DK2444424T3 - Forbedrede nanolegemer (tm) til behandling af aggregeringsmedierede lidelser - Google Patents
Forbedrede nanolegemer (tm) til behandling af aggregeringsmedierede lidelser Download PDFInfo
- Publication number
- DK2444424T3 DK2444424T3 DK12151893.0T DK12151893T DK2444424T3 DK 2444424 T3 DK2444424 T3 DK 2444424T3 DK 12151893 T DK12151893 T DK 12151893T DK 2444424 T3 DK2444424 T3 DK 2444424T3
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- DK
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- Prior art keywords
- amino acid
- polypeptide
- seq
- sequence
- nanobody
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Surgery (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (15)
1. Protein eller polypeptid, som omfatter to VHH'er, humaniserede VHH-domæner eller kameliserede VH-domæner, hvor VHH'erne, de humaniserede VHH-domæner eller de kameliserede VH-domæner er rettet mod von Willebrands faktor (vWF), og VHH'erne, de humaniserede VHH-domæner eller de kameliserede VH-domæner består af 4 frameworkregioner (de respektive FRI til FR4) og 3 komplementaritetsbestemmende regioner (complementarity determining regions) (de respektive CDR1 til CDR3), hvor: i) CDR1 omfatter eller består af aminosyresekvensen YNPMG [SEQ ID NO: 22]; og hvor: ii) CDR2 omfatter eller består af en aminosyresekvens valgt fra gruppen bestående af:
2. Protein eller polypeptid ifølge krav 1, hvor: i) CDR1 består af aminosyresekvensen YNPMG [SEQ ID NO: 22]; og hvor: ii) CDR2 består af aminosyresekvensen AISRTGGSTYYPDSVEG [SEQ ID NO: 32]; og hvor: iii) CDR3 består af aminosyresekvensen AGVRAE DGRVRT L P S E Y T F [SEQ ID NO: 42] .
3. Protein eller polypeptid ifølge et hvilket som helst af kravene 1-2, hvor Vm/erne, de humaniserede VHH-domæner eller de kameliserede VH-domæner er VHH'er, humaniserede VHH-domæner eller kameliserede VH-domæner fra KERE-klassen.
4. Protein eller polypeptid ifølge et hvilket som helst af kravene 1-3, hvor VHH'erne, de humaniserede VHH-domæner eller de kameliserede VH-domæner er humaniserede varianter af VHH'erne, de humaniserede VHH-domæner eller de kameliserede VH-domæner.
5. Protein eller polypeptid ifølge et hvilket som helst af kravene 1-4, hvor VHH'erne, de humaniserede VHH-domæner eller de kameliserede VH-domæner, som er til stede i proteinet eller polypeptidet, er valgt fra gruppen bestående af VHH'erne, de humaniserede VHH-domæner eller de kameliserede VH-domæner 12B6 (SEQ ID NO: 62); 12A2 (SEQ ID NO: 71); 12F2 (SEQ ID NO: 72); 14H10 (SEQ ID NO: 73); 12B6H1 (SEQ ID NO: 86); 12B6H2 (SEQ ID NO: 87); 12B6H3 (SEQ ID NO: 88); 12B6H4 (SEQ ID NO: 89); 12A2H1 (SEQ ID NO: 90); 12A2H3 (SEQ ID NO: 91); 12A2H4 (SEQ ID NO: 92); 12A2H11 (SEQ ID NO: 93) og 12A2H13 (SEQ ID NO: 94).
6. Protein eller polypeptid ifølge et hvilket som helst af kravene 1-5, hvor VHH'erne, de humaniserede VHH-domæner eller de kameliserede VH-domæner, som er til stede i proteinet eller polypeptidet, består af VHH'et, det humaniserede VHH-domæne eller det kameliserede VH-domæne 12A2H1 (SEQ ID NO: 90).
7. Protein eller polypeptid ifølge et hvilket som helst af kravene 1-6, hvor de to VHH'er, humaniserede VHH-domæner eller kameliserede VH-domæner er direkte bundet til hinanden eller bundet til hinanden via en linker, hvilken linker fortrinsvis er en aminosyresekvens, hvilken linker mere fortrinsvis omfatter mellem 1 og 40 aminosyrerester, såsom mellem 2 og 30 aminosyrerester, fortrinsvis hvor linkeren omfatter eller i det væsentlige består af glycin- og serinrester; eller hvor linkeren omfatter eller i det væsentlige består af alaninrester.
8. Protein eller polypeptid valgt fra gruppen bestående af SEQ ID NO: 74-76, SEQ ID NO: 80-82 og SEQ ID NO: 98-106, fortrinsvis polypeptidet ifølge SEQ ID NO: 98.
9. Protein eller polypeptid, som består af SEQ ID NO: 98.
10. Nukleotidsekvens eller nukleinsyre, som koder for et protein eller polypeptid ifølge et hvilket som helst af de foregående krav.
11. Værtscelle, som omfatter en nukleotidsekvens eller nukleinsyre ifølge krav 10, eller som udtrykker eller er i stand til at udtrykke et protein eller polypeptid ifølge et hvilket som helst af kravene 1-9.
12. Fremgangsmåde til fremstilling af et protein eller polypeptid ifølge et hvilket som helst af kravene 1-9, hvilken fremgangsmåde omfatter dyrkning eller bibeholdelse af en værtscelle ifølge krav 11 under sådanne betingelser, at værtscellen fremstiller eller udtrykker et protein eller polypeptid ifølge et hvilket som helst af kravene 1-9; og hvilken fremgangsmåde eventuelt endvidere omfatter isolering af proteinet eller polypeptidet ifølge et hvilket som helst af kravene 1-9.
13. Farmaceutisk sammensætning, som omfatter mindst ét protein eller polypeptid ifølge et hvilket som helst af kravene 1-9 og eventuelt mindst én farmaceutisk acceptabel bærer.
14. Farmaceutisk sammensætning ifølge krav 13, eller protein eller polypeptid ifølge et hvilket som helst af kravene 1-9, til anvendelse ved en fremgangsmåde til forebyggelse eller behandling af en sygdom eller lidelse relateret til trombocytmedieret aggregering valgt blandt ikke-okklusiv trombe, dannelse af en okklusiv trombe, arteriel trombedannelse, akut koronarokklusion, perifer arteriel okklusiv sygdom, restenose og lidelser forårsaget af koronar-bypasstransplantat, koronararterie-klapudskiftning og koronarinterventioner såsom angioplastik, stenting eller aterektomi, hyperplasi efter angioplastik, aterektomi eller arteriel stenting, okklusivt syndrom i et vaskulært system eller manglende åbenhed af sygdomsramte arterier, trombotisk trombocytopenisk purpura (TTP), transitorisk cerebralt iskæmisk attak og apopleksi, ustabil eller stabil angina pectoris, cerebralt infarkt, HELLP-syndrom, carotis-endarterektomi, stenose i arteria carotis, kritisk iskæmi i ekstremitet, kardioemboli, perifer vaskulær sygdom, restenose og myokardieinfarkt, og eventuelt yderligere indeholdende et eller flere andre aktive stoffer til forebyggelse eller behandling af aggregeringsmedierede lidelser, såsom aspirin (Aspegic), heparin, Plavix® og/eller ReoPro®.
15. Anvendelse af et protein eller polypeptid ifølge et hvilket som helst af kravene 1-9 til fremstilling af et lægemiddel til forebyggelse eller behandling af en sygdom eller lidelse relateret til trombocytmedieret aggregering valgt blandt ikke-okklusiv trombe, dannelse af en okklusiv trombe, arteriel trombedannelse, akut koronarokklusion, perifer arteriel okklusiv sygdom, restenose og lidelser forårsaget af koronar-bypasstransplantat, koronararterie-klapudskiftning og koronarinterventioner såsom angioplastik, stenting eller aterektomi, hyperplasi efter angioplastik, aterektomi eller arteriel stenting, okklusivt syndrom i et vaskulært system eller manglende åbenhed af sygdomsramte arterier, trombotisk trombocytopenisk purpura (TTP), transitorisk cerebralt iskæmisk attak og apopleksi, ustabil eller stabil angina pectoris, cerebralt infarkt, HELLP-syndrom, carotis-endarterektomi, stenose i arteria carotis, kritisk iskæmi i ekstremitet, kardioemboli, perifer vaskulær sygdom, restenose og myokardieinfarkt.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68347405P | 2005-05-20 | 2005-05-20 | |
| EP06776035A EP2007814A2 (en) | 2005-05-20 | 2006-05-19 | Single domain vhh antibodies against von willebrand factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2444424T3 true DK2444424T3 (da) | 2018-12-03 |
Family
ID=37431613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12151893.0T DK2444424T3 (da) | 2005-05-20 | 2006-05-19 | Forbedrede nanolegemer (tm) til behandling af aggregeringsmedierede lidelser |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US7807162B2 (da) |
| EP (4) | EP2444424B1 (da) |
| JP (1) | JP4986997B2 (da) |
| KR (1) | KR101414438B1 (da) |
| CN (1) | CN101213214B (da) |
| AU (1) | AU2006249090B2 (da) |
| BE (1) | BE2019C503I2 (da) |
| BR (1) | BRPI0609797B8 (da) |
| CA (2) | CA2960105A1 (da) |
| CY (2) | CY1122579T1 (da) |
| DK (1) | DK2444424T3 (da) |
| ES (2) | ES2852423T3 (da) |
| FR (1) | FR19C1005I2 (da) |
| HU (2) | HUE039846T2 (da) |
| IL (2) | IL187168A (da) |
| LT (2) | LT2444424T (da) |
| LU (1) | LUC00099I2 (da) |
| MX (1) | MX2007014564A (da) |
| NL (1) | NL300966I2 (da) |
| NO (3) | NO20076475L (da) |
| NZ (1) | NZ563392A (da) |
| PL (2) | PL2444424T3 (da) |
| PT (2) | PT2444424T (da) |
| RU (1) | RU2433139C2 (da) |
| SI (1) | SI2444424T1 (da) |
| TR (1) | TR201815552T4 (da) |
| WO (1) | WO2006122825A2 (da) |
| ZA (1) | ZA200709570B (da) |
Families Citing this family (260)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003251238A1 (en) | 2002-08-07 | 2004-02-25 | Umc Utrecht Holding B.V. | Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha |
| WO2010081856A1 (en) * | 2009-01-14 | 2010-07-22 | Ablynx Nv | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
| US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
| EP1587838B1 (en) | 2003-01-10 | 2015-04-15 | Ablynx N.V. | Therapeutic polypeptides, homologues thereof, fragments thereof and their use in modulating platelet-mediated aggregation |
| SI2311874T1 (sl) | 2004-07-22 | 2017-12-29 | Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics | Vezavne molekule |
| DK1836500T3 (da) * | 2005-01-14 | 2010-11-01 | Ablynx Nv | Fremgangsmåde og assays til at skelne mellem forskellige former af sygdomme og lidelser, der er kendetegnet ved thrombocytopeni og/eller ved spantan interaktion mellem von Willbrandfaktor 8vWF) og blodplader |
| ES2852423T3 (es) | 2005-05-20 | 2021-09-13 | Ablynx Nv | NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación |
| WO2008049881A2 (en) * | 2006-10-25 | 2008-05-02 | Umc Utrecht Holding Bv | Polypeptides and pharmaceutical compositions comprising the same for the prevention and treatment of complications associated with infectious diseases |
| US20100129354A1 (en) * | 2006-10-27 | 2010-05-27 | Ablynx N.V. | Intranasal delivery of polypeptides and proteins |
| WO2008074839A2 (en) | 2006-12-19 | 2008-06-26 | Ablynx N.V. | Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders |
| EP2102244A2 (en) | 2006-12-19 | 2009-09-23 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders |
| US9512236B2 (en) | 2006-12-19 | 2016-12-06 | Ablynx N.V. | Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
| JP2010518839A (ja) * | 2007-02-21 | 2010-06-03 | アブリンクス エン．ヴェー． | 血管内皮増殖因子に指向性を有するアミノ酸配列、及び過度の及び／もしくは病的な血管形成又は血管新生を特徴とする症状及び疾患を治療するためにこれを含むポリペプチド |
| CN101796072B (zh) * | 2007-05-24 | 2014-09-24 | 埃博灵克斯股份有限公司 | 用于治疗骨疾病和病症的针对rank-l的氨基酸序列以及包括其的多肽 |
| EP2173772A2 (en) | 2007-07-03 | 2010-04-14 | Ablynx N.V. | Providing improved immunoglobulin sequences by mutating cdr and/or fr positions |
| EP2220120A2 (en) | 2007-11-27 | 2010-08-25 | Ablynx N.V. | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same |
| US20110183861A1 (en) * | 2008-01-29 | 2011-07-28 | Ablynn N.V. | Methods to stabilize proteins and polypeptides |
| CN101965362A (zh) * | 2008-03-05 | 2011-02-02 | 埃博灵克斯股份有限公司 | 新型抗原结合二聚体-复合物及其制备方法和应用 |
| EP2252303A2 (en) * | 2008-03-21 | 2010-11-24 | Ablynx NV | Von willebrand factor specific binders and methods of use therefor |
| AU2009235467A1 (en) | 2008-04-07 | 2009-10-15 | Ablynx Nv | Single variable domains against the Notch pathways |
| EP2268668A1 (en) | 2008-04-17 | 2011-01-05 | Ablynx N.V. | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
| US8444976B2 (en) | 2008-07-02 | 2013-05-21 | Argen-X B.V. | Antigen binding polypeptides |
| GB2461546B (en) * | 2008-07-02 | 2010-07-07 | Argen X Bv | Antigen binding polypeptides |
| WO2010010119A1 (en) | 2008-07-22 | 2010-01-28 | Ablynx Nv | Amino acid sequences directed against multitarget scavenger receptors and polypeptides |
| WO2011026948A1 (en) | 2009-09-03 | 2011-03-10 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| WO2010100135A1 (en) | 2009-03-05 | 2010-09-10 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
| US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| GB0905023D0 (en) * | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| ES2551854T3 (es) | 2009-04-30 | 2015-11-24 | Ablynx N.V. | Procedimiento para la producción de anticuerpos de dominio |
| HUE051430T2 (hu) | 2009-07-10 | 2021-03-01 | Ablynx Nv | Eljárás variábilis domének elõállítására |
| US20110172398A1 (en) * | 2009-10-02 | 2011-07-14 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules for anti-angiogenesis therapy |
| US20120321640A1 (en) | 2009-12-01 | 2012-12-20 | Ablynx N.V. | Von willebrand factor specific binding agents and uses thereof |
| EP2513145B1 (en) | 2009-12-14 | 2018-01-24 | Ablynx N.V. | Single variable domain antibodies against ox40l, constructs and therapeutic use |
| WO2011083141A2 (en) | 2010-01-08 | 2011-07-14 | Ablynx Nv | Method for generation of immunoglobulin sequences by using lipoprotein particles |
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