DK2281602T3 - Apparat til behandling af en tumor med et elektrisk felt - Google Patents
Apparat til behandling af en tumor med et elektrisk felt Download PDFInfo
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- DK2281602T3 DK2281602T3 DK10012702.6T DK10012702T DK2281602T3 DK 2281602 T3 DK2281602 T3 DK 2281602T3 DK 10012702 T DK10012702 T DK 10012702T DK 2281602 T3 DK2281602 T3 DK 2281602T3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00084—Temperature
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Otolaryngology (AREA)
- Plasma & Fusion (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Electrotherapy Devices (AREA)
- Professional, Industrial, Or Sporting Protective Garments (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Claims (18)
1. Apparat til selektivt at ødelægge delende celler i et målområde af levende væv, hvor de delende celler har polariserbare eller polære eller ladede intracellulære elementer, hvilket apparat omfatter: en første isoleret elektrode (230; 1210), som har en første leder; en anden isoleret elektrode (230; 1200), som har en anden leder; en elektrisk felt-kilde forbundet til de første og anden isolerede elektroder (230; 1210, 1200) til påføring afen vekslende elektrisk potentialforskel over de første og anden ledere, som har en frekvens på mellem omkring 50 kHz til omkring 500 kHz og en elektrisk felt-intensitet på mellem omkring 0,1 V/cm til omkring 10,0 V/cm for at skabe en tilstand i de delende celler, som fremmer ødelæggelsen deraf; et mellemliggende element (270) dannet af et fyldmateriale anbragt mellem en af de første og anden isolerede elektroder (230; 1210, 1200) og en hudoverflade, når anbragt på levende væv, hvilket fyldmateriale har en høj ledningsevne; og en tredje leder (1100; 1400) anbragt i det mellemliggende element (270), således at fyldmaterialet af det mellemliggende element (270) fuldkommen omgiver den tredje leder (1100; 1400).
2. Apparatet ifølge krav 1, hvor den tredje leder (1100) har en længde lig med eller omkring lig med en længde af de første og anden ledere (230; 1200, 1210).
3. Apparatet ifølge krav 1 eller 2, hvor den første isolerede elektrode (1210) er af en første størrelse og den anden isolerede elektrode (1200) er af en anden størrelse som er større end den første størrelse, og det mellemliggende element (270) associeret med den første isolerede elektrode (1210) er afen mindre størrelse end det mellemliggende element (270) associeret med den anden isolerede elektrode (1200).
4. Apparatet ifølge krav 3, hvor apparatet er konfigureret således at det elektriske felt (1230) nær den første isolerede elektrode (1210) er afen højere feltdensitet end det elektriske felt i andre positioner mellem de første og anden isolerede elektroder (1210; 1200).
5. Apparatet ifølge et hvilket som helst af kravene 1 til 4, omfattende: første og andet mellemliggende elementer (270) anbragt mellem nogle respektive af de første og anden isolerede elektroder (230; 1210, 1200) og en hudoverflade, når anbragt på levende væv; og første og anden tredje ledere (1100; 1400) anbragt i nogle respektive af de første og andet mellemliggende elementer (270).
6. Apparatet ifølge et hvilket som helst af kravene 1 til 5, hvor den tredje leder (1100; 1400) omfatter en flad lederplade.
7. Apparatet ifølge et hvilket som helst af kravene 1 til 6, hvor det mellemliggende fyldmateriale omfatter en gel dannet af mindst et materiale valgt fra gruppen bestående af hydrogeler, gelatiner og agar, eventuelt hvor gelen indeholder opløste salte til at øge ledeevne.
8. Apparatet ifølge krav 7, hvor det mellemliggende fyldmateriale har en tykkelse på omkring 0,5 mm til omkring 2 mm.
9. Apparatet ifølge krav 7 eller 8, hvor det mellemliggende fyldmateriale er indeholdt i et dielektrisk element af en rand dannet som en del af det dielektrisk element.
10. Apparatet ifølge et hvilket som helst af kravene 1 til 9, hvor den første elektrode (230; 1210) inkluderer et første dielektrisk element, som er i kontakt med den første leder, hvor det første dielektriske element er til placering mod det levende væv for at danne en kondensator, og den anden elektrode (230; 1200) inkluderer et andet dielektrisk element, som er i kontakt med den anden leder, hvor det andet dielektriske element er til placering mod det levende væv for at danne en kondensator.
11. Apparatet ifølge krav 10, hvor de dielektriske elementer har en dielektrisk konstant på 20-200 eller 50-200.
12. Apparatet ifølge krav 10 eller 11, hvor de dielektriske elementer er dannet af titaniumdioxid, litiumniobat (LiNbO3), yttrium-jerngranat (YIG), bariumtitanat (BaTiO3), kaliumtantalat (KTa03), litiumtantalat (LiTa03).
13. Apparatet ifølge et hvilket som helst af kravene 10 til 12, hvor de dielektriske elementer omfatter en dielektrisk coating, som har en tykkelse mellem 1-50 mikrometer.
14. Apparatet ifølge krav 13, hvor apparatet yderligere inkluderer: et løst net anbragt omkring den dielektriske coating til at begrænse adgang til en overflade af den dielektriske coating mens kun at have en minimal effekt på et overfladeareal af den dielektriske coating.
15. Apparatet ifølge krav 13 eller 14, hvor apparatet yderligere inkluderer: en tynd ledende coating anbragt på den dielektriske coating til at kontakte vævet.
16. Apparatet ifølge krav 15, hvor den tynde ledende coating er en guldcoating, som har en tykkelse fra omkring 0,1 mikrometer til omkring 0,1 mm.
17. Apparatet ifølge et hvilket som helst af kravene 1 til 16, hvor det vekslende elektriske potential har en frekvens på mellem omkring 100 kHz til omkring 300 kHz, og/eller er tilvejebragt som et pulserende vekslende elektrisk potential.
18. Apparatet ifølge et hvilket som helst af kravene 1 til 17, hvor den tredje leder (1100; 1400) er flydende i det mellemliggende element (270).
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/263,329 US7136699B2 (en) | 2002-10-02 | 2002-10-02 | Apparatus for destroying dividing cells |
| US10/285,313 US7089054B2 (en) | 2002-10-02 | 2002-10-31 | Apparatus and method for treating a tumor or the like |
| US10/315,576 US6868289B2 (en) | 2002-10-02 | 2002-12-10 | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| EP03799042.1A EP1545704B1 (en) | 2002-10-02 | 2003-10-01 | Apparatus for treating a tumor by an electric field |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2281602T3 true DK2281602T3 (da) | 2018-10-01 |
Family
ID=32074281
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19183539.6T DK3572123T3 (da) | 2002-10-02 | 2003-10-01 | Apparat til behandling af en tumor med et elektrisk felt |
| DK19219623.6T DK3656441T3 (da) | 2002-10-02 | 2003-10-01 | Apparat til behandling af en tumor med et elektrisk felt |
| DK10012702.6T DK2281602T3 (da) | 2002-10-02 | 2003-10-01 | Apparat til behandling af en tumor med et elektrisk felt |
| DK10012706.7T DK2281603T3 (da) | 2002-10-02 | 2003-10-01 | Apparat til behandling af en tumor med et elektrisk felt |
| DK10012777.8T DK2281605T3 (da) | 2002-10-02 | 2003-10-01 | Apparat til behandling af en tumor med et elektrisk felt |
| DK03799042.1T DK1545704T3 (da) | 2002-10-02 | 2003-10-01 | Apparat til behandling af en tumor med et elektrisk felt |
| DK10012716.6T DK2281604T3 (da) | 2002-10-02 | 2003-10-01 | Apparat til behandling af en tumor med et elektrisk felt |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19183539.6T DK3572123T3 (da) | 2002-10-02 | 2003-10-01 | Apparat til behandling af en tumor med et elektrisk felt |
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| DK10012777.8T DK2281605T3 (da) | 2002-10-02 | 2003-10-01 | Apparat til behandling af en tumor med et elektrisk felt |
| DK03799042.1T DK1545704T3 (da) | 2002-10-02 | 2003-10-01 | Apparat til behandling af en tumor med et elektrisk felt |
| DK10012716.6T DK2281604T3 (da) | 2002-10-02 | 2003-10-01 | Apparat til behandling af en tumor med et elektrisk felt |
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- 2003-10-01 HU HUE19219623A patent/HUE055320T2/hu unknown
- 2003-10-01 PT PT192196236T patent/PT3656441T/pt unknown
- 2003-10-01 EP EP19219623.6A patent/EP3656441B1/en not_active Expired - Lifetime
- 2003-10-01 EP EP10012702.6A patent/EP2281602B1/en not_active Expired - Lifetime
- 2003-10-01 CA CA3100056A patent/CA3100056A1/en not_active Abandoned
- 2003-10-01 EP EP19183539.6A patent/EP3572123B1/en not_active Expired - Lifetime
- 2003-10-01 CN CNA2003801008725A patent/CN1703258A/zh active Pending
- 2003-10-01 PT PT37990421T patent/PT1545704T/pt unknown
- 2003-10-01 CA CA2499845A patent/CA2499845C/en not_active Expired - Lifetime
- 2003-10-01 ES ES10012702.6T patent/ES2688188T3/es not_active Expired - Lifetime
- 2003-10-01 HU HUE19183539A patent/HUE050725T2/hu unknown
- 2003-10-01 AU AU2003265066A patent/AU2003265066A1/en not_active Abandoned
- 2003-10-01 ES ES03799042T patent/ES2813059T3/es not_active Expired - Lifetime
- 2003-10-01 EP EP10012777.8A patent/EP2281605B1/en not_active Expired - Lifetime
- 2003-10-01 JP JP2004541094A patent/JP4350042B2/ja not_active Expired - Lifetime
- 2003-10-01 HU HUE10012706A patent/HUE050650T2/hu unknown
- 2003-10-01 DK DK19183539.6T patent/DK3572123T3/da active
- 2003-10-01 PT PT191835396T patent/PT3572123T/pt unknown
- 2003-10-01 ES ES10012716T patent/ES2811751T3/es not_active Expired - Lifetime
- 2003-10-01 DK DK19219623.6T patent/DK3656441T3/da active
- 2003-10-01 DK DK10012702.6T patent/DK2281602T3/da active
- 2003-10-01 PT PT100127778T patent/PT2281605T/pt unknown
- 2003-10-01 PT PT10012702T patent/PT2281602T/pt unknown
- 2003-10-01 CA CA2930736A patent/CA2930736C/en not_active Expired - Lifetime
- 2003-10-01 ES ES10012777T patent/ES2812531T3/es not_active Expired - Lifetime
- 2003-10-01 DK DK10012706.7T patent/DK2281603T3/da active
- 2003-10-01 ES ES19183539T patent/ES2813058T3/es not_active Expired - Lifetime
- 2003-10-01 WO PCT/IB2003/004321 patent/WO2004030760A2/en not_active Ceased
- 2003-10-01 DK DK10012777.8T patent/DK2281605T3/da active
- 2003-10-01 PT PT100127067T patent/PT2281603T/pt unknown
- 2003-10-01 EP EP19219652.5A patent/EP3659671A1/en not_active Withdrawn
- 2003-10-01 HU HUE10012777A patent/HUE051961T2/hu unknown
- 2003-10-01 EP EP03799042.1A patent/EP1545704B1/en not_active Expired - Lifetime
- 2003-10-01 EP EP10012706.7A patent/EP2281603B1/en not_active Expired - Lifetime
- 2003-10-01 DK DK03799042.1T patent/DK1545704T3/da active
- 2003-10-01 ES ES10012706T patent/ES2812499T3/es not_active Expired - Lifetime
- 2003-10-01 DK DK10012716.6T patent/DK2281604T3/da active
- 2003-10-01 HU HUE03799042A patent/HUE050874T2/hu unknown
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2005
- 2005-03-07 US US11/074,318 patent/US7706890B2/en active Active
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