SG69193G - Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof,compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions - Google Patents

Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof,compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions

Info

Publication number
SG69193G
SG69193G SG691/93A SG69193A SG69193G SG 69193 G SG69193 G SG 69193G SG 691/93 A SG691/93 A SG 691/93A SG 69193 A SG69193 A SG 69193A SG 69193 G SG69193 G SG 69193G
Authority
SG
Singapore
Prior art keywords
preparing
compounds
cycloheptenes
piperidylidene
dihydrodibenzo
Prior art date
Application number
SG691/93A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27419175&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG69193(G) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/838,974 external-priority patent/US4659716A/en
Priority claimed from US06/839,016 external-priority patent/US4731447A/en
Application filed by Schering Corp filed Critical Schering Corp
Publication of SG69193G publication Critical patent/SG69193G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG691/93A 1985-05-13 1993-05-27 Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof,compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions SG69193G (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73342885A 1985-05-13 1985-05-13
US06/838,974 US4659716A (en) 1984-02-15 1986-03-12 Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines
US06/839,016 US4731447A (en) 1985-05-13 1986-03-12 Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof

Publications (1)

Publication Number Publication Date
SG69193G true SG69193G (en) 1993-08-06

Family

ID=27419175

Family Applications (1)

Application Number Title Priority Date Filing Date
SG691/93A SG69193G (en) 1985-05-13 1993-05-27 Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof,compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions

Country Status (15)

Country Link
EP (1) EP0208855B1 (da)
JP (2) JP2511412B2 (da)
AR (1) AR241463A1 (da)
AU (2) AU600665B2 (da)
CA (1) CA1272480A (da)
DE (1) DE3677842D1 (da)
DK (1) DK173765B1 (da)
ES (1) ES8800679A1 (da)
FI (2) FI90977C (da)
HK (1) HK75993A (da)
HU (1) HU199138B (da)
IE (1) IE59110B1 (da)
IL (1) IL78771A (da)
PT (1) PT82570B (da)
SG (1) SG69193G (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804666A (en) * 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
NZ228888A (en) * 1988-04-28 1991-12-23 Schering Corp Derivatives of piperidine, piperidylidene and piperazine and pharmaceutical compositions
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
US5095022A (en) * 1989-07-04 1992-03-10 Hokuriku Pharmaceutical Co., Ltd. Piperidine derivatives and pharmaceutical compositions comprising the same
ES2080699B1 (es) * 1994-07-27 1996-10-16 Farmahispania S A Nuevos derivados de 2-(1-etoxicarbonil-4-piperidiliden)metil)piridina y un procedimiento para su obtencion.
ES2080700B1 (es) * 1994-07-27 1996-10-16 Farmihispania S A Nuevo procedimiento para la obtencion de loratadina.
CN1047774C (zh) * 1996-09-10 1999-12-29 上海华联制药有限公司 氮杂二苯并环庚烯酮类化合物的制备方法
DE69714081T2 (de) * 1997-04-25 2002-11-14 Schering-Plough K.K., Osaka Augentropfen enthaltend ein loratidinmetabolit
UA62976C2 (en) * 1997-07-02 2004-01-15 Schering Corp Polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5h-benzo[5,6]cyclohepta[1,2-b]pyridine
DE69919720D1 (de) * 1998-07-24 2004-09-30 Russinsky Ltd Verfahren zur herstellung von benzocycloheptapyridin-11-one
US6372909B1 (en) 1998-11-20 2002-04-16 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
HK1038698A1 (zh) * 1998-11-20 2002-03-28 Merck Sharp & Dohme Corp. 合成有效制备三环化合物的中间体
JP4558942B2 (ja) * 1998-12-18 2010-10-06 シェーリング コーポレイション 抗ヒスタミン活性を有する三環式化合物を調製するためのプロセス
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
ES2391585T3 (es) 2006-06-01 2012-11-28 Msd Consumer Care, Inc. Formulación farmacéutica de liberación sostenida que comprende fenilefrina
TR200806298A2 (tr) 2008-08-22 2010-03-22 Bi̇lgi̇ç Mahmut Farmasötik formülasyon
CN115141229B (zh) * 2022-07-21 2023-12-12 华创合成制药股份有限公司 抗组胺类化合物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (da) * 1963-04-24
US3717647A (en) * 1971-04-09 1973-02-20 Schering Corp Alpha-nicotinoyl phenylacetonitriles
GB1489332A (en) * 1973-10-11 1977-10-19 Beecham Group Ltd Reduced bicyclic pyridone derivatives
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
WO1985003707A1 (en) * 1984-02-15 1985-08-29 Schering Corporation 8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDYLIDENE)-5H-BENZO AD5,6 BDCYCLOHEPTA AD1,2-b BDPYRIDINE AND ITS SALTS, PROCESSES FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS

Also Published As

Publication number Publication date
ES8800679A1 (es) 1987-11-16
IE861259L (en) 1986-11-13
IE59110B1 (en) 1994-01-12
PT82570A (en) 1986-06-01
AU638019B2 (en) 1993-06-17
ES554898A0 (es) 1987-11-16
DK220986A (da) 1986-11-14
FI87648B (fi) 1992-10-30
FI861987L (fi) 1986-11-14
AR241463A1 (es) 1992-07-31
HK75993A (en) 1993-08-06
HUT41731A (en) 1987-05-28
HU199138B (en) 1990-01-29
DK220986D0 (da) 1986-05-13
FI902315A0 (fi) 1990-05-09
EP0208855B1 (en) 1991-03-06
DK173765B1 (da) 2001-09-17
CA1272480A (en) 1990-08-07
FI861987A0 (fi) 1986-05-13
JP2519880B2 (ja) 1996-07-31
JPH0859657A (ja) 1996-03-05
IL78771A (en) 1990-11-29
AU600665B2 (en) 1990-08-23
AU5737486A (en) 1986-12-18
JP2511412B2 (ja) 1996-06-26
DE3677842D1 (de) 1991-04-11
FI87648C (fi) 1993-02-10
JPS61289087A (ja) 1986-12-19
EP0208855A1 (en) 1987-01-21
AU5702690A (en) 1990-10-04
FI90977C (fi) 1994-04-25
IL78771A0 (en) 1986-08-31
FI90977B (fi) 1994-01-14
PT82570B (pt) 1988-11-30

Similar Documents

Publication Publication Date Title
HUT42321A (en) Process for preparing pharmaceutical compositions
ZA877530B (en) Imidazopyridine derivatives and pharmaceutical compositions containing the same as well as processes for production thereof
HU896444D0 (en) Process for the preparation of pharmaceutical compositions
HUT42101A (en) Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
IL85741A0 (en) Substituted 9-amino-tetrahydroacridines and related compounds,a process for their preparation and pharmaceutical compositions containing them
SG69193G (en) Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof,compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions
ZA899434B (en) 9-a2a-3-(oxa-thia)-biocyclo 3,2,1 nonane derivatives,process intermediates for their preparation and pharmaceutical compositions containing them
PT86320A (en) Process for the preparation of a herbicid and or fungicid compound containing pyrazolin-5-ona replaced by products and of novel pyrazolin-5-ona replaced derivatives
HUT48619A (en) Process for producing new heteroaromatic amine derivatives and pharmaceutical compositions comprising such compounds
HUT41737A (en) Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds
IL80914A0 (en) New conjugates of vinblastine and its derivatives,a process for the preparation thereof and pharmaceutical compositions containing them
CS405391A3 (en) N-aminobutyl-n-phenylarylamide derivatives, process of their preparationand pharmaceutical compositions containing said derivatives
IL86027A (en) 2-acylpyrrolidine derivatives,a process for the preparation thereof,compositions containing them,and their use
HUT46652A (en) Process for producing amine derivatives and pharmaceutical compositions comprising such compounds and fungicides
HU905358D0 (en) Substituted bicycloheptane-dion-derivatives, process for the production of the compounds, and herbicide preparations containing the derivatives
EP0258096A3 (en) Indane derivatives, process for their preparation, their use as medicines, pharmaceutical compositions containing them and the intermediates obtained
PT81954A (en) Process for the preparation of pharmaceutical compositions containing 9,10-dihydro alkalloids of ergot
AR242206A1 (es) Procedimiento para la preparacion de derivados de acido 3-desmetil-mevalonico, preparados farmaceuticos en base a los mismos,y productos intermediarios para uso exclusivo.
IL82294A0 (en) 1,3-dihydropyridine derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
EP0371492A3 (en) Process for the preparation of 1,4-dihydropyridine derivatives
EP0297496A3 (en) Novel process for the preparation of 6,7-diacyl-7-deacetylforskolin derivatives
EP0329563A3 (en) Benzocyclohexane and benzocycloheptane derivatives and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them
GB2216521B (en) Process for the preparation of 1,4-dihydro-pyridine derivatives
PT86455A (en) Process for the preparation of pharmaceutical compositions containing pyranoquinoline derivatives
PT83884B (en) Process for the preparation of 1 azolyl-3,3-dimethyl-tutan-2-on-and-ol derivatives