DK2292736T3 - Identificering og isolering af multipotente celler fra ikke-osteochondralt mesenchymalvæv - Google Patents

Identificering og isolering af multipotente celler fra ikke-osteochondralt mesenchymalvæv Download PDF

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DK2292736T3
DK2292736T3 DK10183073.5T DK10183073T DK2292736T3 DK 2292736 T3 DK2292736 T3 DK 2292736T3 DK 10183073 T DK10183073 T DK 10183073T DK 2292736 T3 DK2292736 T3 DK 2292736T3
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cells
cell
multipotent adult
isolated
cell population
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DK10183073.5T
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Castro Rosa Ana García
Miguel María Gema Fernández
Arranz Mariano García
De La Peña Manuel Angel González
Olmo Damián García
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Tigenix S A U
Univ Autónoma De Madrid
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells
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Claims (4)

1. I det væsentlige homogen konsekutivt passeret isoleret cellepopulation, som omfatter multipotente voksne celler, som (a) er isoleret fra fedtvæv, (b) udtrykker CD9, CD10, CD13, CD29, CD44, CD49A, CD51, CD54, CD55, CD58, CD59, CD90 og CD105; og (c) mangler ekspression af CD11b, CD14, CD15, CD16, CD31, CD34, CD45, CD49f, CD102, CD104, CD106 og CD133.
2. Multipotent voksen cellepopulation ifølge krav 1, som isoleres ved en fremgangsmåde, der omfatter: (a) opsamling affedtvæv; (b) opnåelse af en cellesuspension ved enzymatisk spaltning; (c) sedimentering og resuspendering af cellerne i et dyrkningsmedium; og (d) dyrkning af cellerne på en fast overflade og eliminering af celler, som ikke udviser nogen adhæsion til den faste overflade; (e) ekspandering ved konsekutiv passage af cellerne.
3. Farmaceutisk præparat, som omfatter en cellepopulation ifølge krav 1 eller 2 og en farmaceutisk acceptabel bærer.
4. Isoleret cellepopulation ifølge krav 1 eller 2 til anvendelse i terapi.
DK10183073.5T 2004-10-04 2005-10-04 Identificering og isolering af multipotente celler fra ikke-osteochondralt mesenchymalvæv DK2292736T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200402355A ES2313805B1 (es) 2004-10-04 2004-10-04 Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
EP05796904A EP1812558A1 (en) 2004-10-04 2005-10-04 Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue

Publications (1)

Publication Number Publication Date
DK2292736T3 true DK2292736T3 (da) 2015-04-20

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ID=35457282

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DK10183073.5T DK2292736T3 (da) 2004-10-04 2005-10-04 Identificering og isolering af multipotente celler fra ikke-osteochondralt mesenchymalvæv

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US (3) US20060073124A1 (da)
EP (5) EP3342857A1 (da)
JP (2) JP2008515413A (da)
KR (1) KR20070085294A (da)
CN (1) CN101056974B (da)
AU (1) AU2005291353A1 (da)
CA (1) CA2583151C (da)
CY (1) CY1116198T1 (da)
DK (1) DK2292736T3 (da)
ES (2) ES2313805B1 (da)
HU (1) HUE025155T2 (da)
IL (1) IL182441A (da)
PL (1) PL2292736T3 (da)
PT (1) PT2292736E (da)
SG (2) SG158853A1 (da)
SI (1) SI2292736T1 (da)
WO (1) WO2006037649A1 (da)

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