DK2556071T3 - Kinasehæmmere og deres anvendelse til behandling af cancer - Google Patents

Kinasehæmmere og deres anvendelse til behandling af cancer Download PDF

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Publication number
DK2556071T3
DK2556071T3 DK11764988.9T DK11764988T DK2556071T3 DK 2556071 T3 DK2556071 T3 DK 2556071T3 DK 11764988 T DK11764988 T DK 11764988T DK 2556071 T3 DK2556071 T3 DK 2556071T3
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Prior art keywords
mmol
indazol
title compound
cancer
nmr
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DK11764988.9T
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English (en)
Inventor
Peter Brent Sampson
Yong Liu
Sze-Wan Li
Bryan T Forrest
Heinz W Pauls
Louise G Edwards
Miklos Feher
Narendra Kumar B Patel
Radoslaw Laufer
Guohua Pan
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Univ Health Network
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Priority claimed from PCT/CA2010/000518 external-priority patent/WO2010115279A1/en
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Publication of DK2556071T3 publication Critical patent/DK2556071T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Claims (13)

1. Forbindelse med følgende strukturformel:
eller et farmaceutisk acceptabelt salt deraf, hvor: Ra er F, methoxy, methyl eller ethyl; R4 er H eller methyl; og R6 er -CH=CH-(eventuelt substitueret phenyl), hvor phenyl i -CH=CH-(phenyl) eventuelt er substitueret med en eller flere substituenter udvalgt uafhængigt fra gruppen, der består af halogen, Ci-6 alkyl, Ci-6 haloalkyl, (Ci-6aminoalkyl), (Ci-6alkylamino)Ci-6 alkyl, (phenyl)Ci-e alkyl, amino, C-i-6alkylamino, Ci-6dialkylamino, -(CH2)0-3-A/-piperidinyl, -(CH2)o-3 -N- morpholinyl, -(CH2)0-3-A/-pyrrolidinyl, -(CH2)0-3-/V-piperazinyl og -(CH2)0-3-A/-oxazepanyl, hvor /V-piperazinyl eventuelt er Ν'-substitueret med C1-6 alkyl eller C-i-6 acyl.
2. Forbindelse ifølge krav 1, hvor forbindelsen har følgende strukturformel:
eller et farmaceutisk acceptabelt salt deraf.
3. Forbindelse ifølge krav 1, hvor forbindelsen har følgende strukturformel:
eller et farmaceutisk acceptabelt salt deraf.
4. Forbindelsen med følgende strukturformel:
eller et farmaceutisk acceptabelt salt deraf.
5. Forbindelse med følgende strukturformel:
eller et farmaceutisk acceptabelt salt deraf.
6. Forbindelse ifølge et hvilket som helst af kravene 1-5 eller et farmaceutisk acceptabelt salt deraf til anvendelse som et medikament.
7. Forbindelse ifølge et hvilket som helst af kravene 1-5 eller et farmaceutisk acceptabelt salt deraf til anvendelse til behandling af cancer.
8. Forbindelse eller salt deraf til anvendelse ifølge krav 7, hvor canceren er udvalgt fra gruppen, der består af lungecancer, brystcancer, coloncancer, hjernecancer, neuroblastom, prostatacancer, melanom, glioblastoma multiforme, ovariecancer, lymfom, leukæmi, melanom, sarkom, paraneoplasi, osteosarkom, germinom, gliom og mesoteliom.
9. Forbindelse eller salt deraf til anvendelse ifølge krav 8, hvor canceren er udvalgt fra gruppen, der består af lungecancer, brystcancer eller coloncancer.
10. Forbindelse eller salt deraf til anvendelse ifølge krav 9, hvor canceren er basal undertype brystcancer eller en luminal B-undertype brystcancer.
11. Forbindelse eller salt deraf til anvendelse ifølge krav 10, hvor canceren er en basal undertype brystcancer, der overudtrykker PLK4.
12. Forbindelse eller salt deraf til anvendelse ifølge krav 9, hvor canceren er basal undertype brystcancer, som er ER-, FIER2- og PR-negativ brystcancer.
13. Forbindelse eller salt deraf til anvendelse ifølge krav 7, hvor canceren er en bløddelscancer, hvor bløddelscanceren er et sarkom, der fortrinsvis er udvalgt fra gruppen, der består af et fibrosarkom, et gastrointestinalt sarkom, et leiomyosarkom, et dedifferentieret liposarkom, et pleomorfisk liposarkom, et malignt fibrøst histiocytom, et rundcellesarkom og et synovialt sarkom.
DK11764988.9T 2010-04-06 2011-04-06 Kinasehæmmere og deres anvendelse til behandling af cancer DK2556071T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32132910P 2010-04-06 2010-04-06
US32133210P 2010-04-06 2010-04-06
PCT/CA2010/000518 WO2010115279A1 (en) 2009-04-06 2010-04-06 Kinase inhibitors and method of treating cancer with same
PCT/CA2011/000386 WO2011123946A1 (en) 2010-04-06 2011-04-06 Kinase inhibitors and method of treating cancer with same

Publications (1)

Publication Number Publication Date
DK2556071T3 true DK2556071T3 (da) 2016-12-12

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Country Status (25)

Country Link
US (9) US8921545B2 (da)
EP (2) EP2556071B1 (da)
JP (1) JP5442906B2 (da)
KR (1) KR101782668B1 (da)
CN (1) CN102892766B (da)
AU (1) AU2011238384B2 (da)
BR (1) BR112012025496B1 (da)
CY (1) CY1118610T1 (da)
DK (1) DK2556071T3 (da)
EA (1) EA023173B1 (da)
ES (2) ES2603613T3 (da)
HR (1) HRP20161498T1 (da)
HU (1) HUE030651T2 (da)
IL (1) IL221556A (da)
LT (1) LT2556071T (da)
ME (1) ME02545B (da)
MX (1) MX2012011516A (da)
NZ (1) NZ602350A (da)
PL (1) PL2556071T3 (da)
PT (1) PT2556071T (da)
SG (1) SG183875A1 (da)
SI (1) SI2556071T1 (da)
SM (1) SMT201600430B (da)
TW (1) TWI516262B (da)
WO (2) WO2011123947A1 (da)

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