DK2189176T3 - De-agglomerator til åndedrætsaktiveret tørpulverinhalator - Google Patents

De-agglomerator til åndedrætsaktiveret tørpulverinhalator Download PDF

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Publication number
DK2189176T3
DK2189176T3 DK10002414.0T DK10002414T DK2189176T3 DK 2189176 T3 DK2189176 T3 DK 2189176T3 DK 10002414 T DK10002414 T DK 10002414T DK 2189176 T3 DK2189176 T3 DK 2189176T3
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DK
Denmark
Prior art keywords
agglomerator
dry powder
vortex chamber
axis
chamber
Prior art date
Application number
DK10002414.0T
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English (en)
Inventor
David O'leary
Lawrence Keane
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Norton Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of DK2189176T3 publication Critical patent/DK2189176T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/22—Design features of general application for visual indication of the result of count on counting mechanisms, e.g. by window with magnifying lens
    • G06M1/24—Drums; Dials; Pointers
    • G06M1/246—Bands; Sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (10)

1. De-agglomerator (10) til anvendelse med en åndedrætsaktiveret tørpulverinhalator som inkluderer en gennemgangskanal for tørt pulver og en beholder for tørt pulver til at frigive en forudbestemt mængde af tørpulver til gennemgangskanalen fortørt pulver, de-agglomeratoren omfattende: en indervæg (12) som definerer et hvirvelkammer (14) som strækker sig langs en akse (A) fra en første ende til en anden ende; en tørpulver-tilføringsåbning (22) i den første ende (18) af hvirvelkammeret (14) til at tilvejebringe fluidforbindelse mellem en gennemgangskanal for tørt pulver af en inhalator og den første ende (18) af hvirvelkammeret (14); mindst en indgangsåbning (24) i indervæggen (12) af hvirvelkammeret (14) tilstødende den første ende (18) af hvirvelkammeret (14) tilvejebringende fluidforbindelse mellem et uden for de-agglomeratoren værende område og den første ende (18) af hvirvelkammeret (14); en udgangsåbning (32) tilvejebringende fluidforbindelse mellem den anden ende (20) af hvirvelkammeret (14) og et uden for de-agglomeratoren værende område (10); og skovlblade (26) ved den første ende (18) af hvirvelkammeret (14) som strækker sig mindst delvist radialt udad fra aksen (A) af kammeret, hvor hver af skovlbladene (26) har en skrå flade som vender mindst delvist i en retning på tværs af aksen (A); hvorved et åndedrætsinduceret lavtryk ved udgangsåbningen (32) forårsager luftstrømme ind i hvirvelkammeret (14) igennem tørpulver-tilføringsåbningen (22) og indgangsåbningen (24), kendetegnet ved at hvirvelkammeret (14) inkluderer generelt cirkulære tværsnitsarealer koaksialt anbragt omkring aksen (A), og den mindst ene indgangsåbning (24) strækker sig i en retning i alt væsentligt på tværs af aksen (A) og i alt væsentligt tangentialt med de cirkulære tværsnitsarealer.
2. De-agglomerator ifølge krav 1, hvor skovlbladene (26) omfatter fire skovlblade som strækker sig fra et nav (30) bragt på linje med aksen (A) til væggen (12) af hvirvelkammeret (14).
3. De-agglomerator ifølge krav 1, hvor hvirvelkammeret inkluderer tværsnitsarealer anbragt på tværs af aksen (a), tværsnitsarealerne aftagende fra den første ende (18) til den anden ende (20) af hvirvelkammeret (14).
4. De-agglomerator ifølge krav 3, hvor tværsnitsarealerne af hvirvelkammeret (14) aftager monotont.
5. De-agglomerator ifølge krav 1, hvor indervæggen (12) af hvirvelkammeret (14) er konveks.
6. De-agglomerator ifølge krav 1, hvor tørpulver-tilføringsåbningen (22) vender i en retning i alt væsentligt parallel med aksen (A).
7. De-agglomerator ifølge krav 1, hvor udgangsåbningen (32) strækker sig i alt væsentligt på tværs af aksen (A).
8. De-agglomerator ifølge krav 1, hvor den mindst ene indgangsåbning (24) omfatter to diametralt modstående indgangsåbninger (24).
9. De-agglomerator ifølge krav 1, hvor skovlbladene (26) inkluderer et antistatisk additiv.
10. De-agglomerator ifølge krav 1, samlet fra en bægeragtig underdel (40) lukket med en kappe (42), hvor underdelen (40) definerer indervæggen (12), den anden ende (20) af kammeret og udgangsåbningen (32), hvor kappen (42) definerer den første ende (18) af kammeret, hvor skovlbladene (26) og tilførselsåbningen (22), og indgangsåbningen (24) er defineret af både underdelen (40) og kappen (42).
DK10002414.0T 2000-06-23 2001-06-23 De-agglomerator til åndedrætsaktiveret tørpulverinhalator DK2189176T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21338200P 2000-06-23 2000-06-23
US21366700P 2000-06-23 2000-06-23
US21366800P 2000-06-23 2000-06-23
EP01963716A EP1294421B1 (en) 2000-06-23 2001-06-23 Dry Powder Inhaler

Publications (1)

Publication Number Publication Date
DK2189176T3 true DK2189176T3 (da) 2016-02-01

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ID=27395855

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10002414.0T DK2189176T3 (da) 2000-06-23 2001-06-23 De-agglomerator til åndedrætsaktiveret tørpulverinhalator
DK01963716.4T DK1294421T3 (da) 2000-06-23 2001-06-23 Inhalator til tørt pulver

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01963716.4T DK1294421T3 (da) 2000-06-23 2001-06-23 Inhalator til tørt pulver

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US (2) US6748947B2 (da)
EP (2) EP2189176B1 (da)
JP (1) JP4511785B2 (da)
KR (1) KR100503235B1 (da)
AR (2) AR028747A1 (da)
AT (1) ATE460955T1 (da)
AU (2) AU8464301A (da)
CA (1) CA2407051C (da)
CY (1) CY1110161T1 (da)
DE (1) DE60141579D1 (da)
DK (2) DK2189176T3 (da)
ES (2) ES2559760T3 (da)
GB (1) GB2366740A (da)
PE (1) PE20020067A1 (da)
PT (2) PT2189176E (da)
SI (1) SI1294421T1 (da)
TW (1) TWI224511B (da)
UY (1) UY26793A1 (da)
WO (1) WO2001097889A2 (da)

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PE20020067A1 (es) 2002-02-05
EP2189176A2 (en) 2010-05-26
US20020088463A1 (en) 2002-07-11
CY1110161T1 (el) 2015-01-14
EP1294421A2 (en) 2003-03-26
PT1294421E (pt) 2010-05-06
WO2001097889A2 (en) 2001-12-27
SI1294421T1 (sl) 2010-08-31
DE60141579D1 (de) 2010-04-29
JP2003535656A (ja) 2003-12-02
ES2559760T3 (es) 2016-02-15
EP2189176A3 (en) 2014-07-16
KR20030028738A (ko) 2003-04-10
JP4511785B2 (ja) 2010-07-28
AU2001284643B2 (en) 2004-09-09
AR064449A2 (es) 2009-04-01
EP2189176B1 (en) 2015-11-04
CA2407051C (en) 2008-12-02
US20040200475A1 (en) 2004-10-14
WO2001097889A3 (en) 2002-05-02
ATE460955T1 (de) 2010-04-15
EP1294421B1 (en) 2010-03-17
CA2407051A1 (en) 2001-12-27
DK1294421T3 (da) 2010-07-12
GB2366740A (en) 2002-03-20
UY26793A1 (es) 2002-01-31
TWI224511B (en) 2004-12-01
AR028747A1 (es) 2003-05-21
WO2001097889A9 (en) 2003-03-06
US6871646B2 (en) 2005-03-29
US6748947B2 (en) 2004-06-15
AU8464301A (en) 2002-01-02
PT2189176E (pt) 2016-02-24
KR100503235B1 (ko) 2005-07-22
ES2343511T3 (es) 2010-08-03
GB0115520D0 (en) 2001-08-15

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