DK220986A - Fremgangsmaade til fremstilling af piperidyliden-dihydrodibenzo(a,d)cycloheptener og aza-derivater deraf, forbindelser vundet ved fremgangsmaaden og disses anvendelse til fremstilling af farmaceutiske kompositioner - Google Patents

Fremgangsmaade til fremstilling af piperidyliden-dihydrodibenzo(a,d)cycloheptener og aza-derivater deraf, forbindelser vundet ved fremgangsmaaden og disses anvendelse til fremstilling af farmaceutiske kompositioner Download PDF

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Publication number
DK220986A
DK220986A DK220986A DK220986A DK220986A DK 220986 A DK220986 A DK 220986A DK 220986 A DK220986 A DK 220986A DK 220986 A DK220986 A DK 220986A DK 220986 A DK220986 A DK 220986A
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DK
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Prior art keywords
piperidylide
dihydrodibenzo
procedure
preparation
Prior art date
Application number
DK220986A
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English (en)
Other versions
DK220986D0 (da
DK173765B1 (da
Inventor
Doris Pickel Schumacher
Frank J Villani
Jesse Kwok-Keung Wong
Bruce Lee Murphy
Jon Edward Clark
Original Assignee
Schering Corp
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27419175&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK220986(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/838,974 external-priority patent/US4659716A/en
Priority claimed from US06/839,016 external-priority patent/US4731447A/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of DK220986D0 publication Critical patent/DK220986D0/da
Publication of DK220986A publication Critical patent/DK220986A/da
Application granted granted Critical
Publication of DK173765B1 publication Critical patent/DK173765B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK198602209A 1985-05-13 1986-05-13 Fremgangsmåde til fremstilling af piperyliden-dihydro-dibenzo[a,d]cycloheptener og aza-derivater deraf, samt 8-(halogen/trifluormethyl)-11-(4-piperidyliden)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridiner....... DK173765B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US73342885A 1985-05-13 1985-05-13
US73342885 1985-05-13
US06/838,974 US4659716A (en) 1984-02-15 1986-03-12 Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines
US83897486 1986-03-12
US06/839,016 US4731447A (en) 1985-05-13 1986-03-12 Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
US83901686 1986-03-12

Publications (3)

Publication Number Publication Date
DK220986D0 DK220986D0 (da) 1986-05-13
DK220986A true DK220986A (da) 1986-11-14
DK173765B1 DK173765B1 (da) 2001-09-17

Family

ID=27419175

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198602209A DK173765B1 (da) 1985-05-13 1986-05-13 Fremgangsmåde til fremstilling af piperyliden-dihydro-dibenzo[a,d]cycloheptener og aza-derivater deraf, samt 8-(halogen/trifluormethyl)-11-(4-piperidyliden)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridiner.......

Country Status (15)

Country Link
EP (1) EP0208855B1 (da)
JP (2) JP2511412B2 (da)
AR (1) AR241463A1 (da)
AU (2) AU600665B2 (da)
CA (1) CA1272480A (da)
DE (1) DE3677842D1 (da)
DK (1) DK173765B1 (da)
ES (1) ES8800679A1 (da)
FI (2) FI90977C (da)
HK (1) HK75993A (da)
HU (1) HU199138B (da)
IE (1) IE59110B1 (da)
IL (1) IL78771A (da)
PT (1) PT82570B (da)
SG (1) SG69193G (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804666A (en) * 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
NZ228888A (en) * 1988-04-28 1991-12-23 Schering Corp Derivatives of piperidine, piperidylidene and piperazine and pharmaceutical compositions
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
US5095022A (en) * 1989-07-04 1992-03-10 Hokuriku Pharmaceutical Co., Ltd. Piperidine derivatives and pharmaceutical compositions comprising the same
ES2080699B1 (es) * 1994-07-27 1996-10-16 Farmahispania S A Nuevos derivados de 2-(1-etoxicarbonil-4-piperidiliden)metil)piridina y un procedimiento para su obtencion.
ES2080700B1 (es) * 1994-07-27 1996-10-16 Farmihispania S A Nuevo procedimiento para la obtencion de loratadina.
CN1047774C (zh) * 1996-09-10 1999-12-29 上海华联制药有限公司 氮杂二苯并环庚烯酮类化合物的制备方法
DE69714081T2 (de) * 1997-04-25 2002-11-14 Schering-Plough K.K., Osaka Augentropfen enthaltend ein loratidinmetabolit
UA62976C2 (en) * 1997-07-02 2004-01-15 Schering Corp Polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
DE69919720D1 (de) * 1998-07-24 2004-09-30 Russinsky Ltd Verfahren zur herstellung von benzocycloheptapyridin-11-one
US6372909B1 (en) 1998-11-20 2002-04-16 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
HK1038698A1 (zh) * 1998-11-20 2002-03-28 Merck Sharp & Dohme Corp. 合成有效制备三环化合物的中间体
JP4558942B2 (ja) * 1998-12-18 2010-10-06 シェーリング コーポレイション 抗ヒスタミン活性を有する三環式化合物を調製するためのプロセス
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
ES2391585T3 (es) 2006-06-01 2012-11-28 Msd Consumer Care, Inc. Formulación farmacéutica de liberación sostenida que comprende fenilefrina
TR200806298A2 (tr) 2008-08-22 2010-03-22 Bi̇lgi̇ç Mahmut Farmasötik formülasyon
CN115141229B (zh) * 2022-07-21 2023-12-12 华创合成制药股份有限公司 抗组胺类化合物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (da) * 1963-04-24
US3717647A (en) * 1971-04-09 1973-02-20 Schering Corp Alpha-nicotinoyl phenylacetonitriles
GB1489332A (en) * 1973-10-11 1977-10-19 Beecham Group Ltd Reduced bicyclic pyridone derivatives
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
WO1985003707A1 (en) * 1984-02-15 1985-08-29 Schering Corporation 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS

Also Published As

Publication number Publication date
ES8800679A1 (es) 1987-11-16
IE861259L (en) 1986-11-13
SG69193G (en) 1993-08-06
IE59110B1 (en) 1994-01-12
PT82570A (en) 1986-06-01
AU638019B2 (en) 1993-06-17
ES554898A0 (es) 1987-11-16
FI87648B (fi) 1992-10-30
FI861987L (fi) 1986-11-14
AR241463A1 (es) 1992-07-31
HK75993A (en) 1993-08-06
HUT41731A (en) 1987-05-28
HU199138B (en) 1990-01-29
DK220986D0 (da) 1986-05-13
FI902315A0 (fi) 1990-05-09
EP0208855B1 (en) 1991-03-06
DK173765B1 (da) 2001-09-17
CA1272480A (en) 1990-08-07
FI861987A0 (fi) 1986-05-13
JP2519880B2 (ja) 1996-07-31
JPH0859657A (ja) 1996-03-05
IL78771A (en) 1990-11-29
AU600665B2 (en) 1990-08-23
AU5737486A (en) 1986-12-18
JP2511412B2 (ja) 1996-06-26
DE3677842D1 (de) 1991-04-11
FI87648C (fi) 1993-02-10
JPS61289087A (ja) 1986-12-19
EP0208855A1 (en) 1987-01-21
AU5702690A (en) 1990-10-04
FI90977C (fi) 1994-04-25
IL78771A0 (en) 1986-08-31
FI90977B (fi) 1994-01-14
PT82570B (pt) 1988-11-30

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired