DK2228441T3 - Enzym, der er involveret i syntese af equol. - Google Patents

Enzym, der er involveret i syntese af equol.

Info

Publication number: DK2228441T3
Authority: DK; Denmark
Prior art keywords: equol; enzym; involved; synthesis; enzym involved
Prior art date: 2007-12-27

Application number

DK08867315.7T

Other languages

English (en)

Inventor

Setsuko Yasuda

Yoshikazu Shimada

Masayuki Takahashi

Takashi Hayashi

Norihiro Miyazawa

Yasuhiro Abiru

Tadaaki Ohtani

Ikutaro Sato

Original Assignee

Otsuka Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-27

Filing date

2008-12-25

Publication date

2013-09-08

2008-12-25 Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd

2013-09-08 Application granted granted Critical

2013-09-08 Publication of DK2228441T3 publication Critical patent/DK2228441T3/da

Links

230000015572 biosynthetic process Effects 0.000 title 1
ADFCQWZHKCXPAJ-GFCCVEGCSA-N equol Chemical compound C1=CC(O)=CC=C1[C@@H]1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-GFCCVEGCSA-N 0.000 title 1
235000019126 equol Nutrition 0.000 title 1
ADFCQWZHKCXPAJ-UHFFFAOYSA-N indofine Natural products C1=CC(O)=CC=C1C1CC2=CC=C(O)C=C2OC1 ADFCQWZHKCXPAJ-UHFFFAOYSA-N 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

DK08867315.7T 2007-12-27 2008-12-25 Enzym, der er involveret i syntese af equol. DK2228441T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2007336227		2007-12-27
JP2008054874		2008-03-05
JP2008080570		2008-03-26
PCT/JP2008/073649 WO2009084603A1 (ja)	2007-12-27	2008-12-25	エクオール合成に関与する酵素

Publications (1)

Publication Number	Publication Date
DK2228441T3 true DK2228441T3 (da)	2013-09-08

Family

ID=40824317

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK08867315.7T DK2228441T3 (da)	2007-12-27	2008-12-25	Enzym, der er involveret i syntese af equol.
DK11170947.3T DK2404995T3 (da)	2007-12-27	2008-12-25	Enzym associeret med equolsyntese
DK11170943.2T DK2404994T3 (da)	2007-12-27	2008-12-25	Enzym associeret med equolsyntese.

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK11170947.3T DK2404995T3 (da)	2007-12-27	2008-12-25	Enzym associeret med equolsyntese
DK11170943.2T DK2404994T3 (da)	2007-12-27	2008-12-25	Enzym associeret med equolsyntese.

Country Status (15)

Country	Link
US (4)	US8399232B2 (da)
EP (3)	EP2404994B1 (da)
JP (2)	JP5230654B2 (da)
KR (5)	KR20130133894A (da)
CN (5)	CN102703395A (da)
AR (1)	AR070058A1 (da)
CA (1)	CA2710812C (da)
DK (3)	DK2228441T3 (da)
ES (3)	ES2424470T3 (da)
MY (1)	MY156222A (da)
PT (3)	PT2404995E (da)
SG (2)	SG2013066634A (da)
SI (3)	SI2228441T1 (da)
TW (1)	TWI468516B (da)
WO (1)	WO2009084603A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20130133894A (ko) *	2007-12-27	2013-12-09	오츠카 세이야쿠 가부시키가이샤	에쿠올 합성에 관여하는 효소
CN105936897A (zh) *	2009-11-30	2016-09-14	细胞制药有限公司	新的7β-羟类固醇脱氢酶及它们的用途
AU2014226126B2 (en)	2013-03-08	2019-02-14	Genzyme Corporation	Continuous purification of therapeutic proteins
JP6343899B2 (ja) *	2013-10-08	2018-06-20	東洋紡株式会社	黄色ブドウ球菌の検出方法
WO2015053061A1 (ja) *	2013-10-08	2015-04-16	東洋紡株式会社	メチシリン耐性遺伝子の検出方法および黄色ブドウ球菌の検出方法
TWI709569B (zh)	2014-01-17	2020-11-11	美商健臻公司	無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh)	2014-01-17	2020-11-11	美商健臻公司	無菌層析法及製法
CN108350508B (zh) *	2015-10-29	2021-09-17	株式会社益力多本社	雌马酚产生能力的测定方法
CN105861363B (zh) *	2016-04-15	2019-11-12	河北农业大学	爱格氏菌、s-雌马酚产生工程菌及其构建方法和应用
KR102005237B1 (ko) *	2017-02-28	2019-07-30	서울대학교산학협력단	에쿠올 유도체를 생산하는 재조합 대장균 및 이를 이용한 에쿠올 유도체 합성 방법
CN107641611B (zh) *	2017-06-29	2020-09-04	浙江省农业科学院	一种具有s-雌马酚抗性的大肠杆菌突变株及应用
JP2018186823A (ja) *	2018-07-13	2018-11-29	株式会社ダイセル	イソフラバノン類の製造方法
KR102079003B1 (ko)	2018-08-10	2020-02-19	서울대학교산학협력단	활성이 증대된 테트라하이드로다이드제인 환원효소 및 에쿠올 유도체 생산에의 응용
JP7699537B2 (ja)	2018-08-31	2025-06-27	ジェンザイム・コーポレーション	無菌クロマトグラフィー樹脂および製造方法におけるその使用
KR20210084558A (ko)	2018-10-29	2021-07-07	가즈히로 다테다	에쿠올을 유효 성분으로서 포함하는 장내 세균에 대한 항균제
CN112442490B (zh) *	2020-11-26	2022-03-01	湖南科技学院	一种转化酶及其在产s-雌马酚中的应用
WO2023056413A1 (en) *	2021-09-30	2023-04-06	Board Of Regents, The University Of Texas System	Engineered vectors and organisms containing the same for isoflavone conversion in the gut
CN115747240B (zh) *	2022-08-05	2025-04-22	华熙生物科技股份有限公司	一种生产雌马酚的重组大肠杆菌工程菌株及应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU735713B2 (en) *	1997-08-08	2001-07-12	Otsuka Pharmaceutical Co., Ltd.	Isoflavone-containing composition
AUPQ008299A0 (en)	1999-04-30	1999-05-27	G.J. Consultants Pty Ltd	Isoflavone metabolites
AU2001278683A1 (en) *	2000-08-01	2002-02-13	Kaneka Corporation	Novel carbonyl reductase, gene thereof and method of using the same
US7416866B2 (en)	2002-02-01	2008-08-26	Schering Ag	Process for the overexpression of dehydrogenases
US7314974B2 (en) *	2002-02-21	2008-01-01	Monsanto Technology, Llc	Expression of microbial proteins in plants for production of plants with improved properties
SI2548455T1 (sl)	2003-06-30	2016-11-30	Otsuka Pharmaceutical Co., Ltd.	Sestavek, ki vsebuje mlečno kislinsko bakterijo, ki proizvaja ekvol
JP4610525B2 (ja)	2003-06-30	2011-01-12	大塚製薬株式会社	エクオール産生乳酸菌含有組成物
DE602005012127D1 (de) *	2004-08-06	2009-02-12	Kaneka Corp	Neue carbonylreduktase, deren gen sowie verfahren zur verwendung davon
CA2628803C (en) *	2005-11-02	2016-07-05	Kabushiki Kaisha Yakult Honsha	Equol level regulator
WO2007066655A1 (ja) *	2005-12-06	2007-06-14	Otsuka Pharmaceutical Co., Ltd.	エクオール含有大豆胚軸発酵物、及びその製造方法
JP5005672B2 (ja) *	2006-02-28	2012-08-22	株式会社カネカ	新規カルボニル還元酵素、その遺伝子、およびそれらを利用した光学活性アルコールの製造方法
KR20130133894A (ko) *	2007-12-27	2013-12-09	오츠카 세이야쿠 가부시키가이샤	에쿠올 합성에 관여하는 효소
JP5414368B2 (ja) *	2009-05-29	2014-02-12	大塚製薬株式会社	ジヒドロダイゼインをラセミ化する酵素

2008
- 2008-12-25 KR KR1020137027981A patent/KR20130133894A/ko not_active Ceased
- 2008-12-25 SG SG2013066634A patent/SG2013066634A/en unknown
- 2008-12-25 EP EP11170943.2A patent/EP2404994B1/en not_active Not-in-force
- 2008-12-25 ES ES11170943T patent/ES2424470T3/es active Active
- 2008-12-25 CA CA2710812A patent/CA2710812C/en active Active
- 2008-12-25 KR KR1020107016700A patent/KR101265400B1/ko active Active
- 2008-12-25 CN CN2012101265049A patent/CN102703395A/zh active Pending
- 2008-12-25 US US12/810,742 patent/US8399232B2/en active Active
- 2008-12-25 CN CN2012101265354A patent/CN102676463A/zh active Pending
- 2008-12-25 ES ES08867315T patent/ES2423937T3/es active Active
- 2008-12-25 TW TW97150642A patent/TWI468516B/zh active
- 2008-12-25 CN CN200880127246.8A patent/CN101952417B/zh active Active
- 2008-12-25 PT PT111709473T patent/PT2404995E/pt unknown
- 2008-12-25 SG SG2013066642A patent/SG2013066642A/en unknown
- 2008-12-25 KR KR1020127030666A patent/KR101543500B1/ko not_active Expired - Fee Related
- 2008-12-25 DK DK08867315.7T patent/DK2228441T3/da active
- 2008-12-25 SI SI200831018T patent/SI2228441T1/sl unknown
- 2008-12-25 EP EP11170947.3A patent/EP2404995B1/en not_active Not-in-force
- 2008-12-25 PT PT88673157T patent/PT2228441E/pt unknown
- 2008-12-25 DK DK11170947.3T patent/DK2404995T3/da active
- 2008-12-25 JP JP2009548072A patent/JP5230654B2/ja active Active
- 2008-12-25 CN CN201510191176.4A patent/CN104830813A/zh active Pending
- 2008-12-25 ES ES11170947T patent/ES2424960T3/es active Active
- 2008-12-25 KR KR1020127030667A patent/KR101543501B1/ko not_active Expired - Fee Related
- 2008-12-25 PT PT111709432T patent/PT2404994E/pt unknown
- 2008-12-25 WO PCT/JP2008/073649 patent/WO2009084603A1/ja not_active Ceased
- 2008-12-25 CN CN201210126502XA patent/CN102676462A/zh active Pending
- 2008-12-25 EP EP08867315.7A patent/EP2228441B1/en active Active
- 2008-12-25 DK DK11170943.2T patent/DK2404994T3/da active
- 2008-12-25 SI SI200831028T patent/SI2404994T1/sl unknown
- 2008-12-25 KR KR1020137027968A patent/KR20130133893A/ko not_active Ceased
- 2008-12-25 MY MYPI2010002883A patent/MY156222A/en unknown
- 2008-12-25 SI SI200831033T patent/SI2404995T1/sl unknown
- 2008-12-29 AR ARP080105754A patent/AR070058A1/es not_active Application Discontinuation
2012
- 2012-11-05 US US13/668,924 patent/US8669088B2/en active Active
- 2012-11-08 JP JP2012246695A patent/JP5689104B2/ja not_active Expired - Fee Related
2014
- 2014-01-15 US US14/155,557 patent/US8993296B2/en active Active
2015
- 2015-02-13 US US14/621,871 patent/US20150240275A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP5230654B2 (ja)	2013-07-10
US20140315264A1 (en)	2014-10-23
CN101952417A (zh)	2011-01-19
US8669088B2 (en)	2014-03-11
KR20130008074A (ko)	2013-01-21
AU2008344416A1 (en)	2009-07-09
HK1166103A1 (en)	2012-10-19
EP2404995B1 (en)	2013-07-17
CN101952417B (zh)	2015-04-29
US8993296B2 (en)	2015-03-31
JPWO2009084603A1 (ja)	2011-05-19
PT2228441E (pt)	2013-08-27
CA2710812A1 (en)	2009-07-09
SI2228441T1 (sl)	2013-09-30
CN104830813A (zh)	2015-08-12
JP5689104B2 (ja)	2015-03-25
PT2404994E (pt)	2013-09-25
ES2424470T3 (es)	2013-10-02
HK1145189A1 (en)	2011-04-08
KR101543501B1 (ko)	2015-08-11
EP2228441A4 (en)	2010-12-29
TWI468516B (zh)	2015-01-11
CA2710812C (en)	2018-06-05
HK1166104A1 (en)	2012-10-19
PT2404995E (pt)	2013-09-26
KR101265400B1 (ko)	2013-05-29
US20130150568A1 (en)	2013-06-13
EP2404994A1 (en)	2012-01-11
KR101543500B1 (ko)	2015-08-11
KR20130006513A (ko)	2013-01-16
US20100330627A1 (en)	2010-12-30
KR20100101161A (ko)	2010-09-16
TW200934868A (en)	2009-08-16
KR20130133893A (ko)	2013-12-09
SG2013066642A (en)	2015-04-29
SG2013066634A (en)	2015-04-29
JP2013051966A (ja)	2013-03-21
EP2404995A1 (en)	2012-01-11
MY156222A (en)	2016-01-29
US8399232B2 (en)	2013-03-19
BRPI0821816A2 (pt)	2014-10-14
CN102676463A (zh)	2012-09-19
SI2404994T1 (sl)	2013-10-30
AR070058A1 (es)	2010-03-10
DK2404995T3 (da)	2013-10-14
WO2009084603A1 (ja)	2009-07-09
CN102703395A (zh)	2012-10-03
CN102676462A (zh)	2012-09-19
SI2404995T1 (sl)	2013-10-30
EP2228441B1 (en)	2013-06-19
US20150240275A1 (en)	2015-08-27
DK2404994T3 (da)	2013-09-08
ES2424960T3 (es)	2013-10-10
EP2404994B1 (en)	2013-07-03
ES2423937T3 (es)	2013-09-25
KR20130133894A (ko)	2013-12-09
EP2228441A1 (en)	2010-09-15

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