DK223488A - N-(pyridinyl)-1h-indol-1-aminer, deres fremstilling og anvendelse - Google Patents

N-(pyridinyl)-1h-indol-1-aminer, deres fremstilling og anvendelse

Info

Publication number: DK223488A
Authority: DK; Denmark
Prior art keywords: loweralkyl; arylloweralkyl; sec; aryl; halogen
Prior art date: 1987-04-24

Application number

DK223488A

Other languages

English (en)

Other versions

DK172153B1 (da

DK223488D0 (da

Inventor

Richard Charles Effland

Joseph Thomas Klein

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-24

Filing date

1988-04-22

Publication date

1988-10-25

1988-04-22 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1988-04-22 Publication of DK223488D0 publication Critical patent/DK223488D0/da

1988-10-25 Publication of DK223488A publication Critical patent/DK223488A/da

1997-12-01 Application granted granted Critical

1997-12-01 Publication of DK172153B1 publication Critical patent/DK172153B1/da

Links

FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical class [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 title 1
-1 hydroxy, nitro, amino Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 5
150000002431 hydrogen Chemical group 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
125000003435 aroyl group Chemical group 0.000 abstract 1
125000005239 aroylamino group Chemical group 0.000 abstract 1
125000005100 aryl amino carbonyl group Chemical group 0.000 abstract 1
125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004802 cyanophenyl group Chemical group 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000006501 nitrophenyl group Chemical group 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK223488A 1987-04-24 1988-04-22 N-(Pyridinyl)-1H-indol-1-aminer, fremgangsmåde til deres fremstilling, farmaceutisk præparat indeholdende dem samt deres anvendelse til fremstilling af et lægemiddel DK172153B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4207987A	1987-04-24	1987-04-24
US4207987		1987-04-24

Publications (3)

Publication Number	Publication Date
DK223488D0 DK223488D0 (da)	1988-04-22
DK223488A true DK223488A (da)	1988-10-25
DK172153B1 DK172153B1 (da)	1997-12-01

Family

ID=21919923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK223488A DK172153B1 (da)	1987-04-24	1988-04-22	N-(Pyridinyl)-1H-indol-1-aminer, fremgangsmåde til deres fremstilling, farmaceutisk præparat indeholdende dem samt deres anvendelse til fremstilling af et lægemiddel

Country Status (17)

Country	Link
EP (1)	EP0287982B1 (da)
JP (1)	JP2683360B2 (da)
KR (1)	KR960015003B1 (da)
AT (1)	ATE115143T1 (da)
AU (1)	AU594876B2 (da)
CA (1)	CA1330661C (da)
DE (1)	DE3852335T2 (da)
DK (1)	DK172153B1 (da)
ES (1)	ES2065324T3 (da)
FI (1)	FI90978C (da)
IE (1)	IE65349B1 (da)
IL (1)	IL86154A (da)
NO (1)	NO168104C (da)
NZ (1)	NZ224338A (da)
PH (1)	PH26127A (da)
PT (1)	PT87308B (da)
ZA (1)	ZA882810B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4868190A (en) *	1988-12-27	1989-09-19	Hoechst-Roussel Pharmaceuticals, Inc.	N-pyridinyl-9H-carbazol-9-amines
US4983615A (en) *	1989-06-28	1991-01-08	Hoechst-Roussel Pharmaceuticals Inc.	Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US5179099A (en) *	1989-08-02	1993-01-12	Hoechst-Roussel Pharmaceuticals Incorporated	2,3-dihydro-1-(pyridinylamino)-indoles
DK0415103T3 (da) *	1989-08-02	1995-06-19	Hoechst Roussel Pharma	2,3-Dihydro-1-(pyridinylamino)-indoler, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
US5006537A (en) *	1989-08-02	1991-04-09	Hoechst-Roussel Pharmaceuticals, Inc.	1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US5179119A (en) *	1989-08-02	1993-01-12	Hoechst-Roussel Pharmaceuticals Incorporated	1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates for the preparation thereof
US4983608A (en)	1989-09-05	1991-01-08	Hoechst-Roussell Pharmaceuticals, Inc.	N-substituted-4-pyrimidinamines and pyrimidinediamines
US5102891A (en) *	1990-07-23	1992-04-07	Hoechst-Roussel Pharmaceuticals Inc.	1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates
US5214038A (en) *	1991-04-15	1993-05-25	Hoechst-Roussel Pharmaceuticals Inc.	1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US5328920A (en) *	1991-04-17	1994-07-12	Hoechst-Roussel Pharmaceuticals Incorporated	Substituted (pyridinylamino)-indoles
US5185350A (en) *	1991-09-23	1993-02-09	Hoechst-Roussel Pharmaceuticals Incorporated	Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles
US5356910A (en)	1993-07-19	1994-10-18	Hoechst-Roussel Pharmaceuticals Inc.	Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
US5459274A (en) *	1994-05-13	1995-10-17	Hoechst-Roussel Pharmaceuticals Inc.	Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
JP4189029B2 (ja) *	1995-07-27	2008-12-03	アベンティス・ファーマスーティカルズ・インコーポレイテッド	抗けいれん剤としての未置換および置換ｎ−（ピロール−１−イル）ピリジンアミンの使用
US5776955A (en) *	1995-07-27	1998-07-07	Hoechst Marion Roussel, Inc.	Use of unsubstituted and substituted n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents
DE69715668T2 (de) *	1996-12-27	2003-07-31	Aventis Pharmaceuticals Inc., Bridgewater	N-(pyridinylamino)isoindoline und verwandte verbindungen
JP4779185B2 (ja) *	1999-03-10	2011-09-28	東ソー株式会社	含窒素複素環化合物及びその製造方法
DE60016068T2 (de) *	1999-03-10	2005-11-03	Tosoh Corp., Shinnanyo	Verfahren zur Herstellung Stickstoffheterocyclischer Verbindungen
JP4683166B2 (ja) *	1999-03-10	2011-05-11	東ソー株式会社	含窒素複素環化合物の製造方法
GB0119435D0 (en) *	2001-02-15	2001-10-03	Aventis Pharm Prod Inc	Method of treating of demyelinating diseases or conditions
US7538227B2 (en)	2004-01-13	2009-05-26	Sanofi-Aventis Deutschland Gmbh	Process for stabilizing 4-halopyridines
GT200500063A (es) *	2004-04-01	2005-10-14		Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
FR2888238B1 (fr) *	2005-07-07	2007-09-07	Servier Lab	Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
FR2911780A1 (fr) *	2007-01-26	2008-08-01	Urogene	Traitement de l'incontinence fecale.
AU2008238379A1 (en) *	2007-04-13	2008-10-23	Sanofi-Aventis	A transition metal catalyzed synthesis of N-aminoindoles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3242185A (en) *	1963-10-07	1966-03-22	Merck & Co Inc	Lower aliphatic acids, salts and derivatives thereof
DE1670184A1 (de) *	1967-01-20	1971-01-21	Boehringer Sohn Ingelheim	Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2)
CH603581A5 (da) *	1974-03-29	1978-08-31	Siegfried Ag
US4260767A (en) *	1979-12-26	1981-04-07	American Cyanamid Company	2-Pyridylhydrazides
US4792562A (en) *	1985-12-04	1988-12-20	Hoechst-Roussel Pharmaceuticals, Inc.	N-(pyrrol-1-yl)pyridinamines having memory enhancing activity

1988
- 1988-04-18 DE DE3852335T patent/DE3852335T2/de not_active Expired - Lifetime
- 1988-04-18 EP EP88106121A patent/EP0287982B1/en not_active Expired - Lifetime
- 1988-04-18 ES ES88106121T patent/ES2065324T3/es not_active Expired - Lifetime
- 1988-04-18 AT AT88106121T patent/ATE115143T1/de not_active IP Right Cessation
- 1988-04-21 FI FI881874A patent/FI90978C/fi not_active IP Right Cessation
- 1988-04-21 ZA ZA882810A patent/ZA882810B/xx unknown
- 1988-04-22 IE IE121388A patent/IE65349B1/en not_active IP Right Cessation
- 1988-04-22 NO NO881776A patent/NO168104C/no not_active IP Right Cessation
- 1988-04-22 PH PH36833A patent/PH26127A/en unknown
- 1988-04-22 PT PT87308A patent/PT87308B/pt not_active IP Right Cessation
- 1988-04-22 CA CA000564923A patent/CA1330661C/en not_active Expired - Lifetime
- 1988-04-22 JP JP63098467A patent/JP2683360B2/ja not_active Expired - Lifetime
- 1988-04-22 NZ NZ224338A patent/NZ224338A/en unknown
- 1988-04-22 IL IL86154A patent/IL86154A/xx not_active IP Right Cessation
- 1988-04-22 DK DK223488A patent/DK172153B1/da not_active IP Right Cessation
- 1988-04-22 AU AU15100/88A patent/AU594876B2/en not_active Expired
- 1988-04-23 KR KR1019880004605A patent/KR960015003B1/ko not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI90978C (fi)	1994-04-25
ZA882810B (en)	1988-10-20
JP2683360B2 (ja)	1997-11-26
FI90978B (fi)	1994-01-14
DK172153B1 (da)	1997-12-01
EP0287982A3 (en)	1991-03-27
FI881874A0 (fi)	1988-04-21
PT87308B (pt)	1992-08-31
IE65349B1 (en)	1995-10-18
NO881776L (no)	1988-10-25
NO168104B (no)	1991-10-07
JPS63280079A (ja)	1988-11-17
IL86154A (en)	1992-03-29
DE3852335T2 (de)	1995-05-11
KR960015003B1 (ko)	1996-10-23
NO168104C (no)	1992-01-15
NO881776D0 (no)	1988-04-22
AU594876B2 (en)	1990-03-15
IL86154A0 (en)	1988-11-15
CA1330661C (en)	1994-07-12
NZ224338A (en)	1991-07-26
FI881874A7 (fi)	1988-10-25
KR880012591A (ko)	1988-11-28
DK223488D0 (da)	1988-04-22
PH26127A (en)	1992-02-24
ES2065324T3 (es)	1995-02-16
DE3852335D1 (de)	1995-01-19
EP0287982B1 (en)	1994-12-07
EP0287982A2 (en)	1988-10-26
PT87308A (pt)	1988-05-01
IE881213L (en)	1988-10-24
AU1510088A (en)	1988-10-27
ATE115143T1 (de)	1994-12-15

Legal Events

Date	Code	Title	Description
1997-12-01	B1	Patent granted (law 1993)
2008-05-13	PUP	Patent expired

Publication	Publication Date	Title
DK223488D0 (da)	1988-04-22	N-(pyridinyl)-1h-indol-1-aminer, deres fremstilling og anvendelse
CA2009678A1 (en)	1990-08-11	Pyridazinone, oxadiazinone, thiadiazinone and triazinone cardiotonic agents
CS260191A3 (en)	1992-04-15	6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -oles, process of their preparation and their application as medicaments
AU8121691A (en)	1992-01-30	1-(substituted pyridinylamino)-1h-indole-5-yl substituted carbamates, a process and intermediates for their preparation and their use as medicaments
ZA937823B (en)	1994-05-19	Substituted (pyridinylamino)-benzisoxazoles and -benzo-(B)thiophenes, a process for their preparation and their use as medicaments
IL85401A0 (en)	1988-07-31	9-amino-1,4-ethano-1,2,3,4-tetra-hydroacridine and related compounds,process for their preparation and pharmaceutical compositions containing same
DK0471296T3 (da)	1996-03-11	1-(Pyridinylalkyl)-1H-indoler, -indoliner og beslægtede analoge
DK0471298T3 (da)	1996-03-04	Carbamoyl-1-(pyridinylalkyl)-1H-indoler, -indoliner og belægtede forbindelser