DK2201099T3 - Fremgangsmåde til chondrocytopformering med fænotypebevaring - Google Patents

Fremgangsmåde til chondrocytopformering med fænotypebevaring Download PDF

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Publication number
DK2201099T3
DK2201099T3 DK08831789.6T DK08831789T DK2201099T3 DK 2201099 T3 DK2201099 T3 DK 2201099T3 DK 08831789 T DK08831789 T DK 08831789T DK 2201099 T3 DK2201099 T3 DK 2201099T3
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DK
Denmark
Prior art keywords
phenotypic
conservation
chondrocyte proliferation
chondrocyte
proliferation
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Application number
DK08831789.6T
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English (en)
Inventor
Iv H Davis Adkisson
Curt L Milliman
Neil Kizer
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Isto Technologies Inc
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Application filed by Isto Technologies Inc filed Critical Isto Technologies Inc
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Publication of DK2201099T3 publication Critical patent/DK2201099T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/80—Hyaluronan

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK08831789.6T 2007-09-21 2008-09-22 Fremgangsmåde til chondrocytopformering med fænotypebevaring DK2201099T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/859,524 US8017394B2 (en) 2004-10-01 2007-09-21 Method for chondrocyte expansion with phenotype retention
PCT/US2008/077161 WO2009039469A1 (en) 2007-09-21 2008-09-22 Method for chondrocyte expansion with phenotype retention

Publications (1)

Publication Number Publication Date
DK2201099T3 true DK2201099T3 (da) 2015-02-23

Family

ID=40469879

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08831789.6T DK2201099T3 (da) 2007-09-21 2008-09-22 Fremgangsmåde til chondrocytopformering med fænotypebevaring

Country Status (7)

Country Link
US (1) US8017394B2 (da)
EP (1) EP2201099B1 (da)
JP (1) JP2010539905A (da)
AU (1) AU2008302088B2 (da)
DK (1) DK2201099T3 (da)
ES (1) ES2530757T3 (da)
WO (1) WO2009039469A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE220564T1 (de) * 1997-08-14 2002-08-15 Sulzer Innotec Ag Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
ES2404682T3 (es) 2003-12-11 2013-05-28 Isto Technologies Inc. Sistema de cartílago particulado
US8889127B2 (en) 2004-07-01 2014-11-18 Icahn School Of Medicine At Mount Sinai Targeted protein replacement for the treatment of lysosomal storage disorders
AU2006282754A1 (en) 2005-08-26 2007-03-01 Zimmer, Inc. Implants and methods for repair, replacement and treatment of joint disease
EP1764117A1 (en) * 2005-09-20 2007-03-21 Zimmer GmbH Implant for the repair of a cartilage defect and method for manufacturing the implant
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US20080154233A1 (en) * 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Apparatus for delivering a biocompatible material to a surgical site and method of using same
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
US8426196B2 (en) * 2008-06-05 2013-04-23 Lynn L. H. Huang Method for regulating proliferation of cells
US20100041149A1 (en) * 2008-08-15 2010-02-18 Mark Weidenbecher Bioreactor and method for generating cartilage tissue constructs
KR20220100999A (ko) * 2008-11-25 2022-07-18 코오롱 티슈진 인크. 감작 세포 치료요법
JP5721319B2 (ja) * 2009-08-17 2015-05-20 国立大学法人北海道大学 軟骨細胞培養基材及び培養方法
JP5544635B2 (ja) * 2009-09-30 2014-07-09 国立大学法人北海道大学 軟骨細胞再分化誘導用基材およびこれを用いた軟骨細胞の製造方法
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
GB201010422D0 (en) * 2010-06-22 2010-08-04 Univ Cardiff Cartilage repair
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
US9133438B2 (en) 2011-06-29 2015-09-15 Biorestorative Therapies, Inc. Brown fat cell compositions and methods
DK2753346T3 (da) 2011-09-07 2020-05-25 Sinai School Medicine Ceramidase og celledifferentiering
EP2854910B1 (en) 2012-06-01 2020-04-15 Icahn School of Medicine at Mount Sinai Ceramide levels in the treatment and prevention of infections
WO2014015109A1 (en) 2012-07-20 2014-01-23 The Regents Of The University Of California Methods for producing cartilage and bone
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
EP3659619A1 (en) 2013-03-14 2020-06-03 Icahn School of Medicine at Mount Sinai Therapeutic acid ceramidase compositions and methods of making and using them
EP3795678B1 (en) 2013-04-19 2023-07-12 Biorestorative Therapies, Inc. Human brown adipose derived stem cells and uses
SG10202011272UA (en) * 2013-06-07 2020-12-30 Nissan Chemical Ind Ltd Ion complex material having function of inhibiting adhesion of biological substance and method for manufacturing the same
JP6921737B2 (ja) * 2014-08-01 2021-08-18 イスト・テクノロジーズ・インコーポレイテッドＩｓｔｏ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． 軟骨組成物及びプロテオグリカン含量の修正方法
WO2016019168A1 (en) * 2014-08-01 2016-02-04 Isto Technologies, Inc. Cell expansion methods and systems
CA3177726A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US11470841B2 (en) 2016-06-15 2022-10-18 Nissan Chemical Corporation Cryopreservation vessel
US20190270969A1 (en) * 2016-07-25 2019-09-05 Ube Industries, Ltd. Method to suppress dedifferentiation of cells that readily dedifferentiate, method for preparing said cells, and method for producing substance
US12291701B2 (en) 2017-09-26 2025-05-06 Nissan Chemical Corporation Cell culture container having minute volume

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356261A (en) 1980-04-22 1982-10-26 Rush-Presbyterian-St. Luke's Medical Center Anti-invasion factor containing cultures
IT1219587B (it) 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US5326357A (en) * 1992-03-18 1994-07-05 Mount Sinai Hospital Corporation Reconstituted cartridge tissue
IT1263316B (it) 1993-02-12 1996-08-05 Fidia Advanced Biopolymers Srl Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico
US5723331A (en) * 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
CA2189646C (en) 1994-06-24 1999-05-25 Francis E. Dwulet A purified mixture of collagenases and two other proteases obtained from clostridium histolyticum
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
IT1288290B1 (it) 1996-06-21 1998-09-11 Fidia Spa In Amministrazione S Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie
WO1998004681A2 (en) * 1996-07-25 1998-02-05 Genzyme Corporation Chondrocyte media formulations and culture procedures
US5830741A (en) 1996-12-06 1998-11-03 Boehringer Mannheim Corporation Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease
US5866165A (en) * 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
EP1018987B1 (en) 1997-04-04 2014-10-29 Barnes-Jewish Hospital Neocartilage and methods of use
AU7984498A (en) 1997-06-25 1999-01-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Serum-free cell growth medium
CA2344399A1 (en) 1998-09-18 2000-03-30 Massachusetts Institute Of Technology Use of growth factors and hormones for expansion of mammalian cells and tissue engineering
IT1302534B1 (it) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
US6197061B1 (en) * 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
WO2001035968A1 (en) * 1999-11-19 2001-05-25 Children's Medical Center Corporation Methods for inducing chondrogenesis and producing de novo cartilage in vitro
US6932977B2 (en) * 2000-04-14 2005-08-23 Depuy Spine, Inc. Method of inducing or enhancing chondrogenesis with extracellular matrix containing BMP-4
EP1435980A4 (en) 2001-09-15 2006-06-07 Univ California LAMINATED CARTILAGINOUS FABRIC AND MANUFACTURING METHOD THEREOF
WO2003084385A2 (en) 2002-04-02 2003-10-16 William Marsh Rice University Redifferentiated cells for repairing cartilage defects
US7074615B2 (en) 2003-08-15 2006-07-11 Becton, Dickinson And Company Peptides for enhanced cell attachment and cell growth
US7273756B2 (en) 2004-10-01 2007-09-25 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
AU2007212085B2 (en) 2006-02-07 2011-11-17 Spinalcyte, Llc Methods and compositions for repair of cartilage using an in vivo bioreactor

Also Published As

Publication number Publication date
JP2010539905A (ja) 2010-12-24
US8017394B2 (en) 2011-09-13
AU2008302088B2 (en) 2014-02-20
WO2009039469A1 (en) 2009-03-26
EP2201099B1 (en) 2014-11-19
EP2201099A1 (en) 2010-06-30
EP2201099A4 (en) 2011-06-01
US20080081369A1 (en) 2008-04-03
AU2008302088A1 (en) 2009-03-26
ES2530757T3 (es) 2015-03-05

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