DK2373305T3 - Transdermale farmaceutiske sammensætninger omfattende en serm - Google Patents
Transdermale farmaceutiske sammensætninger omfattende en serm Download PDFInfo
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- DK2373305T3 DK2373305T3 DK09764869.5T DK09764869T DK2373305T3 DK 2373305 T3 DK2373305 T3 DK 2373305T3 DK 09764869 T DK09764869 T DK 09764869T DK 2373305 T3 DK2373305 T3 DK 2373305T3
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- transdermal pharmaceutical
- breast
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (9)
1. Transdermal farmaceutisk sammensætning til transdermal indgivelse til en hudoverflade, hvor sammensætningen omfatter: (i) 0,01 til 10 % (v/v), fortrinsvis 2 til 5 % (v/v) endoxifen eller et farmaceutisk acceptabelt salt deraf, (ii) 60 til 80 % (v/v) af mindst en monoalkohol, hvor den mindst ene monoalkohol er udvalgt blandt C2-C4 monoalkoholer, fortrinsvis ethanol eller isopro-panol, (iii) 0,1 til 10 % (v/v) af mindst en penetrationsforstærker, hvor den mindst ene penetrationsforstærker er oliesyre, og forudsat at isopropylmyristat er udelukket, (iv) 0 til 5 % (v/v) af mindst et geleringsmiddel, fortrinsvis polyacrylsyrer, cellulosematerialer eller blandinger deraf, (v) 0,01 til 30 % (v/v) af mindst et befugtningsmiddel, fortrinsvis glycerin, (vi) q.s. 100 % (v/v) vand.
2. Transdermal farmaceutisk sammensætning ifølge krav 1, hvor den mindst ene penetrationsforstærker er en blanding af oliesyre og propylenglycol.
3. Transdermal farmaceutisk sammensætning ifølge krav 1, til anvendelse i en fremgangsmåde til indgivelse af en terapeutisk virksom mængde af endoxifen eller det farmaceutisk acceptable salt deraf til en patient med behov herfor, omfattende at indgive sammensætningen transdermalt på en hudoverflade hos patienten.
4. Transdermal farmaceutisk sammensætning til anvendelse ifølge krav 3, hvor patienten lider af en brystsygdom.
5. Transdermal farmaceutisk sammensætning ifølge krav 3, hvor patienten lider af østrogenforstyrrelse.
6. Transdermal farmaceutisk sammensætning ifølge krav 5, hvor østrogenforstyrrelsen er en brystsygdom udvalgt blandt godartede brystsygdomme, gynækomasti, brystcancer, mastalgi og tilstande, der involverer tæt bryst- væv.
7. Dosispakke, enhedsdosispakke eller flerdosispakke indeholdende en transdermal farmaceutisk sammensætning ifølge krav 1.
8. Dispenser, eventuelt med håndpumpe, indeholdende en transdermal farmaceutisk sammensætning ifølge krav 1.
9. Fremgangsmåde til fremstilling af en transdermal farmaceutisk sammensætning ifølge krav 1, omfattende trinnene til fremstilling af en blanding omfattende: (i) mindst en monoalhohol udvalgt blandt C2-C4-monoalkoholer, (ii) endoxifen eller de farmaceutisk acceptable salte deraf, (iii) en vandig vehikel, (iv) mindst en penetrationsforstærker, hvor den mindst ene penetrationsforstærker er oliesyre, og forudsat at isopropyl-myristat er udelukket, (v) eventuelt mindst et geleringsmiddel, (vi) mindst et befugtningsmiddel.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12184808P | 2008-12-11 | 2008-12-11 | |
| EP08305924 | 2008-12-11 | ||
| PCT/EP2009/066768 WO2010066810A1 (en) | 2008-12-11 | 2009-12-09 | Transdermal pharmaceutical compositions comprising a serm |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2373305T3 true DK2373305T3 (da) | 2017-05-15 |
Family
ID=40521639
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17157911.3T DK3202420T3 (da) | 2008-12-11 | 2009-12-09 | Transdermale farmaceutiske sammensætninger omfattende en serm |
| DK09764869.5T DK2373305T3 (da) | 2008-12-11 | 2009-12-09 | Transdermale farmaceutiske sammensætninger omfattende en serm |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17157911.3T DK3202420T3 (da) | 2008-12-11 | 2009-12-09 | Transdermale farmaceutiske sammensætninger omfattende en serm |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20120010245A1 (da) |
| EP (3) | EP3656376A1 (da) |
| DK (2) | DK3202420T3 (da) |
| ES (1) | ES2624557T3 (da) |
| HU (1) | HUE034680T2 (da) |
| PL (1) | PL3202420T3 (da) |
| PT (1) | PT2373305T (da) |
| SI (2) | SI3202420T1 (da) |
| WO (1) | WO2010066810A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10080760B2 (en) | 2009-10-27 | 2018-09-25 | Besins Healthcare Luxembourg Sarl | Transdermal pharmaceutical compositions comprising active agents |
| WO2015179282A1 (en) * | 2014-05-20 | 2015-11-26 | Topokine Therapeutics, Inc. | Topical compositions comprising a thiazolidinedione |
| US10185559B2 (en) * | 2014-06-25 | 2019-01-22 | Entit Software Llc | Documentation notification |
| WO2017011623A1 (en) * | 2015-07-14 | 2017-01-19 | Atossa Genetics Inc. | Transpapillary methods and compositions for treating breast disorders |
| US20170304232A1 (en) | 2016-04-20 | 2017-10-26 | Northwestern University | Endoxifen For Local Transdermal Therapy To The Breast |
| CN111212631A (zh) * | 2017-09-11 | 2020-05-29 | 阿托莎医疗公司 | 局部用组合物和治疗方法 |
| TWI793165B (zh) | 2017-09-11 | 2023-02-21 | 美商阿托薩醫療公司 | 製造及使用因多昔芬(endoxifen)之方法 |
| MX2022000203A (es) | 2019-07-03 | 2022-03-22 | Atossa Therapeutics Inc | Composiciones de liberacion sostenida de endoxifeno. |
| GB2608397B (en) * | 2021-06-29 | 2025-04-09 | Chaitowitz Ilan | Gynecomastia treatment |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9207437D0 (en) * | 1992-04-03 | 1992-05-20 | Orion Yhtymae Oy | Topical administration of toremifene and its metabolites |
| DE4407742C1 (de) * | 1994-03-08 | 1995-06-22 | Hexal Pharma Gmbh | Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat |
| FR2718372B1 (fr) | 1994-04-08 | 1996-06-28 | Sofab | Dispensateur de produits fluides. |
| FR2723356B1 (fr) | 1994-08-08 | 1996-10-18 | Innovation Rech Plastique Sa | Dispositif de conditionnement d'un produit avec pompe manuelle de distribution en doses unitaires |
| FR2726810B1 (fr) | 1994-11-10 | 1997-01-31 | Soc D Promotion Rech Et Innova | Pompe doseuse a commande manuelle pour flacon a enveloppe deformable |
| IL120268A0 (en) * | 1996-02-28 | 1997-06-10 | Pfizer | Use of (E)-1-[4'-(2-alkylaminoethioxy)phenyl]1-(3'-hydroxyphenyl)-2-phenylbut-1-enes in inhibiting pathological conditions |
| BR9708248A (pt) * | 1996-03-26 | 1999-07-27 | Lilly Co Eli | Benzotiofenos formulações contendo os mesmos e metódos |
| US5747509A (en) * | 1996-06-03 | 1998-05-05 | Schering Aktiengesellschaft | Method for lowering plasma levels of lipoprotein(a) |
| US6319913B1 (en) * | 1997-11-10 | 2001-11-20 | Cellegy Pharmaceuticals, Inc. | Penetration enhancing and irritation reducing systems |
| FI982733L (fi) * | 1998-12-17 | 2000-06-18 | Orion Yhtymae Oyj | Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia |
| US6582724B2 (en) * | 1999-12-16 | 2003-06-24 | Dermatrends, Inc. | Dual enhancer composition for topical and transdermal drug delivery |
| FR2851470B1 (fr) * | 2003-02-20 | 2007-11-16 | Besins Int Belgique | Composition pharmaceutique pour administration transdermique ou transmuqueuse |
| EP1634583A1 (en) * | 2004-09-09 | 2006-03-15 | Laboratoires Besins International | Testosterone gels comprising propylene glycol as penetration enhancer |
| WO2006125642A1 (en) * | 2005-05-27 | 2006-11-30 | Antares Pharma Ipl Ag | Methods and apparatus for transdermal or transmucosal application of testosterone |
| CA2645080A1 (en) * | 2006-03-07 | 2007-09-13 | Novavax,Inc. | Nanoemulsions of poorly soluble pharmaceutical active ingredients and methods of making the same |
| US20080220068A1 (en) * | 2006-07-31 | 2008-09-11 | Laboratories Besins International | Treatment and prevention of excessive scarring |
| WO2008039864A1 (en) * | 2006-09-26 | 2008-04-03 | Novavax, Inc. | Emulsion formulations for transdermal delivery of poorly water soluble active agents |
| PT2101731T (pt) * | 2006-11-21 | 2018-04-18 | Jina Pharmaceuticals Inc | Endoxifeno para utilização no tratamento de cancro |
-
2009
- 2009-12-09 PL PL17157911T patent/PL3202420T3/pl unknown
- 2009-12-09 SI SI200932049T patent/SI3202420T1/sl unknown
- 2009-12-09 ES ES09764869.5T patent/ES2624557T3/es active Active
- 2009-12-09 DK DK17157911.3T patent/DK3202420T3/da active
- 2009-12-09 HU HUE09764869A patent/HUE034680T2/en unknown
- 2009-12-09 EP EP20151652.3A patent/EP3656376A1/en active Pending
- 2009-12-09 SI SI200931650T patent/SI2373305T1/sl unknown
- 2009-12-09 DK DK09764869.5T patent/DK2373305T3/da active
- 2009-12-09 US US13/133,071 patent/US20120010245A1/en not_active Abandoned
- 2009-12-09 EP EP09764869.5A patent/EP2373305B1/en not_active Not-in-force
- 2009-12-09 PT PT97648695T patent/PT2373305T/pt unknown
- 2009-12-09 WO PCT/EP2009/066768 patent/WO2010066810A1/en not_active Ceased
- 2009-12-09 EP EP17157911.3A patent/EP3202420B1/en active Active
-
2019
- 2019-01-14 US US16/246,649 patent/US20190380948A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010066810A8 (en) | 2010-10-21 |
| WO2010066810A1 (en) | 2010-06-17 |
| HUE034680T2 (en) | 2018-02-28 |
| PL3202420T3 (pl) | 2020-07-13 |
| EP3202420A1 (en) | 2017-08-09 |
| SI2373305T1 (sl) | 2017-09-29 |
| DK3202420T3 (da) | 2020-04-06 |
| ES2624557T3 (es) | 2017-07-14 |
| PT2373305T (pt) | 2017-06-14 |
| EP3202420B1 (en) | 2020-03-04 |
| US20190380948A1 (en) | 2019-12-19 |
| EP3656376A1 (en) | 2020-05-27 |
| EP2373305A1 (en) | 2011-10-12 |
| EP2373305B1 (en) | 2017-03-15 |
| US20120010245A1 (en) | 2012-01-12 |
| SI3202420T1 (sl) | 2020-08-31 |
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