DK217889A - Rekombinant-dna-udtrykkelsesvektorer og dna-forbindelser, der koder for desacetoxycephalosporin c synthetase - Google Patents

Rekombinant-dna-udtrykkelsesvektorer og dna-forbindelser, der koder for desacetoxycephalosporin c synthetase Download PDF

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Publication number
DK217889A
DK217889A DK217889A DK217889A DK217889A DK 217889 A DK217889 A DK 217889A DK 217889 A DK217889 A DK 217889A DK 217889 A DK217889 A DK 217889A DK 217889 A DK217889 A DK 217889A
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Prior art keywords
desacetoxycephalosporin
synthetase
coding
expression vectors
dna
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DK217889A
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English (en)
Other versions
DK217889D0 (da
Inventor
Thomas Dominick Ingolia
Steven Kovacevic
James Robert Miller
Paul Luther Skatrud
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Lilly Co Eli
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Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DK217889D0 publication Critical patent/DK217889D0/da
Publication of DK217889A publication Critical patent/DK217889A/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK217889A 1988-05-09 1989-05-03 Rekombinant-dna-udtrykkelsesvektorer og dna-forbindelser, der koder for desacetoxycephalosporin c synthetase DK217889A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/192,273 US5070020A (en) 1988-05-09 1988-05-09 Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase

Publications (2)

Publication Number Publication Date
DK217889D0 DK217889D0 (da) 1989-05-03
DK217889A true DK217889A (da) 1989-11-13

Family

ID=22708994

Family Applications (1)

Application Number Title Priority Date Filing Date
DK217889A DK217889A (da) 1988-05-09 1989-05-03 Rekombinant-dna-udtrykkelsesvektorer og dna-forbindelser, der koder for desacetoxycephalosporin c synthetase

Country Status (7)

Country Link
US (1) US5070020A (da)
EP (1) EP0341892A1 (da)
JP (1) JPH0227984A (da)
AU (1) AU622662B2 (da)
DK (1) DK217889A (da)
HU (1) HU209581B (da)
IL (1) IL90129A0 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3789880T2 (de) * 1986-01-31 1994-09-08 Beecham Group Plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
US6709859B1 (en) 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
CA2045951A1 (en) * 1990-07-06 1992-01-07 Steven Kovacevic Recombinant dna expression vectors and dna compounds that encode deacetylcephalosporin c synthase activity
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정
US5554507A (en) * 1992-07-30 1996-09-10 American Cyanamid Company Bacillus subtilis siderophore genes
ES2194873T3 (es) * 1993-07-30 2003-12-01 Dsm Ip Assets Bv Procedimiento para la produccion eficaz de 7-adca a traves de 3-(carboxietil)propionil-7-adca.
CA2188257A1 (en) * 1994-04-22 1995-11-02 Juan Jose R. Coque Dna encoding cephamycin biosynthesis late enzymes
CN101659926A (zh) * 1994-06-30 2010-03-03 诺沃奇梅兹有限公司 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子
CN1084791C (zh) * 1995-06-02 2002-05-15 吉斯特·布罗卡迪斯股份有限公司 通过扩环酶活性作用于青霉素g生产7－adca的方法
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
GB2323361A (en) * 1995-11-27 1998-09-23 Gist Brocades Bv Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin G
AU4114697A (en) * 1996-07-16 1998-02-09 Gist-Brocades B.V. Improved process for the production of adipoyl cephalosporins
US5958730A (en) * 1996-12-13 1999-09-28 Eli Lilly And Company Streptococcus pneumoniae gene sequence FtsY
CN100390285C (zh) * 1998-05-19 2008-05-28 Dsm公司 体内生产头孢菌素的改良
US7094953B2 (en) 1998-05-29 2006-08-22 Iowa State University Research Foundation, Inc. Plant retroelements and methods related thereto
US6720479B1 (en) * 1998-05-29 2004-04-13 Iowa State University Research Foundation, Inc. Plant retroelements and methods related thereto
US6284483B1 (en) * 1999-10-06 2001-09-04 Board Of Trustees Operating Michigan State University Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate
CA2451654A1 (en) * 2001-06-22 2003-01-03 Ceres, Inc. Chimeric histone acetyltransferase polypeptides
IL159756A0 (en) 2001-07-12 2004-06-20 Univ Massachusetts IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING
EP1900815B1 (en) 2001-07-12 2016-09-07 University of Massachusetts In vivo production of small interfering RNAs that mediate gene silencing
US6699699B2 (en) 2002-03-26 2004-03-02 Synmax Biochemical Co., Ltd. Mutated penicillin expandases
KR20060061295A (ko) 2003-05-28 2006-06-07 디에스엠 아이피 어셋츠 비.브이. 세펨 화합물
PT1633767T (pt) 2003-06-02 2019-02-27 Univ Massachusetts Métodos e composições para controlar a eficácia do silenciamento de arn
EP1633890B2 (en) 2003-06-02 2020-11-18 University of Massachusetts METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF FNAi
WO2007107810A1 (en) * 2006-03-20 2007-09-27 Council Of Scientific And Industrial Research A method for detecting the presence of water born pathogens and indicator microorganism
US9637746B2 (en) 2008-12-15 2017-05-02 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
CN105132387A (zh) * 2008-12-22 2015-12-09 绿光生物科学公司 用于制造化合物的组合物和方法
EP2566953B1 (en) 2010-05-07 2019-01-02 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
EP2611922A1 (en) 2010-08-31 2013-07-10 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
CN104093848A (zh) 2011-09-09 2014-10-08 绿光生物科学公司 碳青霉烯(carbapenem)的无细胞制备
AU2014306074B2 (en) 2013-08-05 2018-08-30 Greenlight Biosciences, Inc. Engineered proteins with a protease cleavage site
BR112017020690A2 (pt) 2015-03-30 2018-06-26 Greenlight Biosciences Inc produção livre de células de ácido ribonucleico
CA3020312A1 (en) 2016-04-06 2017-10-12 Greenlight Biosciences, Inc. Cell-free production of ribonucleic acid
KR102894284B1 (ko) 2017-10-11 2025-12-03 그린라이트 바이오사이언시스, 아이엔씨. 뉴클레오시드 트리포스페이트 및 리보핵산 생산을 위한 방법 및 조성물
CN117363591B (zh) * 2023-10-10 2026-04-10 上海邦林生物科技有限公司 用于合成g-7-adca的扩环酶突变体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4510246A (en) * 1982-08-23 1985-04-09 Queen's University At Kingston Isolation of cyclase, epimerase and a ring expansion enzyme for producing unnatural cephalosporins
US4536476A (en) * 1982-08-23 1985-08-20 Queen's University At Kingston Stable epimerase reagent, cyclase reagent and ring expansion reagent for cell-free production of cephalosporins
DE3789880T2 (de) * 1986-01-31 1994-09-08 Beecham Group Plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.

Also Published As

Publication number Publication date
IL90129A0 (en) 1989-12-15
EP0341892A1 (en) 1989-11-15
HUT51672A (en) 1990-05-28
JPH0227984A (ja) 1990-01-30
DK217889D0 (da) 1989-05-03
AU3408289A (en) 1989-11-09
HU209581B (en) 1994-08-29
US5070020A (en) 1991-12-03
AU622662B2 (en) 1992-04-16

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