DK2029554T3 - Pyrazinderivater og anvendelser heraf til nyreovervågning - Google Patents

Pyrazinderivater og anvendelser heraf til nyreovervågning

Info

Publication number
DK2029554T3
DK2029554T3 DK07809706.0T DK07809706T DK2029554T3 DK 2029554 T3 DK2029554 T3 DK 2029554T3 DK 07809706 T DK07809706 T DK 07809706T DK 2029554 T3 DK2029554 T3 DK 2029554T3
Authority
DK
Denmark
Prior art keywords
applications
pyrazine derivatives
renal monitoring
renal
monitoring
Prior art date
Application number
DK07809706.0T
Other languages
English (en)
Inventor
William L Neumann
Raghavan Rajagopalan
Richard B Dorshow
Original Assignee
Medibeacon Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medibeacon Llc filed Critical Medibeacon Llc
Application granted granted Critical
Publication of DK2029554T3 publication Critical patent/DK2029554T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DK07809706.0T 2006-06-22 2007-06-20 Pyrazinderivater og anvendelser heraf til nyreovervågning DK2029554T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81571206P 2006-06-22 2006-06-22
PCT/US2007/014370 WO2007149479A1 (en) 2006-06-22 2007-06-20 Pyrazine derivatives and uses thereof in renal monitoring

Publications (1)

Publication Number Publication Date
DK2029554T3 true DK2029554T3 (da) 2014-06-10

Family

ID=38577613

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07809706.0T DK2029554T3 (da) 2006-06-22 2007-06-20 Pyrazinderivater og anvendelser heraf til nyreovervågning

Country Status (10)

Country Link
US (6) US8115000B2 (da)
EP (1) EP2029554B1 (da)
JP (1) JP2009534396A (da)
CN (1) CN101351454A (da)
AU (1) AU2007261398A1 (da)
CA (1) CA2628661A1 (da)
DK (1) DK2029554T3 (da)
ES (1) ES2456042T3 (da)
IL (1) IL189221A0 (da)
WO (1) WO2007149479A1 (da)

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US20100311903A1 (en) * 2007-11-07 2010-12-09 Raghavan Rajagopalan Photonic Shell-Core Cross Linked and Functionalized Nanostructures for Biological Applications
CA2641297A1 (en) * 2008-07-11 2010-01-11 Richard B. Dorshow Pyrazine derivatives, methods of use, and methods for preparing same
US8703100B2 (en) * 2008-12-17 2014-04-22 Medibeacon, LLC Modified pyrazine derivatives and uses thereof
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US11077211B2 (en) 2013-11-11 2021-08-03 Medibeacon Inc. Compositions and methods for assessing gut function
JP6602779B2 (ja) 2014-02-13 2019-11-06 インサイト・コーポレイション Ｌｓｄ１阻害剤としてのシクロプロピルアミン類
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MY189367A (en) 2015-08-12 2022-02-08 Incyte Corp Salts of an lsd1 inhibitor
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WO2019084425A1 (en) * 2017-10-27 2019-05-02 Medibeacon Inc. METHODS FOR EVALUATING RENAL FUNCTION
IL269617B2 (en) * 2017-10-27 2024-09-01 Medibeacon Inc Compositions and systems for renal function determination
RU2746503C1 (ru) 2017-11-20 2021-04-14 Медибикон Инк. Способ получения и анализа флуоресцентных соединений в плазме
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
KR20210102371A (ko) * 2018-12-12 2021-08-19 메디비콘 아이엔씨. 지속적 신장 대체 요법에서 경피 사구체 여과율 측정의 용도
CN115844391A (zh) * 2019-01-16 2023-03-28 麦迪贝肯有限公司 两件式传感器组件及其使用方法
EP3917378B8 (en) 2019-01-28 2025-04-23 MediBeacon Inc. Systems and methods for home transdermal gfr monitoring
WO2023016483A1 (zh) * 2021-08-11 2023-02-16 杭州中美华东制药有限公司 制备作为荧光示踪剂的吡嗪羧酸类衍生物的方法
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Also Published As

Publication number Publication date
US8115000B2 (en) 2012-02-14
AU2007261398A1 (en) 2007-12-27
US9480687B2 (en) 2016-11-01
EP2029554A1 (en) 2009-03-04
CA2628661A1 (en) 2007-12-27
US20150320745A1 (en) 2015-11-12
CN101351454A (zh) 2009-01-21
ES2456042T3 (es) 2014-04-21
EP2029554B1 (en) 2014-03-19
US20090198053A1 (en) 2009-08-06
USRE47413E1 (en) 2019-06-04
USRE47255E1 (en) 2019-02-26
JP2009534396A (ja) 2009-09-24
US20120100078A1 (en) 2012-04-26
US9114160B2 (en) 2015-08-25
US8722685B2 (en) 2014-05-13
US20140286874A1 (en) 2014-09-25
IL189221A0 (en) 2008-06-05
WO2007149479A1 (en) 2007-12-27

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