DK2188258T3 - Substituerede nikotinamidforbindelser og anvendelser deraf i lægemidler - Google Patents
Substituerede nikotinamidforbindelser og anvendelser deraf i lægemidlerInfo
- Publication number
- DK2188258T3 DK2188258T3 DK08802179.5T DK08802179T DK2188258T3 DK 2188258 T3 DK2188258 T3 DK 2188258T3 DK 08802179 T DK08802179 T DK 08802179T DK 2188258 T3 DK2188258 T3 DK 2188258T3
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceuticals
- nicotinamide compounds
- substituted nicotinamide
- substituted
- compounds
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 150000005480 nicotinamides Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007044277A DE102007044277A1 (de) | 2007-09-17 | 2007-09-17 | Substituierte Nicotinamid-Verbindungen und deren Verwendung in Arzneimitteln |
| PCT/EP2008/007633 WO2009036938A1 (de) | 2007-09-17 | 2008-09-15 | Substituierte nicotinamid-verbindungen und deren verwendung in arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2188258T3 true DK2188258T3 (da) | 2013-01-14 |
Family
ID=40347805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08802179.5T DK2188258T3 (da) | 2007-09-17 | 2008-09-15 | Substituerede nikotinamidforbindelser og anvendelser deraf i lægemidler |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8084470B2 (da) |
| EP (1) | EP2188258B1 (da) |
| JP (1) | JP5539205B2 (da) |
| KR (1) | KR20100068453A (da) |
| CN (1) | CN101801932A (da) |
| AR (1) | AR068467A1 (da) |
| BR (1) | BRPI0817044A2 (da) |
| CA (1) | CA2699689C (da) |
| CO (1) | CO6260092A2 (da) |
| CY (1) | CY1113551T1 (da) |
| DE (1) | DE102007044277A1 (da) |
| DK (1) | DK2188258T3 (da) |
| ES (1) | ES2400407T3 (da) |
| HR (1) | HRP20130166T1 (da) |
| IL (1) | IL204496A (da) |
| MX (1) | MX2010002506A (da) |
| NZ (1) | NZ583684A (da) |
| PE (1) | PE20090652A1 (da) |
| PL (1) | PL2188258T3 (da) |
| PT (1) | PT2188258E (da) |
| RU (1) | RU2489425C2 (da) |
| SI (1) | SI2188258T1 (da) |
| WO (1) | WO2009036938A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI475020B (zh) * | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| DK2609083T3 (da) * | 2010-08-27 | 2015-03-30 | Gruenenthal Gmbh | Substituerede 2-oxy-quinolin-3-carboxamider som KCNQ2/3 modulatorer |
| PE20140199A1 (es) * | 2010-10-20 | 2014-02-16 | Gruenenthal Chemie | 6-amino-nicotinamidas sustituidas como moduladores de kcnq2/3 |
| FR2968661B1 (fr) * | 2010-12-14 | 2016-01-01 | Oreal | Procede de depigmentation des matieres keratiniques a l'aide de composes thiopyridinones |
| US9775843B2 (en) | 2012-10-11 | 2017-10-03 | Grünenthal GmbH | Treatment and/or prophylaxis of TSPO mediated diseases and/or disorders |
| BR112015012418A2 (pt) | 2012-11-28 | 2017-07-11 | Gruenenthal Gmbh | carboxamidas específicas como moduladores de kcnq2/3 |
| US9248122B2 (en) | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
| EP3558992A4 (en) | 2016-12-15 | 2020-12-02 | ONO Pharmaceutical Co., Ltd. | TREK CHANNEL ACTIVATOR (K + CHANNELS ASSOCIATED WITH TWIK) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022884A (en) * | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
| GB9919588D0 (en) * | 1999-08-18 | 1999-10-20 | Hoechst Schering Agrevo Gmbh | Fungicidal compounds |
| CA2438868A1 (en) | 2001-02-20 | 2002-09-19 | Valentin K. Gribkoff | Modulators of kcnq potassium channels and use thereof in treating migraine and mechanistically related diseases |
| GB0319793D0 (en) * | 2003-08-22 | 2003-09-24 | Lilly Co Eli | Pyridinylmorpholine derivatives |
-
2007
- 2007-09-17 DE DE102007044277A patent/DE102007044277A1/de not_active Withdrawn
-
2008
- 2008-09-15 RU RU2010115184/04A patent/RU2489425C2/ru not_active IP Right Cessation
- 2008-09-15 BR BRPI0817044 patent/BRPI0817044A2/pt not_active IP Right Cessation
- 2008-09-15 SI SI200830849T patent/SI2188258T1/sl unknown
- 2008-09-15 HR HRP20130166AT patent/HRP20130166T1/hr unknown
- 2008-09-15 CA CA2699689A patent/CA2699689C/en not_active Expired - Fee Related
- 2008-09-15 DK DK08802179.5T patent/DK2188258T3/da active
- 2008-09-15 CN CN200880107279A patent/CN101801932A/zh active Pending
- 2008-09-15 WO PCT/EP2008/007633 patent/WO2009036938A1/de not_active Ceased
- 2008-09-15 JP JP2010524410A patent/JP5539205B2/ja not_active Expired - Fee Related
- 2008-09-15 EP EP08802179A patent/EP2188258B1/de not_active Not-in-force
- 2008-09-15 PL PL08802179T patent/PL2188258T3/pl unknown
- 2008-09-15 MX MX2010002506A patent/MX2010002506A/es active IP Right Grant
- 2008-09-15 ES ES08802179T patent/ES2400407T3/es active Active
- 2008-09-15 KR KR1020107008408A patent/KR20100068453A/ko not_active Withdrawn
- 2008-09-15 PT PT88021795T patent/PT2188258E/pt unknown
- 2008-09-15 NZ NZ583684A patent/NZ583684A/en not_active IP Right Cessation
- 2008-09-17 AR ARP080104040A patent/AR068467A1/es not_active Application Discontinuation
- 2008-09-17 PE PE2008001619A patent/PE20090652A1/es not_active Application Discontinuation
- 2008-09-17 US US12/212,369 patent/US8084470B2/en not_active Expired - Fee Related
-
2010
- 2010-03-12 CO CO10029446A patent/CO6260092A2/es not_active Application Discontinuation
- 2010-03-15 IL IL204496A patent/IL204496A/en not_active IP Right Cessation
-
2013
- 2013-01-15 CY CY20131100043T patent/CY1113551T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO6260092A2 (es) | 2011-03-22 |
| MX2010002506A (es) | 2010-03-26 |
| CY1113551T1 (el) | 2016-06-22 |
| RU2010115184A (ru) | 2011-10-27 |
| US8084470B2 (en) | 2011-12-27 |
| JP5539205B2 (ja) | 2014-07-02 |
| EP2188258B1 (de) | 2012-11-28 |
| CA2699689C (en) | 2015-03-24 |
| CA2699689A1 (en) | 2009-03-26 |
| HRP20130166T1 (hr) | 2013-03-31 |
| WO2009036938A1 (de) | 2009-03-26 |
| KR20100068453A (ko) | 2010-06-23 |
| ES2400407T3 (es) | 2013-04-09 |
| PL2188258T3 (pl) | 2013-04-30 |
| HK1144422A1 (en) | 2011-02-18 |
| EP2188258A1 (de) | 2010-05-26 |
| JP2010539124A (ja) | 2010-12-16 |
| IL204496A (en) | 2013-02-28 |
| AR068467A1 (es) | 2009-11-18 |
| AU2008300945A1 (en) | 2009-03-26 |
| US20090076086A1 (en) | 2009-03-19 |
| CN101801932A (zh) | 2010-08-11 |
| DE102007044277A1 (de) | 2009-03-19 |
| RU2489425C2 (ru) | 2013-08-10 |
| SI2188258T1 (sl) | 2013-01-31 |
| NZ583684A (en) | 2011-04-29 |
| PT2188258E (pt) | 2013-01-23 |
| PE20090652A1 (es) | 2009-05-28 |
| BRPI0817044A2 (pt) | 2015-03-24 |
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