DK2254890T3 - Fremgangsmåde til diastereomerisk racematspaltning af methyltetrahydrofolsyre - Google Patents

Fremgangsmåde til diastereomerisk racematspaltning af methyltetrahydrofolsyre Download PDF

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Publication number
DK2254890T3
DK2254890T3 DK08709117.9T DK08709117T DK2254890T3 DK 2254890 T3 DK2254890 T3 DK 2254890T3 DK 08709117 T DK08709117 T DK 08709117T DK 2254890 T3 DK2254890 T3 DK 2254890T3
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DK
Denmark
Prior art keywords
methyltetrahydropholic
racemat
diastereomeric
division
procedure
Prior art date
Application number
DK08709117.9T
Other languages
English (en)
Inventor
Ermanno Valoti
Davide Bianchi
Marco Valetti
Original Assignee
Gnosis Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gnosis Spa filed Critical Gnosis Spa
Application granted granted Critical
Publication of DK2254890T3 publication Critical patent/DK2254890T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK08709117.9T 2008-02-20 2008-02-20 Fremgangsmåde til diastereomerisk racematspaltning af methyltetrahydrofolsyre DK2254890T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2008/052034 WO2009103333A1 (en) 2008-02-20 2008-02-20 Process for the diastereoisomeric resolution of 5-methyltetrahydrofolic acid

Publications (1)

Publication Number Publication Date
DK2254890T3 true DK2254890T3 (da) 2015-07-13

Family

ID=39938455

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08709117.9T DK2254890T3 (da) 2008-02-20 2008-02-20 Fremgangsmåde til diastereomerisk racematspaltning af methyltetrahydrofolsyre

Country Status (10)

Country Link
EP (1) EP2254890B1 (da)
CY (1) CY1116434T1 (da)
DK (1) DK2254890T3 (da)
ES (1) ES2541314T3 (da)
HR (1) HRP20150747T1 (da)
HU (1) HUE026535T2 (da)
PL (1) PL2254890T3 (da)
PT (1) PT2254890E (da)
SI (1) SI2254890T1 (da)
WO (1) WO2009103333A1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104530051B (zh) * 2012-01-20 2016-08-24 连云港金康和信药业有限公司 稳定的(6r,s)-5-甲基四氢叶酸晶型及其制备方法
CN102775408B (zh) * 2012-01-20 2015-09-02 连云港金康医药科技有限公司 稳定的5-甲基四氢叶酸晶型及其制备方法
DE202015100275U1 (de) 2015-01-22 2015-03-10 Mibe Gmbh Arzneimittel Nährstoffzubereitung zur Vitalisierung
JP7204662B2 (ja) * 2017-03-20 2023-01-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 異性体的に純粋な１８ｆ－標識されたテトラヒドロ葉酸
EP3646873A1 (en) 2018-10-31 2020-05-06 Aprofol AG Folate salts

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH680731A5 (da) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
EP0627435A1 (en) 1993-06-01 1994-12-07 ACS DOBFAR S.p.A. Method for the industrial preparation of (6S) folic acid derivatives by chromatographic separation
CN101143863B (zh) * 2006-09-13 2010-08-11 南京莱因医药科技有限公司 5-甲基四氢叶酸的拆分及其成盐方法

Also Published As

Publication number Publication date
SI2254890T1 (sl) 2015-08-31
PT2254890E (pt) 2015-07-31
EP2254890A1 (en) 2010-12-01
EP2254890B1 (en) 2015-04-08
HRP20150747T1 (hr) 2015-08-14
CY1116434T1 (el) 2017-02-08
WO2009103333A1 (en) 2009-08-27
HUE026535T2 (en) 2016-06-28
PL2254890T3 (pl) 2015-10-30
ES2541314T3 (es) 2015-07-17

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