DK2193196T3 - Antidoter mod faktor xa-inhibitorer og fremgangsmåder til anvendelse deraf - Google Patents
Antidoter mod faktor xa-inhibitorer og fremgangsmåder til anvendelse deraf Download PDFInfo
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- DK2193196T3 DK2193196T3 DK08834136.7T DK08834136T DK2193196T3 DK 2193196 T3 DK2193196 T3 DK 2193196T3 DK 08834136 T DK08834136 T DK 08834136T DK 2193196 T3 DK2193196 T3 DK 2193196T3
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- Denmark
- Prior art keywords
- fxa
- gly
- glu
- lys
- thr
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- C12N9/6424—Serine endopeptidases (3.4.21)
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Claims (12)
1. FXa-derivat, som er et isoleret polypeptid, der omfatter aminosyresekvensen ifølge SEQ ID NO: 12.
2. FXa-derivat, som er et isoleret tokædet polypeptid, der har et let kædefragment, der består af aminosyresekvensen ifølge SEQ ID NO: 14, og et tungt kædefragment, der består af aminosyresekvensen ifølge SEQ ID NO: 15.
3. FXa-derivat, som er et isoleret tokædet polypeptid, der omfatter aminosyresekvensen ifølge SEQ ID NO: 13.
4. Fremgangsmåde til fremstilling af et polypeptid ifølge krav 1, der omfatter ekspression af et polynukleotid, der omfatter nukleotidsekvensen ifølge SEQ ID NO: 16, i en prokaryot eller eukaryot værtscelle.
5. Tokædet polypeptid, der kan opnås ved hjælp af fremgangsmåden ifølge krav 4.
6. Farmaceutisk sammensætning, der omfatter et bæremateriale og et polypeptid ifølge et hvilket som helst af kravene 1-3 eller 5.
7. Polynukleotid, der koder for et polypeptid ifølge et hvilket som helst af kravene 1-3.
8. Sammensætning ifølge krav 6 til anvendelse i en fremgangsmåde til forebyggelse eller reducering af blødning hos en person, der gennemgår antikoagulationsbehandling med en faktor Xa-inhibitor.
9. Sammensætning ifølge krav 6 til anvendelse i en fremgangsmåde til selektiv binding og inhibering af en exogent administreret faktor Xa-inhibitor til behandling af over-antikoagulation.
10. Sammensætning til anvendelse ifølge krav 8 eller 9, hvor faktor Xa-inhibitoren er en direkte faktor Xa-inhibitor.
11. Sammensætning til anvendelse ifølge krav 8 eller 9, hvor faktor Xa-inhibitoren er en indirekte faktor Xa-inhibitor.
12. Sammensætning til anvendelse ifølge krav 10 eller 11, hvor faktor Xa-inhibitoren er udvalgt fra gruppen, der består af fondaparinux, idraparinux, biotinyleret idraparinux, enoxaparin, fragmin, NAP-5, rNAPc2, en inhibitor af vævsfaktor-aktiveringssystemet, DX-9065a, YM-60828, YM-150, apixaban, rivaroxaban, PD-348292, otamixaban, DU-176b, LY517717, GSK913893, razaxaban, lavmolekylær heparin, betrixaban eller et farmaceutisk acceptabelt salt deraf og kombinationer deraf.
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| US9057408P | 2008-08-20 | 2008-08-20 | |
| PCT/US2008/078014 WO2009042962A2 (en) | 2007-09-28 | 2008-09-26 | Antidotes for factor xa inhibitors and methods of using the same |
Publications (1)
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| DK2193196T3 true DK2193196T3 (da) | 2016-11-07 |
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| DK16167534.3T DK3078743T3 (da) | 2007-09-28 | 2008-09-26 | Antidoter til faktor xa-inhibitorer og fremgangsmåder til anvendelse af disse |
| DK08834136.7T DK2193196T3 (da) | 2007-09-28 | 2008-09-26 | Antidoter mod faktor xa-inhibitorer og fremgangsmåder til anvendelse deraf |
| DK14197779.3T DK2915564T3 (da) | 2007-09-28 | 2008-09-26 | Antidoter mod faktor XA-inhibitorer og fremgangsmåder til anvendelse deraf |
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| EP (4) | EP2915564B1 (da) |
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| CN (4) | CN102533702A (da) |
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| BR (2) | BRPI0816837B1 (da) |
| CA (1) | CA2697583C (da) |
| CY (3) | CY1118482T1 (da) |
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| NO (2) | NO2019040I1 (da) |
| NZ (1) | NZ583944A (da) |
| PL (3) | PL3078743T3 (da) |
| PT (3) | PT3078743T (da) |
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| SI (3) | SI2915564T1 (da) |
| WO (1) | WO2009042962A2 (da) |
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| US7696352B2 (en) * | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
| NZ572418A (en) | 2006-05-05 | 2011-08-26 | Millennium Pharm Inc | Factor xa inhibitors |
| EP2915564B1 (en) | 2007-09-28 | 2020-11-04 | Portola Pharmaceuticals, Inc. | Antidotes for factor XA inhibitors and methods of using the same |
| MX2011004907A (es) | 2008-11-14 | 2011-07-29 | Portola Pharm Inc | Antidotos para inhibidores del factor xa y metodos para el uso de los mismos en combinacion con agentes de coagulacion de sangre. |
| KR101792032B1 (ko) * | 2008-12-19 | 2017-11-02 | 백스터 인터내셔널 인코포레이티드 | Ｔｆｐｉ 억제제 및 사용 방법 |
| EP3121271B1 (en) * | 2009-03-30 | 2019-07-24 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
| ES2605801T3 (es) * | 2009-07-15 | 2017-03-16 | Portola Pharmaceuticals, Inc. | Formulación de dosis unitaria de antídoto para inhibidores del factor Xa para su uso en la prevención de la hemorragia |
| GB0916576D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| ES2620421T3 (es) * | 2009-10-30 | 2017-06-28 | Senova Gesellschaft für Biowissenschaft und Technik mbH | Peptidasas acopladas a polímero |
| US8742120B2 (en) * | 2009-12-17 | 2014-06-03 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
| CN102762550B (zh) | 2009-12-17 | 2015-04-01 | 米伦纽姆医药公司 | Xa因子抑制剂的盐和结晶形式 |
| AR079944A1 (es) | 2010-01-20 | 2012-02-29 | Boehringer Ingelheim Int | Anticuerpo neutralizante de la actividad de un anticoagulante |
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