DK2219642T3 - Silibininbestandel til behandling af hepatitis - Google Patents

Silibininbestandel til behandling af hepatitis

Info

Publication number: DK2219642T3
Authority: DK; Denmark
Prior art keywords: hepatitis; treatment; silibinin; stock; ribavirin
Prior art date: 2007-11-15

Application number

DK08849759.9T

Other languages

English (en)

Inventor

Lucio Claudio Rovati

Amato Massimo Maria D

Ulrich Mengs

Ralf-Torsten Pohl

Peter Ferenci

Original Assignee

Madaus Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-11-15

Filing date

2008-11-14

Publication date

2011-12-05

2008-11-14 Application filed by Madaus Gmbh filed Critical Madaus Gmbh

2011-12-05 Application granted granted Critical

2011-12-05 Publication of DK2219642T3 publication Critical patent/DK2219642T3/da

Links

SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 title abstract 2
SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 title abstract 2
229950000628 silibinin Drugs 0.000 title abstract 2
235000014899 silybin Nutrition 0.000 title abstract 2
208000006454 hepatitis Diseases 0.000 title 1
231100000283 hepatitis Toxicity 0.000 title 1
208000005176 Hepatitis C Diseases 0.000 abstract 1
102000014150 Interferons Human genes 0.000 abstract 1
108010050904 Interferons Proteins 0.000 abstract 1
IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 abstract 1
229940079322 interferon Drugs 0.000 abstract 1
229960000329 ribavirin Drugs 0.000 abstract 1
HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Zoology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

DK08849759.9T 2007-11-15 2008-11-14 Silibininbestandel til behandling af hepatitis DK2219642T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US98816807P	2007-11-15	2007-11-15
EP07022187		2007-11-15
EP08005459		2008-03-25
PCT/EP2008/009659 WO2009062737A1 (en)	2007-11-15	2008-11-14	Silibinin component for the treatment of hepatitis

Publications (1)

Publication Number	Publication Date
DK2219642T3 true DK2219642T3 (da)	2011-12-05

Family

ID=40259958

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08849759.9T DK2219642T3 (da)	2007-11-15	2008-11-14	Silibininbestandel til behandling af hepatitis

Country Status (14)

Country	Link
US (2)	US20110182858A1 (da)
EP (2)	EP2392326B9 (da)
JP (1)	JP5349486B2 (da)
KR (1)	KR101435242B1 (da)
CN (1)	CN102300570B (da)
AT (1)	ATE525070T1 (da)
AU (1)	AU2008323156B2 (da)
CA (1)	CA2703834C (da)
DK (1)	DK2219642T3 (da)
ES (2)	ES2374117T3 (da)
MX (1)	MX2010005107A (da)
PL (2)	PL2219642T3 (da)
PT (1)	PT2219642E (da)
WO (1)	WO2009062737A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2430017B1 (en)	2009-05-14	2016-06-29	Madaus GmbH	A method for preparing AMORPHOUS SILIBININ
WO2011051742A1 (en) *	2009-10-28	2011-05-05	Modutech S.A.	Preparation comprising amino acids and plants and its activity in the alcohol detoxification
US8492386B2 (en)	2011-10-21	2013-07-23	Abbvie Inc.	Methods for treating HCV
CA2811203C (en)	2011-10-21	2015-05-05	Abbvie Inc.	Methods for treating hcv
US8466159B2 (en)	2011-10-21	2013-06-18	Abbvie Inc.	Methods for treating HCV
CN104023726A (zh)	2011-10-21	2014-09-03	艾伯维公司	用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333)
WO2015112171A1 (en) *	2014-01-27	2015-07-30	Kaohsiung Medical University	A silibinin nanoparticle and a method of treating hepatitis c thereof
WO2015127494A1 (en) *	2014-02-26	2015-09-03	Commonwealth Scientific And Industrial Research Organisation	Process of forming a photoactive layer of a perovskite photoactive device
CA2963872C (en) *	2014-10-09	2023-09-12	Distretto Tecnologico Sicilia Micro E Nano Sistemi S.C.A.R.L.	Nanostructured formulations for the delivery of silibinin and other active ingredients for treating ocular diseases
WO2017059447A1 (en) *	2015-10-02	2017-04-06	PACHECO, Theresa	Topical silibinin formulations and uses thereofor
JP7129703B2 (ja)	2016-04-28	2022-09-02	エモリーユニバーシティー	アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
JP6765273B2 (ja) *	2016-10-05	2020-10-07	株式会社ファンケル	シリマリン粉砕物
CN111841501A (zh) *	2020-06-23	2020-10-30	五邑大学	一种治疗炎症性疾病的药物组合物及其应用
WO2023008981A1 (ko) *	2021-07-30	2023-02-02	경희대학교 산학협력단	항바이러스 조성물 및 이의 이용
CN117269374B (zh) *	2023-11-22	2024-01-16	汤臣倍健股份有限公司	一种水飞蓟提取物中人为掺假的鉴别方法
CN117919256B (zh) *	2024-03-25	2024-05-24	潍坊众邦制药有限公司	一种含有药用甾醇活性物质组合物在制备治疗肝炎的用途

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US4061765A (en) *	1973-01-19	1977-12-06	Dr. Madaus & Co.	Polyhydroxyphenylchromanone salts and therapeutic composition
DE3442639A1 (de) *	1984-11-22	1986-05-22	Dr. Madaus & Co, 5000 Köln	Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten
DE3537656A1 (de) *	1984-11-22	1986-05-22	Dr. Madaus GmbH & Co, 5000 Köln	Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin
IT1215291B (it) *	1985-07-17	1990-01-31	Inverni Della Beffa Spa	Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.
IT1241673B (it)	1989-10-09	1994-01-27	Istituto Biochimico Italiano	Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono.
DE4401902C2 (de) *	1994-01-24	2000-02-03	Madaus Ag	Verwendung von Flavolignanen als Adjuvans in der Tumortherapie
JP2002504514A (ja) *	1998-02-27	2002-02-12	ニュートラマックスラボラトリーズ，インコーポレイテッド	肝臓傷害の予防、治療及び修復のためのｌ−エルゴチオネイン、ノゲシ及びｓ−アデノシルメテオニン
WO1999055326A1 (en) *	1998-04-30	1999-11-04	Vit-Immune, L.C.	Method of treatment of glutathione deficient mammals
IL142942A0 (en) *	1998-11-24	2002-04-21	Holis Eden Pharmaceuticals Inc	Use of 17-ketosteroid compounds and derivatives, metabolites and precursors thereof in the treatment of hepatitis c virus and other toga viruses
US6849254B1 (en) *	1999-04-19	2005-02-01	Schering Corporation	HCV combination therapy
WO2002067853A2 (en) *	2000-10-06	2002-09-06	Probiochem, Llc	A combination and method of treatment of hiv and viral diseases, vascular disease and cancer utilizing a cox-2 inhibitor and cystine
US6699900B2 (en)	2001-04-07	2004-03-02	Jan E. Zielinski	Hydrophilic and lipophilic silibinin pro-forms
CN100451501C (zh)	2003-08-26	2009-01-14	株式会社东芝	冰箱
US7078064B2 (en)	2003-12-03	2006-07-18	George Zabrecky	Compositions and methods useful for treating and preventing chronic liver disease, chronic HCV infection and non-alcoholic steatohepatitis
CN1762345A (zh)	2005-09-29	2006-04-26	丛晓东	一种水飞蓟宾注射剂及其制备方法
CN100389767C (zh) *	2005-09-30	2008-05-28	天津药物研究院	一种含活性成分水飞蓟宾及其盐经注射给药的稳定的药物组合物
CN100534992C (zh) *	2005-12-26	2009-09-02	浙江海正药业股份有限公司	水飞蓟宾酯类衍生物及其制备方法和制备药物的用途
CN101244059B (zh)	2008-03-31	2010-11-17	广州佳科生物科技有限公司	一种复方水飞蓟宾注射剂及其制备方法和应用
CN101439018A (zh)	2008-11-11	2009-05-27	扬子江药业集团四川海蓉药业有限公司	一种静脉注射用水飞蓟宾类化合物乳剂及其制备方法

2008
- 2008-11-14 US US12/742,916 patent/US20110182858A1/en not_active Abandoned
- 2008-11-14 KR KR1020107011714A patent/KR101435242B1/ko not_active Expired - Fee Related
- 2008-11-14 CA CA2703834A patent/CA2703834C/en not_active Expired - Fee Related
- 2008-11-14 AT AT08849759T patent/ATE525070T1/de active
- 2008-11-14 CN CN200880116206.3A patent/CN102300570B/zh not_active Expired - Fee Related
- 2008-11-14 DK DK08849759.9T patent/DK2219642T3/da active
- 2008-11-14 AU AU2008323156A patent/AU2008323156B2/en not_active Ceased
- 2008-11-14 EP EP11005445.9A patent/EP2392326B9/en not_active Not-in-force
- 2008-11-14 ES ES08849759T patent/ES2374117T3/es active Active
- 2008-11-14 ES ES11005445.9T patent/ES2662700T3/es active Active
- 2008-11-14 PL PL08849759T patent/PL2219642T3/pl unknown
- 2008-11-14 MX MX2010005107A patent/MX2010005107A/es active IP Right Grant
- 2008-11-14 EP EP08849759A patent/EP2219642B1/en not_active Not-in-force
- 2008-11-14 JP JP2010533503A patent/JP5349486B2/ja not_active Expired - Fee Related
- 2008-11-14 PT PT08849759T patent/PT2219642E/pt unknown
- 2008-11-14 PL PL11005445T patent/PL2392326T3/pl unknown
- 2008-11-14 WO PCT/EP2008/009659 patent/WO2009062737A1/en not_active Ceased
2013
- 2013-04-26 US US13/871,045 patent/US9248115B2/en active Active

Also Published As

Publication number	Publication date
ATE525070T1 (de)	2011-10-15
AU2008323156B2 (en)	2012-05-31
US20130236420A1 (en)	2013-09-12
US20110182858A1 (en)	2011-07-28
PL2219642T3 (pl)	2012-02-29
CA2703834C (en)	2014-05-20
PT2219642E (pt)	2011-10-18
US9248115B2 (en)	2016-02-02
KR101435242B1 (ko)	2014-08-29
PL2392326T3 (pl)	2018-07-31
ES2662700T3 (es)	2018-04-09
EP2219642B1 (en)	2011-09-21
MX2010005107A (es)	2010-05-27
KR20100094981A (ko)	2010-08-27
EP2392326B9 (en)	2018-09-05
CN102300570B (zh)	2015-01-14
WO2009062737A1 (en)	2009-05-22
CN102300570A (zh)	2011-12-28
JP5349486B2 (ja)	2013-11-20
EP2392326A1 (en)	2011-12-07
HK1142270A1 (en)	2010-12-03
EP2392326B1 (en)	2018-01-24
ES2374117T3 (es)	2012-02-13
AU2008323156A1 (en)	2009-05-22
EP2219642A1 (en)	2010-08-25
CA2703834A1 (en)	2009-05-22
JP2011503133A (ja)	2011-01-27
ES2662700T9 (es)	2018-08-27

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ATE525070T1 (de)	2011-10-15	Silbininkomponente zur behandlung von hepatitis
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BRPI0808246A2 (pt)	2018-10-30	"fralda descartável".
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DK1663347T3 (da)	2008-05-19	Afereseindretning
BRPI0807804A2 (pt)	2014-06-17	" arilciclopentenos substituídos como agentes terapêuticos ".
DE602006000349D1 (de)	2008-02-07	Medizinisches Instrument mit medizinischer Behandlungselektrode
EP2096927A4 (en)	2009-12-23	THERAPEUTIC COMPOSITIONS AND METHODS OF TREATING WITH CAPSIANOSIDE COMPOUNDS
DK1670482T4 (da)	2022-08-22	Anvendelse af ciclesonid til behandlingen af respiratoriske sygdomme
SI1940409T1 (sl)	2010-12-31	Nove zdravilske kombinacije za zdravljenje bolezni dihalnih poti
DK1962869T3 (da)	2013-06-24	Behandling af luftvejssygdomme
MX2011006516A (es)	2011-08-04	Terapia de combinacion de virus de hepatitis c.
JO2662B1 (en)	2012-06-17	Use of 4-cyclopropylmethoxy -N-(3,5-dichloro-1-oxido-4-pyridin-4-yl)-5-(methoxy) pyridine-2-carboxamide in the treatment of spinal cord traumas
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