CY2016005I2 - Αλκαλικη φωσφαταση στοχευμενη στα οστα, κιτ και μεθοδοι χρησης αυτων - Google Patents

Αλκαλικη φωσφαταση στοχευμενη στα οστα, κιτ και μεθοδοι χρησης αυτων

Info

Publication number: CY2016005I2
Authority: CY; Cyprus
Prior art keywords: kits; bone; methods; alkaline phosphatase; targeted alkaline
Prior art date: 2007-05-11

Application number

CY2016005C

Other languages

English (en)

Other versions

CY2016005I1 (el

Original Assignee

Alexion Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-05-11

Filing date

2016-02-23

Publication date

2016-08-31

2016-02-23 Application filed by Alexion Pharmaceuticals, Inc. filed Critical Alexion Pharmaceuticals, Inc.

2016-08-31 Publication of CY2016005I1 publication Critical patent/CY2016005I1/el

2016-08-31 Publication of CY2016005I2 publication Critical patent/CY2016005I2/el

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03001—Alkaline phosphatase (3.1.3.1)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/025—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a parvovirus

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Materials For Medical Uses (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Adornments (AREA)
Cereal-Derived Products (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

CY2016005C 2007-05-11 2016-02-23 Αλκαλικη φωσφαταση στοχευμενη στα οστα, κιτ και μεθοδοι χρησης αυτων CY2016005I2 (el)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US91758907P	2007-05-11	2007-05-11
EP08757088A EP2158319B1 (en)	2007-05-11	2008-05-12	Bone targeted alkaline phosphatase, kits and methods of use thereof

Publications (2)

Publication Number	Publication Date
CY2016005I1 CY2016005I1 (el)	2016-08-31
CY2016005I2 true CY2016005I2 (el)	2016-08-31

Family

ID=40001639

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY2016005C CY2016005I2 (el)	2007-05-11	2016-02-23	Αλκαλικη φωσφαταση στοχευμενη στα οστα, κιτ και μεθοδοι χρησης αυτων

Country Status (25)

Country	Link
US (1)	US20100297119A1 (el)
EP (3)	EP2158319B1 (el)
JP (1)	JP5732603B2 (el)
AT (1)	ATE536413T1 (el)
AU (1)	AU2008250945B2 (el)
BR (2)	BRPI0811198B8 (el)
CA (1)	CA2687001C (el)
CY (1)	CY2016005I2 (el)
DE (1)	DE202008018131U1 (el)
DK (3)	DK2158319T3 (el)
ES (3)	ES2471915T3 (el)
FR (1)	FR16C0007I2 (el)
HR (1)	HRP20140416T1 (el)
HU (2)	HUE031655T2 (el)
IL (1)	IL202057A0 (el)
LT (1)	LTC2368999I2 (el)
LU (1)	LU92976I2 (el)
ME (1)	ME01828B (el)
NL (1)	NL300798I1 (el)
NO (1)	NO2016002I1 (el)
PL (3)	PL2158319T4 (el)
PT (3)	PT2662448T (el)
RS (1)	RS53302B (el)
SI (2)	SI2662448T1 (el)
WO (1)	WO2008138131A1 (el)

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HUE055861T2 (hu)	2004-04-21	2021-12-28	Alexion Pharma Inc	Csontbejuttató konjugátumok és azok alkalmazási módszere fehérjék csonthoz kötéséhez
US20070081984A1 (en)	2005-10-11	2007-04-12	Shunji Tomatsu	Compositions and methods for treating hypophosphatasia
US8784833B2 (en) *	2006-06-27	2014-07-22	Saint Louis University	Prenatal enzyme replacement therapy for hypophosphatasia
MX367012B (es)	2007-06-01	2019-08-02	Univ Maryland	Agentes de union al receptor de la region constante fc de inmunoglobulina.
WO2011113027A2 (en)	2010-03-12	2011-09-15	Synageva Biopharma Corp	Npp1 fusion proteins
BR112012027765A2 (pt) *	2010-04-30	2019-09-24	Enobia Pharma Inc	métodos, composições e kits para tratamento de distúrbios de mineralização da matriz.
AU2011282579B2 (en)	2010-07-28	2014-10-23	Gliknik Inc.	Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin Fc compositions
US9266939B2 (en)	2010-12-27	2016-02-23	Alexion Pharmaceuticals, Inc.	Compositions comprising natriuretic peptides and methods of use thereof
SG11201401605QA (en) *	2011-10-19	2014-09-26	Alexion Pharma Holding	Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
US10052366B2 (en)	2012-05-21	2018-08-21	Alexion Pharmaceuticsl, Inc.	Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
EP2885320A4 (en)	2012-08-20	2016-04-06	Gliknik Inc	MOLECULES WITH ANTIGEN-BINDING AND POLYVALENT FC GAMMA RECEPTOR BINDING ACTIVITY
PE20161442A1 (es) *	2014-01-24	2017-01-12	Am-Pharma B V	Proteinas quimericas tipo fosfatasa alcalina
WO2016007873A1 (en)	2014-07-11	2016-01-14	The Regents Of The University Of Michigan	Compositions and methods for treating craniosynostosis
CA2967851C (en)	2014-12-05	2024-02-27	Alexion Pharmaceuticals, Inc.	Treating seizure with recombinant alkaline phosphatase
AU2016211447B2 (en)	2015-01-28	2021-09-23	Alexion Pharmaceuticals, Inc.	Methods of treating a subject with an alkaline phosphatase deficiency
FI3325011T6 (fi)	2015-07-24	2023-05-11		Ihmisen proteiinifragmenttien fuusioproteiineja järjestyksenmukaisesti multimerisoitujen, paremmin komplementtia sitovien immunoglobuliini-fc-koostumusten muodostamiseksi
EP3337894A1 (en) *	2015-08-17	2018-06-27	Alexion Pharmaceuticals, Inc.	Manufacturing of alkaline phosphatases
JP6868617B2 (ja) *	2015-09-28	2021-05-12	アレクシオンファーマシューティカルズ，インコーポレイテッド	低ホスファターゼ血症の組織非特異的アルカリホスファターゼ（ｔｎｓａｌｐ）酵素補充療法に有効な投薬計画の特定
US11400140B2 (en)	2015-10-30	2022-08-02	Alexion Pharmaceuticals, Inc.	Methods for treating craniosynostosis in a patient
US11065306B2 (en)	2016-03-08	2021-07-20	Alexion Pharmaceuticals, Inc.	Methods for treating hypophosphatasia in children
WO2017171871A1 (en) *	2016-04-01	2017-10-05	Alexion Pharmaceuticals, Inc.	Methods for treating hypophosphatasia in adolescents and adults
KR20220162816A (ko) *	2016-04-01	2022-12-08	알렉시온 파마슈티칼스, 인코포레이티드	알칼리성 포스파타아제로 근육 약화의 치료
WO2017173395A1 (en) *	2016-04-01	2017-10-05	Alexion Pharmaceuticals, Inc.	Methods for treating hypophosphatasia in adolescents and adults
US10988744B2 (en)	2016-06-06	2021-04-27	Alexion Pharmaceuticals, Inc.	Method of producing alkaline phosphatase
US11034775B2 (en)	2016-06-07	2021-06-15	Gliknik Inc.	Cysteine-optimized stradomers
EP3474886B1 (en)	2016-06-27	2021-08-04	Alexion Pharmaceuticals, Inc.	Methods for treating hypophosphatasia in children and adolescents
WO2018035420A1 (en)	2016-08-18	2018-02-22	Alexion Pharmaceuticals, Inc.	Methods for treating tracheobronchomalacia
WO2018102616A1 (en) *	2016-11-30	2018-06-07	Purdue Research Foundation	Fracture targeted bone regeneration through parathyroid hormone receptor stimulation
JP7519774B2 (ja)	2016-12-09	2024-07-22	グリックニックインコーポレイテッド	多価ｆｃ化合物を用いる炎症性疾患の治療方法
KR102729723B1 (ko)	2016-12-09	2024-11-15	글리크닉 인코포레이티드	다합체화 스트라도머인 gl-2045의 제조 최적화
US20220348977A1 (en) *	2017-03-09	2022-11-03	Alexion Pharmaceuticals, Inc.	Glycoprotein manufacturing process
JP2020512363A (ja) *	2017-03-31	2020-04-23	アレクシオンファーマシューティカルズ，インコーポレイテッド	成人及び青年における低ホスファターゼ症（ｈｐｐ）を治療する方法
WO2019067502A1 (en)	2017-09-27	2019-04-04	Alexion Pharmaceuticals, Inc.	METHODS FOR IMPROVING CARDIOVASCULAR FUNCTION AND TREATING CARDIOVASCULAR DISEASE USING RECOMBINANT ECTO-NUCLEOTIDE PYROPHOSPHATASE / PHOSPHODIESTERASE
EP3737750B1 (en)	2018-01-09	2024-06-05	Theriva Biologics, Inc.	Alkaline phosphatase agents for treatment of neurodevelopmental disorders
JP7214962B2 (ja) *	2018-01-17	2023-01-31	東ソー株式会社	アルカリホスファターゼ高発現動物細胞
ES3032290T3 (en)	2018-03-20	2025-07-16	Theriva Biologics Inc	Intestinal alkaline phosphatase formulations
WO2019183209A1 (en)	2018-03-20	2019-09-26	Synthetic Biologics, Inc.	Alkaline phosphatase agents for treatment of radiation disorders
JP2021519590A (ja) *	2018-03-30	2021-08-12	アレクシオンファーマシューティカルズ，インコーポレイテッド	糖タンパク質の製造
CN110499284A (zh) *	2018-05-17	2019-11-26	西安组织工程与再生医学研究所	Wnt信号通路激活剂在制备治疗基因ALPL敲除小鼠牙硬组织矿化异常产品中的应用
US20210214408A1 (en)	2018-05-30	2021-07-15	Purdue Research Foundation	Targeting anabolic drugs for accelerated fracture repair
WO2020033867A2 (en)	2018-08-10	2020-02-13	Alexion Pharmaceuticals, Inc.	Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase
AU2020270046B2 (en)	2019-05-06	2026-02-05	Theriva Biologics, Inc.	Alkaline phosphate-based oncology treatments
JP7796645B2 (ja) *	2019-12-09	2026-01-09	アレクシオンファーマシューティカルズ，インコーポレイテッド	アルカリホスファターゼポリペプチド及びその使用方法
EP4084819A1 (en)	2020-01-03	2022-11-09	The United States of America, as represented by the Secretary, Department of Health and Human Services	Tnap locally administered for promoting periodontal health
KR20230117327A (ko) *	2020-09-03	2023-08-08	어빈 에스.와이. 첸	가용성 알칼리성 포스파타제 작제물 및 가용성 알칼리성 포스파타제 작제물을 인코딩하는 폴리뉴클레오티드를 포함하는 발현 벡터
KR102571967B1 (ko) *	2021-01-21	2023-08-30	주식회사 마라나노텍코리아	Alp 측정용 바이오 센서
CA3173631A1 (en)	2021-02-12	2022-08-18	Walter C. Voegtli	Alkaline phosphatase polypeptides and methods of use thereof
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2008
- 2008-05-12 PL PL08757088T patent/PL2158319T4/pl unknown
- 2008-05-12 CA CA2687001A patent/CA2687001C/en active Active
- 2008-05-12 DK DK08757088.3T patent/DK2158319T3/da active
- 2008-05-12 US US12/599,679 patent/US20100297119A1/en not_active Abandoned
- 2008-05-12 WO PCT/CA2008/000923 patent/WO2008138131A1/en not_active Ceased
- 2008-05-12 BR BRPI0811198A patent/BRPI0811198B8/pt active IP Right Grant
- 2008-05-12 SI SI200831780A patent/SI2662448T1/sl unknown
- 2008-05-12 JP JP2010507770A patent/JP5732603B2/ja active Active
- 2008-05-12 ES ES11004496.3T patent/ES2471915T3/es active Active
- 2008-05-12 ES ES08757088T patent/ES2380546T3/es active Active
- 2008-05-12 EP EP08757088A patent/EP2158319B1/en active Active
- 2008-05-12 EP EP13002327.8A patent/EP2662448B1/en active Active
- 2008-05-12 ME MEP-2014-48A patent/ME01828B/me unknown
- 2008-05-12 RS RS20140237A patent/RS53302B/sr unknown
- 2008-05-12 AT AT08757088T patent/ATE536413T1/de active
- 2008-05-12 DE DE202008018131U patent/DE202008018131U1/de not_active Expired - Lifetime
- 2008-05-12 DK DK11004496.3T patent/DK2368999T3/da active
- 2008-05-12 PL PL13002327T patent/PL2662448T3/pl unknown
- 2008-05-12 BR BR122019000505-2A patent/BR122019000505B1/pt active Search and Examination
- 2008-05-12 HU HUE13002327A patent/HUE031655T2/hu unknown
- 2008-05-12 PL PL11004496T patent/PL2368999T3/pl unknown
- 2008-05-12 DK DK13002327.8T patent/DK2662448T3/en active
- 2008-05-12 AU AU2008250945A patent/AU2008250945B2/en active Active
- 2008-05-12 PT PT130023278T patent/PT2662448T/pt unknown
- 2008-05-12 SI SI200831200T patent/SI2368999T1/sl unknown
- 2008-05-12 PT PT110044963T patent/PT2368999E/pt unknown
- 2008-05-12 EP EP11004496.3A patent/EP2368999B1/en active Active
- 2008-05-12 PT PT08757088T patent/PT2158319E/pt unknown
- 2008-05-12 ES ES13002327T patent/ES2619332T3/es active Active
2009
- 2009-11-11 IL IL202057A patent/IL202057A0/en unknown
2014
- 2014-05-08 HR HRP20140416AT patent/HRP20140416T1/hr unknown
2016
- 2016-01-15 HU HUS1600005C patent/HUS1600005I1/hu unknown
- 2016-01-28 LT LTPA2016004C patent/LTC2368999I2/lt unknown
- 2016-02-02 NO NO2016002C patent/NO2016002I1/no not_active IP Right Cessation
- 2016-02-10 LU LU92976C patent/LU92976I2/xx unknown
- 2016-02-19 FR FR16C0007C patent/FR16C0007I2/fr active Active
- 2016-02-23 CY CY2016005C patent/CY2016005I2/el unknown
- 2016-02-26 NL NL300798C patent/NL300798I1/nl unknown

Also Published As

Publication number	Publication date
PT2662448T (pt)	2017-03-29
PT2158319E (pt)	2012-03-06
JP5732603B2 (ja)	2015-06-10
HK1191372A1 (en)	2014-07-25
JP2010526543A (ja)	2010-08-05
DK2368999T3 (da)	2014-05-26
EP2158319B1 (en)	2011-12-07
LU92976I2 (en)	2016-04-11
CY2016005I1 (el)	2016-08-31
ES2619332T3 (es)	2017-06-26
HK1141047A1 (en)	2010-10-29
PT2368999E (pt)	2014-05-26
HK1162589A1 (en)	2012-08-31
SI2368999T1 (sl)	2014-07-31
NL300798I2 (el)	2016-03-16
LTC2368999I2 (lt)	2017-09-25
HUS1600005I1 (hu)	2016-02-29
FR16C0007I2 (fr)	2017-01-27
EP2662448B1 (en)	2016-12-21
WO2008138131A9 (en)	2009-08-06
BRPI0811198B8 (pt)	2021-05-25
PL2158319T4 (pl)	2016-04-29
PL2158319T3 (pl)	2012-05-31
PL2662448T3 (pl)	2017-07-31
CA2687001C (en)	2019-02-12
BRPI0811198A2 (pt)	2014-10-21
BR122019000505A2 (pt)	2021-12-14
BR122019000505B1 (pt)	2022-01-18
EP2662448A1 (en)	2013-11-13
HUE031655T2 (hu)	2017-07-28
BRPI0811198B1 (pt)	2021-03-09
AU2008250945A2 (en)	2009-12-24
NL300798I1 (el)	2016-03-16
AU2008250945B2 (en)	2013-12-12
EP2158319A1 (en)	2010-03-03
AU2008250945A1 (en)	2008-11-20
RS53302B (sr)	2014-08-29
DK2158319T3 (da)	2012-03-19
SI2662448T1 (sl)	2017-05-31
EP2368999B1 (en)	2014-03-12
US20100297119A1 (en)	2010-11-25
WO2008138131A1 (en)	2008-11-20
PL2368999T3 (pl)	2014-08-29
LTPA2016004I1 (lt)	2016-02-25
NO2016002I2 (no)	2016-02-02
EP2368999A1 (en)	2011-09-28
DK2662448T3 (en)	2017-03-20
ATE536413T1 (de)	2011-12-15
EP2158319A4 (en)	2010-07-21
ES2471915T3 (es)	2014-06-27
CA2687001A1 (en)	2008-11-20
WO2008138131A4 (en)	2008-12-31
IL202057A0 (en)	2011-08-01
FR16C0007I1 (el)	2016-04-15
NO2016002I1 (no)	2016-02-02
ES2380546T3 (es)	2012-05-16
ME01828B (me)	2014-12-20
DE202008018131U1 (de)	2011-12-30
BRPI0811198A8 (pt)	2018-08-14
HRP20140416T1 (hr)	2014-06-20

Publication	Publication Date	Title
CY2016005I2 (el)	2016-08-31	Αλκαλικη φωσφαταση στοχευμενη στα οστα, κιτ και μεθοδοι χρησης αυτων
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