DK2207526T3 - Fremgangsmåde til fremstilling af et farmaceutisk produkt omfattende citronsyre, magnesiumoxid, kaliumbicarbonat og natriumpicosulfat, farmaceutisk sammensætning omfattende granuler opnået ved sådanne fremgangsmåder og mellemprodukter deraf. - Google Patents

Fremgangsmåde til fremstilling af et farmaceutisk produkt omfattende citronsyre, magnesiumoxid, kaliumbicarbonat og natriumpicosulfat, farmaceutisk sammensætning omfattende granuler opnået ved sådanne fremgangsmåder og mellemprodukter deraf.

Info

Publication number: DK2207526T3
Authority: DK; Denmark
Prior art keywords: various varieties; available; varieties available; preparation; citric acid
Prior art date: 2007-10-12

Application number

DK08837670.2T

Other languages

English (en)

Inventor

Haijun Xu

Tiejun Diao

Original Assignee

Ferring Int Center Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-12

Filing date

2008-10-10

Publication date

2018-01-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42082803&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2207526(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-11-09 Priority claimed from CNA2007101860236A external-priority patent/CN101406457A/zh

2008-04-01 Priority claimed from GB0805953A external-priority patent/GB0805953D0/en

2008-10-10 Application filed by Ferring Int Center Sa filed Critical Ferring Int Center Sa

2018-01-29 Application granted granted Critical

2018-01-29 Publication of DK2207526T3 publication Critical patent/DK2207526T3/da

Links

KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 title abstract 6
239000000395 magnesium oxide Substances 0.000 title abstract 2
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 title abstract 2
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
229910000028 potassium bicarbonate Inorganic materials 0.000 title abstract 2
235000015497 potassium bicarbonate Nutrition 0.000 title abstract 2
239000011736 potassium bicarbonate Substances 0.000 title abstract 2
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
GOZDTZWAMGHLDY-UHFFFAOYSA-L sodium picosulfate Chemical compound [Na+].[Na+].C1=CC(OS(=O)(=O)[O-])=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OS([O-])(=O)=O)C=C1 GOZDTZWAMGHLDY-UHFFFAOYSA-L 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
229940127557 pharmaceutical product Drugs 0.000 title 1
FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 abstract 1
239000008240 homogeneous mixture Substances 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
239000007968 orange flavor Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
229940085605 saccharin sodium Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/009—Sachets, pouches characterised by the material or function of the envelope
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK08837670.2T 2007-10-12 2008-10-10 Fremgangsmåde til fremstilling af et farmaceutisk produkt omfattende citronsyre, magnesiumoxid, kaliumbicarbonat og natriumpicosulfat, farmaceutisk sammensætning omfattende granuler opnået ved sådanne fremgangsmåder og mellemprodukter deraf. DK2207526T3 (da)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
EP07254049		2007-10-12
US98054907P	2007-10-17	2007-10-17
CNA2007101860236A CN101406457A (zh)	2007-10-12	2007-11-09	制备药物产品的方法
GB0805953A GB0805953D0 (en)	2008-04-01	2008-04-01	Process for the manufacture of a pharmaceutical product
PCT/IB2008/003199 WO2009047633A2 (en)	2007-10-12	2008-10-10	Process for the manufacure of a pharmaceutical product comprising citric acid, magnesium oxide, potassium bicarbonate and sodium picosulfate, pharmaceutical composition comprising granules obtained by such process and intermediate

Publications (1)

Publication Number	Publication Date
DK2207526T3 true DK2207526T3 (da)	2018-01-29

Family

ID=42082803

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08837670.2T DK2207526T3 (da)	2007-10-12	2008-10-10	Fremgangsmåde til fremstilling af et farmaceutisk produkt omfattende citronsyre, magnesiumoxid, kaliumbicarbonat og natriumpicosulfat, farmaceutisk sammensætning omfattende granuler opnået ved sådanne fremgangsmåder og mellemprodukter deraf.

Country Status (24)

Country	Link
US (2)	US8481083B2 (da)
EP (1)	EP2207526B1 (da)
JP (1)	JP5654873B2 (da)
KR (2)	KR101381263B1 (da)
CN (1)	CN101820859B (da)
AU (1)	AU2008309287B2 (da)
BR (1)	BRPI0818541B8 (da)
CA (1)	CA2702152A1 (da)
DK (1)	DK2207526T3 (da)
ES (1)	ES2659716T3 (da)
HR (1)	HRP20180215T1 (da)
HU (1)	HUE038174T2 (da)
IL (1)	IL204500A (da)
JO (1)	JO3406B1 (da)
LT (1)	LT2207526T (da)
MX (1)	MX2010003588A (da)
NZ (1)	NZ583899A (da)
PL (1)	PL2207526T3 (da)
PT (1)	PT2207526T (da)
RU (1)	RU2473332C2 (da)
SI (1)	SI2207526T1 (da)
TW (1)	TWI418352B (da)
WO (1)	WO2009047633A2 (da)
ZA (1)	ZA201002131B (da)

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NZ583899A (en)	2007-10-12	2011-12-22	Ferring Int Ct Sa	Process for the manufacure of a pharmaceutical product comprising citric acid, magnesium oxide, potassium bicarbonate and sodium picosulfate, pharmaceutical composition comprising granules obtained by such process and intermediate
KR101155099B1 (ko) *	2012-03-29	2012-06-11	남봉길	장 세척용 조성물의 제조 방법 및 이에 의해 제조된 장 세척용 조성물
HUE043852T2 (hu) *	2012-07-27	2019-09-30	Redhill Biopharma Ltd	A vastagbél kiürítésére szolgáló készítmények és a készítmények elõállítási módszerei
JP2014224080A (ja) *	2013-05-17	2014-12-04	協和化学工業株式会社	大腸の検査または手術のための処置剤
KR101517520B1 (ko)	2013-08-05	2015-05-04	이희엽	피코황산나트륨 함유 장 세척용 조성물의 제조방법
IN2013MU02911A (da) *	2013-09-10	2015-07-03	Cadila Healthcare Ltd
KR101420315B1 (ko)	2014-03-19	2014-07-17	남봉길	약학적 액제 조성물
AU2016207821A1 (en) *	2015-01-14	2017-07-13	Pf Consumer Healthcare 1 Llc	Oral delivery product
CA2995798A1 (en)	2015-08-17	2017-02-23	Nipul Ghanshyambhai PATEL	Liquid formulations containing picosulfate and magnesium citrate
CN105456264B (zh) *	2015-12-03	2018-07-10	广州瑞尔医药科技有限公司	双效缓泻的药物组合物及其制备方法
TW201804996A (zh)	2016-07-08	2018-02-16	輝凌責任有限公司	含有匹可硫酸鹽(picosulfate)之安定液體調配物
US11471447B2 (en)	2019-06-20	2022-10-18	Hetero Labs Limited	Stable pharmaceutical product and vessel comprising sodium picosulfate, magnesium oxide and citric acid
CA3155646A1 (en) *	2019-09-24	2021-04-01	Medisca Pharmaceutique Inc.	Gel base composition for compounding into a mucoadhesive delivery system
CN110638786A (zh) *	2019-10-09	2020-01-03	杭州百诚医药科技股份有限公司	一种匹可硫酸钠与枸橼酸、氧化镁的药物组合物及制备方法
CN113648327B (zh) *	2021-08-24	2023-03-28	山东京卫制药有限公司	一种药物组合物及其制备方法
CN115040512B (zh) *	2022-07-28	2023-06-20	苏州中化药品工业有限公司	一种药物组合物及其制备方法

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GB1300969A (en)	1969-03-26	1972-12-29	Organon Nv	Novel modified acid crystals and a process for their preparation
JPS5731864A (en) *	1980-08-04	1982-02-20	Teijin Ltd	Oral activated carbon microcapsule
US5290962A (en) *	1989-09-06	1994-03-01	Exxon Chemical Patents Inc.	Method for preparation of anti-calking coating with pigment therein
GB9011034D0 (en)	1990-05-16	1990-07-04	Programme 3 Patent Holdings	Electrochemical cell
US5045459A (en) *	1990-10-05	1991-09-03	Haarmann & Reimer Corp.	Method for the production of granular citric acid
US5102682A (en)	1991-01-31	1992-04-07	Kraft General Foods, Inc.	Sucrose and fructose-containing food mix and process
US5219598A (en)	1991-11-15	1993-06-15	Kraft General Foods, Inc.	Reducing sugar-containing mix and process therefore
EP0724441A1 (en) *	1993-10-19	1996-08-07	The Procter & Gamble Company	Picosulphate dosage form
US5498425A (en) *	1995-03-17	1996-03-12	Block Drug Company, Inc.	Phosphosoda buffered saline laxative
US5674529A (en) *	1995-06-06	1997-10-07	Church & Dwight Co., Inc.	Alkalinizing potassium salt controlled release preparations
CA2186938A1 (en)	1995-10-18	1997-04-19	Dalip K. Nayyar	Dry mix for producing a slush beverage
AUPN634595A0 (en) *	1995-11-03	1995-11-30	Borody, Thomas Julius	Improved method for colonic evacuation
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AUPS088702A0 (en) *	2002-03-04	2002-03-28	Borody, Thomas Julius	Electrolyte purgative
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NZ583899A (en)	2007-10-12	2011-12-22	Ferring Int Ct Sa	Process for the manufacure of a pharmaceutical product comprising citric acid, magnesium oxide, potassium bicarbonate and sodium picosulfate, pharmaceutical composition comprising granules obtained by such process and intermediate

2008
- 2008-10-10 NZ NZ583899A patent/NZ583899A/en unknown
- 2008-10-10 SI SI200831915T patent/SI2207526T1/en unknown
- 2008-10-10 US US12/677,857 patent/US8481083B2/en active Active
- 2008-10-10 PT PT88376702T patent/PT2207526T/pt unknown
- 2008-10-10 MX MX2010003588A patent/MX2010003588A/es active IP Right Grant
- 2008-10-10 BR BRPI0818541A patent/BRPI0818541B8/pt active IP Right Grant
- 2008-10-10 CN CN2008801112524A patent/CN101820859B/zh not_active Ceased
- 2008-10-10 CA CA2702152A patent/CA2702152A1/en not_active Abandoned
- 2008-10-10 RU RU2010112483/15A patent/RU2473332C2/ru active
- 2008-10-10 KR KR1020137023315A patent/KR101381263B1/ko active Active
- 2008-10-10 HR HRP20180215TT patent/HRP20180215T1/hr unknown
- 2008-10-10 WO PCT/IB2008/003199 patent/WO2009047633A2/en not_active Ceased
- 2008-10-10 LT LTEP08837670.2T patent/LT2207526T/lt unknown
- 2008-10-10 HU HUE08837670A patent/HUE038174T2/hu unknown
- 2008-10-10 ES ES08837670.2T patent/ES2659716T3/es active Active
- 2008-10-10 DK DK08837670.2T patent/DK2207526T3/da active
- 2008-10-10 AU AU2008309287A patent/AU2008309287B2/en active Active
- 2008-10-10 KR KR1020107007932A patent/KR101330096B1/ko active Active
- 2008-10-10 EP EP08837670.2A patent/EP2207526B1/en active Active
- 2008-10-10 JP JP2010528503A patent/JP5654873B2/ja active Active
- 2008-10-10 PL PL08837670T patent/PL2207526T3/pl unknown
- 2008-10-12 JO JOP/2008/0454A patent/JO3406B1/ar active
- 2008-10-13 TW TW097139185A patent/TWI418352B/zh active
2010
- 2010-03-15 IL IL204500A patent/IL204500A/en active IP Right Grant
- 2010-03-25 ZA ZA2010/02131A patent/ZA201002131B/en unknown
2011
- 2011-09-27 US US13/246,739 patent/US8450338B2/en active Active

Also Published As

Publication number	Publication date
IL204500A (en)	2016-07-31
PT2207526T (pt)	2018-01-25
TW200924759A (en)	2009-06-16
SI2207526T1 (en)	2018-04-30
US20110104285A1 (en)	2011-05-05
RU2473332C2 (ru)	2013-01-27
NZ583899A (en)	2011-12-22
CA2702152A1 (en)	2009-04-16
PL2207526T3 (pl)	2018-06-29
BRPI0818541B1 (pt)	2020-12-29
EP2207526B1 (en)	2017-11-22
BRPI0818541A2 (pt)	2015-06-16
ZA201002131B (en)	2010-12-29
CN101820859B (zh)	2013-05-01
CN101820859A (zh)	2010-09-01
WO2009047633A3 (en)	2009-09-03
KR101381263B1 (ko)	2014-04-04
US8450338B2 (en)	2013-05-28
KR20100072020A (ko)	2010-06-29
KR20130105757A (ko)	2013-09-25
US8481083B2 (en)	2013-07-09
HUE038174T2 (hu)	2018-09-28
HRP20180215T1 (hr)	2018-03-23
KR101330096B1 (ko)	2013-11-15
US20120015036A1 (en)	2012-01-19
RU2010112483A (ru)	2011-11-20
JO3406B1 (ar)	2019-10-20
AU2008309287B2 (en)	2014-10-30
LT2207526T (lt)	2018-02-12
AU2008309287A1 (en)	2009-04-16
ES2659716T3 (es)	2018-03-19
WO2009047633A2 (en)	2009-04-16
MX2010003588A (es)	2010-04-21
JP5654873B2 (ja)	2015-01-14
EP2207526A2 (en)	2010-07-21
BRPI0818541B8 (pt)	2021-05-25
JP2011500549A (ja)	2011-01-06
TWI418352B (zh)	2013-12-11

Publication	Publication Date	Title
DK2207526T3 (da)	2018-01-29	Fremgangsmåde til fremstilling af et farmaceutisk produkt omfattende citronsyre, magnesiumoxid, kaliumbicarbonat og natriumpicosulfat, farmaceutisk sammensætning omfattende granuler opnået ved sådanne fremgangsmåder og mellemprodukter deraf.
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