DK2209496T3 - Multifunktionelle nedbrydelige nanopartikler med kontrol over størrelse og funktioner - Google Patents
Multifunktionelle nedbrydelige nanopartikler med kontrol over størrelse og funktioner Download PDFInfo
- Publication number
- DK2209496T3 DK2209496T3 DK08846997.8T DK08846997T DK2209496T3 DK 2209496 T3 DK2209496 T3 DK 2209496T3 DK 08846997 T DK08846997 T DK 08846997T DK 2209496 T3 DK2209496 T3 DK 2209496T3
- Authority
- DK
- Denmark
- Prior art keywords
- functions
- control over
- over size
- degradable nanoparticles
- multifunctional degradable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G71/00—Macromolecular compounds obtained by reactions forming a ureide or urethane link, otherwise, than from isocyanate radicals in the main chain of the macromolecule
- C08G71/02—Polyureas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
- A61K49/0067—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle quantum dots, fluorescent nanocrystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0089—Particulate, powder, adsorbate, bead, sphere
- A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
- A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
- C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/14—Powdering or granulating by precipitation from solutions
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2300/00—Characterised by the use of unspecified polymers
- C08J2300/16—Biodegradable polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nanotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98560807P | 2007-11-05 | 2007-11-05 | |
| US3804108P | 2008-03-19 | 2008-03-19 | |
| US10075208P | 2008-09-28 | 2008-09-28 | |
| US10103908P | 2008-09-29 | 2008-09-29 | |
| PCT/US2008/082529 WO2009061854A2 (en) | 2007-11-05 | 2008-11-05 | Multifunctional degradable nanoparticles with control over size and functionalities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2209496T3 true DK2209496T3 (da) | 2019-08-05 |
Family
ID=40626424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08846997.8T DK2209496T3 (da) | 2007-11-05 | 2008-11-05 | Multifunktionelle nedbrydelige nanopartikler med kontrol over størrelse og funktioner |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7935782B2 (da) |
| EP (2) | EP2209496B1 (da) |
| CA (2) | CA2704956C (da) |
| DK (1) | DK2209496T3 (da) |
| ES (1) | ES2744834T3 (da) |
| WO (1) | WO2009061854A2 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8969622B2 (en) | 2006-08-23 | 2015-03-03 | Vanderbilt University | Dendritic molecular intracellular transporters and methods of making and using same |
| US11254786B2 (en) | 2007-11-05 | 2022-02-22 | Vanderbilt University | Multifunctional degradable nanoparticles with control over size and functionalities |
| DK2209496T3 (da) | 2007-11-05 | 2019-08-05 | Univ Vanderbilt | Multifunktionelle nedbrydelige nanopartikler med kontrol over størrelse og funktioner |
| US20130142733A1 (en) | 2007-11-05 | 2013-06-06 | Vanderbilt University | Multifunctional degradable nanoparticles with control over size and functionalities |
| US20110274620A1 (en) * | 2007-11-05 | 2011-11-10 | Harth Eva M | Multifunctional degradable nanoparticles with control over size and functionalities |
| WO2010095056A2 (en) * | 2009-02-21 | 2010-08-26 | Sofradim Production | Medical devices with an activated coating |
| EP2398524B1 (en) * | 2009-02-21 | 2017-07-12 | Covidien LP | Medical devices having activated surfaces |
| US8535477B2 (en) * | 2009-02-21 | 2013-09-17 | Sofradim Production | Medical devices incorporating functional adhesives |
| WO2011156686A2 (en) * | 2010-06-11 | 2011-12-15 | The Regents Of The University Of Colorado, A Body Corporate | Method for synthesizing a cyclic multivalent peptide using a thiol-mediated reaction |
| CN103764668B (zh) | 2011-07-09 | 2016-08-17 | 加利福尼亚大学董事会 | 白血病干细胞靶向配体及应用方法 |
| WO2013033513A1 (en) | 2011-08-31 | 2013-03-07 | University Of Georgia Research Foundation, Inc. | Apoptosis-targeting nanoparticles |
| WO2013036827A2 (en) | 2011-09-08 | 2013-03-14 | The Regents Of The University Of California | Fungal-specific metalloproteases and uses thereof |
| KR20130084091A (ko) | 2012-01-16 | 2013-07-24 | 삼성전자주식회사 | 화상형성장치 |
| EP2814496B1 (en) | 2012-02-17 | 2018-04-11 | University Of Georgia Research Foundation, Inc. | Nanoparticles for mitochondrial trafficking of agents |
| ES2922848T3 (es) * | 2013-09-05 | 2022-09-20 | Penn State Res Found | Bioelastómeros y aplicaciones de los mismos |
| WO2015138992A1 (en) | 2014-03-14 | 2015-09-17 | University Of Georgia Research Foundation, Inc. | Mitochondrial delivery of 3-bromopyruvate |
| CA3001329A1 (en) | 2015-10-09 | 2017-04-13 | Frantz Le Devedec | Crosslinked degradable particles.and methods of producing the same |
| WO2018156443A1 (en) * | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Novel substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (ido) inhibitors |
| US10513568B2 (en) | 2017-12-01 | 2019-12-24 | Rohm and Haas Electronic Materials | Methods of making stable and thermally polymerizable vinyl, amino or oligomeric phenoxy benzocyclobutene monomers with improved curing kinetics |
| US11905377B2 (en) | 2019-01-17 | 2024-02-20 | Pendant Biosciences, Inc. | Factors controlling drug release in cross-linked poly(valerolactone) based matrices |
| CN112961329B (zh) * | 2021-02-08 | 2022-03-18 | 浙江大学 | 通过多取代六元环内酯共聚合制备功能化聚酯和聚碳酸酯及其后修饰的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2576897B1 (fr) * | 1985-02-01 | 1987-02-27 | Centre Nat Rech Scient | Nouveaux derives epoxydiques, leur preparation et leur application, notamment comme medicaments antitumoraux |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US6196993B1 (en) | 1998-04-20 | 2001-03-06 | Eyelab Group, Llc | Ophthalmic insert and method for sustained release of medication to the eye |
| US7097856B2 (en) | 2000-09-29 | 2006-08-29 | The Regents Of The University Of California | Dendrimeric support or carrier macromolecule |
| US6635690B2 (en) | 2001-06-19 | 2003-10-21 | 3M Innovative Properties Company | Reactive oligomers |
| US6730772B2 (en) | 2001-06-22 | 2004-05-04 | Venkatram P. Shastri | Degradable polymers from derivatized ring-opened epoxides |
| KR20050111586A (ko) | 2003-02-13 | 2005-11-25 | 내셔널 센터 포 사이언티픽 리서치 데모크리토스 | 드러그 및 유전자 전달 시스템으로서의 다기능의 덴드리머및 다중결합된 폴리머 |
| WO2006051506A2 (en) | 2004-11-11 | 2006-05-18 | The University Of Akron | Convenient synthesis of 1 --> 3 c-branched dendrons |
| WO2006082588A2 (en) | 2005-02-07 | 2006-08-10 | Pharmalight Inc. | Method and device for ophthalmic administration of active pharmaceutical ingredients |
| JP2008535790A (ja) | 2005-03-03 | 2008-09-04 | サートリス ファーマシューティカルズ, インコーポレイテッド | サーチュインモジュレーターであるn−フェニルベンズアミド誘導体 |
| US7358733B2 (en) | 2006-02-28 | 2008-04-15 | Ge Security, Inc. | High performance security inspection system with physically isolated detection sensors |
| US8969622B2 (en) | 2006-08-23 | 2015-03-03 | Vanderbilt University | Dendritic molecular intracellular transporters and methods of making and using same |
| US8927682B2 (en) | 2007-08-24 | 2015-01-06 | Board Of Trustees Of Michigan State University | Functionalization of polyglycolides by “click” chemistry |
| US20110274620A1 (en) | 2007-11-05 | 2011-11-10 | Harth Eva M | Multifunctional degradable nanoparticles with control over size and functionalities |
| DK2209496T3 (da) | 2007-11-05 | 2019-08-05 | Univ Vanderbilt | Multifunktionelle nedbrydelige nanopartikler med kontrol over størrelse og funktioner |
-
2008
- 2008-11-05 DK DK08846997.8T patent/DK2209496T3/da active
- 2008-11-05 US US12/265,701 patent/US7935782B2/en active Active
- 2008-11-05 EP EP08846997.8A patent/EP2209496B1/en active Active
- 2008-11-05 EP EP19172669.4A patent/EP3574925A1/en not_active Withdrawn
- 2008-11-05 WO PCT/US2008/082529 patent/WO2009061854A2/en not_active Ceased
- 2008-11-05 CA CA2704956A patent/CA2704956C/en active Active
- 2008-11-05 CA CA3007559A patent/CA3007559C/en active Active
- 2008-11-05 ES ES08846997T patent/ES2744834T3/es active Active
-
2010
- 2010-11-23 US US12/953,173 patent/US8492510B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2209496B1 (en) | 2019-05-08 |
| CA3007559A1 (en) | 2009-05-14 |
| US8492510B2 (en) | 2013-07-23 |
| EP2209496A2 (en) | 2010-07-28 |
| CA3007559C (en) | 2022-08-02 |
| WO2009061854A2 (en) | 2009-05-14 |
| US20110257343A1 (en) | 2011-10-20 |
| US20090306335A1 (en) | 2009-12-10 |
| EP2209496A4 (en) | 2012-08-01 |
| ES2744834T3 (es) | 2020-02-26 |
| EP3574925A1 (en) | 2019-12-04 |
| US7935782B2 (en) | 2011-05-03 |
| CA2704956C (en) | 2019-02-12 |
| WO2009061854A3 (en) | 2009-12-30 |
| CA2704956A1 (en) | 2009-05-14 |
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