DK2382232T3 - Fremgangsmåde til fremstilling af bivalirudin - Google Patents

Fremgangsmåde til fremstilling af bivalirudin

Info

Publication number: DK2382232T3
Authority: DK; Denmark
Prior art keywords: bivalirudin; preparation
Prior art date: 2008-12-29

Application number

DK09795927.4T

Other languages

English (en)

Inventor

Geoffroy Sommen

Luciano Forni

Original Assignee

Lonza Braine Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-29

Filing date

2009-12-17

Publication date

2013-12-16

2009-12-17 Application filed by Lonza Braine Sa filed Critical Lonza Braine Sa

2013-12-16 Application granted granted Critical

2013-12-16 Publication of DK2382232T3 publication Critical patent/DK2382232T3/da

Links

OIRCOABEOLEUMC-GEJPAHFPSA-N bivalirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 OIRCOABEOLEUMC-GEJPAHFPSA-N 0.000 title 1
229960001500 bivalirudin Drugs 0.000 title 1
108010055460 bivalirudin Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Tropical Medicine & Parasitology (AREA)
Gastroenterology & Hepatology (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK09795927.4T 2008-12-29 2009-12-17 Fremgangsmåde til fremstilling af bivalirudin DK2382232T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08022479		2008-12-29
US26047109P	2009-11-12	2009-11-12
PCT/EP2009/009080 WO2010075983A1 (en)	2008-12-29	2009-12-17	Process for the production of bivalirudin

Publications (1)

Publication Number	Publication Date
DK2382232T3 true DK2382232T3 (da)	2013-12-16

Family

ID=42060981

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK09795927.4T DK2382232T3 (da)	2008-12-29	2009-12-17	Fremgangsmåde til fremstilling af bivalirudin

Country Status (18)

Country	Link
US (2)	US8921517B2 (da)
EP (1)	EP2382232B1 (da)
JP (2)	JP5730781B2 (da)
KR (1)	KR101653950B1 (da)
CN (3)	CN102264757B (da)
AR (1)	AR074944A1 (da)
AU (1)	AU2009335350A1 (da)
CA (2)	CA2916716C (da)
CO (1)	CO6400148A2 (da)
DK (1)	DK2382232T3 (da)
EA (1)	EA201101015A1 (da)
ES (1)	ES2439502T3 (da)
IL (1)	IL213457A (da)
MX (1)	MX2011006950A (da)
SG (1)	SG171859A1 (da)
TW (3)	TWI538919B (da)
WO (1)	WO2010075983A1 (da)
ZA (1)	ZA201104195B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE480561T1 (de)	2004-10-19	2010-09-15	Lonza Ag	Verfahren zur festphasen-peptidsynthese
US20100081788A1 (en) *	2008-09-03	2010-04-01	Scinopharm Taiwan Ltd.	Process for the Preparation of Pramlintide
US7985733B1 (en)	2010-01-06	2011-07-26	The Medicines Company	Buffer-based method for preparing bivalirudin drug product
CN102816208B (zh) *	2011-06-10	2016-11-23	江苏豪森药业集团有限公司	一种比伐卢定的液相合成方法
CN102532274B (zh) *	2012-02-13	2014-04-23	成都圣诺生物制药有限公司	一种比伐卢定的制备方法
CN102731624B (zh) *	2012-06-14	2015-09-23	无锡市凯利药业有限公司	一种固相片段法合成比伐卢定的方法
CN102702325B (zh) *	2012-06-19	2015-09-23	深圳翰宇药业股份有限公司	一种抗凝血多肽的制备方法
WO2013192430A2 (en) *	2012-06-20	2013-12-27	The Regents Of The University Of California	Dynamic biomimetic synzyme catalyst, catalysis, and catalytic systems
WO2014032257A1 (zh) *	2012-08-30	2014-03-06	深圳翰宇药业股份有限公司	一种比伐卢定的制备方法
CN103965293B (zh) *	2013-02-05	2020-02-14	深圳信立泰药业股份有限公司	一种高纯度比伐卢定及其工业化制备方法
CN103242431B (zh) *	2013-05-20	2015-05-13	齐鲁制药有限公司	一种比伐卢定的制备方法
CN110204611B (zh) *	2019-06-26	2023-11-07	海南中和药业股份有限公司	一种固相片段法合成比伐卢定
CN115073587B (zh) *	2022-07-08	2024-08-23	厦门胜泽泰医药科技有限公司	一种半连续液相合成比伐芦定的合成工艺

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04500802A (ja) *	1988-09-29	1992-02-13	バイオジェンインコーポレイテッド	ヒルジンペプチド
US5196404B1 (en)	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
GB9708918D0 (en)	1997-05-01	1997-06-25	Ppl Therapeutics Scotland Ltd	Methods
US7569225B2 (en) *	2002-08-12	2009-08-04	The Council Of The Queensland Institute Of Medical Research	Immunogenic lipopeptides comprising T-helper and B-cell epitopes
AU2004285951A1 (en) *	2003-10-30	2005-05-12	The University Of Massachusetts	New coupling agents for peptide synthesis
ATE480561T1 (de) *	2004-10-19	2010-09-15	Lonza Ag	Verfahren zur festphasen-peptidsynthese
CA2595695A1 (en)	2005-01-25	2006-08-03	Cell Therapeutics, Inc.	Biologically active protein conjugates comprising (nn[s/t]) peptide repeats and having increased plasma half-life
CN101111516B (zh) *	2005-01-25	2013-02-27	细胞治疗学公司	体内半衰期改变的生物活性蛋白质偶联物
EP1805204A2 (en) *	2005-09-14	2007-07-11	Novetide Ltd.	Process for production of bivalirudin
US20070213505A1 (en) *	2006-03-08	2007-09-13	David Epstein	Solution Synthesis of Peptide Cell Growth Stimulators
CN101033249B (zh) *	2006-03-10	2011-05-11	周逸明	固相多肽合成比筏芦定的制备方法
US20100081788A1 (en) *	2008-09-03	2010-04-01	Scinopharm Taiwan Ltd.	Process for the Preparation of Pramlintide

2009
- 2009-12-17 DK DK09795927.4T patent/DK2382232T3/da active
- 2009-12-17 WO PCT/EP2009/009080 patent/WO2010075983A1/en not_active Ceased
- 2009-12-17 JP JP2011543985A patent/JP5730781B2/ja not_active Expired - Fee Related
- 2009-12-17 ES ES09795927.4T patent/ES2439502T3/es active Active
- 2009-12-17 CA CA2916716A patent/CA2916716C/en active Active
- 2009-12-17 CN CN200980152943.3A patent/CN102264757B/zh not_active Expired - Fee Related
- 2009-12-17 CN CN201410073797.8A patent/CN103864895A/zh active Pending
- 2009-12-17 US US13/139,956 patent/US8921517B2/en active Active
- 2009-12-17 CA CA2744627A patent/CA2744627C/en active Active
- 2009-12-17 EP EP09795927.4A patent/EP2382232B1/en active Active
- 2009-12-17 SG SG2011039179A patent/SG171859A1/en unknown
- 2009-12-17 KR KR1020117017887A patent/KR101653950B1/ko not_active Expired - Fee Related
- 2009-12-17 MX MX2011006950A patent/MX2011006950A/es unknown
- 2009-12-17 EA EA201101015A patent/EA201101015A1/ru unknown
- 2009-12-17 CN CN201410073688.6A patent/CN103864894B/zh not_active Expired - Fee Related
- 2009-12-17 AU AU2009335350A patent/AU2009335350A1/en not_active Abandoned
- 2009-12-21 TW TW103128940A patent/TWI538919B/zh not_active IP Right Cessation
- 2009-12-21 TW TW105115041A patent/TWI599580B/zh not_active IP Right Cessation
- 2009-12-21 TW TW098143850A patent/TWI453216B/zh not_active IP Right Cessation
- 2009-12-29 AR ARP090105164A patent/AR074944A1/es not_active Application Discontinuation
2011
- 2011-06-06 ZA ZA2011/04195A patent/ZA201104195B/en unknown
- 2011-06-09 IL IL213457A patent/IL213457A/en active IP Right Grant
- 2011-06-20 CO CO11076777A patent/CO6400148A2/es not_active Application Discontinuation
2014
- 2014-11-25 US US14/552,807 patent/US20150080550A1/en not_active Abandoned
- 2014-11-27 JP JP2014240227A patent/JP5996618B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP5996618B2 (ja)	2016-09-21
TW201630927A (zh)	2016-09-01
CN103864895A (zh)	2014-06-18
US8921517B2 (en)	2014-12-30
CO6400148A2 (es)	2012-03-15
KR20110112385A (ko)	2011-10-12
US20150080550A1 (en)	2015-03-19
CN102264757A (zh)	2011-11-30
IL213457A (en)	2016-06-30
ES2439502T3 (es)	2014-01-23
CA2744627A1 (en)	2010-07-08
JP5730781B2 (ja)	2015-06-10
HK1162527A1 (zh)	2012-08-31
EP2382232B1 (en)	2013-09-18
MX2011006950A (es)	2011-07-28
TW201500378A (zh)	2015-01-01
EA201101015A1 (ru)	2012-02-28
CN102264757B (zh)	2014-05-21
TW201024317A (en)	2010-07-01
CN103864894A (zh)	2014-06-18
TWI599580B (zh)	2017-09-21
WO2010075983A1 (en)	2010-07-08
AR074944A1 (es)	2011-02-23
KR101653950B1 (ko)	2016-09-05
JP2012514015A (ja)	2012-06-21
CA2744627C (en)	2016-08-16
ZA201104195B (en)	2012-04-25
WO2010075983A8 (en)	2010-08-26
US20110251372A1 (en)	2011-10-13
TWI453216B (zh)	2014-09-21
JP2015107967A (ja)	2015-06-11
AU2009335350A1 (en)	2011-07-21
EP2382232A1 (en)	2011-11-02
IL213457A0 (en)	2011-07-31
CA2916716C (en)	2018-06-26
TWI538919B (zh)	2016-06-21
CA2916716A1 (en)	2010-07-08
CN103864894B (zh)	2019-08-23
SG171859A1 (en)	2011-07-28

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