DK25587A - Toer, stabiliseret, partikelformig, fritstroemmende tocopherolsammensaetning - Google Patents

Toer, stabiliseret, partikelformig, fritstroemmende tocopherolsammensaetning

Info

Publication number: DK25587A
Authority: DK; Denmark
Prior art keywords: free; particulated; tours; stabilized; floating
Prior art date: 1986-01-16

Application number

DK025587A

Other languages

English (en)

Other versions

DK169230B1 (da

DK25587D0 (da

Inventor

Bruce E Wenzel

James P Clark

Original Assignee

Henkel Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-01-16

Filing date

1987-01-16

Publication date

1987-07-17

1987-01-16 Application filed by Henkel Corp filed Critical Henkel Corp

1987-01-16 Publication of DK25587D0 publication Critical patent/DK25587D0/da

1987-07-17 Publication of DK25587A publication Critical patent/DK25587A/da

1994-09-19 Application granted granted Critical

1994-09-19 Publication of DK169230B1 publication Critical patent/DK169230B1/da

Links

GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title abstract 5
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 title abstract 3
229960001295 tocopherol Drugs 0.000 title 1
229930003799 tocopherol Natural products 0.000 title 1
235000010384 tocopherol Nutrition 0.000 title 1
239000011732 tocopherol Substances 0.000 title 1
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
229930003427 Vitamin E Natural products 0.000 abstract 2
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 2
239000003381 stabilizer Substances 0.000 abstract 2
229940046009 vitamin E Drugs 0.000 abstract 2
235000019165 vitamin E Nutrition 0.000 abstract 2
239000011709 vitamin E Substances 0.000 abstract 2
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
229940087168 alpha tocopherol Drugs 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
235000010323 ascorbic acid Nutrition 0.000 abstract 1
229960005070 ascorbic acid Drugs 0.000 abstract 1
239000011668 ascorbic acid Substances 0.000 abstract 1
235000015165 citric acid Nutrition 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
150000001261 hydroxy acids Chemical class 0.000 abstract 1
235000006109 methionine Nutrition 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
229960000984 tocofersolan Drugs 0.000 abstract 1
239000002076 α-tocopherol Substances 0.000 abstract 1
235000004835 α-tocopherol Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Hematology (AREA)
Nutrition Science (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Compositions Of Macromolecular Compounds (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polyurethanes Or Polyureas (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Cosmetics (AREA)

DK025587A 1986-01-16 1987-01-16 Tør, styrkestabiliseret, partikelformig, fritstrømmende tocopherolsammensætning DK169230B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US81977986		1986-01-16
US06/819,779 US4711894A (en)	1986-01-16	1986-01-16	Stabilized tocopherol in dry, particulate, free-flowing form

Publications (3)

Publication Number	Publication Date
DK25587D0 DK25587D0 (da)	1987-01-16
DK25587A true DK25587A (da)	1987-07-17
DK169230B1 DK169230B1 (da)	1994-09-19

Family

ID=25229038

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK025587A DK169230B1 (da)	1986-01-16	1987-01-16	Tør, styrkestabiliseret, partikelformig, fritstrømmende tocopherolsammensætning

Country Status (9)

Country	Link
US (1)	US4711894A (da)
EP (1)	EP0229652B1 (da)
JP (1)	JP2677554B2 (da)
AT (1)	ATE68971T1 (da)
DE (1)	DE3774137D1 (da)
DK (1)	DK169230B1 (da)
ES (1)	ES2026851T3 (da)
FI (1)	FI87524C (da)
NO (1)	NO173318C (da)

Families Citing this family (45)

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DE3820693A1 (de) *	1988-06-18	1989-12-21	Henkel Kgaa	Topische kosmetische und pharmazeutische zubereitungen
US5120761A (en) *	1988-10-14	1992-06-09	Finnan Jeffrey L	Method of making a free-flowing spray dried edible powder comprising an oil
FI901046A7 (fi) *	1989-03-17	1990-09-18	Eisai Co Ltd	Polyprenyyliyhdisteen stabiloiminen
FI915717A7 (fi) *	1990-04-06	1991-12-04	Eisai Co Ltd	Katekoliyhdistettä sisältävä kiinteä oraalinen valmiste
US5234695A (en) *	1990-07-24	1993-08-10	Eastman Kodak Company	Water dispersible vitamin E composition
US6020003A (en) *	1998-02-23	2000-02-01	Basf Corporation	Method of making spray-dried powders with high edible-oil loadings based on non-hydrolyzed gelatin
US6613821B2 (en) *	1998-10-09	2003-09-02	Canon Kabushiki Kaisha	Cloth treating agent, cloth, textile printing process and print
US6303167B1 (en)	1998-11-09	2001-10-16	Archer-Daniels-Midland Company	Method of producing vitamin powders
US6716451B1 (en) *	1999-11-30	2004-04-06	Soft Gel Technologies, Inc.	Formulation and delivery method to enhance antioxidant potency of vitamin E
GB0017060D0 (en) *	2000-07-11	2000-08-30	Hunter Fleming Ltd	Production, stabilisation and use of reduced forms of pharmaceutical compounds
US7776314B2 (en)	2002-06-17	2010-08-17	Grunenthal Gmbh	Abuse-proofed dosage system
US7329688B2 (en) *	2002-12-17	2008-02-12	Soft Gel Technologies, Inc.	Natural vitamin E compositions with superior antioxidant potency
DE10311585A1 (de) *	2003-03-14	2004-09-23	Basf Ag	Wirkstoffhaltige Adsorbate
US20070237834A1 (en) *	2003-04-18	2007-10-11	Bioderm Research	Zinc Zeolite for the Treatment for Diaper Rash (Diaper Dermatitis)
DE102004032051A1 (de)	2004-07-01	2006-01-19	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE102005005446A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en)	2003-08-06	2007-03-01	Elisabeth Arkenau-Maric	Abuse-proofed dosage form
US8075872B2 (en)	2003-08-06	2011-12-13	Gruenenthal Gmbh	Abuse-proofed dosage form
DE10336400A1 (de)	2003-08-06	2005-03-24	Grünenthal GmbH	Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de)	2003-12-24	2005-09-29	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US9247765B2 (en)	2004-01-14	2016-02-02	Omniactive Health Technologies Limited	Stable beadlets of lipophilic nutrients
DE102004032049A1 (de)	2004-07-01	2006-01-19	Grünenthal GmbH	Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
KR20080098586A (ko) *	2005-12-22	2008-11-11	바스프 에스이	비타민 ｅ-흡착물의 제조 방법
DE102007011485A1 (de)	2007-03-07	2008-09-11	Grünenthal GmbH	Darreichungsform mit erschwertem Missbrauch
TWI454288B (zh)	2008-01-25	2014-10-01	Gruenenthal Chemie	藥物劑型
ES2599031T3 (es)	2008-05-09	2017-01-31	Grünenthal GmbH	Proceso para la preparación de una formulación de polvo intermedia y una forma de dosificación solida final utilizando un paso de congelación por pulverización
BR112012001466A2 (pt) *	2009-07-22	2020-08-11	Grünenthal GmbH	forma de dosagem resistente à falsificação para opioides sensíveis à oxidação, seu processo de fabricação, e embalagem
ES2534908T3 (es)	2009-07-22	2015-04-30	Grünenthal GmbH	Forma de dosificación de liberación controlada extruida por fusión en caliente
US9579285B2 (en)	2010-02-03	2017-02-28	Gruenenthal Gmbh	Preparation of a powdery pharmaceutical composition by means of an extruder
WO2012028318A1 (en)	2010-09-02	2012-03-08	Grünenthal GmbH	Tamper resistant dosage form comprising an anionic polymer
CA2808219C (en)	2010-09-02	2019-05-14	Gruenenthal Gmbh	Tamper resistant dosage form comprising inorganic salt
JP6063462B2 (ja)	2011-07-29	2017-01-18	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	即時薬剤放出を提供するタンパーレジスタント錠剤
BR112014002022A2 (pt)	2011-07-29	2017-02-21	Gruenenthal Gmbh	comprimido resistente à violação proporcionando liberação de fármaco imediata
BR112014019988A8 (pt)	2012-02-28	2017-07-11	Gruenenthal Gmbh	Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico
LT2838512T (lt)	2012-04-18	2018-11-12	GrĆ¼nenthal GmbH	Pažeidimui atspari ir dozės atpalaidavimo nuokrypiui atspari farmacinė vaisto forma
US10064945B2 (en)	2012-05-11	2018-09-04	Gruenenthal Gmbh	Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
MX2015016254A (es)	2013-05-29	2016-04-20	Gruenenthal Gmbh	Forma de dosificacion resistente al uso indebido con perfil de liberacion bimodal.
AU2014273227B2 (en)	2013-05-29	2019-08-15	Grunenthal Gmbh	Tamper-resistant dosage form containing one or more particles
AU2014289187B2 (en)	2013-07-12	2019-07-11	Grunenthal Gmbh	Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
HK1224189A1 (zh)	2013-11-26	2017-08-18	Grünenthal GmbH	通过低温研磨制备粉状药物组合物
WO2015173195A1 (en)	2014-05-12	2015-11-19	Grünenthal GmbH	Tamper resistant immediate release capsule formulation comprising tapentadol
US9872835B2 (en)	2014-05-26	2018-01-23	Grünenthal GmbH	Multiparticles safeguarded against ethanolic dose-dumping
WO2016170097A1 (en)	2015-04-24	2016-10-27	Grünenthal GmbH	Tamper-resistant dosage form with immediate release and resistance against solvent extraction
CA2998259A1 (en)	2015-09-10	2017-03-16	Grunenthal Gmbh	Protecting oral overdose with abuse deterrent immediate release formulations

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US3608083A (en) *	1968-06-05	1971-09-21	Hoffmann La Roche	Vitamin e powder
US3655852A (en) *	1969-08-01	1972-04-11	Hoffmann La Roche	Method of forming a stable vitamin e-c granulation
GB1444024A (en) *	1973-07-20	1976-07-28	Passwaterr A	Food and feed supplents
FR2244468A1 (en) *	1973-07-31	1975-04-18	Passwater Richard	Anticarcinogenic food supplements - contg antioxidants and S-contg amino acids
US3873694A (en) *	1973-09-27	1975-03-25	Cpc International Inc	Direct compression tabletting composition and pharmaceutical tablets produced therefrom
JPS5421403B2 (da) *	1974-01-18	1979-07-30
JPS53148546A (en) *	1977-05-31	1978-12-25	Asahi Denka Kogyo Kk	Cosmetic base composition
JPS56164749A (en) *	1980-05-22	1981-12-17	Chubu Shiryo Kk	Breeding method of livestock
US4395422A (en) *	1981-04-06	1983-07-26	Basf Wyandotte Corporation	Spray dried vitamin E powder
EP0107885B1 (en) *	1982-10-29	1987-07-29	Crinos Industria Farmacobiologica S.p.A.	Cosmetic preparations promoting the trophism of the skin and of the related hair follicles
JPS6025918A (ja) *	1983-07-25	1985-02-08	Ajinomoto Co Inc	脂溶性薬物含有水性液

1986
- 1986-01-16 US US06/819,779 patent/US4711894A/en not_active Expired - Fee Related
1987
- 1987-01-13 EP EP87100296A patent/EP0229652B1/en not_active Expired - Lifetime
- 1987-01-13 AT AT87100296T patent/ATE68971T1/de not_active IP Right Cessation
- 1987-01-13 ES ES198787100296T patent/ES2026851T3/es not_active Expired - Lifetime
- 1987-01-13 DE DE8787100296T patent/DE3774137D1/de not_active Expired - Lifetime
- 1987-01-15 NO NO870159A patent/NO173318C/no unknown
- 1987-01-16 DK DK025587A patent/DK169230B1/da not_active IP Right Cessation
- 1987-01-16 FI FI870169A patent/FI87524C/fi not_active IP Right Cessation
- 1987-01-16 JP JP62008862A patent/JP2677554B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3774137D1 (de)	1991-12-05
ES2026851T3 (es)	1992-05-16
US4711894A (en)	1987-12-08
NO870159L (no)	1987-07-17
NO173318B (no)	1993-08-23
NO870159D0 (no)	1987-01-15
FI870169L (fi)	1987-07-17
JP2677554B2 (ja)	1997-11-17
ATE68971T1 (de)	1991-11-15
FI87524C (fi)	1993-01-25
FI87524B (fi)	1992-10-15
JPS62190181A (ja)	1987-08-20
DK169230B1 (da)	1994-09-19
EP0229652A2 (en)	1987-07-22
FI870169A0 (fi)	1987-01-16
NO173318C (no)	1993-12-01
DK25587D0 (da)	1987-01-16
EP0229652B1 (en)	1991-10-30
EP0229652A3 (en)	1987-10-14

Legal Events

Date	Code	Title	Description
1994-09-19	B1	Patent granted (law 1993)
1997-09-15	PBP	Patent lapsed

Publication	Publication Date	Title
DK25587D0 (da)	1987-01-16	Toer, stabiliseret, partikelformig, fristroemmende tocopherolsammensaetning
AU532114B2 (en)	1983-09-15	Salts of n-substituted-2-pyrrolidone-4-carboxylic acids
DK581185A (da)	1986-06-15	Farmaceutisk praeparat indeholdende 13-cis-a-vitaminsyre
NO170126C (no)	1992-09-16	Fremgangsmaate for fremstilling av farmasoeytiske preparater i form av suspensjoner som inneholder sucralfat
NO172389C (no)	1993-07-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzotiazoler
DK0588539T3 (da)	1997-03-10	Stabiliserede farmaceutiske præparater indeholdende derivater af vitamin D2 og D3
NO843002L (no)	1985-01-28	Vandig loesning inneholdende en lipid-loeselig farmasoeytisk substans
DE69031219D1 (de)	1997-09-11	Stabile zusammensetzungen von askorbinsäure
DK605786A (da)	1987-06-18	Stabiliserede human-vaevsplasminogenaktivator-praeparater
IL75637A (en)	1990-02-09	Thymopentin analogs and pharmaceutical compositions containing them
NZ214967A (en)	1988-08-30	4h-1-benzopyran-4-one derivatives, sulphur analogues and pharmaceutical compositions
HUT51298A (en)	1990-04-28	Process for producing retarde hirudine derivatives and pharmaceutical compositions containing them as active components
DE3873688D1 (de)	1992-09-17	Stabilisierte pergolidzubereitungen.
FI883338A0 (fi)	1988-07-13	Vattenloesningar av doxorubicinhydroklorid.
SE7904284L (sv)	1979-11-18	Farmaceutiska beredningar som innehaller prostaglandiner samt forfarande for framstellning av dem
DK218388A (da)	1988-04-21	Aktivt princip isoleret fra hajvaev
ES2043959T3 (es)	1994-01-01	Preparado farmaceutico estabilizado, que contiene n-acetilcisteina.
ATE103178T1 (de)	1994-04-15	T-pa pro stabilisierung.
GB1350878A (en)	1974-04-24	Coumarin derivatives and production thereof
ES2012456B3 (es)	1990-04-01	Nuevos analogos de compuestos polipeptidicos hipocalcemicos que economizan el calcio del organismo, su preparacion, su aplicacion a titulo de medicamentos y las composiciones que encierran.
JPS57170151A (en)	1982-10-20	Feed for mulberry silkworm