DK2421852T3 - Heteroaromatiske og aromatiske piperazinylazetidinylamider som monoacylglycerollipaseinhibitor - Google Patents
Heteroaromatiske og aromatiske piperazinylazetidinylamider som monoacylglycerollipaseinhibitorInfo
- Publication number
- DK2421852T3 DK2421852T3 DK10719479.7T DK10719479T DK2421852T3 DK 2421852 T3 DK2421852 T3 DK 2421852T3 DK 10719479 T DK10719479 T DK 10719479T DK 2421852 T3 DK2421852 T3 DK 2421852T3
- Authority
- DK
- Denmark
- Prior art keywords
- piperazinylazetidinylamides
- monoacylgyleric
- heteroaromatic
- aromatic
- lipase inhibitor
- Prior art date
Links
- 229940086609 Lipase inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17166009P | 2009-04-22 | 2009-04-22 | |
| PCT/US2010/032098 WO2010124121A1 (en) | 2009-04-22 | 2010-04-22 | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2421852T3 true DK2421852T3 (da) | 2014-08-18 |
Family
ID=42224827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10719479.7T DK2421852T3 (da) | 2009-04-22 | 2010-04-22 | Heteroaromatiske og aromatiske piperazinylazetidinylamider som monoacylglycerollipaseinhibitor |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8815839B2 (da) |
| EP (1) | EP2421852B9 (da) |
| JP (1) | JP2012524809A (da) |
| KR (1) | KR20120014154A (da) |
| CN (1) | CN102548983B (da) |
| AR (1) | AR076375A1 (da) |
| AU (1) | AU2010238745A1 (da) |
| BR (1) | BRPI1014888A2 (da) |
| CA (1) | CA2759714A1 (da) |
| DK (1) | DK2421852T3 (da) |
| ES (1) | ES2486674T3 (da) |
| IL (1) | IL215796A (da) |
| PT (1) | PT2421852E (da) |
| RU (1) | RU2558141C2 (da) |
| TW (1) | TWI495637B (da) |
| WO (1) | WO2010124121A1 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010239188B2 (en) | 2009-04-22 | 2016-03-31 | Janssen Pharmaceutica Nv | Azetidinyl diamides as monoacylglycerol lipase inhibitors |
| KR20130101040A (ko) | 2010-09-03 | 2013-09-12 | 얀센 파마슈티카 엔.브이. | 모노아실글리세롤 리파아제 억제제로서의 다이-아제티디닐 다이아미드 |
| EP2621918A1 (en) * | 2010-09-27 | 2013-08-07 | Janssen Pharmaceutica, N.V. | Oxopiperazine-azetidine amides and oxodiazepine-azetidine amides as monoacylglycerol lipase inhibitors |
| US8513423B2 (en) | 2010-10-22 | 2013-08-20 | Janssen Pharmaceutica, Nv | Piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors |
| KR20130140020A (ko) | 2010-10-22 | 2013-12-23 | 얀센 파마슈티카 엔.브이. | 모노아실글리세롤 리파아제 억제제로서의 아미노-피롤리딘-아제티딘 다이아미드 |
| US9624170B2 (en) | 2013-12-26 | 2017-04-18 | Takeda Pharmaceutical Company Limited | 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (MAGL) inhibitors |
| NZ726874A (en) * | 2014-05-19 | 2018-03-23 | Merial Inc | Anthelmintic compounds |
| US10106556B2 (en) | 2015-03-30 | 2018-10-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP3331536A4 (en) * | 2015-08-03 | 2019-03-27 | The Regents of The University of California | COMPOSITIONS AND METHODS OF MODULATING THE ABHD2 ACTIVITY |
| US10463753B2 (en) | 2016-02-19 | 2019-11-05 | Lundbeck La Jolla Research Center, Inc. | Radiolabeled monoacylglycerol lipase occupancy probe |
| WO2017170830A1 (ja) | 2016-03-31 | 2017-10-05 | 武田薬品工業株式会社 | 複素環化合物 |
| UY37174A (es) | 2016-03-31 | 2017-10-31 | Takeda Pharmaceuticals Co | Un compuesto heterocíclico que tiene una acción inhibidora de monoacilglicerol lipasa |
| AU2018338855B2 (en) | 2017-09-29 | 2022-04-28 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2020104494A1 (en) | 2018-11-22 | 2020-05-28 | F. Hoffmann-La Roche Ag | New heterocyclic compounds |
| JP7575952B2 (ja) * | 2019-01-08 | 2024-10-30 | 杏林製薬株式会社 | １５－ｐｇｄｈ阻害薬 |
| WO2020160151A1 (en) | 2019-01-31 | 2020-08-06 | Kyorin Pharmaceutical Co., Ltd. | 15-pgdh inhibitors |
| IL313987A (en) | 2021-12-29 | 2024-08-01 | Psy Therapeutics Inc | Inhibiting monoacylglycerol lipase (magl) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| CA2509406C (en) * | 2002-12-23 | 2012-07-03 | Janssen Pharmaceutica N.V. | Substituted 1-piperidin-4-yl-4-azetidin-3-yl-piperazine derivatives and their use as neurokinin antagonists |
| EP1702916A1 (en) * | 2005-03-18 | 2006-09-20 | Santhera Pharmaceuticals (Schweiz) GmbH | DPP-IV inhibitors |
| FR2915199B1 (fr) * | 2007-04-18 | 2010-01-22 | Sanofi Aventis | Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique. |
| US8257698B2 (en) * | 2008-04-25 | 2012-09-04 | Janssen Pharmaceutica N.V. | Protein engineering of monoacylglycerol lipase (MGLL) |
| US8080400B2 (en) * | 2008-04-25 | 2011-12-20 | Janssen Pharmaceutica N.V. | Crystal structure of monoacylglycerol lipase (MGLL) |
| EP2180048B1 (en) * | 2008-10-09 | 2014-12-17 | Janssen Pharmaceutica N.V. | Alternative crystal form of monoacylglycerol lipase (MGLL) |
| US8435977B2 (en) * | 2009-04-22 | 2013-05-07 | Janssen Pharmaceutica, Nv | Heteroaromatic and aromatic piperazinyl azetidinyl amides as monoacylglycerol lipase inhibitors |
-
2010
- 2010-04-22 RU RU2011147203/04A patent/RU2558141C2/ru not_active IP Right Cessation
- 2010-04-22 JP JP2012507394A patent/JP2012524809A/ja active Pending
- 2010-04-22 ES ES10719479.7T patent/ES2486674T3/es active Active
- 2010-04-22 CA CA2759714A patent/CA2759714A1/en not_active Abandoned
- 2010-04-22 AU AU2010238745A patent/AU2010238745A1/en not_active Abandoned
- 2010-04-22 BR BRPI1014888A patent/BRPI1014888A2/pt not_active IP Right Cessation
- 2010-04-22 AR ARP100101336A patent/AR076375A1/es not_active Application Discontinuation
- 2010-04-22 DK DK10719479.7T patent/DK2421852T3/da active
- 2010-04-22 TW TW099112744A patent/TWI495637B/zh not_active IP Right Cessation
- 2010-04-22 PT PT107194797T patent/PT2421852E/pt unknown
- 2010-04-22 WO PCT/US2010/032098 patent/WO2010124121A1/en not_active Ceased
- 2010-04-22 KR KR1020117027425A patent/KR20120014154A/ko not_active Ceased
- 2010-04-22 EP EP10719479.7A patent/EP2421852B9/en active Active
- 2010-04-22 CN CN201080028748.2A patent/CN102548983B/zh not_active Expired - Fee Related
-
2011
- 2011-10-23 IL IL215796A patent/IL215796A/en not_active IP Right Cessation
-
2013
- 2013-03-04 US US13/784,036 patent/US8815839B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010124121A8 (en) | 2012-03-08 |
| EP2421852A1 (en) | 2012-02-29 |
| PT2421852E (pt) | 2014-07-31 |
| CA2759714A1 (en) | 2010-10-28 |
| WO2010124121A1 (en) | 2010-10-28 |
| TW201103917A (en) | 2011-02-01 |
| HK1170239A1 (en) | 2013-02-22 |
| HK1166794A1 (en) | 2012-11-09 |
| US20130184251A1 (en) | 2013-07-18 |
| CN102548983A (zh) | 2012-07-04 |
| KR20120014154A (ko) | 2012-02-16 |
| EP2421852B9 (en) | 2015-07-01 |
| BRPI1014888A2 (pt) | 2019-09-24 |
| IL215796A (en) | 2015-04-30 |
| US8815839B2 (en) | 2014-08-26 |
| RU2011147203A (ru) | 2013-05-27 |
| ES2486674T3 (es) | 2014-08-19 |
| AR076375A1 (es) | 2011-06-08 |
| RU2558141C2 (ru) | 2015-07-27 |
| CN102548983B (zh) | 2014-09-17 |
| AU2010238745A1 (en) | 2011-11-10 |
| EP2421852B1 (en) | 2014-05-21 |
| JP2012524809A (ja) | 2012-10-18 |
| TWI495637B (zh) | 2015-08-11 |
| IL215796A0 (en) | 2012-01-31 |
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