DK2290108T3 - Udvikling af mutationer, der er anvendelige til svækkelse af dengue-vira, samt kimære dengue-vira - Google Patents
Udvikling af mutationer, der er anvendelige til svækkelse af dengue-vira, samt kimære dengue-viraInfo
- Publication number
- DK2290108T3 DK2290108T3 DK10181776.5T DK10181776T DK2290108T3 DK 2290108 T3 DK2290108 T3 DK 2290108T3 DK 10181776 T DK10181776 T DK 10181776T DK 2290108 T3 DK2290108 T3 DK 2290108T3
- Authority
- DK
- Denmark
- Prior art keywords
- dengue viruses
- development
- well
- attenuating
- chimeric
- Prior art date
Links
- 241000710829 Dengue virus group Species 0.000 title 2
- 230000035772 mutation Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24161—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24161—Methods of inactivation or attenuation
- C12N2770/24162—Methods of inactivation or attenuation by genetic engineering
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24161—Methods of inactivation or attenuation
- C12N2770/24163—Methods of inactivation or attenuation by chemical treatment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24171—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/18—Togaviridae; Flaviviridae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29304901P | 2001-05-22 | 2001-05-22 | |
| EP02739358A EP1402075B1 (en) | 2001-05-22 | 2002-05-22 | Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2290108T3 true DK2290108T3 (da) | 2014-10-20 |
Family
ID=23127420
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02739358.6T DK1402075T3 (da) | 2001-05-22 | 2002-05-22 | Udvikling af egnede mutationer til svækkelse af dengue-vira samt kimære dengue-vira |
| DK10181786.4T DK2290109T3 (da) | 2001-05-22 | 2002-05-22 | Udvikling af mutationer, der er anvendelige til svækkelse af dengue-vira samt kimære dengue-vira |
| DK10181776.5T DK2290108T3 (da) | 2001-05-22 | 2002-05-22 | Udvikling af mutationer, der er anvendelige til svækkelse af dengue-vira, samt kimære dengue-vira |
| DK10181804.5T DK2292802T3 (da) | 2001-05-22 | 2002-05-22 | Udvikling af mutationer, der er anvendelige til svækkelse af dengue-vira og kimære dengue-vira |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02739358.6T DK1402075T3 (da) | 2001-05-22 | 2002-05-22 | Udvikling af egnede mutationer til svækkelse af dengue-vira samt kimære dengue-vira |
| DK10181786.4T DK2290109T3 (da) | 2001-05-22 | 2002-05-22 | Udvikling af mutationer, der er anvendelige til svækkelse af dengue-vira samt kimære dengue-vira |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10181804.5T DK2292802T3 (da) | 2001-05-22 | 2002-05-22 | Udvikling af mutationer, der er anvendelige til svækkelse af dengue-vira og kimære dengue-vira |
Country Status (8)
| Country | Link |
|---|---|
| US (10) | US7226602B2 (da) |
| EP (5) | EP1402075B1 (da) |
| AU (2) | AU2002312011B2 (da) |
| BR (2) | BRPI0209943B8 (da) |
| CA (5) | CA2755964C (da) |
| DK (4) | DK1402075T3 (da) |
| ES (4) | ES2399420T3 (da) |
| WO (1) | WO2002095075A1 (da) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2355719T3 (es) | 2002-05-03 | 2011-03-30 | The United States Government As Represented By The Department Of Health And Human Services | Vacuna contra el dengue que contiene una deleción común de 30 nucleótidos en la utr en 3' del dengue tipos 1 y 2. |
| US7851194B2 (en) * | 2004-06-14 | 2010-12-14 | The United States Of America As Represented By The Department Of Health And Human Services | West Nile viruses with mutations in the 3′ terminal stem and loop secondary structure for use as live virus vaccines |
| US8124398B2 (en) | 2005-04-24 | 2012-02-28 | Sanofi Pasteur Biologics Co. | Recombinant flavivirus vaccines |
| WO2006134433A1 (en) | 2005-06-17 | 2006-12-21 | Sanofi Pasteur | Dengue serotype 1 attenuated strain |
| DE602006015807D1 (de) * | 2005-06-17 | 2010-09-09 | Ct S For Disease Control & Pre | Abgeschwächter dengue-serotyp-2-stamm |
| CU23578A1 (es) * | 2005-09-16 | 2010-09-30 | Ct Ingenieria Genetica Biotech | Proteína de la cápsida del virus dengue inductora de respuesta protectora y composición vacunal |
| FR2906724B1 (fr) | 2006-10-04 | 2009-03-20 | Sanofi Pasteur Sa | Methode d'immunisation contre les 4 serotypes de la dengue. |
| US20100316670A1 (en) * | 2007-06-14 | 2010-12-16 | Blaney Joseph E | Chimeric sle/dengue type 4 antigenic viruses |
| CN105944095B (zh) | 2008-03-05 | 2021-04-02 | 赛诺菲巴斯德有限公司 | 一种使含佐剂的疫苗组合物稳定的方法 |
| WO2009152147A2 (en) * | 2008-06-09 | 2009-12-17 | La Jolla Institute For Allergy And Immunology | Compositions and methods for dengue virus (dv) treatment and vaccination |
| EP2143440A1 (fr) | 2008-07-09 | 2010-01-13 | Sanofi Pasteur | Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués |
| NZ700477A (en) | 2009-02-17 | 2016-04-29 | Glaxosmithkline Biolog Sa | Inactivated dengue virus vaccine with aluminium-free adjuvant |
| EP2430444B1 (en) * | 2009-05-12 | 2014-01-08 | Janssen R&D Ireland | Method for identifying inhibitors against dengue virus |
| CN102449172A (zh) | 2009-06-01 | 2012-05-09 | 伊维拉根公司 | 施用针对登革病毒的疫苗的组合物和方法 |
| US8968996B2 (en) | 2009-06-01 | 2015-03-03 | Takeda Vaccines, Inc. | Compositions and methods for rapid immunization against dengue virus |
| EP2442711B1 (en) * | 2009-06-17 | 2024-02-21 | Human Chimp Pty Ltd | Determining haemodynamic performance |
| AU2010286368B2 (en) | 2009-08-31 | 2015-09-03 | Gen-Probe Incorporated | Dengue virus assay |
| EP2353609A1 (en) | 2010-02-04 | 2011-08-10 | Sanofi Pasteur | Immunization compositions and methods |
| US10308689B2 (en) | 2010-06-24 | 2019-06-04 | La Jolla Institute For Allergy And Immunology | Dengue virus (DV) polypeptide sequences, T cell epitopes and methods and uses thereof |
| US8895028B2 (en) | 2012-07-20 | 2014-11-25 | Arbovax, Inc. | Methods and compositions for dengue virus 3 (DV3) infectious clone |
| KR20150036592A (ko) | 2012-07-24 | 2015-04-07 | 사노피 파스퇴르 | 백신 조성물 |
| EP3010536A4 (en) | 2013-06-21 | 2016-11-30 | Merck Sharp & Dohme | DENGUE VIRUS VACCINE COMPOSITIONS AND METHODS FOR USE THEREOF |
| JP6764348B2 (ja) | 2014-02-11 | 2020-09-30 | ビステラ, インコーポレイテッド | デングウイルスに対する抗体分子およびその使用 |
| BR112017004452B1 (pt) | 2014-09-05 | 2023-12-12 | The Research Foundation For The State University Of New York | Vírus atenuado, arbovírus atenuado, seus usos, composição de vacina, método de produção de um genoma de vírus atenuado, método de produção de um arbovírus atenuado e genoma de arbovírus atenuado |
| AU2015369875A1 (en) | 2014-12-22 | 2017-06-15 | Merck Sharp & Dohme Corp. | Dengue virus vaccine compositions and methods of use thereof |
| JP6893174B2 (ja) * | 2015-01-16 | 2021-06-23 | タケダ ワクチン,インコーポレイテッド | 粒子に含まれる逆転写酵素活性の検出 |
| US10105434B2 (en) | 2015-08-03 | 2018-10-23 | The United States Of America As Represented By The Secretary Of The Navy | Immune enhancing recombinant dengue protein |
| EP3355916A4 (en) | 2015-09-30 | 2018-08-29 | Panacea Biotec Limited | Stable live attenuated recombinant dengue vaccine |
| BE1024160B9 (fr) | 2015-12-22 | 2017-12-06 | Glaxosmithkline Biologicals Sa | Formulation immunogène |
| BR112018068342A2 (pt) * | 2016-03-11 | 2019-01-15 | Univ Johns Hopkins | vacina de vírus zika vivo atenuado |
| EP3433274A1 (en) | 2016-03-25 | 2019-01-30 | Visterra, Inc. | Formulation of antibody molecules to dengue virus |
| CN109196095A (zh) * | 2016-04-14 | 2019-01-11 | 新加坡国立大学 | 产生活减毒疫苗的快速方法 |
| WO2018129160A1 (en) | 2017-01-06 | 2018-07-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Live attenuated flavivirus vaccines and methods of using and making same |
| JP7313345B2 (ja) | 2017-10-05 | 2023-07-24 | サノフィ・パスツール | デング熱に対するブースターワクチン接種のための組成物 |
| IL316312A (en) | 2017-12-07 | 2024-12-01 | Merck Sharp ַ& Dohme Llc | Dengue virus vaccine compound formulations |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990014837A1 (en) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5494671A (en) * | 1990-08-27 | 1996-02-27 | The United States Of America As Represented By The Department Of Health And Human Services | C-terminally truncated dengue and Japanese encephalitis virus envelope proteins |
| IT1253009B (it) | 1991-12-31 | 1995-07-10 | Sclavo Ricerca S R L | Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini |
| GB9513371D0 (en) | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
| GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| US6074865A (en) * | 1995-07-20 | 2000-06-13 | The United States Of America As Represented By The Secretary Of The Army | Recombinant dengue virus DNA fragment |
| US6455509B1 (en) * | 1996-06-04 | 2002-09-24 | The United States Of America As Represented By The Secretary Of The Navy | Dengue nucleic acid vaccines that induce neutralizing antibodies |
| US6537557B1 (en) * | 1999-03-26 | 2003-03-25 | The United States Of America As Represented By The Secretary Of The Army | Attenuated dengue-4 virus vaccine |
| AU779280B2 (en) * | 1999-03-26 | 2005-01-13 | Walter Reed Army Institute Of Research | Multivalent dengue virus vaccine |
-
2002
- 2002-05-22 CA CA2755964A patent/CA2755964C/en not_active Expired - Lifetime
- 2002-05-22 EP EP02739358A patent/EP1402075B1/en not_active Expired - Lifetime
- 2002-05-22 DK DK02739358.6T patent/DK1402075T3/da active
- 2002-05-22 ES ES02739358T patent/ES2399420T3/es not_active Expired - Lifetime
- 2002-05-22 ES ES10181804.5T patent/ES2533085T3/es not_active Expired - Lifetime
- 2002-05-22 EP EP15150784.5A patent/EP2940154B1/en not_active Expired - Lifetime
- 2002-05-22 CA CA3114957A patent/CA3114957C/en not_active Expired - Lifetime
- 2002-05-22 AU AU2002312011A patent/AU2002312011B2/en not_active Expired
- 2002-05-22 DK DK10181786.4T patent/DK2290109T3/da active
- 2002-05-22 EP EP10181786.4A patent/EP2290109B1/en not_active Expired - Lifetime
- 2002-05-22 CA CA2448329A patent/CA2448329C/en not_active Expired - Lifetime
- 2002-05-22 DK DK10181776.5T patent/DK2290108T3/da active
- 2002-05-22 BR BRPI0209943-8 patent/BRPI0209943B8/pt not_active IP Right Cessation
- 2002-05-22 ES ES10181776.5T patent/ES2512715T3/es not_active Expired - Lifetime
- 2002-05-22 CA CA3060687A patent/CA3060687C/en not_active Expired - Lifetime
- 2002-05-22 ES ES10181786.4T patent/ES2523168T3/es not_active Expired - Lifetime
- 2002-05-22 EP EP10181776.5A patent/EP2290108B1/en not_active Expired - Lifetime
- 2002-05-22 BR BR122019026154A patent/BR122019026154B8/pt not_active IP Right Cessation
- 2002-05-22 CA CA2966716A patent/CA2966716C/en not_active Expired - Lifetime
- 2002-05-22 DK DK10181804.5T patent/DK2292802T3/da active
- 2002-05-22 EP EP10181804.5A patent/EP2292802B1/en not_active Expired - Lifetime
- 2002-05-22 WO PCT/US2002/016308 patent/WO2002095075A1/en not_active Ceased
-
2003
- 2003-11-21 US US10/719,547 patent/US7226602B2/en not_active Ceased
-
2006
- 2006-06-02 US US11/446,050 patent/US7560118B2/en not_active Ceased
-
2008
- 2008-07-23 AU AU2008203275A patent/AU2008203275B2/en not_active Expired
-
2009
- 2009-03-02 US US12/396,376 patent/US8039003B2/en not_active Ceased
-
2011
- 2011-09-22 US US13/240,849 patent/US8632782B2/en not_active Expired - Fee Related
-
2013
- 2013-05-17 US US13/896,411 patent/USRE45053E1/en not_active Expired - Lifetime
- 2013-05-17 US US13/896,396 patent/USRE45016E1/en not_active Expired - Lifetime
- 2013-05-17 US US13/896,409 patent/USRE45123E1/en not_active Expired - Fee Related
- 2013-12-04 US US14/096,424 patent/US9707287B2/en not_active Expired - Fee Related
-
2017
- 2017-07-14 US US15/650,482 patent/US10500264B2/en not_active Expired - Lifetime
-
2019
- 2019-11-14 US US16/684,103 patent/US11318196B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2290109T3 (da) | Udvikling af mutationer, der er anvendelige til svækkelse af dengue-vira samt kimære dengue-vira | |
| DE60139127D1 (de) | Von hepatitis c virus | |
| DE60329367D1 (de) | Verwendung bei der bekämpfung von hepatitis c virusinfektion | |
| DK1620437T3 (da) | 5,7-diaminopyrazolo-4,3-d-pyrimidiner, der er anvendelige til behandling af hypertension | |
| NO20023283D0 (no) | Flammestopper | |
| DK1501921T4 (da) | Forbedrede virusrensningsmetoder | |
| DK1448523T3 (da) | Heterocycliske forbindelser samt metoder til anvendelse deraf | |
| IS8476A (is) | Lifrarbólgu C-veirutálmar | |
| IS8475A (is) | Lifrarbólgu C-veirutálmar | |
| DE50109189D1 (de) | Schaufelanordnung mit Dämpfungselementen | |
| DK1309545T3 (da) | Fremgangsmåde til fremstilling af alkylarylsulfonater | |
| IS7520A (is) | Pyrimidínonefnasambönd, samsetningar og aðferðir | |
| DK1373256T3 (da) | CCR5-antagonister, der er nyttige til behandling af AIDS | |
| FR15C0005I2 (fr) | Composes derives de benzothiazole, compositions et utilisations | |
| NO20035121D0 (no) | Ny anvendelse | |
| NO20030239D0 (no) | Modifisert virus | |
| DE50206722D1 (de) | Zusammensetzungen, enthaltend quaternäre Ammoniumverbindungen | |
| EP1692279A4 (en) | VIRUS PREPARATIONS CONTAINING A CONSERVATIVE | |
| DE60202489D1 (de) | Lysin enthaltende kautablette | |
| DK1605759T3 (da) | Herbicid blanding, der omfatter ufarliggörelsesmiddel | |
| DE602004010285D1 (de) | Statisches latch | |
| DE60201463D1 (de) | Indanon-Derivate als Duftstoffe | |
| DE60336338D1 (de) | Sulfonylaminopyrazole als pestizide | |
| DE50209313D1 (de) | Selektive arylguanidinpeptide als urokinaseinhibitoren | |
| DE50211466D1 (de) | Substituierte 4-aminocyclohexanolderivate |