DK2167169T4 - Tokammerkarpule med tilbehør - Google Patents
Tokammerkarpule med tilbehør Download PDFInfo
- Publication number
- DK2167169T4 DK2167169T4 DK08758924.8T DK08758924T DK2167169T4 DK 2167169 T4 DK2167169 T4 DK 2167169T4 DK 08758924 T DK08758924 T DK 08758924T DK 2167169 T4 DK2167169 T4 DK 2167169T4
- Authority
- DK
- Denmark
- Prior art keywords
- exendin
- asp28
- des pro36
- cylinder
- lys
- Prior art date
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- JUFFVKRROAPVBI-PVOYSMBESA-N chembl1210015 Chemical group C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@H]1[C@@H]([C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@]3(O[C@@H](C[C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C3)C(O)=O)O2)O)[C@@H](CO)O1)NC(C)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 JUFFVKRROAPVBI-PVOYSMBESA-N 0.000 claims description 152
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- 206010012601 diabetes mellitus Diseases 0.000 claims description 3
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- 238000003780 insertion Methods 0.000 description 3
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- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 2
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 description 2
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
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- 229940071643 prefilled syringe Drugs 0.000 description 1
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
- A61M2005/31506—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit formed as a single piece, e.g. moulded
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Pens And Brushes (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Nozzles (AREA)
Claims (10)
1. Tokammerkarpule bestående af a) en cylinder indeholdende en endeprop, som er placeret på den proksimale ende af cylinderen, valgfrit et stop (13) på den proksimale ende (9), en midterprop (6), en bypass (3) , en distal ende (8) til forbindelse med tilbehør, og b) tilbehøret bestående af en lukkeanordning med en distal åbning, som er egnet til at stikke en applikationsnål igennem, og valgfrit en nåleholder, et eller flere tætningselementer til tætning af den distale ende på lukkeanordningen og/eller til tætning af forbindelsen mellem lukkeanordning og cylinder, kendetegnet ved, at lukninganordningen er udført i to eller tre stykker, og en proksimal ende på tilbehøret er enden af et hoved, som i samlet tilstand er forbundet med den distale ende på cylinderen, idet der er tilvejebragt en aksial not (11) på den proksimale ende af hovedet eller på den distale ende på cylinderen på indersiden af den optagende del.
2. Tokammerkarpule ifølge krav 1, idet tilbehøret består af hovedet (2) og en lukkekappe (5) med distal åbning, som er egnet til at stikke en applikationsnål igennem, og valgfrit en nåleholder, et tætningselement til tætning af forbindelsen mellem hoved (2) og lukkekappe (5) og valgfrit et yderligere tætningselement (7) til tætning af forbindelsen mellem hoved (2) og cylinder (1) .
3. Tokammerkarpule ifølge krav 1, idet udstyret består af hovedet (2), en hovedholder (19) og en lukkekappe (5) med distal åbning, som er egnet til at stikke en applikationsnål igennem, og valgfrit en nåleholder, et tætningselement til tætning af forbindelsen mellem hoved (2) og lukkekappe (5) og valgfrit et yderligere tætningselement (7) til tætning af forbindelsen mellem hoved (2) og cylinder (1).
4. Tokammerkarpule ifølge et af kravene 1 til 3, idet den proksimale ende på cylinderen (1) har et stop (13).
5. Tokammerkarpule ifølge et af kravene 1 til 4, idet tokammerkarpulen har et medikament, som skal administreres, og idet det medikament, der skal administreres, er et peptid til behandling af diabetes mellitus eller komplikationer i forbindelse med diabetes mellitus.
6. Tokammerkarpule ifølge krav 5, idet peptidet er exendin-4(1-39) eller et peptid udvalgt af gruppen H-(Lys)4-des Pro36, des Pro37 exendin-4 (1-39) -NH2, H-(Lys)5-des Pro36, des Pro37 exendin-4 (1-39) -NH2, des Pro36 [Asp28] exendin-4 (1-39) , des Pro36 [IsoAsp28] exendin-4 (1-39) , des Pro36 [Met (O)14, Asp28] exendin-4 (1-39) , des Pro36 [Met (O)14, IsoAsp28] exendin-4 (1-39) , des Pro36 [Trp(02) 25, Asp28] exendin-4 (1-39) , des Pro36 [Trp(C>2)25, IsoAsp28] exendin-4 (1-39) , des Pro36 [Met (0) 14 Trp(02) 25, Asp28] exendin-4 (1-39) , des Pro36 [Met (0) 14 Trp(02) 25, IsoAsp28] exendin-4 (1-39) , H-(Lys)6_des Pro36 [Asp28] exendin-4 (1-39)-Lys6-NH2, des Asp28 Pro36, Pro37, Pro38exendin-4 (1-39)-NH2, H-(Lys)6_des Pro36, Pro38 [Asp28] exendin-4 (1-39) -NH2, H-Asn- (Glu) 5des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39) -NH2, des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39) - (Lys) 6_NH2, H-(Lys)6_des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39) - (Lys) e~ NH2, H-Asn-(Glu) 5-des Pro36, Pro37, Pro38 [Asp28] exendin-4 (1-39)-(Lys) 6-NH2, H-(Lys)6_des Pro36 [Trp(C>2)25, Asp28] exendin-4 (1-39) -Lys6-NH2, H-des Asp28 Pro36, Pro37, Pro38 [Trp(C>2)25] exendin-4 (1-39) -NH2, H-(Lys)6_des Pro36, Pro37, Pro38 [Trp(C>2)25, Asp28] exendin-4 (1-39) -NH2, H-Asn-(Glu) 5-des Pro36, Pro37, Pro38 [Trp(C>2)25, Asp28] exendin-4 (1-39) -NH2, des Pro36, Pro37, Pro38 [Trp(C>2)25, Asp28] exendin-4 (1-39) - (Lys) e~ NH2, H-(Lys)6_des Pro36, Pro37, Pro38 [Trp(02) 25, Asp28] exendin-4(1-39) - (Lys) 6-NH2, H-Asn-(Glu)5-des Pro36, Pro37, Pro38 [Trp(02) 25, Asp28] exendin-4 (1-39) - (Lys) 6-NH2, H-(Lys)6_des Pro36 [Met(O)14, Asp28] exendin-4 (1-39)-Lys6-NH2, des Met (0) 14 Asp28 Pro36, Pro37, Pro38 exendin-4 (1-39) -NH2, H-(Lys) 6_desPro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1-39)-NH2, H-Asn-(Glu) 5-des Pro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1-39) -NH2, des Pro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1-39) - (Lys) e~ NH2, H-(Lys)6_des Pro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1- 39) - (Lys) 6-NH2, H-Asn-(Glu) s des Pro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1-39) - (Lys) 6-NH2, H-Lys6-des Pro36 [Met(O)14, Trp(02) 25, Asp28] exendin-4 (1-39) - Lys6-NH2, H-des Asp28 Pro36, Pro37, Pro38 [Met(O)14, Trp(02) 25] exendin-4 (1-
39) -NH2, H-(Lys)6_des Pro36, Pro37, Pro38 [Met(O)14, Asp28] exendin-4 (1-
39) -NH2, H-Asn-(Glu) 5-des Pro36, Pro37, Pro38 [Met(O)14, Trp(02) 25, Asp28] exendin-4 (1-39) -NH2, des Pro36, Pro37, Pro38 [Met(O)14, Trp(02) 25, Asp28] exendin-4 (1- 39) - (Lys) 6-NH2, H-(LyS)6_des Pro36, Pro37, Pro38 [Met(O)14, Trp(02) 25, Asp28] exendin-4 (S1 — 39) - (Lys) 6_NH2, H-Asn-(Glu) 5-des Pro36, Pro37, Pro38 [Met(O)14, Trp(02) 25, Asp28] exendin-4(1-39)-(Lys) 6_NH2; eller des Pro36 [Asp28] exendin-4 (1-39) , des Pro36 [IsoAsp28] exendin-4 (1-39) , des Pro36 [Met(O)14, Asp28] exendin-4 (1-39) , des Pro36 [Met(O)14, IsoAsp28] exendin-4 (1-39) , des Pro36 [Trp(02) 25, Asp28] exendin-4 (1-39) , des Pro36 [Trp(02) 25, IsoAsp28] exendin-4 (1-39) , des Pro36 [Met (0) 14 Trp(C>2)2s, Asp28] exendin-4 (1-39) , des Pro36 [Met (0) 14 Trp(C>2)25, IsoAsp28] exendin-4 (1-39) , idet gruppen -Lys6-NH2 er knyttet sammen med C-terminus på exendin-4-derivatet; eller et farmaceutisk acceptabelt salt eller solvat heraf.
7. Applikationsapparat indeholdende en tokammerkarpule ifølge et af kravene 1 til 6.
8. Fremgangsmåde til fremstilling og påfyldning af en tokammerkarpule ifølge et af kravene 1 til 6, kendetegnet ved, at a) en cylinder indeholdende en bypass forsynes med et midterprop mellem bypass og den proksimale ende; b) kammeret mellem midterprop og den proksimale ende påfyldes med en flydende bestanddel; c) det kammer, der indeholder den flydende bestanddel, lukkes med en endeprop; d) en flydende eller fortrinsvis fast bestanddel fyldes i kammeret mellem midterproppen og den distale ende på cylinderen; og e) den distale ende på cylinderen lukkes med tilbehøret.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07011687 | 2007-06-14 | ||
| PCT/EP2008/004355 WO2008151736A1 (de) | 2007-06-14 | 2008-05-31 | Zweikammerkarpule mit aufsatz |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2167169T3 DK2167169T3 (da) | 2012-09-03 |
| DK2167169T4 true DK2167169T4 (da) | 2016-05-30 |
Family
ID=38621207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08758924.8T DK2167169T4 (da) | 2007-06-14 | 2008-05-31 | Tokammerkarpule med tilbehør |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8092422B2 (da) |
| EP (1) | EP2167169B2 (da) |
| JP (1) | JP2010528791A (da) |
| CN (1) | CN101678175A (da) |
| AR (1) | AR066986A1 (da) |
| DK (1) | DK2167169T4 (da) |
| ES (1) | ES2386166T5 (da) |
| TW (1) | TW200916140A (da) |
| WO (1) | WO2008151736A1 (da) |
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| CN102256618A (zh) | 2008-10-17 | 2011-11-23 | 赛诺菲-安万特德国有限公司 | 胰岛素和glp-1激动剂的组合 |
| PL2451437T3 (pl) | 2009-07-06 | 2017-05-31 | Sanofi-Aventis Deutschland Gmbh | Wodne preparaty insuliny zawierające metioninę |
| TR201809460T4 (tr) | 2009-11-13 | 2018-07-23 | Sanofi Aventis Deutschland | Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim. |
| NZ599847A (en) | 2009-11-13 | 2013-09-27 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist and methionine |
| WO2012028172A1 (en) | 2010-08-30 | 2012-03-08 | Sanofi-Aventis Deutschland Gmbh | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| AR087693A1 (es) | 2011-08-29 | 2014-04-09 | Sanofi Aventis Deutschland | Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2 |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| US9751056B2 (en) | 2012-01-23 | 2017-09-05 | Merit Medical Systems, Inc. | Mixing syringe |
| US8834449B2 (en) | 2012-01-23 | 2014-09-16 | Ikomed Technologies, Inc. | Mixing syringe |
| US8870028B2 (en) | 2012-05-25 | 2014-10-28 | Restek Corporation | Dispensing device |
| WO2014093926A1 (en) | 2012-12-14 | 2014-06-19 | Larson Bryan | Dual medicament carpule for dental syringes |
| TWI780236B (zh) | 2013-02-04 | 2022-10-11 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
| ITRM20130457A1 (it) * | 2013-08-05 | 2015-02-06 | Orofino Pharmaceuticals Group Srl | Prodotto intermedio per la realizzazione di siringhe o cartucce a doppia camera pre-riempite e procedimento di produzione di detto prodotto intermedio |
| USD755957S1 (en) | 2013-12-13 | 2016-05-10 | Bryan Larson | Dental carpule |
| JP6723921B2 (ja) | 2014-01-09 | 2020-07-15 | サノフイＳａｎｏｆｉ | インスリンアナログおよび／またはインスリン誘導体の、グリセリンを含まない安定化された医薬製剤 |
| CN105960249B (zh) | 2014-01-09 | 2021-03-16 | 赛诺菲 | 胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂 |
| JP6810031B2 (ja) | 2014-10-29 | 2021-01-06 | ウォックハート リミテッドＷｏｃｋｈａｒｄｔ Ｌｉｍｉｔｅｄ | ユーザ操作可能な可変用量ロッキング機構を有する独立してユーザ選択可能な２つ以上の複数用量の薬剤を送達するための薬品送達装置 |
| PE20171622A1 (es) | 2014-12-12 | 2017-11-02 | Sanofi Aventis Deutschland | Formulacion de relacion fija de insulina glargina/lixisenatida |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| TWI746569B (zh) | 2016-06-08 | 2021-11-21 | 瑞士商瑞健醫療股份有限公司 | 計量器具、注射裝置、及其應用 |
| CN109996576A (zh) | 2016-11-28 | 2019-07-09 | 爱杜西亚制药有限公司 | 用于输注物质的装置 |
| DE102017208255A1 (de) * | 2017-05-16 | 2018-11-22 | Vetter Pharma-Fertigung GmbH & Co. KG | Medikamentenbehälter mit einem Endstopfen, Verwendung eines Stopfensicherungsteils zum Sichern eines Endstopfens in einem Medikamentenbehälter und Stopfensicherungsteil |
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-
2008
- 2008-05-31 CN CN200880020128A patent/CN101678175A/zh active Pending
- 2008-05-31 DK DK08758924.8T patent/DK2167169T4/da active
- 2008-05-31 JP JP2010511522A patent/JP2010528791A/ja not_active Abandoned
- 2008-05-31 EP EP08758924.8A patent/EP2167169B2/de active Active
- 2008-05-31 WO PCT/EP2008/004355 patent/WO2008151736A1/de not_active Ceased
- 2008-05-31 ES ES08758924.8T patent/ES2386166T5/es active Active
- 2008-06-12 AR ARP080102520A patent/AR066986A1/es unknown
- 2008-06-12 TW TW097121824A patent/TW200916140A/zh unknown
-
2009
- 2009-12-14 US US12/636,963 patent/US8092422B2/en active Active
-
2011
- 2011-12-09 US US13/315,710 patent/US20120078171A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2167169B2 (de) | 2016-03-09 |
| JP2010528791A (ja) | 2010-08-26 |
| EP2167169A1 (de) | 2010-03-31 |
| EP2167169B1 (de) | 2012-05-23 |
| ES2386166T5 (es) | 2016-06-21 |
| US20120078171A1 (en) | 2012-03-29 |
| AR066986A1 (es) | 2009-09-23 |
| WO2008151736A1 (de) | 2008-12-18 |
| CN101678175A (zh) | 2010-03-24 |
| ES2386166T3 (es) | 2012-08-10 |
| US8092422B2 (en) | 2012-01-10 |
| US20100274186A1 (en) | 2010-10-28 |
| DK2167169T3 (da) | 2012-09-03 |
| TW200916140A (en) | 2009-04-16 |
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