DK2436765T3 - Rekombinant faktor X uden glycosylering og fremgangsmåde til fremstilling deraf - Google Patents

Rekombinant faktor X uden glycosylering og fremgangsmåde til fremstilling deraf

Info

Publication number
DK2436765T3
DK2436765T3 DK11190376.1T DK11190376T DK2436765T3 DK 2436765 T3 DK2436765 T3 DK 2436765T3 DK 11190376 T DK11190376 T DK 11190376T DK 2436765 T3 DK2436765 T3 DK 2436765T3
Authority
DK
Denmark
Prior art keywords
glycosylation
preparation
recombinant factor
recombinant
factor
Prior art date
Application number
DK11190376.1T
Other languages
English (en)
Inventor
Kenji Soejima
Takayuki Imamura
Ryoichi Kawamura
Hiroshi Nakatake
Arisa Maeyashiki
Hitomi Togo
Original Assignee
Chemo Sero Therapeut Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeut Res Inst filed Critical Chemo Sero Therapeut Res Inst
Application granted granted Critical
Publication of DK2436765T3 publication Critical patent/DK2436765T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK11190376.1T 2007-10-09 2008-10-08 Rekombinant faktor X uden glycosylering og fremgangsmåde til fremstilling deraf DK2436765T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007263640 2007-10-09
EP08837781A EP2202306B1 (en) 2007-10-09 2008-10-08 Recombinant factor x with no glycosylation and method for preparing the same

Publications (1)

Publication Number Publication Date
DK2436765T3 true DK2436765T3 (da) 2014-01-13

Family

ID=40549211

Family Applications (2)

Application Number Title Priority Date Filing Date
DK08837781.7T DK2202306T3 (da) 2007-10-09 2008-10-08 Rekombinant faktor x uden glycosylering og fremgangsmåde til fremstilling deraf
DK11190376.1T DK2436765T3 (da) 2007-10-09 2008-10-08 Rekombinant faktor X uden glycosylering og fremgangsmåde til fremstilling deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK08837781.7T DK2202306T3 (da) 2007-10-09 2008-10-08 Rekombinant faktor x uden glycosylering og fremgangsmåde til fremstilling deraf

Country Status (5)

Country Link
US (3) US8173777B2 (da)
EP (2) EP2202306B1 (da)
JP (1) JP5513120B2 (da)
DK (2) DK2202306T3 (da)
WO (1) WO2009048067A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5513120B2 (ja) * 2007-10-09 2014-06-04 一般財団法人化学及血清療法研究所 糖鎖を持たない遺伝子組換え血液凝固第ｘ因子およびその製法
KR20120045218A (ko) * 2010-10-29 2012-05-09 삼성전자주식회사 멀티 터치를 이용한 문자 입력 방법 및 장치
WO2014008172A2 (en) * 2012-07-03 2014-01-09 Expression Therapeutics, Llc High yield suspension cell line, system and method for making same
US9145552B2 (en) 2012-07-25 2015-09-29 Catalyst Biosciences, Inc. Modified factor X polypeptides and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2824434B2 (ja) 1989-11-28 1998-11-11 財団法人化学及血清療法研究所 新規発現ベクター
US20040072757A1 (en) * 1990-09-04 2004-04-15 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
US5278144A (en) * 1990-09-04 1994-01-11 Cor Therapeutics, Inc. Antithrombosis agents
AU681074B2 (en) * 1992-03-20 1997-08-21 Millennium Pharmaceuticals, Inc. Glycosylation-mediated inhibition of factor X
EP1379667A2 (en) * 2000-12-05 2004-01-14 The Penn State Research Foundation Methods and compositions for highly efficient production of heterologous proteins in yeast
JP2006280253A (ja) * 2005-03-31 2006-10-19 Yamaguchi Univ 耐熱性酵素を高生産できる酵母変異株
EP1728798A1 (en) * 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
JP5513120B2 (ja) * 2007-10-09 2014-06-04 一般財団法人化学及血清療法研究所 糖鎖を持たない遺伝子組換え血液凝固第ｘ因子およびその製法

Also Published As

Publication number Publication date
EP2202306B1 (en) 2012-12-19
US8173777B2 (en) 2012-05-08
US20120039863A1 (en) 2012-02-16
US20100285568A1 (en) 2010-11-11
EP2202306A1 (en) 2010-06-30
WO2009048067A1 (ja) 2009-04-16
US20120231523A1 (en) 2012-09-13
EP2436765A3 (en) 2012-05-09
US8679783B2 (en) 2014-03-25
JPWO2009048067A1 (ja) 2011-02-17
EP2436765A2 (en) 2012-04-04
EP2436765B1 (en) 2013-12-11
DK2202306T3 (da) 2013-01-21
JP5513120B2 (ja) 2014-06-04
US8293874B2 (en) 2012-10-23
EP2202306A4 (en) 2011-03-30

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