DK2202306T3 - Rekombinant faktor x uden glycosylering og fremgangsmåde til fremstilling deraf - Google Patents

Rekombinant faktor x uden glycosylering og fremgangsmåde til fremstilling deraf

Info

Publication number
DK2202306T3
DK2202306T3 DK08837781.7T DK08837781T DK2202306T3 DK 2202306 T3 DK2202306 T3 DK 2202306T3 DK 08837781 T DK08837781 T DK 08837781T DK 2202306 T3 DK2202306 T3 DK 2202306T3
Authority
DK
Denmark
Prior art keywords
glycosylation
producing
recombinant factor
recombinant
factor
Prior art date
Application number
DK08837781.7T
Other languages
English (en)
Inventor
Kenji Soejima
Takayuki Imamura
Ryoichi Kawamura
Hiroshi Nakatake
Arisa Maeyashiki
Hitomi Togo
Original Assignee
Chemo Sero Therapeut Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeut Res Inst filed Critical Chemo Sero Therapeut Res Inst
Application granted granted Critical
Publication of DK2202306T3 publication Critical patent/DK2202306T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK08837781.7T 2007-10-09 2008-10-08 Rekombinant faktor x uden glycosylering og fremgangsmåde til fremstilling deraf DK2202306T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007263640 2007-10-09
PCT/JP2008/068271 WO2009048067A1 (ja) 2007-10-09 2008-10-08 糖鎖を持たない遺伝子組換え血液凝固第x因子およびその製法

Publications (1)

Publication Number Publication Date
DK2202306T3 true DK2202306T3 (da) 2013-01-21

Family

ID=40549211

Family Applications (2)

Application Number Title Priority Date Filing Date
DK11190376.1T DK2436765T3 (da) 2007-10-09 2008-10-08 Rekombinant faktor X uden glycosylering og fremgangsmåde til fremstilling deraf
DK08837781.7T DK2202306T3 (da) 2007-10-09 2008-10-08 Rekombinant faktor x uden glycosylering og fremgangsmåde til fremstilling deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK11190376.1T DK2436765T3 (da) 2007-10-09 2008-10-08 Rekombinant faktor X uden glycosylering og fremgangsmåde til fremstilling deraf

Country Status (5)

Country Link
US (3) US8173777B2 (da)
EP (2) EP2202306B1 (da)
JP (1) JP5513120B2 (da)
DK (2) DK2436765T3 (da)
WO (1) WO2009048067A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2202306B1 (en) * 2007-10-09 2012-12-19 The Chemo-Sero-Therapeutic Research Institute Recombinant factor x with no glycosylation and method for preparing the same
KR20120045218A (ko) * 2010-10-29 2012-05-09 삼성전자주식회사 멀티 터치를 이용한 문자 입력 방법 및 장치
US8986991B2 (en) * 2012-07-03 2015-03-24 Expression Therapeutics, Llc High yield suspension cell line, system and method for making same
SG11201500579SA (en) 2012-07-25 2015-02-27 Catalyst Biosciences Inc Modified factor x polypeptides and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2824434B2 (ja) 1989-11-28 1998-11-11 財団法人化学及血清療法研究所 新規発現ベクター
US5278144A (en) * 1990-09-04 1994-01-11 Cor Therapeutics, Inc. Antithrombosis agents
US20040072757A1 (en) * 1990-09-04 2004-04-15 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
DE69329333D1 (de) * 1992-03-20 2000-10-05 Cor Therapeutics Inc Durch glykosylierung vermittelte hemmung des faktors x
CN1592786A (zh) * 2000-12-05 2005-03-09 宾夕法尼亚州立研究基金会 在酵母菌中高效生产异源性蛋白质的方法和组合物
JP2006280253A (ja) * 2005-03-31 2006-10-19 Yamaguchi Univ 耐熱性酵素を高生産できる酵母変異株
EP1728798A1 (en) * 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
EP2202306B1 (en) * 2007-10-09 2012-12-19 The Chemo-Sero-Therapeutic Research Institute Recombinant factor x with no glycosylation and method for preparing the same

Also Published As

Publication number Publication date
US20100285568A1 (en) 2010-11-11
EP2202306B1 (en) 2012-12-19
US20120039863A1 (en) 2012-02-16
WO2009048067A1 (ja) 2009-04-16
DK2436765T3 (da) 2014-01-13
US8173777B2 (en) 2012-05-08
EP2202306A4 (en) 2011-03-30
EP2436765B1 (en) 2013-12-11
US20120231523A1 (en) 2012-09-13
JP5513120B2 (ja) 2014-06-04
JPWO2009048067A1 (ja) 2011-02-17
US8293874B2 (en) 2012-10-23
EP2202306A1 (en) 2010-06-30
US8679783B2 (en) 2014-03-25
EP2436765A2 (en) 2012-04-04
EP2436765A3 (en) 2012-05-09

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