DK2496698T3 - TRUNKERERET EPIDERIMAL VÆKSTFAKTORRECEPTOR (EGFRt) TIL TRUNKERET T-CELLEUDVÆLGELSE - Google Patents
TRUNKERERET EPIDERIMAL VÆKSTFAKTORRECEPTOR (EGFRt) TIL TRUNKERET T-CELLEUDVÆLGELSE Download PDFInfo
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- DK2496698T3 DK2496698T3 DK10829041.2T DK10829041T DK2496698T3 DK 2496698 T3 DK2496698 T3 DK 2496698T3 DK 10829041 T DK10829041 T DK 10829041T DK 2496698 T3 DK2496698 T3 DK 2496698T3
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/34—Antigenic peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
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Claims (14)
1. Modificeret EGFR-gen, der består af en sekvens, der koder for en trunkeret EGFR, der består af EGFR-domæne III, EGFR-transmembrandomæne og EGFR-domæne IV.
2. Gen ifølge krav 1, hvor det modificerede EGFR-gen er bundet til en nukleotidsekvens, der kun koder for GMCSFR-alfa-kædesignalsekvensen.
3. Gen ifølge krav 1 eller krav 2, hvor aminosyresekvensen kodet for af det modificerede EGFR-gen er mindst 90 % identisk med SEQ ID NO: 3.
4. Gen ifølge et hvilket som helst af krav 1-3, hvor aminosyresekvensen kodet for af det modificerede EGFR-gen består af SEQ ID NO: 3.
5. Konstrukt, der omfatter genet ifølge et hvilket som helst af krav 1-4, hvor det modificerede EGFR-gen er koblet med en nukleotidsekvens, der koder for en kimærisk antigenreceptor, der er specifik for et tumor-associeret antigen, hvor nukleotidsekvensen, der koder for en kimærisk antigenreceptor, er efterfulgt af en nukleotidsekvens, der koder for en fraspaltelig C-terminal 2A-linker og kodnings sekvensen for det modificerede EGFR-gen.
6. Konstrukt ifølge krav 5, hvor den kimæriske antigenreceptor, der er specifik for et tumor-associeret antigen er valgt fra CD19, CD20 og CD22.
7. Konstrukt ifølge krav 6, hvor det tumorassocierede antigen er CD 19.
8. Konstrukt ifølge krav 5 eller krav 7, hvor konstruktet er CD19R-CD28gg-Zeta(CO)-T2A-EGFRt, og omfatter en nukleotidsekvens, der koder for aminosyresekvensen SEQ ID NO: 6.
9. Genetisk modificeret population af T-celler transduceret med genet ifølge et hvilket som helst af krav 1-4, hvor genet er koblet til et a gen, der koder for en tumor-targetterende kimærisk antigenreceptor (CAR), hvor T-cellerne udtrykket inaktiv modificeret EGFR.
10. Population af T-celler ifølge krav 9, hvor T-cellerne er til anvendelse i adoptiv immunterapi.
11. Population af T-celler til anvendelse ifølge krav 10, hvor adoptiv immunterapi er til anvendelse ved behandling af cancer.
12. Ikke-immunogen udvælgelsesepitop kodet for at genet ifølge et hvilket som helst af krav 1-4 eller konstruktet ifølge et hvilket som helst af krav 5-8.
13. Udvælgelsesepitop ifølge krav 12, hvor udvælgelsesepitopen er til anvendelse i en anvendelse valgt fra: (a) anvendelse som et ikke-immunogent udvælgelsesredskab, der er foreneligt med immunmagnetisk udvælgelse; (b) anvendelse som en sporingsmarkør for in vivo T-cellepodning; og (c) anvendelse som et selvmordsgen til transducerede T-celler, der har immunterapeutisk potentiale, eventuelt til anvendelse som et selvmordsgen via cetuximabmedieret komplement og/eller antistofafhængig cellemedieret cytotoksicitets- (ADCC) baner.
14. Udvælgelsesepitop ifølge krav 12, hvor udvælgelsesepitopen er forenelig med immunmagnetisk udvælgelse og fremmer immunterapi hos cancerpatienter uden uønsket immunologisk afstødning af celleprodukter.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25756709P | 2009-11-03 | 2009-11-03 | |
| PCT/US2010/055329 WO2011056894A2 (en) | 2009-11-03 | 2010-11-03 | TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRANSDUCED T CELL SELECTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2496698T3 true DK2496698T3 (da) | 2019-04-15 |
Family
ID=43970727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10829041.2T DK2496698T3 (da) | 2009-11-03 | 2010-11-03 | TRUNKERERET EPIDERIMAL VÆKSTFAKTORRECEPTOR (EGFRt) TIL TRUNKERET T-CELLEUDVÆLGELSE |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US8802374B2 (da) |
| EP (3) | EP2496698B1 (da) |
| JP (6) | JP5956342B2 (da) |
| AU (4) | AU2010315243B2 (da) |
| CA (1) | CA2779526C (da) |
| DK (1) | DK2496698T3 (da) |
| ES (2) | ES2717629T3 (da) |
| HR (1) | HRP20190556T1 (da) |
| HU (1) | HUE044461T2 (da) |
| PL (1) | PL2496698T3 (da) |
| PT (1) | PT2496698T (da) |
| SI (1) | SI2496698T1 (da) |
| TR (1) | TR201904484T4 (da) |
| WO (1) | WO2011056894A2 (da) |
Families Citing this family (320)
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| DK2496698T3 (da) | 2009-11-03 | 2019-04-15 | Hope City | TRUNKERERET EPIDERIMAL VÆKSTFAKTORRECEPTOR (EGFRt) TIL TRUNKERET T-CELLEUDVÆLGELSE |
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| DK2496698T3 (da) | 2009-11-03 | 2019-04-15 | Hope City | TRUNKERERET EPIDERIMAL VÆKSTFAKTORRECEPTOR (EGFRt) TIL TRUNKERET T-CELLEUDVÆLGELSE |
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