DK2408922T3 - Thraustochytrider, fedtsyresammensætninger og fremgangsmåder til fremstilling og anvendelse deraf - Google Patents
Thraustochytrider, fedtsyresammensætninger og fremgangsmåder til fremstilling og anvendelse deraf Download PDFInfo
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- DK2408922T3 DK2408922T3 DK09841993.0T DK09841993T DK2408922T3 DK 2408922 T3 DK2408922 T3 DK 2408922T3 DK 09841993 T DK09841993 T DK 09841993T DK 2408922 T3 DK2408922 T3 DK 2408922T3
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
- C12N1/125—Unicellular algae isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/89—Algae ; Processes using algae
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Animal Husbandry (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Cosmetics (AREA)
Claims (21)
1. Mikrobiel olie, der omfatter en triglyceridfraktion på mindst 70 vægt-%, hvor docosahexaensyreindholdet i triglyceridfraktionen er mindst 40 vægt-%, hvor docosapentaensyre n-6-indholdet i triglyceridfraktionen er fra mindst 0,5 vægt-% til 6 vægt-%, og hvor a) docosahexaensyreindholdet i triglyceridfraktionen er mindst 50 vægt-%; eller b) forholdet mellem docosahexaensyre og docosapentaensyre n-6 er større end 6:1.
2. Mikrobiel olie ifølge krav 1, hvor docosahexaensyreindholdet i triglyceridfraktionen er mindst 50 vægt-%.
3. Mikrobiel olie ifølge krav 2, der yderligere omfatter et arachidonsyreindhold i triglyceridfraktionen på 1,5 vægt-% eller mindre.
4. Mikrobiel olie ifølge krav 1, hvor forholdet mellem docosahexaensyre og docosapentaensyre n-6 er større end 6:1.
5. Mikrobiel olie ifølge et hvilket som helst af kravene 1 til 4, hvor mindst 20 % af triglyceriderne i triglyceridfraktionen indeholder docosahexaensyre i to positioner i triglyceridet, der er udvalgt blandt hvilke som helst to af sn-1-, sn-2- og sn-3-positionerne.
6. Mikrobiel olie ifølge et hvilket som helst af kravene 1 til 4, hvor mindst 5 % af triglyceriderne i triglyceridfraktionen indeholder docosahexaensyre i alle tre af sn-1-, sn-2- og sn-3-positionerne i triglyceridet.
7. Mikrobiel olie ifølge et hvilket som helst af kravene 1 til 4, der yderligere omfatter 5 vægt-% eller mindre af heptadecansyre.
8. Mikrobiel olie ifølge et hvilket som helst af kravene 1 til 7, der yderligere omfatter 10 vægt-% eller mindre af eicosapentaensyre.
9. Mikrobiel olie ifølge et hvilket som helst af kravene 1 til 8, hvor olien er en råolie ekstraheret fra en biomasse af en mikroorganisme uden yderligere forarbejdning eller en raffineret olie opnået ved behandling af en rå mikrobiel olie med yderligere forabejdningstrin udvalgt blandt raffinering, blegning og/eller desodorisering.
10. Mikrobiel olie ifølge et hvilket som helst af kravene 1 til 9, hvor olien er en thraustochytrid-olie.
11. Fødevare, kosmetisk produkt eller farmaceutisk sammensætning til dyr eller mennesker, der omfatter en mikrobiel olie ifølge et hvilket som helst af kravene 1 til 10 .
12. Fødevare ifølge krav 11, hvor fødevaren er en modermælkserstatning.
13. Fødevare ifølge krav 12, hvor modermælkserstatningen er egnet til præmature børn.
14. Modermælkserstatning, der omfatter olien ifølge et hvilket som helst af kravene 1 til 10 i kombination med en fysisk raffineret olie, der stammer fra en arachidonsyreproducerende mikroorganisme.
15. Modermælkserstatning ifølge krav 14, hvor mikroorganismen er Mortierella alpina eller Mortierella sect, schmuckeri.
16. Modermælkserstatning tilsat olien ifølge et hvilket som helst af kravene 1 til 10 i kombination med en olie, der er rig på arachidonsyre.
17. Fødevare ifølge krav 11, hvor fødevaren er mælk, en drikkevare, en terapeutisk drik, en næringsdrik eller en kombination deraf.
18. Fødevare ifølge krav 11, hvor fødevaren er et additiv til dyre- eller menneskeføde.
19. Fødevare ifølge krav 11, hvor fødevaren er et ernæringstilskud.
20. Fødevare ifølge krav 11, hvor fødevaren er et dyrefoder.
21. Dyrefoder ifølge krav 20, hvor dyrefoderet er et akvakulturfoder, eller hvor dyrefoderet er et husdyrsfoder, et zoologisk dyrefoder, et trækdyrsfoder, et foder til en husdyrsbesætning eller en kombination deraf.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2009/001720 WO2010107415A1 (en) | 2009-03-19 | 2009-03-19 | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2408922T3 true DK2408922T3 (da) | 2016-12-05 |
Family
ID=42739887
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18198460.0T DK3530740T3 (da) | 2009-03-19 | 2009-03-19 | Thraustochytrider, fedtsyresammensætninger og fremgangsmåder til fremstilling deraf og anvendelser deraf |
| DK16180878T DK3196309T3 (da) | 2009-03-19 | 2009-03-19 | Thraustochytrider, fedtsyresammensætninger og fremgangsmåder til fremstilling og anvendelse deraf |
| DK09841993.0T DK2408922T3 (da) | 2009-03-19 | 2009-03-19 | Thraustochytrider, fedtsyresammensætninger og fremgangsmåder til fremstilling og anvendelse deraf |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18198460.0T DK3530740T3 (da) | 2009-03-19 | 2009-03-19 | Thraustochytrider, fedtsyresammensætninger og fremgangsmåder til fremstilling deraf og anvendelser deraf |
| DK16180878T DK3196309T3 (da) | 2009-03-19 | 2009-03-19 | Thraustochytrider, fedtsyresammensætninger og fremgangsmåder til fremstilling og anvendelse deraf |
Country Status (17)
| Country | Link |
|---|---|
| EP (6) | EP4183883A1 (da) |
| JP (1) | JP5762393B2 (da) |
| KR (1) | KR101861375B1 (da) |
| CN (2) | CN102428185B (da) |
| AU (2) | AU2009342676B2 (da) |
| BR (1) | BRPI0923968B1 (da) |
| CA (1) | CA2754952C (da) |
| DK (3) | DK3530740T3 (da) |
| EA (1) | EA030161B1 (da) |
| ES (3) | ES2757878T3 (da) |
| IL (1) | IL215141A0 (da) |
| MX (2) | MX356532B (da) |
| NZ (3) | NZ703725A (da) |
| PL (1) | PL2408922T3 (da) |
| SG (1) | SG174383A1 (da) |
| WO (1) | WO2010107415A1 (da) |
| ZA (1) | ZA201107517B (da) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ703725A (en) | 2009-03-19 | 2017-06-30 | Dsm Ip Assets Bv | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| WO2011090493A1 (en) | 2010-01-19 | 2011-07-28 | Martek Biosciences Corporation | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| CN103124791B (zh) | 2010-06-01 | 2016-08-24 | 帝斯曼知识产权资产管理有限公司 | 从细胞中提取脂质以及由此获得的产品 |
| HK1198515A1 (en) * | 2011-07-21 | 2015-05-15 | Dsm Ip Assets B.V. | Fatty acid compositions |
| CN104011217B (zh) * | 2011-07-21 | 2018-09-04 | 帝斯曼知识产权资产管理有限公司 | 生产二十碳五烯酸的微生物、脂肪酸组合物及其制作方法与用途 |
| KR102416853B1 (ko) | 2013-12-20 | 2022-07-05 | 마라 리뉴어블즈 코퍼레이션 | 미생물로부터 오일을 회수하는 방법 |
| WO2015095693A2 (en) | 2013-12-20 | 2015-06-25 | Dsm Ip Assets B.V. | Processes for obtaining microbial oil from microbial cells |
| AU2014369042B2 (en) | 2013-12-20 | 2020-04-30 | Dsm Ip Assets B.V. | Processes for obtaining microbial oil from microbial cells |
| NZ721409A (en) | 2013-12-20 | 2022-10-28 | Dsm Ip Assets Bv | Processes for obtaining microbial oil from microbial cells |
| PL3082793T3 (pl) | 2013-12-20 | 2020-10-05 | Dsm Ip Assets B.V. | Sposoby otrzymywania oleju drobnoustrojowego z komórek drobnoustrojowych |
| SG11201605043TA (en) | 2013-12-20 | 2016-07-28 | Dsm Ip Assets Bv | Processes for obtaining microbial oil from microbial cells |
| CN103725617A (zh) * | 2014-01-01 | 2014-04-16 | 北京大学深圳研究生院 | 一株富含甘油酯型DHA的破囊壶菌Aurantiochytrium sp.及其应用 |
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| CN104206864A (zh) * | 2014-08-28 | 2014-12-17 | 青岛海智源生命科技有限公司 | 一种富含二十二碳六烯酸的饲料 |
| JP2018504887A (ja) * | 2014-12-12 | 2018-02-22 | ディーエスエム アイピー アセッツ ビー．ブイ． | 水産養殖試料における使用のための試料添加材料 |
| FR3038913B1 (fr) * | 2015-07-17 | 2020-05-01 | Fermentalg | Biomasse de thraustochytrides, procede de culture et utilisations |
| FR3038914B1 (fr) * | 2015-07-17 | 2020-03-13 | Fermentalg | Biomasse de thraustochytrides, procede de culture et utilisations |
| WO2017131188A1 (ja) * | 2016-01-28 | 2017-08-03 | 日本水産株式会社 | 高度不飽和脂肪酸を含む油脂の製造方法 |
| US11419350B2 (en) | 2016-07-01 | 2022-08-23 | Corbion Biotech, Inc. | Feed ingredients comprising lysed microbial cells |
| GB201718423D0 (en) * | 2017-11-07 | 2017-12-20 | Polglase Jane Lesley | Microorganism |
| FR3085825B1 (fr) | 2018-09-14 | 2021-07-16 | Fermentalg | Huile de microorganismes riche en acide docosahexaenoique |
| FR3085962B1 (fr) | 2018-09-14 | 2021-06-18 | Fermentalg | Procede d'extracton d'une huile riche en pufa |
| CN119498443A (zh) | 2019-01-03 | 2025-02-25 | 柯碧恩生物技术公司 | 制造裂解细胞悬浮液的方法 |
| KR20220163979A (ko) | 2020-04-03 | 2022-12-12 | 마라 리뉴어블즈 코퍼레이션 | 높은 수준의 오메가-3 지방산을 갖는 미생물 오일 |
| FR3111912B1 (fr) | 2020-06-24 | 2025-10-03 | Fermentalg | Procédé de culture de microorganismes pour l’accumulation de lipides |
| SE2151489A1 (en) * | 2021-12-07 | 2023-06-08 | Mycorena Ab | A food product or food ingredient comprising fungi biomass with an increased intracellular fat content |
| CN115976123B (zh) * | 2022-12-28 | 2025-09-09 | 湖北欣和生物科技有限公司 | 一种高山被孢霉诱变菌发酵生产的Sn-2位ARA油脂及其制备方法 |
| CN116479063B (zh) * | 2023-05-04 | 2024-02-20 | 厦门汇盛生物有限公司 | 一种ω-3多不饱和脂肪酸的生产方法 |
| CN119285728B (zh) * | 2024-10-09 | 2025-10-31 | 西安惠普生物科技有限公司 | 具有修复功效的多肽及其应用 |
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| CA2659272C (en) * | 2006-07-28 | 2015-06-16 | Bioriginal Food & Science Corporation | Fat containing composition |
| CN101981201A (zh) | 2006-08-01 | 2011-02-23 | 加拿大海洋营养食品有限公司 | 产油微生物及改良这些微生物的方法 |
| WO2008049512A1 (en) * | 2006-10-27 | 2008-05-02 | Lonza Ag | Production of omega-3 fatty acids in microflora of thraustochytriales using modified media |
| CL2008002020A1 (es) | 2007-07-12 | 2008-11-14 | Ocean Nutrition Canada Ltd | Metodo de modificacion de un aceite, que comprende hidrolizar gliceridos con una solucion de lipasa thermomyces lanuginosus, separar la fraccion de acido graso saturado de la fraccion de glicerido hidrolizado y esterificar los gliceridos hidrolizados en la presencia de candida antarctica lipasa b; y composicion de aceite. |
| TWI337229B (en) | 2007-08-27 | 2011-02-11 | Htc Corp | Portable electronic apparatus with dual hinges |
| NZ703725A (en) | 2009-03-19 | 2017-06-30 | Dsm Ip Assets Bv | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
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