-12-24
HK1191372A1 (en)	2014-07-25
HUS1600005I1 (hu)	2016-02-29
CA2687001A1 (en)	2008-11-20
PT2368999E (pt)	2014-05-26
WO2008138131A4 (en)	2008-12-31
EP2662448B1 (en)	2016-12-21
EP2158319A4 (en)	2010-07-21
IL202057A0 (en)	2011-08-01
ME01828B (me)	2014-12-20
WO2008138131A9 (en)	2009-08-06
DE202008018131U1 (de)	2011-12-30
NL300798I1 (da)	2016-03-16
PL2158319T4 (pl)	2016-04-29
PL2158319T3 (pl)	2012-05-31
BRPI0811198A2 (pt)	2014-10-21
EP2368999B1 (en)	2014-03-12
LU92976I2 (en)	2016-04-11
JP2010526543A (ja)	2010-08-05
EP2158319B1 (en)	2011-12-07
EP2662448A1 (en)	2013-11-13
HUE031655T2 (hu)	2017-07-28
BRPI0811198B1 (pt)	2021-03-09
SI2368999T1 (sl)	2014-07-31
BR122019000505B1 (pt)	2022-01-18
PT2158319E (pt)	2012-03-06
SI2662448T1 (sl)	2017-05-31

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BR112012014082A2 (pt)	2017-05-23	composições e métodos que compreendem variantes de protease
MA29135B1 (fr)	2008-01-02	Potentialisateurs de recepteurs du glutamate
BRPI0414593A (pt)	2006-11-07	derivados de ácido sulfonamida substituìda-indol-2-carboxìlico como inibidores de pai-1
BRPI0414598A (pt)	2006-11-07	indóis substituìdos
ATE542803T1 (de)	2012-02-15	Verfahren zur herstellung von dihydrochinazolinen
PT1791571E (pt)	2008-11-19	Péptidos radiofluorados
DE602006018856D1 (de)	2011-01-27	Neue nutrazeutika-zusammensetzungen
SE0403171D0 (sv)	2004-12-23	New compounds
EA200601743A1 (ru)	2007-08-31	Выделенный полипептид реналазы и его применение
ATE469896T1 (de)	2010-06-15	Aminosäuresalze von rosiglitazon
DK2084198T3 (da)	2010-05-31	Beklædningssammensætning
ES2573462T3 (es)	2016-06-08	Polipéptidos de PH20 soluble extendida y usos de los mismos
ATE539762T1 (de)	2012-01-15	Aminosäureersatz für peptidkonstruktionen
DE602007006493D1 (de)	2010-06-24	Peptide mit proliferationshemmender wirkung
CY1115263T1 (el)	2016-08-31	Αλκαλικη φωσφαταση στοχευμενη στα οστα, κιτ και μεθοδοι χρησης αυτων
CU20120123A7 (es)	2014-02-28	Formas cristalinas de la 4-metil-n-[3-(4-metil-imidazol-1-il)-5-trifluoro-metil-fenil]-3-il-pirimidin-2-il-amino)-benzamida