DK2406263T3 - Pyrazolo[1,5-a]-1,3,5-triazinderivater, deres fremstilling samt deres terapeutiske anvendelse - Google Patents

Pyrazolo[1,5-a]-1,3,5-triazinderivater, deres fremstilling samt deres terapeutiske anvendelse

Info

Publication number: DK2406263T3
Authority: DK; Denmark
Prior art keywords: pyrazolo; preparation; therapeutic use; triazine derivatives; triazine
Prior art date: 2009-03-11

Application number

DK10710681.7T

Other languages

English (en)

Inventor

Laurent Meijer

Herve Galons

Benoit Joseph

Florence Popowycz

Nassima Oumata

Original Assignee

Centre Nat Rech Scient

Univ Paris Descartes

Univ Claude Bernard Lyon

Inst Nat Sante Rech Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-11

Filing date

2010-03-11

Publication date

2014-01-13

2010-03-11 Application filed by Centre Nat Rech Scient, Univ Paris Descartes, Univ Claude Bernard Lyon, Inst Nat Sante Rech Med filed Critical Centre Nat Rech Scient

2014-01-13 Application granted granted Critical

2014-01-13 Publication of DK2406263T3 publication Critical patent/DK2406263T3/da

Links

JUXWUYWPUDKPSD-UHFFFAOYSA-N pyrazolo[1,5-a][1,3,5]triazine Chemical class N1=CN=CN2N=CC=C21 JUXWUYWPUDKPSD-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Hematology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
AIDS & HIV (AREA)
Biotechnology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Immunology (AREA)

DK10710681.7T 2009-03-11 2010-03-11 Pyrazolo[1,5-a]-1,3,5-triazinderivater, deres fremstilling samt deres terapeutiske anvendelse DK2406263T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US15924609P	2009-03-11	2009-03-11
FR0951521A FR2943058B1 (fr)	2009-03-11	2009-03-11	Derives de pyrazolo°1,5-a!-1,3,5-triazines, leur preparation et leur application en therapeutique.
PCT/IB2010/051063 WO2010103486A1 (fr)	2009-03-11	2010-03-11	Derives de pyrazolo[1,5-a]-1,3,5-triazines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
DK2406263T3 true DK2406263T3 (da)	2014-01-13

Family

ID=41110928

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK10710681.7T DK2406263T3 (da)	2009-03-11	2010-03-11	Pyrazolo[1,5-a]-1,3,5-triazinderivater, deres fremstilling samt deres terapeutiske anvendelse

Country Status (8)

Country	Link
US (1)	US8691982B2 (da)
EP (1)	EP2406263B1 (da)
JP (1)	JP2012520288A (da)
CA (1)	CA2753135A1 (da)
DK (1)	DK2406263T3 (da)
ES (1)	ES2440323T3 (da)
FR (1)	FR2943058B1 (da)
WO (1)	WO2010103486A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20120149708A1 (en) *	2010-06-17	2012-06-14	George Mason University	Modulators of viral transcription, and methods and compositions therewith
US20120083498A1 (en) *	2010-06-17	2012-04-05	Fatah Kashanchi	Modulators of Viral Transcription, and Methods and Compositions Therewith
EP2602248A1 (en)	2011-12-05	2013-06-12	University Of Leicester	Novel pyrrole compounds
EP2634190A1 (en) *	2012-03-01	2013-09-04	Lead Discovery Center GmbH	Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors
EP2634189A1 (en) *	2012-03-01	2013-09-04	Lead Discovery Center GmbH	Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors
WO2014189830A1 (en)	2013-05-20	2014-11-27	University Of Pittsburgh-Of The Commonwealth System Of Higher Education	Calcium channel agonists
ES2899196T3 (es) *	2015-03-09	2022-03-10	Aurigene Discovery Tech Ltd	Derivados de pirazolo[1,5-a][1,3,5]triazina y de pirazolo[1,5-a]pirimidina como inhibidores de CDK
WO2016149756A1 (en)	2015-03-23	2016-09-29	The University Of Melbourne	Treatment of respiratory diseases
SI3302448T1 (sl)	2015-06-04	2024-03-29	Aurigene Oncology Limited	Substituirani heterociklični derivati kot inhibitorji cdk
AU2016284638B2 (en)	2015-06-24	2020-01-23	Curovir Ab	Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy
AU2018248581B2 (en)	2017-04-05	2022-05-26	Curovir Ab	Heteroaromatic compounds useful in therapy
JP7614646B2 (ja)	2018-11-07	2025-01-16	ティアンリバイオテックプロプライエタリリミテッド	呼吸器疾患の処置のための化合物及び組成物
CN111217814B (zh) *	2018-11-26	2022-08-26	天津科技大学	一类联哌啶衍生物及其作为抗肿瘤药物的应用
CN112028891B (zh) *	2019-07-30	2022-07-05	厦门宝太生物科技股份有限公司	腺苷受体拮抗剂
EP4512427A1 (en) *	2023-08-25	2025-02-26	Mablink Bioscience	Antibody-drug conjugates based on molecular glue degraders and uses thereof
EP4512806A1 (en) *	2023-08-25	2025-02-26	Mablink Bioscience	Molecular glue degraders and uses thereof
CN119707984A (zh) *	2023-09-28	2025-03-28	中国科学院上海药物研究所	吡唑并三嗪及吡唑并嘧啶衍生物、其制备方法、药物组合物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6627633B2 (en) *	1999-03-17	2003-09-30	Albany Molecular Research, Inc.	6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
EP1345941A1 (fr)	2000-12-20	2003-09-24	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Inhibiteurs de kinases dependantes des cylines (cdk) et de la glycogene synthase kinase-3 (gsk-3)
US6812232B2 (en)	2001-09-11	2004-11-02	Amr Technology, Inc.	Heterocycle substituted purine derivatives as potent antiproliferative agents
FR2842809A1 (fr)	2002-07-26	2004-01-30	Greenpharma Sas	NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
AR047969A1 (es) *	2004-02-25	2006-03-15	Schering Corp	Pirazolotriazinas como inhibidores de quinasa

2009
- 2009-03-11 FR FR0951521A patent/FR2943058B1/fr not_active Expired - Fee Related
2010
- 2010-03-11 EP EP10710681.7A patent/EP2406263B1/fr active Active
- 2010-03-11 CA CA2753135A patent/CA2753135A1/fr not_active Abandoned
- 2010-03-11 DK DK10710681.7T patent/DK2406263T3/da active
- 2010-03-11 US US13/203,427 patent/US8691982B2/en active Active
- 2010-03-11 JP JP2011553591A patent/JP2012520288A/ja active Pending
- 2010-03-11 WO PCT/IB2010/051063 patent/WO2010103486A1/fr not_active Ceased
- 2010-03-11 ES ES10710681.7T patent/ES2440323T3/es active Active

Also Published As

Publication number	Publication date
WO2010103486A1 (fr)	2010-09-16
FR2943058A1 (fr)	2010-09-17
EP2406263A1 (fr)	2012-01-18
US8691982B2 (en)	2014-04-08
EP2406263B1 (fr)	2013-09-25
CA2753135A1 (fr)	2010-09-16
FR2943058B1 (fr)	2011-06-03
US20120184557A1 (en)	2012-07-19
ES2440323T3 (es)	2014-01-28
JP2012520288A (ja)	2012-09-06

Publication	Publication Date	Title
DK2406263T3 (da)	2014-01-13	Pyrazolo[1,5-a]-1,3,5-triazinderivater, deres fremstilling samt deres terapeutiske anvendelse
IL249651A0 (en)	2017-02-28	Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[b-2,1] 4,2,1]]triazin-2-yl]benzamide and processes related to their preparation
IL223253B (en)	2018-02-28	2-(piperidin-2-yl)-pyrazolo[1,5-a]pyrimidine derivatives and their use for preparing anti-pneumovirinae medicaments
ZA201000075B (en)	2010-09-29	Purin derivatives for use in the treatment of fab-related diseases
IL210802A0 (en)	2011-04-28	Purin derivatives for use in the treatment of fab-related diseases
PT3001903T (pt)	2017-12-18	1h-pirazolo[3,4-b]piridinas e usos terapêuticos destas
BRPI0908225A2 (pt)	2016-11-01	derivados de piridazina e seu uso como agentes terapêuticos
PT2935274T (pt)	2018-12-05	Derivados de 3-oxo-2,3,5,8-tetrahidro-[1,2,4]triazolo[4,3- a]pirimidina para o tratamento de doenças respiratórias
IL209840A0 (en)	2011-02-28	Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors
DK2146991T3 (da)	2010-11-22	Triazolopyridin-carboxamid-derivater, fremstilling af samme samt terapeutisk anvendelse deraf
BR112013022948A2 (pt)	2016-12-06	derivados de pirido [2,3 - b] pirazina e seus usos terapêuticos
PT2448940E (pt)	2014-09-03	Derivados de 6,7,8,9-tetra-hidro-pirimido{1,2-α} pirimidin- 4-ona, sua preparação e sua utilização farmacêutica
IL233808B (en)	2018-03-29	History of triazole[5,4-d]pyrimidine and drugs containing them
PT2448939T (pt)	2017-06-12	Derivados de 2,3-dihidro-1h-imidazo{1,2-a}pirimidin-5-ona, sua preparação e sua utilização farmacêutica
IL215286A0 (en)	2011-11-30	9h-pyrrolo[2,3-b:5,4-c]dipridine azacarboline derivatives, preparation thereof, and therapeutic use thereof
BRPI0821992A2 (pt)	2015-06-23	Derivados de n-heterocíclico-imidazo[1,2-a]piridina-2-carboxamida s, respectivo preparo e respectiva aplicação em terapêutica
IL198481A0 (en)	2010-02-17	Pyrrole derivatives, preparation use of the same in therapy
IL220448A (en)	2015-04-30	Pyridine [3,2 - d] Pyrimidine - 7 (8h) - Their medical uses and uses
IL219116A (en)	2016-05-31	5h– oxo- (Theo / oxa) Zulu [a – 2,3] ortho-compressed pyrimidine with other rings and their use for treating anemia and tissue damage caused by ischemic diseases
IL197500A0 (en)	2009-12-24	Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof
IL206669A0 (en)	2010-12-30	6-HETEROCYCLIC IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
IL215733A0 (en)	2012-01-31	1-pyrazolo[4,3-c]isoquinoline derivatives, preparation thereof and therapeutic use thereof
ZA201100251B (en)	2012-04-25	Substituted 1-benzyl-cinnolin-4(1h)-one derivatives,preparation thereof,and therapeutic use thereof
PL2477990T3 (pl)	2015-02-27	Pochodne 5-fenylopirazolopirydyny, ich wytwarzanie oraz ich zastosowanie terapeutyczne
IL206672A0 (en)	2010-12-30	N-HETEROCYCLIC-6-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF