DK2499139T3 - N1-pyrazolospiroketon-acetyl-coa-carboxylasehæmmere - Google Patents

N1-pyrazolospiroketon-acetyl-coa-carboxylasehæmmere

Info

Publication number: DK2499139T3
Authority: DK; Denmark
Prior art keywords: pyrazolospiroketon; acetyl; coa carboxylase; carboxylase; coa
Prior art date: 2009-11-10

Application number

DK10776438.3T

Other languages

English (en)

Inventor

Scott William Bagley

David Andrew Griffith

Daniel Wei-Shung Kung

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-11-10

Filing date

2010-10-29

Publication date

2014-01-27

2010-10-29 Application filed by Pfizer filed Critical Pfizer

2014-01-27 Application granted granted Critical

2014-01-27 Publication of DK2499139T3 publication Critical patent/DK2499139T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Child & Adolescent Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK10776438.3T 2009-11-10 2010-10-29 N1-pyrazolospiroketon-acetyl-coa-carboxylasehæmmere DK2499139T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25982309P	2009-11-10	2009-11-10
PCT/IB2010/054908 WO2011058474A1 (en)	2009-11-10	2010-10-29	N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors

Publications (1)

Publication Number	Publication Date
DK2499139T3 true DK2499139T3 (da)	2014-01-27

Family

ID=43357094

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK10776438.3T DK2499139T3 (da)	2009-11-10	2010-10-29	N1-pyrazolospiroketon-acetyl-coa-carboxylasehæmmere

Country Status (39)

Country	Link
US (4)	US8288405B2 (da)
EP (3)	EP2947082A1 (da)
JP (1)	JP5114610B1 (da)
KR (2)	KR101550557B1 (da)
CN (1)	CN102695708B (da)
AP (1)	AP3283A (da)
AR (1)	AR078944A1 (da)
AU (1)	AU2010317501B2 (da)
BR (1)	BR112012011072A2 (da)
CA (1)	CA2778886C (da)
CL (1)	CL2012000999A1 (da)
CO (1)	CO6541569A2 (da)
CR (1)	CR20120190A (da)
CU (1)	CU24077B1 (da)
DK (1)	DK2499139T3 (da)
DO (1)	DOP2012000128A (da)
EA (1)	EA020153B1 (da)
EC (1)	ECSP12011880A (da)
ES (1)	ES2444543T3 (da)
GE (1)	GEP20146169B (da)
HN (1)	HN2012000973A (da)
HR (1)	HRP20140025T1 (da)
IL (1)	IL219373A (da)
MA (1)	MA33734B1 (da)
MX (1)	MX2012005429A (da)
NI (1)	NI201200089A (da)
NZ (1)	NZ599815A (da)
PE (1)	PE20121469A1 (da)
PH (1)	PH12012500903A1 (da)
PL (1)	PL2499139T3 (da)
PT (1)	PT2499139E (da)
RS (1)	RS53156B (da)
SI (1)	SI2499139T1 (da)
TN (1)	TN2012000192A1 (da)
TW (1)	TWI394756B (da)
UA (1)	UA102336C2 (da)
UY (1)	UY33020A (da)
WO (1)	WO2011058474A1 (da)
ZA (1)	ZA201204231B (da)

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WO2011058474A1 (en)	2009-11-10	2011-05-19	Pfizer Inc.	N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors
WO2011075643A1 (en)	2009-12-18	2011-06-23	Incyte Corporation	Substituted heteroaryl fused derivatives as pi3k inhibitors
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AR081823A1 (es)	2010-04-14	2012-10-24	Incyte Corp	DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
US9062055B2 (en)	2010-06-21	2015-06-23	Incyte Corporation	Fused pyrrole derivatives as PI3K inhibitors
HRP20161178T1 (hr) *	2010-09-30	2016-11-04	Pfizer Inc.	N1-PIRAZOLOSPIROKETONSKI INHIBITORI ACETIL-CoA-KARBOKSILAZE
BR112013010310A2 (pt)	2010-10-29	2016-11-29	Pfizer	inibidores de acetil-coa carboxilase de lactama n1/n2
EP2655374B1 (en)	2010-12-20	2019-10-23	Incyte Holdings Corporation	N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
US9108984B2 (en)	2011-03-14	2015-08-18	Incyte Corporation	Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en)	2011-03-25	2012-10-04	Incyte Corporation	Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
MY162167A (en) *	2011-04-22	2017-05-31	Pfizer	Substituted acetyl-coa carboxylase inhibitors
KR102507287B1 (ko)	2011-09-02	2023-03-07	인사이트 홀딩스 코포레이션	Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es)	2012-04-02	2014-11-19	Incyte Corp	Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
AR094929A1 (es)	2013-02-28	2015-09-09	Bristol Myers Squibb Co	Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
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ES2731773T3 (es)	2013-03-14	2019-11-19	Celgene Quanticel Res Inc	Inhibidores de la histona desmetilasa
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EP3670496A3 (en)	2013-10-17	2020-09-30	Shionogi&Co., Ltd.	Acc2 inhibitors
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US9896436B2 (en)	2014-09-16	2018-02-20	Celgene Quanticel Research, Inc.	Histone demethylase inhibitors
BR112017005128A2 (pt)	2014-09-16	2018-07-31	Celgene Quanticel Res Inc	inibidores de histona desmetilase
MX2017003463A (es) *	2014-09-17	2017-07-13	Celgene Quanticel Res Inc	Inhibidores de histona desmetilasa.
CN107002262B (zh)	2014-11-10	2019-10-29	国立大学法人横浜国立大学	氧气发生用阳极
SI3831833T1 (sl)	2015-02-27	2023-03-31	Incyte Holdings Corporation	Postopki za pripravo inhibitorja PI3K
US9732097B2 (en)	2015-05-11	2017-08-15	Incyte Corporation	Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en)	2015-05-11	2018-06-05	Incyte Corporation	Crystalline forms of a PI3K inhibitor
US11541046B2 (en)	2017-06-30	2023-01-03	Quixgen, Inc.	Spirolactone compounds
FI3713942T3 (fi)	2017-11-21	2023-05-04	Pfizer	4-(4-(1-isopropyyli-7-okso-1,4,6,7-tetrahydrospiro[indatsoli-5,4'-piperidiini]-1'-karbonyyli)-6-metoksipyridin-2-yyli)bentsoehapon kiteinen 2-amino-2-(hydroksimetyyli)propaani-1,3-diolisuola
US11465991B2 (en)	2018-03-15	2022-10-11	Yale University	Pyrazole-containing macrophage migration inhibitory factor inhibitors
CA3101323A1 (en)	2018-06-01	2019-12-05	Incyte Corporation	Dosing regimen for the treatment of pi3k related disorders
US12521375B2 (en)	2020-05-21	2026-01-13	Shionogi & Co., Ltd.	Pharmaceutical composition for treating fatty liver disease
US10989621B1 (en)	2020-08-20	2021-04-27	Trinity Bay Equipment Holdings, LLC	Online pipe integrity testing system and method
CN112028834B (zh) *	2020-09-11	2022-03-29	济南悟通生物科技有限公司	一种阿贝西利的中间体的合成方法
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2010
- 2010-10-29 WO PCT/IB2010/054908 patent/WO2011058474A1/en not_active Ceased
- 2010-10-29 JP JP2012538444A patent/JP5114610B1/ja not_active Expired - Fee Related
- 2010-10-29 ES ES10776438.3T patent/ES2444543T3/es active Active
- 2010-10-29 BR BR112012011072A patent/BR112012011072A2/pt not_active IP Right Cessation
- 2010-10-29 NZ NZ599815A patent/NZ599815A/xx not_active IP Right Cessation
- 2010-10-29 SI SI201030476T patent/SI2499139T1/sl unknown
- 2010-10-29 PL PL10776438T patent/PL2499139T3/pl unknown
- 2010-10-29 CU CU2012000071A patent/CU24077B1/es active IP Right Grant
- 2010-10-29 EP EP15172294.9A patent/EP2947082A1/en not_active Withdrawn
- 2010-10-29 AP AP2012006269A patent/AP3283A/xx active
- 2010-10-29 UA UAA201205709A patent/UA102336C2/uk unknown
- 2010-10-29 AU AU2010317501A patent/AU2010317501B2/en not_active Ceased
- 2010-10-29 EP EP13183518.3A patent/EP2676958B1/en active Active
- 2010-10-29 KR KR1020147003056A patent/KR101550557B1/ko not_active Expired - Fee Related
- 2010-10-29 GE GEAP201012700A patent/GEP20146169B/en unknown
- 2010-10-29 DK DK10776438.3T patent/DK2499139T3/da active
- 2010-10-29 KR KR1020127014916A patent/KR101478517B1/ko not_active Expired - Fee Related
- 2010-10-29 PH PH1/2012/500903A patent/PH12012500903A1/en unknown
- 2010-10-29 RS RS20140068A patent/RS53156B/sr unknown
- 2010-10-29 CA CA2778886A patent/CA2778886C/en active Active
- 2010-10-29 CN CN201080059647.1A patent/CN102695708B/zh not_active Expired - Fee Related
- 2010-10-29 EP EP10776438.3A patent/EP2499139B1/en active Active
- 2010-10-29 MX MX2012005429A patent/MX2012005429A/es active IP Right Grant
- 2010-10-29 EA EA201290191A patent/EA020153B1/ru not_active IP Right Cessation
- 2010-10-29 PE PE2012000630A patent/PE20121469A1/es not_active Application Discontinuation
- 2010-10-29 HR HRP20140025AT patent/HRP20140025T1/hr unknown
- 2010-10-29 PT PT107764383T patent/PT2499139E/pt unknown
- 2010-11-05 TW TW099138179A patent/TWI394756B/zh not_active IP Right Cessation
- 2010-11-08 US US12/941,133 patent/US8288405B2/en active Active
- 2010-11-08 AR ARP100104147A patent/AR078944A1/es unknown
- 2010-11-10 UY UY0001033020A patent/UY33020A/es not_active Application Discontinuation
2012
- 2012-04-18 CR CR20120190A patent/CR20120190A/es unknown
- 2012-04-19 CL CL2012000999A patent/CL2012000999A1/es unknown
- 2012-04-23 IL IL219373A patent/IL219373A/en not_active IP Right Cessation
- 2012-04-25 TN TNP2012000192A patent/TN2012000192A1/fr unknown
- 2012-05-07 HN HN2012000973A patent/HN2012000973A/es unknown
- 2012-05-08 DO DO2012000128A patent/DOP2012000128A/es unknown
- 2012-05-09 NI NI201200089A patent/NI201200089A/es unknown
- 2012-05-10 CO CO12077270A patent/CO6541569A2/es unknown
- 2012-05-10 MA MA34850A patent/MA33734B1/fr unknown
- 2012-05-10 EC ECSP12011880 patent/ECSP12011880A/es unknown
- 2012-06-08 ZA ZA2012/04231A patent/ZA201204231B/en unknown
- 2012-10-04 US US13/644,415 patent/US8507681B2/en active Active
2013
- 2013-07-11 US US13/939,450 patent/US8802690B2/en active Active
2014
- 2014-05-09 US US14/273,912 patent/US9139587B2/en active Active

Also Published As

Publication number	Publication date
CO6541569A2 (es)	2012-10-16
GEP20146169B (en)	2014-09-25
HN2012000973A (es)	2015-03-02
CU24077B1 (es)	2015-03-30
DOP2012000128A (es)	2012-08-31
JP5114610B1 (ja)	2013-01-09
HK1173724A1 (en)	2013-05-24
CR20120190A (es)	2012-05-24
BR112012011072A2 (pt)	2017-06-20
UA102336C2 (uk)	2013-06-25
US8288405B2 (en)	2012-10-16
EP2676958A1 (en)	2013-12-25
MX2012005429A (es)	2012-06-19
KR101478517B1 (ko)	2015-01-02
TW201127838A (en)	2011-08-16
IL219373A0 (en)	2012-06-28
TWI394756B (zh)	2013-05-01
AP2012006269A0 (en)	2012-06-30
EP2499139A1 (en)	2012-09-19
EA201290191A1 (ru)	2012-12-28
HRP20140025T1 (hr)	2014-02-14
MA33734B1 (fr)	2012-11-01
US20130296319A1 (en)	2013-11-07
EP2499139B1 (en)	2013-12-11
PE20121469A1 (es)	2012-11-01
AU2010317501A1 (en)	2012-05-17
ECSP12011880A (es)	2012-07-31
CU20120071A7 (es)	2013-05-31
IL219373A (en)	2014-04-30
US20140288111A1 (en)	2014-09-25
US8507681B2 (en)	2013-08-13
KR101550557B1 (ko)	2015-09-04
SI2499139T1 (sl)	2014-01-31
US20110111046A1 (en)	2011-05-12
US20130030181A1 (en)	2013-01-31
CA2778886C (en)	2014-01-07
CN102695708A (zh)	2012-09-26
RS53156B (sr)	2014-06-30
AP3283A (en)	2015-05-31
EA020153B1 (ru)	2014-09-30
EP2947082A1 (en)	2015-11-25
AU2010317501B2 (en)	2013-06-06
KR20120099460A (ko)	2012-09-10
CA2778886A1 (en)	2011-05-19
ZA201204231B (en)	2013-02-27
EP2676958B1 (en)	2015-07-01
ES2444543T3 (es)	2014-02-25
WO2011058474A8 (en)	2012-04-26
NZ599815A (en)	2013-04-26
PT2499139E (pt)	2014-02-10
PL2499139T3 (pl)	2014-04-30
NI201200089A (es)	2012-08-20
US9139587B2 (en)	2015-09-22
US8802690B2 (en)	2014-08-12
WO2011058474A1 (en)	2011-05-19
JP2013510192A (ja)	2013-03-21
TN2012000192A1 (fr)	2013-12-12
UY33020A (es)	2011-06-30
AR078944A1 (es)	2011-12-14
KR20140034919A (ko)	2014-03-20
CN102695708B (zh)	2014-10-15
PH12012500903A1 (en)	2014-09-24
CL2012000999A1 (es)	2012-07-20

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DK2499139T3 (da)	2014-01-27	N1-pyrazolospiroketon-acetyl-coa-carboxylasehæmmere
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DE112010004215A5 (de)	2012-08-23	Hydrostataktor
DE112010002949A5 (de)	2012-09-06	Kupplungstastpunkte
EP2469625A4 (en)	2015-11-04	OMNIBUS BAR
EP2445547A4 (en)	2012-12-12	CATHETERISM SYSTEM
EP2491340A4 (en)	2014-12-24	TELEMETRY PHOTOGRAPHIC APPARATUS
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DK2430035T3 (da)	2013-05-27	Uracylspipooxetannukleosider
BRPI1008827A2 (pt)	2016-02-23	deisobutenizador
BRPI1014968A2 (pt)	2016-12-13	subalargador
DE112010002728A5 (de)	2012-06-21	Turboinhalator
DE112010004249A5 (de)	2012-11-29	Spindelaktor
EP2446176A4 (en)	2016-12-14	CYLINDER SEAL
DE112009005323A5 (de)	2012-07-26	Hebelarmprüfmaschine
DK2519512T3 (da)	2019-05-27	N1-acyl-5-fluorpyrimidinonderivater
DE112009005462T8 (de)	2013-03-28	Lenkungsssteuervorrichtung
BRPI1008070A2 (pt)	2016-03-15	tricianoboratos
BR112012004964A2 (pt)	2016-04-05	girocóptero
EP2409976A4 (en)	2012-09-19	GLYCINE TRANSPORTER INHIBITOR
DK2483126T3 (da)	2015-06-22	Skinnekøretøj
DE112010004865T8 (de)	2013-01-24	Lamellennassreibkupplung