DK2244702T3 - Behandling af nervesygdomme eller neurale tilstande - Google Patents
Behandling af nervesygdomme eller neurale tilstande Download PDFInfo
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- DK2244702T3 DK2244702T3 DK09711963.0T DK09711963T DK2244702T3 DK 2244702 T3 DK2244702 T3 DK 2244702T3 DK 09711963 T DK09711963 T DK 09711963T DK 2244702 T3 DK2244702 T3 DK 2244702T3
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- fenretinide
- neural
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- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Claims (15)
1. Præparat til anvendelse til behandling af en nervelæsion eller en neurodegenerativ sygdom hos et individ, hvilket præparat omfatter: (a) fenretinid eller et farmaceutisk acceptabelt salt deraf; og (b) et farmaceutisk acceptabelt bæremateriale.
2. Præparat til anvendelse ifølge krav 1, hvor nervelæsionen er en læsion i centralnervesystemet (CNS).
3. Præparat til anvendelse ifølge krav 2, hvor læsionen i CNS er en rygmarvslæsion (SCI).
4. Præparat til anvendelse ifølge krav 3, hvor SCI'en er akut SCI.
5. Præparat til anvendelse ifølge krav 2, hvor nervelæsionen er en sekundær læsion som følge af en initial SCI.
6. Præparat til anvendelse ifølge et hvilket som helst af kravene 1 til 5, hvor præparatet yderligere er til anvendelse til behandling eller hæmning af en tilstand efter nervelæsionen, hvor tilstanden er udvalgt blandt (a) nerveinflammation; (b) tab af nerveceller eller nervevæv; (c) forhøjede niveauer af neural arachidonsyre (AA); (d) reducerede niveauer af neural docosahexaensyre (DHA); (e) neural oxidativ stress; og (f) en hvilken som helst kombination af (a) til (e).
7. Præparat til anvendelse ifølge krav 1, hvor præparatet yderligere er til anvendelse til behandling eller hæmning af en tilstand, der er forbundet med den neurodegenerative sygdom, hvor tilstanden er udvalgt blandt (a) nedsat motorisk funktion; (b) forhøjede niveauer af neural arachidonsyre (AA) ; (c) reducerede niveauer af neural docosahexaensyre (DHA); (d) neural oxidativ stress; (e) et reduceret antal af motoriske neuroner; (f) øget neural glial aktivering; og (g) en hvilken som helst kombination af (a) til (f).
8. Præparat til anvendelse ifølge krav 1 eller 7, hvor den neurodegenerative sygdom er amyotrofisk lateral sklerose (ALS).
9. Fenretinid eller et farmaceutisk acceptabelt salt deraf til anvendelse til behandling af en nervelæsion eller en neurodegenerativ sygdom hos et individ.
10. Fenretinid eller et farmaceutisk acceptabelt salt deraf til anvendelse ifølge krav 9, hvor nervelæsionen er en læsion i centralnervesystemet (CNS), fortrinsvis en rygmarvslæsion (SCI) .
11. Fenretinid eller et farmaceutisk acceptabelt salt deraf til anvendelse ifølge krav 10, hvor SCI'en er akut SCI.
12. Fenretinid eller et farmaceutisk acceptabelt salt deraf til anvendelse ifølge krav 10, hvor nervelæsionen er en sekundær læsion som følge af en initial SCI.
13. Fenretinid eller et farmaceutisk acceptabelt salt deraf til anvendelse ifølge et hvilket som helst af kravene 9 til 12, hvor fenretinid eller det farmaceutisk acceptable salt deraf yderligere er til anvendelse til behandling eller hæmning af en tilstand efter nervelæsionen, hvor tilstanden er udvalgt blandt (a) nerveinflammation; (b) tab af nerveceller eller nervevæv; (c) forhøjede niveauer af neural arachidonsyre (AA); (d) reducerede niveauer af neural docosahexaensyre (DHA); (e) neural oxidativ stress; og (f) en hvilken som helst kombination af (a) til (e) .
14. Fenretinid eller et farmaceutisk acceptabelt salt deraf til anvendelse ifølge krav 9, hvor fenretinid eller det farmaceutisk acceptable salt deraf yderligere er til anvendelse til behandling eller hæmning af en tilstand, der er forbundet med den neurodegenerative sygdom, hvor tilstanden er udvalgt blandt (a) nedsat motorisk funktion; (b) forhøjede niveauer af neural arachidonsyre (AA); (c) reducerede niveauer af neural docosahexaensyre (DHA); (d) neural oxidativ stress; (e) et reduceret antal af motoriske neuroner; (f) øget neural glial aktivering; og (g) en hvilken som helst kombination af (a) til (f).
15. Fenretinid eller farmaceutisk acceptabelt salt deraf til anvendelse ifølge krav 7 eller 14, hvor den neurodegenerative sygdom er amyotrofisk lateral sklerose (ALS).
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| US3035408P | 2008-02-21 | 2008-02-21 | |
| PCT/CA2009/000208 WO2009103166A1 (en) | 2008-02-21 | 2009-02-20 | Treatment of neural diseases or conditions |
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| DK2244702T3 true DK2244702T3 (da) | 2014-12-01 |
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| JP6649378B2 (ja) | 2014-07-25 | 2020-02-19 | ローラン・ファーマシューティカルズ | フェンレチニドの固体経口処方物 |
| CN106176702A (zh) * | 2016-07-01 | 2016-12-07 | 江南大学 | 一种辅助维甲酸类药物治疗多种肿瘤的药物组合物 |
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| JP4384409B2 (ja) | 2000-12-05 | 2009-12-16 | チルドレンズ・ホスピタル・ロス・アンジエルス | バイオアベイラビリティが増加したフェンレチニドの医薬組成物、およびその使用方法 |
| JP4221547B2 (ja) | 2001-01-26 | 2009-02-12 | ライオン株式会社 | レチノイン酸類またはその誘導体を含有する組成物 |
| CA2513260C (en) | 2003-01-31 | 2013-01-08 | Childrens Hospital Los Angeles | Oral compositions of fenretinide having increased bioavailability and methods of using the same |
| WO2005092314A1 (en) | 2004-03-18 | 2005-10-06 | Istituto Nazionale Per Lo Studio E La Cura Del Tum | 4-oxo-fenretinide, administered alone and in combination with fenretinide, as preventive and therapeutic agent for cancer |
| JP5710855B2 (ja) | 2005-02-02 | 2015-04-30 | ネクスジェニクス・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー | 神経線維腫の局所治療 |
| EP1959945B1 (en) * | 2005-12-13 | 2014-12-03 | McGill University | Fenretinide for correcting a lipid imbalance in a subject |
| WO2007104030A1 (en) * | 2006-03-08 | 2007-09-13 | Kinemed, Inc. | Retinoids and related compounds for the treatment of neuroinflammatory conditions, diseases and disorders |
| AU2007233155B2 (en) | 2006-03-29 | 2012-04-26 | Scitech Development Llc | Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery |
| WO2007136636A1 (en) | 2006-05-17 | 2007-11-29 | Childrens Hospital Los Angeles Research Institute | Drug combinations to treat hyperproliferative disorders |
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| EP2244702A4 (en) | 2011-04-06 |
| ES2525337T3 (es) | 2014-12-22 |
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| US20140113973A1 (en) | 2014-04-24 |
| CA2750762A1 (en) | 2010-08-27 |
| US9050294B2 (en) | 2015-06-09 |
| EP2244702B1 (en) | 2014-09-17 |
| US8642658B2 (en) | 2014-02-04 |
| CA2750762C (en) | 2016-04-12 |
| US20100331417A1 (en) | 2010-12-30 |
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