DK2201099T3 - Fremgangsmåde til chondrocytopformering med fænotypebevaring - Google Patents

Fremgangsmåde til chondrocytopformering med fænotypebevaring Download PDF

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Publication number
DK2201099T3
DK2201099T3 DK08831789.6T DK08831789T DK2201099T3 DK 2201099 T3 DK2201099 T3 DK 2201099T3 DK 08831789 T DK08831789 T DK 08831789T DK 2201099 T3 DK2201099 T3 DK 2201099T3
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DK
Denmark
Prior art keywords
phenotypic
conservation
chondrocyte proliferation
chondrocyte
proliferation
Prior art date
Application number
DK08831789.6T
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English (en)
Inventor
Iv H Davis Adkisson
Curt L Milliman
Neil Kizer
Original Assignee
Isto Technologies Inc
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Publication date
Application filed by Isto Technologies Inc filed Critical Isto Technologies Inc
Application granted granted Critical
Publication of DK2201099T3 publication Critical patent/DK2201099T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/80—Hyaluronan

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK08831789.6T 2007-09-21 2008-09-22 Fremgangsmåde til chondrocytopformering med fænotypebevaring DK2201099T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/859,524 US8017394B2 (en) 2004-10-01 2007-09-21 Method for chondrocyte expansion with phenotype retention
PCT/US2008/077161 WO2009039469A1 (en) 2007-09-21 2008-09-22 Method for chondrocyte expansion with phenotype retention

Publications (1)

Publication Number Publication Date
DK2201099T3 true DK2201099T3 (da) 2015-02-23

Family

ID=40469879

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08831789.6T DK2201099T3 (da) 2007-09-21 2008-09-22 Fremgangsmåde til chondrocytopformering med fænotypebevaring

Country Status (7)

Country Link
US (1) US8017394B2 (da)
EP (1) EP2201099B1 (da)
JP (1) JP2010539905A (da)
AU (1) AU2008302088B2 (da)
DK (1) DK2201099T3 (da)
ES (1) ES2530757T3 (da)
WO (1) WO2009039469A1 (da)

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AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
US8426196B2 (en) * 2008-06-05 2013-04-23 Lynn L. H. Huang Method for regulating proliferation of cells
US20100041149A1 (en) * 2008-08-15 2010-02-18 Mark Weidenbecher Bioreactor and method for generating cartilage tissue constructs
KR20110089876A (ko) * 2008-11-25 2011-08-09 티슈진, 인코포레이티드 감작 세포 치료요법
JP5721319B2 (ja) * 2009-08-17 2015-05-20 国立大学法人北海道大学 軟骨細胞培養基材及び培養方法
JP5544635B2 (ja) * 2009-09-30 2014-07-09 国立大学法人北海道大学 軟骨細胞再分化誘導用基材およびこれを用いた軟骨細胞の製造方法
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
GB201010422D0 (en) * 2010-06-22 2010-08-04 Univ Cardiff Cartilage repair
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
JP6243839B2 (ja) 2011-06-29 2017-12-06 バイオリストーラティブ セラピーズ， インコーポレイテッド 褐色脂肪細胞の組成物および方法
LT2753346T (lt) 2011-09-07 2020-08-10 Mount Sinai School Of Medicine Ceramidazė ir ląstelių diferenciacija
ES2897825T3 (es) 2012-06-01 2022-03-02 Icahn School Med Mount Sinai Niveles de ceramida en el tratamiento y prevención de infecciones
CA2918486C (en) 2012-07-20 2020-12-08 The Regents Of The University Of California Methods for producing cartilage and bone
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
PT2968479T (pt) 2013-03-14 2019-08-07 Icahn School Med Mount Sinai Composições terapêuticas de ceramidase ácida e métodos de fabrico e utilização
JP6887249B2 (ja) 2013-04-19 2021-06-16 バイオリストーラティブ セラピーズ， インコーポレイテッド ヒト褐色脂肪由来幹細胞およびその使用
CA2914618A1 (en) * 2013-06-07 2014-12-11 Nissan Chemical Industries, Ltd. Cell culture vessel
WO2016019168A1 (en) * 2014-08-01 2016-02-04 Isto Technologies, Inc. Cell expansion methods and systems
JP6921737B2 (ja) * 2014-08-01 2021-08-18 イスト・テクノロジーズ・インコーポレイテッドＩｓｔｏ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． 軟骨組成物及びプロテオグリカン含量の修正方法
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
JP6911852B2 (ja) 2016-06-15 2021-07-28 日産化学株式会社 凍結保存用容器
WO2018021362A1 (ja) * 2016-07-25 2018-02-01 宇部興産株式会社 脱分化しやすい細胞の脱分化を抑制する方法、当該細胞の調製方法、及び物質の産生方法
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Also Published As

Publication number Publication date
WO2009039469A1 (en) 2009-03-26
EP2201099A4 (en) 2011-06-01
AU2008302088A1 (en) 2009-03-26
ES2530757T3 (es) 2015-03-05
JP2010539905A (ja) 2010-12-24
EP2201099A1 (en) 2010-06-30
EP2201099B1 (en) 2014-11-19
US20080081369A1 (en) 2008-04-03
AU2008302088B2 (en) 2014-02-20
US8017394B2 (en) 2011-09-13

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