ATE509023T1 - Spirochromanon-derivate als acetyl-koenzym-a- carboxylase-hemmer - Google Patents

Spirochromanon-derivate als acetyl-koenzym-a- carboxylase-hemmer

Info

Publication number
ATE509023T1
ATE509023T1 AT06787451T AT06787451T ATE509023T1 AT E509023 T1 ATE509023 T1 AT E509023T1 AT 06787451 T AT06787451 T AT 06787451T AT 06787451 T AT06787451 T AT 06787451T AT E509023 T1 ATE509023 T1 AT E509023T1
Authority
AT
Austria
Prior art keywords
acetyl coenzyme
carboxylase inhibitors
spirochromanone
derivatives
spirochromanone derivatives
Prior art date
Application number
AT06787451T
Other languages
English (en)
Inventor
Takeru Yamakawa
Hideki Jona
Kenji Niiyama
Koji Yamada
Tomoharu Iino
Mitsuru Ohkubo
Hideaki Imamura
Jun Shibata
Jun Kusunoki
Lihu Yang
Original Assignee
Merck Sharp & Dohme
Msd Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Msd Kk filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE509023T1 publication Critical patent/ATE509023T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT06787451T 2005-07-19 2006-07-14 Spirochromanon-derivate als acetyl-koenzym-a- carboxylase-hemmer ATE509023T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70038205P 2005-07-19 2005-07-19
PCT/US2006/027543 WO2007011809A1 (en) 2005-07-19 2006-07-14 Spirochromanone derivatives as acetyl coenzyme a carboxylase (acc) inhibitors

Publications (1)

Publication Number Publication Date
ATE509023T1 true ATE509023T1 (de) 2011-05-15

Family

ID=37317248

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06787451T ATE509023T1 (de) 2005-07-19 2006-07-14 Spirochromanon-derivate als acetyl-koenzym-a- carboxylase-hemmer

Country Status (20)

Country Link
US (2) US7410976B2 (de)
EP (1) EP1910375B1 (de)
JP (1) JP5076159B2 (de)
KR (1) KR20080036041A (de)
CN (1) CN101238132A (de)
AR (1) AR054842A1 (de)
AT (1) ATE509023T1 (de)
AU (1) AU2006270145B2 (de)
BR (1) BRPI0613427A2 (de)
CA (1) CA2614963C (de)
DO (1) DOP2006000170A (de)
IL (1) IL188417A0 (de)
MX (1) MX2008000966A (de)
NO (1) NO20080865L (de)
NZ (1) NZ564591A (de)
PE (1) PE20070527A1 (de)
RU (1) RU2422446C2 (de)
TW (1) TW200728307A (de)
WO (2) WO2007011811A1 (de)
ZA (1) ZA200711119B (de)

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EP2097420B1 (de) * 2006-11-29 2012-04-04 Pfizer Products Inc. Spiroketone als inhibitoren von acetyl-coa-carboxylase
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US8138197B2 (en) 2007-01-12 2012-03-20 Msd K.K. Spirochromanon derivatives
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BR112013019211A2 (pt) 2011-02-02 2021-07-06 Vertex Pharma amidas de piperidina espirocíclicas de pirrolopirazina como moduladores de canais de íon
CN103443105A (zh) * 2011-02-18 2013-12-11 沃泰克斯药物股份有限公司 作为离子通道调节剂的苯并二氢吡喃-螺环哌啶酰胺
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
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Also Published As

Publication number Publication date
JP2009502785A (ja) 2009-01-29
ZA200711119B (en) 2009-12-30
CA2614963C (en) 2014-10-07
DOP2006000170A (es) 2007-03-31
AR054842A1 (es) 2007-07-18
EP1910375A1 (de) 2008-04-16
US7410976B2 (en) 2008-08-12
RU2008106243A (ru) 2009-08-27
EP1910375B1 (de) 2011-05-11
RU2422446C2 (ru) 2011-06-27
MX2008000966A (es) 2008-03-26
BRPI0613427A2 (pt) 2012-10-30
CN101238132A (zh) 2008-08-06
US7935712B2 (en) 2011-05-03
IL188417A0 (en) 2008-11-03
NO20080865L (no) 2008-04-18
WO2007011809A1 (en) 2007-01-25
CA2614963A1 (en) 2007-01-25
AU2006270145B2 (en) 2011-04-14
AU2006270145A1 (en) 2007-01-25
US20090131464A1 (en) 2009-05-21
US20070021453A1 (en) 2007-01-25
PE20070527A1 (es) 2007-06-14
JP5076159B2 (ja) 2012-11-21
WO2007011811A1 (en) 2007-01-25
KR20080036041A (ko) 2008-04-24
TW200728307A (en) 2007-08-01
NZ564591A (en) 2010-01-29

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