DK2379A - Fremgangsmaade til fremstilling af polysubstiturede og eventuelt hydroxysubstituerede 2-(3-alkylamino-2-hydroxy-propoxy) pyridiner - Google Patents

Fremgangsmaade til fremstilling af polysubstiturede og eventuelt hydroxysubstituerede 2-(3-alkylamino-2-hydroxy-propoxy) pyridiner

Info

Publication number: DK2379A
Authority: DK; Denmark
Prior art keywords: substituted; hydroxy; pyridines; alkylamino; propoxy
Prior art date: 1978-01-04

Application number

DK2379A

Other languages

English (en)

Inventor

J J Baldwin

G S Ponticello

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-01-04

Filing date

1979-01-03

Publication date

1979-08-07

1979-01-03 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1979-08-07 Publication of DK2379A publication Critical patent/DK2379A/da

Links

RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK2379A 1978-01-04 1979-01-03 Fremgangsmaade til fremstilling af polysubstiturede og eventuelt hydroxysubstituerede 2-(3-alkylamino-2-hydroxy-propoxy) pyridiner DK2379A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US86696178A	1978-01-04	1978-01-04

Publications (1)

Publication Number	Publication Date
DK2379A true DK2379A (da)	1979-08-07

Family

ID=25348804

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK2379A DK2379A (da)	1978-01-04	1979-01-03	Fremgangsmaade til fremstilling af polysubstiturede og eventuelt hydroxysubstituerede 2-(3-alkylamino-2-hydroxy-propoxy) pyridiner

Country Status (5)

Country	Link
EP (1)	EP0003278A1 (da)
JP (1)	JPS54106476A (da)
DK (1)	DK2379A (da)
IE (1)	IE47903B1 (da)
IT (1)	IT1188812B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4329351A (en) *	1979-10-01	1982-05-11	Merck & Co., Inc.	2-Substituted propoxy-3-cyano-5-RO-pyridines and intermediates
DE2943774A1 (de) *	1979-10-26	1981-05-14	1000 Berlin Schering Ag Berlin Und Bergkamen	Substituierte pyridine, verfahren zu ihrer herstellung und ihre verwendung
JPS5690060A (en) *	1979-12-24	1981-07-21	Ishihara Sangyo Kaisha Ltd	2-amino-trifluoromethylpyridine derivative and its preparation
US4394382A (en) *	1980-06-17	1983-07-19	Kowa Company, Ltd.	Dihydrobenzopyran compounds and pharmaceutical composition comprising said compounds
US4480102A (en) *	1982-07-23	1984-10-30	The Dow Chemical Company	2,3-Difluoro-5-(trifluoromethyl)pyridine and methods of making and using the same
ES523901A0 (es) *	1983-07-06	1985-04-01	Fabr Prod Quimicos Y Farmaceut	Un procedimiento para la preparacion de derivados de 3-sulfonamidopiridinas 2 -sustituidas.
GB8630847D0 (en) *	1986-12-24	1987-02-04	Ici Plc	Chemical compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR207133A1 (es) *	1973-02-20	1976-09-15	Ciba Geigy Ag	Procedimiento para la elaboracion de derivados de 1-piridiloxi 1-pirimidiniloxi y 1-piraziniloxi-2-hidroxi-3-amino-propano
DE2507902A1 (de) *	1974-04-02	1975-10-09	Ciba Geigy Ag	Neue amine und verfahren zu ihrer herstellung
US4000282A (en) *	1974-12-16	1976-12-28	Merck & Co., Inc.	2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
GB1544952A (en) *	1975-03-26	1979-04-25	Sandoz Ltd	Isoquinolines
US4053605A (en) *	1976-06-15	1977-10-11	Merck & Co., Inc.	Esterified-2(3-lower-alkyl-amino-propoxy)-3-cyano-pyridines and derivatives
US4060601A (en) *	1976-06-15	1977-11-29	Merck & Co., Inc.	Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines

1978
- 1978-12-29 JP JP16450078A patent/JPS54106476A/ja active Pending
1979
- 1979-01-03 IE IE13/79A patent/IE47903B1/en unknown
- 1979-01-03 IT IT47514/79A patent/IT1188812B/it active
- 1979-01-03 DK DK2379A patent/DK2379A/da not_active Application Discontinuation
- 1979-01-04 EP EP79100015A patent/EP0003278A1/en not_active Withdrawn

Also Published As

Publication number	Publication date
IT7947514A0 (it)	1979-01-03
IT1188812B (it)	1988-01-28
JPS54106476A (en)	1979-08-21
IE790013L (en)	1979-07-04
IE47903B1 (en)	1984-07-25
EP0003278A1 (en)	1979-08-08

Legal Events

Date	Code	Title	Description
1985-02-04	ATS	Application withdrawn

Publication	Publication Date	Title
DK471479A (da)	1980-06-14	Fremgangsmaade til fremstilling af imidazolderivater og salte deraf
DK51379A (da)	1979-09-18	Fremgangsmaade til fremstilling af 6-(substitueret)-8-methoxymethylergoliner og 6-(substitueret)-8-methylmercaptomethylergoliner
DK421879A (da)	1980-04-23	Formstofnet og fremgangsmaade til fremstilling af dette
DK421979A (da)	1980-04-17	Formstofnet og fremgangsmaade til fremstilling af dette
DK553379A (da)	1980-06-30	Chitinholdigt formet materiale og femgangsmaade til fremstilling af samme
DK531479A (da)	1980-07-20	Fremgangsmaade til fremstilling af imidazolderivater og salte deraf
DK142990D0 (da)	1990-06-11	2-fluor-4-halogen-1-nitrobenzenderivater og en fremgangsmaade til fremstilling deraf
DK149842C (da)	1987-06-15	Fremgangsmaade til fremstilling af d-camphorat af l-carnitinamid og d-camphorat af d-carnitinamid
DK163517C (da)	1992-08-31	Fremgangsmaade til fremstilling af 4'-epidaunorubicin og 3',4'-diepidaunorubicin
DK275178A (da)	1978-12-21	Fremgangsmaade til fremstilling af lipopeptider og anvendelse deraf
DK149586C (da)	1987-01-05	Fremgangsmaade til fremstilling af 1-amino-cyclopropan-carboxylsyre og derivater deraf
DK374679A (da)	1980-03-09	Fremgangsmaade til fremstilling af 7beta-aminothiazolyl-acetamido-3-cephem-4-carboxylsyreforbindelser og salte deraf
DK147914C (da)	1985-08-26	Lithiumpseudomonat og fremgangsmaade til fremstilling deraf
DK340679A (da)	1980-02-15	Chlorambucilderivater og fremgangsmaade til fremstilling heraf
DK512379A (da)	1980-06-08	Fremgangsmaade til chlorering af pyridinderivater
DK2279A (da)	1979-07-05	Fremgangsmaade til fremstilling af heterocyclisk substituerede og eventuelt hydroxysubstituerede (3-alkylamino-2-hydroxy-propoxy) pyridiner
DK494381A (da)	1982-05-11	Veterinaer-praeparat og fremgangsmaade til fremstilling af et macrolid
DK74578A (da)	1978-08-26	Fremgangsmaade til fremstilling af substituerede pyrroloquinoxalioner og pyrrolobenzodiazepioner
DK135480A (da)	1980-10-01	Fremgangsmaade til fremstilling af 2-(2-pyridyl)-tetrahydrothiopen-derivater
DK333179A (da)	1980-02-11	Fremgangsmaade til fremstilling af substituerede anthranilsyreamider og salte deraf
DK567778A (da)	1979-07-31	Fremgangsmaade til fremstilling af kvaternaere ammoniumsalte af phenylpropylaminer og phenylbutylaminer
NO790047L (no)	1979-07-09	Kompoundmaterialer og fremgangsmaate til deres fremstilling
DK343479A (da)	1980-02-26	N-phenethylamidforbindelser og fremgangsmaade til fremstilling deraf
DK536979A (da)	1980-06-30	Chromogent materiale og fremgangsmaade til fremstilling deraf
DK493780A (da)	1981-05-23	Fremgangsmaade til fremstilling af et nicotinamidderivat