DK2195039T3 - Kirurgisk hydrogel - Google Patents

Kirurgisk hydrogel Download PDF

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Publication number
DK2195039T3
DK2195039T3 DK08828839.4T DK08828839T DK2195039T3 DK 2195039 T3 DK2195039 T3 DK 2195039T3 DK 08828839 T DK08828839 T DK 08828839T DK 2195039 T3 DK2195039 T3 DK 2195039T3
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DK
Denmark
Prior art keywords
polymer
hydrogel
chitosan
derivatised
aldehyde
Prior art date
Application number
DK08828839.4T
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English (en)
Inventor
Theodore Athanasiadis
Lyall Robert Hanton
Stephen Carl Moratti
Brian Harford Robinson
Simon Rae Robinson
Zheng Shi
James Simpson
Peter John Wormald
Original Assignee
Otago Innovation Ltd
Adelaide res & innovation pty ltd
Robinson Squidgel Ltd
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Application filed by Otago Innovation Ltd, Adelaide res & innovation pty ltd, Robinson Squidgel Ltd filed Critical Otago Innovation Ltd
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Publication of DK2195039T3 publication Critical patent/DK2195039T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/738—Cross-linked polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Claims (15)

  1. KIRURGISK HYDROGEL
    1. Polymernetværk omfattende en dicarboxy-derivatiseret chitosan-polymer krydsbundet til en aldehyd-derivatiseret dextran-polymer.
  2. 2. Polymernetværk ifølge krav 1, hvori den dicarboxy-derivatiserede chitosan-polymer er krydsbundet til den aldehydderivat iserede dextran-polymer gennem den dicarboxy-derivatiserede chitosan-polymers amin-gruppe og den aldehyd-derivatiserede dextran-polymers aldehyd-gruppe.
  3. 3. Polymernetværk ifølge krav 1 i form af en hydrogel,
  4. 4. Polymernetværk ifølge krav 2-3, hvori sammensætningen omfatter mellem omtrent 2 vægt-% til 10 vægt-% dicarboxy-derivatiseret chitosan-polymer og mellem omtrent 2 vægt-% til 10 vægt-% aid eh yd e-der i vatiseret dextran-polymer,
  5. 5. Polymernetværk ifølge krav 1 til i, hvori den dicarboxy-derivatiserede chitosan-polymer er N-succinylchitosan.
  6. 6. Hydrogel ifølge krav 3 endvidere omfattende en eller flere biologisk aktive agenser.
  7. 7. Hydrogel ifølge krav 6, hvori den eller de biologisk aktive agenser er udvalgt fra gruppen bestående af plasmaprotein, hormoner, enzymer, antibiotika, antiseptiske agenser, antineoplastiske agenser, antimykotiske agenser, antivirale agenser, antiinflammatoriske agenser, vækstfaktorer, steroider, c e11e s usp e n s i oner, cyt otoxi ne r o g c elleforme r i ng s hæmme r e.
  8. 8. Hydrogel ifølge krav 3 til anvendelse til forebyggelse eller reducering af adhæsion af væv med tilbøjelighed til adhærencedannelse, til accelerering eller fremme af sårheling eller til standsning af blødning fra et sår.
  9. 9. Hydrogel ifølge krav 3 til anvendelse i øre-, næse- og halskirurgi.
  10. 10. Kit omfattende (a) en dicarboxyl-derivatiseret chitosan-polymer og <b> en aldehyd-derivatiseret dextran-polvmer.
  11. 11, Kit ifølge krav 10, hvori en af eller både (a) og (b) tilvejebringes i separate vandige opløsninger,
  12. 12, Kit ifølge krav 10 endvidere omfattende en eller flere b i o 1 o g i s k a k t i v e a g e n s e r.
  13. 13, Kit ifølge krav 10 til anvendelse i øre-, næse- og halskirurgi.
  14. 14, Hydrogel ifølge krav 3 til anvendelse ved kirurgi i næsehulen eller de paranasale sinusser.
  15. 15, Kit ifølge krav 10 til anvendelse ved kirurgi i næsehulen eller de paranasale sinusser.
DK08828839.4T 2007-08-28 2008-08-26 Kirurgisk hydrogel DK2195039T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96841407P 2007-08-28 2007-08-28
PCT/NZ2008/000219 WO2009028965A1 (en) 2007-08-28 2008-08-26 Surgical hydrogel

Publications (1)

Publication Number Publication Date
DK2195039T3 true DK2195039T3 (da) 2017-01-30

Family

ID=40387519

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08828839.4T DK2195039T3 (da) 2007-08-28 2008-08-26 Kirurgisk hydrogel

Country Status (11)

Country Link
US (2) US20100291055A1 (da)
EP (1) EP2195039B1 (da)
JP (1) JP5489999B2 (da)
KR (1) KR101610268B1 (da)
CN (2) CN104874007A (da)
AU (1) AU2008293135B2 (da)
CA (1) CA2709546C (da)
DK (1) DK2195039T3 (da)
ES (1) ES2619181T3 (da)
NZ (1) NZ583819A (da)
WO (1) WO2009028965A1 (da)

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CA2709546C (en) 2017-09-26
US8809301B2 (en) 2014-08-19
AU2008293135B2 (en) 2014-08-07
JP2010537711A (ja) 2010-12-09
ES2619181T3 (es) 2017-06-23
KR101610268B1 (ko) 2016-04-07
NZ583819A (en) 2012-08-31
CN101848739A (zh) 2010-09-29
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US20130244974A1 (en) 2013-09-19
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