DK3560498T3 - Kombination, der omfatter en mek-hæmmer og en b-raf-hæmmer - Google Patents

Kombination, der omfatter en mek-hæmmer og en b-raf-hæmmer Download PDF

Info

Publication number: DK3560498T3
Authority: DK; Denmark
Prior art keywords: inhibitor; combination; raf; mek; mek inhibitor
Prior art date: 2009-10-16

Application number

DK19174594.2T

Other languages

English (en)

Inventor

Melissa Dumble

Rakesh Kumar

Sylvie Laquerre

Peter Lebowitz

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-10-16

Filing date

2010-10-15

Publication date

2022-11-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43876568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3560498(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-10-15 Application filed by Novartis Ag filed Critical Novartis Ag

2022-11-14 Application granted granted Critical

2022-11-14 Publication of DK3560498T3 publication Critical patent/DK3560498T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

DK19174594.2T 2009-10-16 2010-10-15 Kombination, der omfatter en mek-hæmmer og en b-raf-hæmmer DK3560498T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25221309P	2009-10-16	2009-10-16
EP10824148.0A EP2488033B1 (en)	2009-10-16	2010-10-15	Combination comprising an MEK inhibitor and a B-raf inhibitor

Publications (1)

Publication Number	Publication Date
DK3560498T3 true DK3560498T3 (da)	2022-11-14

Family

ID=43876568

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
DK19174594.2T DK3560498T3 (da)	2009-10-16	2010-10-15	Kombination, der omfatter en mek-hæmmer og en b-raf-hæmmer
DK10824148.0T DK2488033T3 (da)	2009-10-16	2010-10-15	Kombination, der omfatter en MEK-hæmmer og en B-raf-hæmmer
DK24175377.1T DK4397376T3 (da)	2009-10-16	2010-10-15	Kombination der omfatter en mek-hæmmer og en b-raf-hæmmer
DK22189749.9T DK4159217T3 (da)	2009-10-16	2010-10-15	Kombination, der omfatter en mek-hæmmer og en b-raf-hæmmer

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
DK10824148.0T DK2488033T3 (da)	2009-10-16	2010-10-15	Kombination, der omfatter en MEK-hæmmer og en B-raf-hæmmer
DK24175377.1T DK4397376T3 (da)	2009-10-16	2010-10-15	Kombination der omfatter en mek-hæmmer og en b-raf-hæmmer
DK22189749.9T DK4159217T3 (da)	2009-10-16	2010-10-15	Kombination, der omfatter en mek-hæmmer og en b-raf-hæmmer

Country Status (35)

Country	Link
US (3)	US8703781B2 (da)
EP (5)	EP2488033B1 (da)
JP (1)	JP5718929B2 (da)
KR (1)	KR101729116B1 (da)
CN (1)	CN102655753B (da)
AU (1)	AU2010306653B2 (da)
BR (1)	BR112012008854B8 (da)
CA (1)	CA2775803C (da)
CL (1)	CL2012000964A1 (da)
CO (1)	CO6531498A2 (da)
CR (1)	CR20120155A (da)
CY (1)	CY1122013T1 (da)
DK (4)	DK3560498T3 (da)
DO (1)	DOP2012000091A (da)
EA (1)	EA020589B1 (da)
ES (4)	ES2745479T3 (da)
FI (2)	FI4159217T3 (da)
HR (3)	HRP20191617T1 (da)
HU (3)	HUE067723T2 (da)
IL (1)	IL219073A (da)
LT (4)	LT2488033T (da)
MA (1)	MA33746B1 (da)
ME (1)	ME03497B (da)
MX (1)	MX2012004413A (da)
MY (1)	MY174759A (da)
NZ (1)	NZ598913A (da)
PE (1)	PE20121093A1 (da)
PH (1)	PH12012500742A1 (da)
PL (4)	PL3560498T3 (da)
PT (4)	PT4159217T (da)
RS (4)	RS63702B1 (da)
SI (3)	SI4397376T1 (da)
UA (1)	UA105064C2 (da)
WO (1)	WO2011047238A1 (da)
ZA (1)	ZA201202612B (da)

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EP2791170A1 (en)	2011-12-16	2014-10-22	Synthon Biopharmaceuticals B.V.	Compounds and methods for treating inflammatory diseases
RU2014122867A (ru) *	2011-12-22	2016-02-20	ГЛАКСОСМИТКЛАЙН ЭлЭлСи	Способ лечения рака иммунотерапевтическим средством, специфичным в отношении MAGEA3, совместно с ингибитором BRAF и/или ингибитором MEK
CA2868954A1 (en) *	2012-03-30	2013-10-03	Takeda Pharmaceutical Company Limited	Administration of a raf inhibitor and a mek inhibitor in the treatment of melanoma
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WO2014066606A2 (en) *	2012-10-25	2014-05-01	Glaxosmithkline Llc	Combination
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CA3042697A1 (en) *	2016-11-03	2018-05-11	The Regents Of The University Of Michigan	Small molecule dual inhibitors of egfr/pi3k and uses thereof
JP2022504905A (ja)	2018-10-16	2022-01-13	ノバルティスアーゲー	標的化療法に対する応答を予測するためのバイオマーカーとしての単独の又は免疫マーカーと組み合わせた腫瘍突然変異負荷
EA202192575A1 (ru)	2019-03-21	2022-01-14	Онксео	Соединения dbait в сочетании с ингибиторами киназ для лечения рака
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2010
- 2010-10-15 HU HUE22189749A patent/HUE067723T2/hu unknown
- 2010-10-15 DK DK19174594.2T patent/DK3560498T3/da active
- 2010-10-15 BR BR112012008854A patent/BR112012008854B8/pt active IP Right Grant
- 2010-10-15 US US13/499,779 patent/US8703781B2/en active Active
- 2010-10-15 EP EP10824148.0A patent/EP2488033B1/en active Active
- 2010-10-15 PL PL19174594.2T patent/PL3560498T3/pl unknown
- 2010-10-15 EP EP24175377.1A patent/EP4397376B1/en active Active
- 2010-10-15 RS RS20220984A patent/RS63702B1/sr unknown
- 2010-10-15 LT LTEP10824148.0T patent/LT2488033T/lt unknown
- 2010-10-15 DK DK10824148.0T patent/DK2488033T3/da active
- 2010-10-15 WO PCT/US2010/052808 patent/WO2011047238A1/en not_active Ceased
- 2010-10-15 UA UAA201204675A patent/UA105064C2/uk unknown
- 2010-10-15 ME MEP-2019-236A patent/ME03497B/me unknown
- 2010-10-15 FI FIEP22189749.9T patent/FI4159217T3/fi active
- 2010-10-15 LT LTEP22189749.9T patent/LT4159217T/lt unknown
- 2010-10-15 EA EA201290149A patent/EA020589B1/ru not_active IP Right Cessation
- 2010-10-15 RS RSP20191095 patent/RS59181B1/sr unknown
- 2010-10-15 SI SI201032168T patent/SI4397376T1/sl unknown
- 2010-10-15 DK DK24175377.1T patent/DK4397376T3/da active
- 2010-10-15 PT PT221897499T patent/PT4159217T/pt unknown
- 2010-10-15 RS RS20240873A patent/RS65800B1/sr unknown
- 2010-10-15 PH PH1/2012/500742A patent/PH12012500742A1/en unknown
- 2010-10-15 ES ES10824148T patent/ES2745479T3/es active Active
- 2010-10-15 PL PL10824148T patent/PL2488033T3/pl unknown
- 2010-10-15 PT PT191745942T patent/PT3560498T/pt unknown
- 2010-10-15 EP EP22189749.9A patent/EP4159217B1/en not_active Revoked
- 2010-10-15 MX MX2012004413A patent/MX2012004413A/es active IP Right Grant
- 2010-10-15 MY MYPI2012001680A patent/MY174759A/en unknown
- 2010-10-15 HR HRP20191617 patent/HRP20191617T1/hr unknown
- 2010-10-15 PL PL22189749.9T patent/PL4159217T3/pl unknown
- 2010-10-15 RS RS20260205A patent/RS67767B1/sr unknown
- 2010-10-15 NZ NZ598913A patent/NZ598913A/xx unknown
- 2010-10-15 AU AU2010306653A patent/AU2010306653B2/en active Active
- 2010-10-15 EP EP25216764.8A patent/EP4706770A2/en active Pending
- 2010-10-15 ES ES19174594T patent/ES2930157T3/es active Active
- 2010-10-15 HR HRP20260236TT patent/HRP20260236T1/hr unknown
- 2010-10-15 SI SI201031933T patent/SI2488033T1/sl unknown
- 2010-10-15 HU HUE19174594A patent/HUE060206T2/hu unknown
- 2010-10-15 LT LTEP24175377.1T patent/LT4397376T/lt unknown
- 2010-10-15 KR KR1020127012649A patent/KR101729116B1/ko active Active
- 2010-10-15 PT PT241753771T patent/PT4397376T/pt unknown
- 2010-10-15 PE PE2012000502A patent/PE20121093A1/es active IP Right Grant
- 2010-10-15 FI FIEP24175377.1T patent/FI4397376T3/fi active
- 2010-10-15 LT LTEP19174594.2T patent/LT3560498T/lt unknown
- 2010-10-15 ES ES22189749T patent/ES2986037T3/es active Active
- 2010-10-15 PL PL24175377.1T patent/PL4397376T3/pl unknown
- 2010-10-15 EP EP19174594.2A patent/EP3560498B1/en not_active Revoked
- 2010-10-15 SI SI201032148T patent/SI4159217T1/sl unknown
- 2010-10-15 ES ES24175377T patent/ES3063926T3/es active Active
- 2010-10-15 CA CA2775803A patent/CA2775803C/en active Active
- 2010-10-15 PT PT10824148T patent/PT2488033T/pt unknown
- 2010-10-15 DK DK22189749.9T patent/DK4159217T3/da active
- 2010-10-15 JP JP2012534386A patent/JP5718929B2/ja active Active
- 2010-10-15 HR HRP20221304TT patent/HRP20221304T1/hr unknown
- 2010-10-15 CN CN201080046640.6A patent/CN102655753B/zh active Active
- 2010-10-15 HU HUE10824148A patent/HUE046139T2/hu unknown
2012
- 2012-03-27 CR CR20120155A patent/CR20120155A/es unknown
- 2012-04-03 DO DO2012000091A patent/DOP2012000091A/es unknown
- 2012-04-05 IL IL219073A patent/IL219073A/en active IP Right Grant
- 2012-04-11 ZA ZA2012/02612A patent/ZA201202612B/en unknown
- 2012-04-16 CL CL2012000964A patent/CL2012000964A1/es unknown
- 2012-04-27 CO CO12069732A patent/CO6531498A2/es active IP Right Grant
- 2012-05-11 MA MA34863A patent/MA33746B1/fr unknown
2014
- 2014-03-05 US US14/197,421 patent/US8952018B2/en active Active
- 2014-12-22 US US14/578,804 patent/US20150111904A1/en not_active Abandoned
2019
- 2019-09-09 CY CY20191100943T patent/CY1122013T1/el unknown

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IL219073A0 (en)	2012-06-28
DK2488033T3 (da)	2019-09-02
BR112012008854A2 (pt)	2015-09-22
JP2013508294A (ja)	2013-03-07
PE20121093A1 (es)	2012-09-04
EP2488033A4 (en)	2014-04-30
EP4397376B1 (en)	2025-11-26
KR101729116B1 (ko)	2017-05-02
PL2488033T3 (pl)	2019-12-31
CY1122013T1 (el)	2020-10-14
MX2012004413A (es)	2012-05-08
KR101729116B9 (ko)	2026-02-05
CR20120155A (es)	2012-07-05
CN102655753A (zh)	2012-09-05
PT4159217T (pt)	2024-08-12
KR20120104547A (ko)	2012-09-21
LT4159217T (lt)	2024-08-26
HUE046139T2 (hu)	2020-02-28
PH12012500742A1 (en)	2015-12-11
US20150111904A1 (en)	2015-04-23
AU2010306653A1 (en)	2012-05-10
EP4159217B1 (en)	2024-05-22
CN102655753B (zh)	2015-11-25
LT3560498T (lt)	2022-11-25
EA020589B1 (ru)	2014-12-30
SI4159217T1 (sl)	2024-09-30
CL2012000964A1 (es)	2012-08-31
HRP20221304T1 (hr)	2022-12-23
ZA201202612B (en)	2013-09-25
PL3560498T3 (pl)	2022-12-12
UA105064C2 (uk)	2014-04-10
NZ598913A (en)	2013-11-29
US8703781B2 (en)	2014-04-22
EP2488033A1 (en)	2012-08-22
IL219073A (en)	2016-05-31
LT2488033T (lt)	2019-09-10
PT4397376T (pt)	2026-02-24
BR112012008854B8 (pt)	2021-05-25
EA201290149A1 (ru)	2012-11-30
RS67767B1 (sr)	2026-03-31
EP4397376A2 (en)	2024-07-10
PL4159217T3 (pl)	2024-09-30
EP4397376A3 (en)	2024-10-30
AU2010306653B2 (en)	2013-10-24
HUE067723T2 (hu)	2024-11-28
HUE060206T2 (hu)	2023-02-28
FI4159217T3 (fi)	2024-08-15
ES2930157T3 (es)	2022-12-07
MY174759A (en)	2020-05-13
CA2775803A1 (en)	2011-04-21
MA33746B1 (fr)	2012-11-01
ES3063926T3 (en)	2026-04-21
EP4159217A1 (en)	2023-04-05
RS65800B1 (sr)	2024-08-30
DK4159217T3 (da)	2024-08-12
PT2488033T (pt)	2019-09-10
US20120196879A1 (en)	2012-08-02
HRP20191617T1 (hr)	2019-12-13
US8952018B2 (en)	2015-02-10
HRP20260236T1 (hr)	2026-04-10
CO6531498A2 (es)	2012-09-28
EP3560498A1 (en)	2019-10-30
SI4397376T1 (sl)	2026-04-30
ES2745479T3 (es)	2020-03-02
DOP2012000091A (es)	2013-09-15
PL4397376T3 (pl)	2026-03-30
DK4397376T3 (da)	2026-02-23
RS59181B1 (sr)	2019-10-31
ES2986037T3 (es)	2024-11-08
RS63702B1 (sr)	2022-11-30
EP3560498B1 (en)	2022-08-17
LT4397376T (lt)	2026-03-10
WO2011047238A1 (en)	2011-04-21
FI4397376T3 (fi)	2026-02-24
EP2488033B1 (en)	2019-06-12
CA2775803C (en)	2017-11-21
ME03497B (me)	2020-04-20
PT3560498T (pt)	2022-11-03
BR112012008854B1 (pt)	2020-12-29
SI2488033T1 (sl)	2019-10-30
US20140187566A1 (en)	2014-07-03
JP5718929B2 (ja)	2015-05-13
EP4706770A2 (en)	2026-03-11

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