DK250181A - Fremgangsmaade til fremstilling af vinblastinderivater - Google Patents

Fremgangsmaade til fremstilling af vinblastinderivater

Info

Publication number: DK250181A
Authority: DK; Denmark
Prior art keywords: preparation; wine; blast; ingredients; procedure
Prior art date: 1980-06-10

Application number

DK250181A

Other languages

English (en)

Other versions

DK160614B (da

DK160614C (da

Inventor

A B L Trouet

K S B Rao

J A A Hannart

Original Assignee

Omnichem Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-10

Filing date

1981-06-09

Publication date

1981-12-11

1980-06-10 Priority claimed from LU82514A external-priority patent/LU82514A1/fr

1980-12-23 Priority claimed from LU83034A external-priority patent/LU83034A1/fr

1981-06-09 Application filed by Omnichem Sa filed Critical Omnichem Sa

1981-12-11 Publication of DK250181A publication Critical patent/DK250181A/da

1991-04-02 Publication of DK160614B publication Critical patent/DK160614B/da

1991-09-23 Application granted granted Critical

1991-09-23 Publication of DK160614C publication Critical patent/DK160614C/da

Links

239000004615 ingredient Substances 0.000 title 1
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 1
150000003862 amino acid derivatives Chemical class 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
-1 peptide derivatives Natural products 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
229960003048 vinblastine Drugs 0.000 abstract 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical class C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

DK250181A 1980-06-10 1981-06-09 Analogifremgangsmaade til fremstilling af vinblastinderivater og farmaceutisk acceptable salte deraf DK160614C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
LU82514		1980-06-10
LU82514A LU82514A1 (fr)	1980-06-10	1980-06-10	Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
LU83034A LU83034A1 (fr)	1980-12-23	1980-12-23	Derives n-(vinblastinoyl-23) d'acides amines et de peptides, leur preparation et leur application therapeutique
LU83034		1980-12-23

Publications (3)

Publication Number	Publication Date
DK250181A true DK250181A (da)	1981-12-11
DK160614B DK160614B (da)	1991-04-02
DK160614C DK160614C (da)	1991-09-23

Family

ID=26640267

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK250181A DK160614C (da)	1980-06-10	1981-06-09	Analogifremgangsmaade til fremstilling af vinblastinderivater og farmaceutisk acceptable salte deraf

Country Status (21)

Country	Link
US (1)	US4388305A (da)
EP (1)	EP0041935B1 (da)
AT (2)	AT390793B (da)
AU (1)	AU541747B2 (da)
CA (1)	CA1196326A (da)
DD (1)	DD160417A5 (da)
DE (2)	DE3122479A1 (da)
DK (1)	DK160614C (da)
ES (1)	ES8203385A1 (da)
FR (1)	FR2483926A1 (da)
GB (1)	GB2078730A (da)
GR (1)	GR74565B (da)
HU (1)	HU185261B (da)
IE (1)	IE51403B1 (da)
IL (1)	IL63038A0 (da)
IT (1)	IT1144601B (da)
NL (1)	NL8102802A (da)
NZ (1)	NZ197299A (da)
OA (1)	OA06421A (da)
PT (1)	PT73161B (da)
SE (1)	SE8103594L (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4639456A (en) *	1980-06-10	1987-01-27	Omnichem S.A.	Vinblastin-23-oyl amino acid derivatives
LU83822A1 (fr) *	1981-12-08	1983-09-01	Omnichem Sa	Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique
IT1170152B (it) *	1982-07-19	1987-06-03	Lilly Co Eli	Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
DK167984A (da) *	1983-03-30	1984-10-01	Lilly Industries Ltd	Alkaloidderivater
ATE64396T1 (de) *	1983-04-29	1991-06-15	Omnichem Sa	Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
FI860456A7 (fi) *	1985-07-16	1987-01-17	Huhtamaeki Oy Laeaeketehdas Le	Bis-indolalkaloiders proteinkonjugat, bis-indolalkaloider, deras framstaellning och anvaendning.
EP0232693A3 (fr) *	1985-12-16	1988-04-06	La Region Wallonne	Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant
JPH075608B2 (ja) *	1986-01-13	1995-01-25	イ−ル−セルタ−クソシエテアノニム	ビンブラスチン誘導体
ES2045092T3 (es) *	1987-11-11	1994-01-16	Akzo Nv	Un procedimiento de manufactura de un producto farmaceutico para tratamiento de cancer.
FR2623504B1 (fr) *	1987-11-25	1990-03-09	Adir	Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2626882B1 (fr) *	1988-02-08	1991-11-08	Ire Celltarg Sa	Conjugues de derives de vinca comportant une chaine detergente en position c-3
US4980343A (en) *	1988-10-27	1990-12-25	Bayer Aktiengesellschaft	Aminooxodihydroisoindoloquinazoline carcinostatic agents
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
US5599686A (en) *	1994-06-28	1997-02-04	Merck & Co., Inc.	Peptides
US6143864A (en) *	1994-06-28	2000-11-07	Merck & Co., Inc.	Peptides
US5866679A (en) *	1994-06-28	1999-02-02	Merck & Co., Inc.	Peptides
JP4157600B2 (ja) *	1994-08-19	2008-10-01	ラレフィオンバロンネ	化合物、製剤用組成物及びこれらを含む診断装置とこれらの利用
BE1008581A3 (fr) *	1994-08-19	1996-06-04	Wallone Region	Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
US5998362A (en) *	1996-09-12	1999-12-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US5948750A (en) *	1996-10-30	1999-09-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US6127333A (en) *	1997-07-10	2000-10-03	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US6391305B1 (en)	1997-09-10	2002-05-21	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
WO2000006582A1 (en) *	1998-07-31	2000-02-10	Goldsmith Seeds, Inc.	Trimeric and polymeric alkaloids
DE19842416A1 (de) *	1998-09-16	2000-04-13	Max Planck Gesellschaft	Sekundäre Amine zur Prävention und Therapie von Erkrankungen, die durch Oxidationsprozesse verursacht oder verstärkt werden
US7425541B2 (en)	1998-12-11	2008-09-16	Medarex, Inc.	Enzyme-cleavable prodrug compounds
JP2004510702A (ja)	2000-06-14	2004-04-08	メダレックス，インコーポレイティド	イソロイシンを有するプロドラッグ化合物
US20030232760A1 (en) *	2001-09-21	2003-12-18	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
WO2005055943A2 (en) *	2003-12-04	2005-06-23	Amr Technology, Inc.	Vinorelbine derivatives
WO2005055939A2 (en) *	2003-12-04	2005-06-23	Amr Technology, Inc.	Vinca derivatives
US20080125451A1 (en) *	2006-09-12	2008-05-29	Amr Technology, Inc.	Vinorelbine derivatives
US8039453B2 (en) *	2006-09-12	2011-10-18	Albany Molecular Research, Inc.	Vinca derivatives
PH12022553378A1 (en)	2020-06-10	2024-03-25	Univ Leuven Kath	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
JP2024525589A (ja)	2021-07-09	2024-07-12	アリゴスセラピューティクスインコーポレイテッド	抗ウイルス化合物
WO2023043816A1 (en)	2021-09-17	2023-03-23	Aligos Therapeutics, Inc.	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
AR204004A1 (es) *	1973-04-02	1975-11-12	Lilly Co Eli	Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
GR69783B (da) *	1976-09-08	1982-07-07	Lilly Co Eli
US4203898A (en) *	1977-08-29	1980-05-20	Eli Lilly And Company	Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

1979
- 1979-12-13 OA OA56972A patent/OA06421A/xx unknown
1981
- 1981-05-30 ES ES502644A patent/ES8203385A1/es not_active Expired
- 1981-06-02 GR GR65133A patent/GR74565B/el unknown
- 1981-06-02 AU AU71262/81A patent/AU541747B2/en not_active Ceased
- 1981-06-03 NZ NZ197299A patent/NZ197299A/en unknown
- 1981-06-03 US US06/269,876 patent/US4388305A/en not_active Expired - Fee Related
- 1981-06-04 IE IE1275/81A patent/IE51403B1/en not_active IP Right Cessation
- 1981-06-04 CA CA000379041A patent/CA1196326A/en not_active Expired
- 1981-06-04 IL IL63038A patent/IL63038A0/xx not_active IP Right Cessation
- 1981-06-05 DE DE19813122479 patent/DE3122479A1/de not_active Withdrawn
- 1981-06-05 AT AT0253881A patent/AT390793B/de not_active IP Right Cessation
- 1981-06-08 IT IT67782/81A patent/IT1144601B/it active
- 1981-06-08 GB GB8117454A patent/GB2078730A/en not_active Withdrawn
- 1981-06-09 EP EP81870028A patent/EP0041935B1/fr not_active Expired
- 1981-06-09 DE DE8181870028T patent/DE3166150D1/de not_active Expired
- 1981-06-09 DK DK250181A patent/DK160614C/da not_active IP Right Cessation
- 1981-06-09 SE SE8103594A patent/SE8103594L/xx not_active Application Discontinuation
- 1981-06-09 PT PT73161A patent/PT73161B/pt unknown
- 1981-06-09 AT AT81870028T patent/ATE9475T1/de active
- 1981-06-09 DD DD81230660A patent/DD160417A5/de not_active IP Right Cessation
- 1981-06-09 FR FR8111330A patent/FR2483926A1/fr active Granted
- 1981-06-10 NL NL8102802A patent/NL8102802A/nl not_active Application Discontinuation
- 1981-06-10 HU HU811725A patent/HU185261B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE3166150D1 (en)	1984-10-25
AU541747B2 (en)	1985-01-17
PT73161B (fr)	1982-07-16
GR74565B (da)	1984-06-29
FR2483926B1 (da)	1983-07-29
CA1196326A (en)	1985-11-05
ATE9475T1 (de)	1984-10-15
FR2483926A1 (fr)	1981-12-11
ES502644A0 (es)	1982-04-01
PT73161A (fr)	1981-07-01
ES8203385A1 (es)	1982-04-01
EP0041935A1 (fr)	1981-12-16
IL63038A0 (en)	1981-09-13
EP0041935B1 (fr)	1984-09-19
NL8102802A (nl)	1982-01-04
HU185261B (en)	1984-12-28
IE51403B1 (en)	1986-12-24
NZ197299A (en)	1985-10-11
IT8167782A0 (it)	1981-06-08
SE8103594L (sv)	1981-12-11
ATA253881A (de)	1989-12-15
OA06421A (fr)	1981-09-30
DK160614B (da)	1991-04-02
DE3122479A1 (de)	1982-06-16
IT1144601B (it)	1986-10-29
GB2078730A (en)	1982-01-13
IE811275L (en)	1981-12-10
AT390793B (de)	1990-06-25
DD160417A5 (de)	1983-07-27
AU7126281A (en)	1981-12-17
US4388305A (en)	1983-06-14
DK160614C (da)	1991-09-23

Legal Events

Date	Code	Title	Description
1993-02-22	PBP	Patent lapsed

Publication	Publication Date	Title
DK250181A (da)	1981-12-11	Fremgangsmaade til fremstilling af vinblastinderivater
DE3166441D1 (en)	1984-11-08	Novel antihistamines, process for their preparation and pharmaceutical compositions containing them
DK0548114T5 (da)	1995-01-30	Mometason-furoat-monohydrat, fremgangsmåde til fremtilling deraf og farmaceutiske præparater indeholdende dette
DK0758248T3 (da)	2003-10-27	Formuleringer til faktor IX
DK165988C (da)	1993-07-26	Modificerede egliner b og c, deres anvendelse som proteaseinhibitorer, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende de modificerede egliner b og c
ATE270557T1 (de)	2004-07-15	Hochkonzentrierte, lyophilisierte und flüssige faktor-ix formulierungen
ES530805A0 (es)	1985-06-16	Un metodo para liberar sustancialmente de los agentes infecciosos a una composicion que contiene una proteina terapeutica o inmunologicamente activa
ATE26115T1 (de)	1987-04-15	Substituierte 8-phenylxanthine.
DK93685A (da)	1985-09-02	Benzisoselenazolthioner, fremgangsmaade til fremstilling af disse forbindelser og farmaceutiske praeparater indeholdende disse forbindelser
IL64292A (en)	1985-07-31	D-homoandrostane-17alpha-carboxylic acids,derivatives thereof and 17alpha-spiroethers,their manufacture and pharmaceutical compositions containing them
NO921382D0 (no)	1992-04-08	Amidinofenylalaninderivater, samt fremstilling, anvendelse og preparater inneholdende forbindelsene
FI813912L (fi)	1982-06-10	I laekemedel anvaendbara tricykliska cytosinderivat och foerfarande foer deras framstaellning
SE7613855L (sv)	1977-06-24	Peptidkarbazater
DE2961609D1 (en)	1982-02-11	Sila-substituted 1,4-dihydropyridine derivatives, processes for their preparation, pharmaceutical compositions and process for their preparation
SE8002831L (sv)	1980-10-17	Oxitetracyklinberedningar
SE8202962D0 (sv)	1982-05-11	2-metoxifenylestrar av n-substiterade aminosyror, forfarande for deras framstellning och farmaceutiska beredningar innehallande desamma
ES474052A1 (es)	1979-04-16	Procedimiento para la obtencion de 1,4-dihidropiridazinas 1-n-sustituidas.
FI810866A7 (fi)	1981-09-23	Substituoituja alkyylitioasyyliaminohappoja, niiden valmistusmenetelmiä ja farmaseuttfarmaseuttisia seoksia.
SE8304111D0 (sv)	1983-07-22	Amino derivatives of benzylidene-pyrrolo(2,1-b)-quinazolines and benzylidene-pyrido(2,1-b)quinazolines
IT8323052A0 (it)	1983-09-29	N-(2-mercaptopropionil)glicina, derivati della procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
JPS51136602A (en)	1976-11-26	Process for preparation of amino acid or peptide