DK2373652T3 - Substituerede piperidin-spiro-pyrrolidinon- og piperidinon-forbindelser anvendt som h3-modulatorer - Google Patents

Substituerede piperidin-spiro-pyrrolidinon- og piperidinon-forbindelser anvendt som h3-modulatorer

Info

Publication number
DK2373652T3
DK2373652T3 DK09793649.6T DK09793649T DK2373652T3 DK 2373652 T3 DK2373652 T3 DK 2373652T3 DK 09793649 T DK09793649 T DK 09793649T DK 2373652 T3 DK2373652 T3 DK 2373652T3
Authority
DK
Denmark
Prior art keywords
piperidinon
pyrrolidinon
spiro
modulators
compounds used
Prior art date
Application number
DK09793649.6T
Other languages
English (en)
Inventor
Zhongli Gao
Daniel Hall
Ryan Hartung
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of DK2373652T3 publication Critical patent/DK2373652T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
DK09793649.6T 2008-12-05 2009-12-04 Substituerede piperidin-spiro-pyrrolidinon- og piperidinon-forbindelser anvendt som h3-modulatorer DK2373652T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12008808P 2008-12-05 2008-12-05
FR0955431 2009-07-31
PCT/US2009/066673 WO2010065803A1 (en) 2008-12-05 2009-12-04 Substituted piperidine spiro pyrrolidinone and piperidinones used as h3 modulators

Publications (1)

Publication Number Publication Date
DK2373652T3 true DK2373652T3 (da) 2014-01-20

Family

ID=41647030

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09793649.6T DK2373652T3 (da) 2008-12-05 2009-12-04 Substituerede piperidin-spiro-pyrrolidinon- og piperidinon-forbindelser anvendt som h3-modulatorer

Country Status (24)

Country Link
US (2) US8227481B2 (da)
EP (1) EP2373652B1 (da)
JP (1) JP5538421B2 (da)
KR (1) KR101687216B1 (da)
CN (1) CN102239168B (da)
AR (1) AR074466A1 (da)
AU (1) AU2009322248B2 (da)
CA (1) CA2745721C (da)
CO (1) CO6390058A2 (da)
CR (1) CR20110294A (da)
DK (1) DK2373652T3 (da)
EC (1) ECSP11011108A (da)
ES (1) ES2441221T3 (da)
IL (1) IL213290A (da)
MA (1) MA32943B1 (da)
MX (1) MX2011004939A (da)
NZ (1) NZ593151A (da)
PE (1) PE20120261A1 (da)
PT (1) PT2373652E (da)
RU (1) RU2011127401A (da)
TN (1) TN2011000233A1 (da)
TW (1) TWI481609B (da)
WO (1) WO2010065803A1 (da)
ZA (1) ZA201103448B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR074467A1 (es) 2008-12-05 2011-01-19 Sanofi Aventis Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras.
AR081498A1 (es) 2010-05-11 2012-09-19 Sanofi Aventis Derivados de n-alquil -y n-acil-tetrahidroisoquinolina sustituidos, preparacion y su uso terapeutico de los mismos
EP2569294B1 (en) 2010-05-11 2015-03-11 Sanofi Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof
EP2569297A1 (en) 2010-05-11 2013-03-20 Sanofi Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof
WO2011143148A1 (en) * 2010-05-11 2011-11-17 Sanofi Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
EP2569280B1 (en) 2010-05-11 2015-02-25 Sanofi Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
TW201206898A (en) * 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof
TW201206444A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
RU2015116540A (ru) 2012-10-11 2016-12-10 Мерк Шарп И Доум Корп. Замещенные соединения спиропиперидинила, применяемые в качестве агонистов gpr120
US9197285B2 (en) * 2012-12-20 2015-11-24 Deere & Company Methods and apparatus for ameliorating signal reception
WO2019089868A1 (en) * 2017-11-03 2019-05-09 Bristol-Myers Squibb Company Diazaspiro rock inhibitors

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3256276A (en) 1961-02-17 1966-06-14 Geschickter Fund Med Res Substituted spiroimides
FR2816940A1 (fr) 2000-11-23 2002-05-24 Lipha Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation
AU2003256755A1 (en) * 2002-07-24 2004-02-09 Ptc Therapeutics, Inc. Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations
EP1556046A1 (en) * 2002-10-23 2005-07-27 Janssen Pharmaceutica N.V. Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators
DE10306250A1 (de) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7223788B2 (en) 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
JP4524550B2 (ja) 2003-08-19 2010-08-18 オイレス工業株式会社 摺動部材用樹脂組成物および摺動部材
ATE547404T1 (de) 2003-09-22 2012-03-15 Msd Kk Piperidinderivate
AU2006232871B9 (en) * 2005-04-01 2011-11-24 Eli Lilly And Company Histamine H3 receptor agents, preparation and therapeutic uses
CA2630492C (en) 2005-12-05 2015-04-14 Incyte Corporation Spiro-lactam compounds
ES2344077T3 (es) * 2005-12-16 2010-08-17 F.Hoffmann-La Roche Ag Derivados de pirrolo(2,3-b)piridina como moduladores del receptor h3.
WO2007093364A1 (en) * 2006-02-15 2007-08-23 Sanofi-Aventis Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
US20080247964A1 (en) 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
CA2656089A1 (en) 2006-06-29 2008-01-03 Janssen Pharmaceutica N.V. Substituted benzyl amine compounds
US20080306102A1 (en) * 2007-05-18 2008-12-11 Kowa Co., Ltd. Novel spirooxyindole compounds and drugs containing same
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
WO2009039431A2 (en) * 2007-09-21 2009-03-26 Neurogen Corporation Substituted aryl-fused spirocyclic amines
SI2212282T1 (sl) * 2007-10-17 2012-01-31 Sanofi Sa Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba
ES2372332T3 (es) 2007-10-17 2012-01-18 Sanofi N-fenil-bipirrolidina carboxamidas sustituidas y su uso terapéutico.
EP2205558B1 (en) 2007-10-17 2012-07-25 Sanofi Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators
MA32929B1 (fr) 2008-11-23 2012-01-02 Pfizer Lactames en tant qu'inhibiteurs de bêta-sécrétase
AR074467A1 (es) 2008-12-05 2011-01-19 Sanofi Aventis Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras.

Also Published As

Publication number Publication date
TWI481609B (zh) 2015-04-21
US8604046B2 (en) 2013-12-10
CO6390058A2 (es) 2012-02-29
IL213290A0 (en) 2011-07-31
WO2010065803A1 (en) 2010-06-10
PE20120261A1 (es) 2012-04-04
AU2009322248B2 (en) 2015-07-16
RU2011127401A (ru) 2013-01-10
JP5538421B2 (ja) 2014-07-02
KR20110100639A (ko) 2011-09-14
US20110257213A1 (en) 2011-10-20
CA2745721A1 (en) 2010-06-10
EP2373652A1 (en) 2011-10-12
TN2011000233A1 (en) 2012-12-17
CA2745721C (en) 2013-09-24
CR20110294A (es) 2011-09-21
AU2009322248A1 (en) 2011-06-23
PT2373652E (pt) 2014-01-16
TW201036974A (en) 2010-10-16
KR101687216B1 (ko) 2016-12-16
ES2441221T3 (es) 2014-02-03
IL213290A (en) 2014-01-30
US8227481B2 (en) 2012-07-24
CN102239168B (zh) 2014-03-12
AR074466A1 (es) 2011-01-19
EP2373652B1 (en) 2013-10-09
CN102239168A (zh) 2011-11-09
JP2012511012A (ja) 2012-05-17
ZA201103448B (en) 2012-01-25
MA32943B1 (fr) 2012-01-02
US20120258979A1 (en) 2012-10-11
ECSP11011108A (es) 2011-11-30
MX2011004939A (es) 2011-05-25
NZ593151A (en) 2012-11-30

Similar Documents

Publication Publication Date Title
HUS1900016I1 (hu) C7-fluorral helyettesített tetraciklin vegyületek
BRPI0813653A2 (pt) Compostos de imidazotiazol moduladores de sirtuína
BRPI0813651A2 (pt) Compostos de tiazolopiridina moduladores de sirtuína
DK2373652T3 (da) Substituerede piperidin-spiro-pyrrolidinon- og piperidinon-forbindelser anvendt som h3-modulatorer
BRPI0919800A2 (pt) embalagem
DK2288375T3 (da) Pegylerede insulin-lispro-forbindelser
BRPI0920707A2 (pt) compostos
DK2242759T3 (da) Forbindelser
DK2364293T3 (da) Hidtil ukendte pyrazol-4-N-alkoxycarboxamider som mikrobiocider
DE602008002756D1 (de) Bauzusammensetzung
DK2340021T3 (da) Substituerede pyrrolidin-2-carboxamider
BRPI0920653A2 (pt) embalagem
BRPI0906749A2 (pt) Composição
BRPI0913808A2 (pt) composição
FIC20240018I1 (fi) Vamoroloni
BRPI0819093A2 (pt) compostos moduladores de sirtuína
BRPI0917231A2 (pt) composição
DK2297162T3 (da) Forbindelser
BRPI0907122A2 (pt) Piridoindóis (1-azinona) substituídos
BRPI0906828A2 (pt) Embalagem
BRPI0915127A2 (pt) composição polimerizável
BRPI0922098A2 (pt) composto inorgânicos
BRPI0916432A2 (pt) compostos
BRPI0822192A2 (pt) Vedações
EP2357204A4 (en) COMPOSITION