DK2335720T3 - Autolog T-cellevacciner mod multiple sclerose - Google Patents

Autolog T-cellevacciner mod multiple sclerose

Info

Publication number
DK2335720T3
DK2335720T3 DK10178920.4T DK10178920T DK2335720T3 DK 2335720 T3 DK2335720 T3 DK 2335720T3 DK 10178920 T DK10178920 T DK 10178920T DK 2335720 T3 DK2335720 T3 DK 2335720T3
Authority
DK
Denmark
Prior art keywords
autologous
multiple sclerosis
cell vaccines
vaccines against
against multiple
Prior art date
Application number
DK10178920.4T
Other languages
English (en)
Inventor
Jingwu Zhang
Original Assignee
Opexa Pharmaceuticals Inc
Baylor College Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opexa Pharmaceuticals Inc, Baylor College Medicine filed Critical Opexa Pharmaceuticals Inc
Application granted granted Critical
Publication of DK2335720T3 publication Critical patent/DK2335720T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/414—Nervous system antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK10178920.4T 2001-09-14 2002-09-12 Autolog T-cellevacciner mod multiple sclerose DK2335720T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/952,532 US7658926B2 (en) 2001-09-14 2001-09-14 Autologous T-cell vaccines materials and methods
EP08004597.4A EP1946767B1 (en) 2001-09-14 2002-09-12 Method of producing an autologous T-cell vaccine against multiple sclerosis

Publications (1)

Publication Number Publication Date
DK2335720T3 true DK2335720T3 (da) 2013-07-08

Family

ID=25492995

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10178920.4T DK2335720T3 (da) 2001-09-14 2002-09-12 Autolog T-cellevacciner mod multiple sclerose
DK02778249T DK1416956T3 (da) 2001-09-14 2002-09-12 Autologe T-celle-vaccinematerialer samt fremgangsmåde til deres fremstilling

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK02778249T DK1416956T3 (da) 2001-09-14 2002-09-12 Autologe T-celle-vaccinematerialer samt fremgangsmåde til deres fremstilling

Country Status (21)

Country Link
US (2) US7658926B2 (da)
EP (3) EP2335720B1 (da)
JP (5) JP2005502721A (da)
KR (1) KR20040066787A (da)
CN (2) CN101229370B (da)
AT (1) ATE395076T1 (da)
AU (1) AU2002339914B2 (da)
BR (1) BR0212504A (da)
CA (1) CA2459969C (da)
DE (1) DE60226612D1 (da)
DK (2) DK2335720T3 (da)
ES (2) ES2418529T3 (da)
HU (1) HUP0401519A3 (da)
IL (2) IL159998A0 (da)
MX (1) MXPA04001862A (da)
NZ (1) NZ530762A (da)
PL (1) PL210442B1 (da)
PT (2) PT2335720E (da)
RU (1) RU2302257C2 (da)
WO (1) WO2003024393A2 (da)
ZA (1) ZA200401502B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020009448A1 (en) * 1997-09-19 2002-01-24 Leslie P. Weiner T-cell vaccination for the treatment of multiple sclerosis
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US7744893B2 (en) * 2002-06-05 2010-06-29 Baylor College Of Medicine T cell receptor CDR3 sequences associated with multiple sclerosis and compositions comprising same
RU2327487C2 (ru) * 2002-08-08 2008-06-27 Бейлор Колледж Оф Медисин Выделение и идентификация т-клеток
US20060204495A1 (en) * 2002-12-31 2006-09-14 Zang Jingwu Z Isolation and identification of cross-reactive t cells
EP1677821B1 (en) * 2003-10-17 2013-02-27 Baylor College Of Medicine A method for increasing cd8+ cytotoxic t cell reponses and for treating multiple sclerosis
CA2651328A1 (en) * 2006-05-05 2007-11-15 Opexa Therapeutics T-cell vaccine
RU2339385C1 (ru) * 2007-04-02 2008-11-27 Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН Способ лечения ревматоидного артрита
EP2318020B1 (en) * 2008-06-30 2015-08-19 Universitätsklinikum Heidelberg Immunosuppressive blood cells and methods of producing same
RU2393218C1 (ru) * 2009-01-30 2010-06-27 Федеральное государственное учреждение "Центральный научно-исследовательский институт травматологии и ортопедии имени Н.Н. Приорова Росмедтехнологий" Среда для выращивания культуры аутологичных лимфоцитов
WO2016037123A2 (en) * 2014-09-05 2016-03-10 Opexa Therapeutics, Inc. Compositions and methods for treating b cell mediated autoimmune disorders
CN109125717B (zh) * 2017-09-08 2022-02-22 江苏苏博生物医学股份有限公司 一种治疗慢性病的自体全细胞疫苗配方及其制备方法
WO2019133793A1 (en) 2017-12-29 2019-07-04 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Compositions and methods for treating autoimmune disease

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Also Published As

Publication number Publication date
HK1071698A1 (zh) 2005-07-29
JP2016188238A (ja) 2016-11-04
BR0212504A (pt) 2004-08-24
EP1416956A2 (en) 2004-05-12
KR20040066787A (ko) 2004-07-27
ATE395076T1 (de) 2008-05-15
JP2007254492A (ja) 2007-10-04
CN101229370B (zh) 2015-09-02
IL196900A0 (en) 2011-07-31
DE60226612D1 (de) 2008-06-26
PT1416956E (pt) 2008-08-26
CA2459969A1 (en) 2003-03-27
CA2459969C (en) 2014-12-02
ZA200401502B (en) 2005-01-26
PT2335720E (pt) 2013-07-08
IL159998A0 (en) 2004-06-20
JP2011168618A (ja) 2011-09-01
EP1416956A4 (en) 2004-10-13
US20030091578A1 (en) 2003-05-15
WO2003024393A3 (en) 2003-11-06
US7658926B2 (en) 2010-02-09
EP1416956B1 (en) 2008-05-14
DK1416956T3 (da) 2008-09-01
ES2306792T3 (es) 2008-11-16
HUP0401519A3 (en) 2009-04-28
US20050186192A1 (en) 2005-08-25
RU2004103626A (ru) 2005-03-27
MXPA04001862A (es) 2005-03-07
AU2002339914B2 (en) 2005-03-24
EP1946767A3 (en) 2008-07-30
HUP0401519A2 (hu) 2004-11-29
EP1946767B1 (en) 2013-12-04
PL367306A1 (pl) 2005-02-21
CN100346824C (zh) 2007-11-07
EP2335720A1 (en) 2011-06-22
JP2015017129A (ja) 2015-01-29
CN101229370A (zh) 2008-07-30
ES2418529T3 (es) 2013-08-14
JP4889581B2 (ja) 2012-03-07
EP2335720B1 (en) 2013-04-03
WO2003024393A2 (en) 2003-03-27
IL196900A (en) 2015-03-31
RU2302257C2 (ru) 2007-07-10
EP1946767A2 (en) 2008-07-23
NZ530762A (en) 2005-10-28
JP2005502721A (ja) 2005-01-27
PL210442B1 (pl) 2012-01-31
CN1553812A (zh) 2004-12-08

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